Adjuvant low-dose rituximab and plasma exchange for acquired TTP
(Source: Blood)
Source: Blood - September 25, 2019 Category: Hematology Authors: Zwicker, J. I., Muia, J., Dolatshahi, L., Westfield, L. A., Nieters, P., Rodrigues, A., Hamdan, A., Antun, A. G., Metjian, A., Sadler, J. E., on behalf of the ART Investigators Tags: Thrombocytopenia, Platelets and Thrombopoiesis, Clinical Trials and Observations Letter to Blood Source Type: research
Synergistic effects of ADAMTS13 deficiency and complement activation in pathogenesis of thrombotic microangiopathy
Severe deficiency of plasma ADAMTS13 activity is the primary cause of thrombotic thrombocytopenic purpura (TTP) whereas overwhelming activation of complement via an alternative pathway results in atypical hemolytic uremic syndrome (aHUS), the prototypes of thrombotic microangiopathy (TMA). However, clinical and pathogenic distinctions between TTP and aHUS are often quite challenging. Clinical reports have suggested that complement activation may play a role in the development of TTP, which is caused by severe deficiency of plasma ADAMTS13 activity. However, the experimental evidence to support this hypothesis is still lack...
Source: Blood - September 25, 2019 Category: Hematology Authors: Zheng, L., Zhang, D., Cao, W., Song, W.-C., Zheng, X. L. Tags: Thrombocytopenia, Platelets and Thrombopoiesis, Thrombosis and Hemostasis Source Type: research
Cirmtuzumab blocks Wnt5a/ROR1 stimulation of NF-{kappa}B to repress autocrine STAT3 activation in chronic lymphocytic leukemia
Coculture of nurse-like cells (NLCs) with chronic lymphocytic leukemia (CLL) cells induced leukemia cell phosphorylation of STAT3 (pSTAT3), which could be blocked by anti-Wnt5a antibodies or the anti-ROR1 monoclonal antibody, cirmtuzumab. Time-course studies revealed Wnt5a could induce activation of NF-B within 30 minutes, but required more than 3 hours to induce pSTAT3. Culture of isolated CLL cells for 24 hours revealed Wnt5a-induced expression of interleukin 6 (IL-6), IL-8, CCL2, CCL3, CCL4, and CXCL1, which in turn could induce pSTAT3 in unstimulated CLL cells within 30 minutes. We found that Wnt5a could induce CLL cel...
Source: Blood - September 25, 2019 Category: Hematology Authors: Chen, Y., Chen, L., Yu, J., Ghia, E. M., Choi, M. Y., Zhang, L., Zhang, S., Sanchez-Lopez, E., Widhopf, G. F., Messer, K., Rassenti, L. Z., Jamieson, C., Kipps, T. J. Tags: Lymphoid Neoplasia Source Type: research
Antibiotics inhibit tumor and disease activity in cutaneous T-cell lymphoma
In conclusion, this study provides novel evidence suggesting that aggressive antibiotic treatment inhibits malignant T cells in lesional skin. Thus, we provide a novel rationale for treatment of SA in advanced CTCL. (Source: Blood)
Source: Blood - September 25, 2019 Category: Hematology Authors: Lindahl, L. M., Willerslev-Olsen, A., Gjerdrum, L. M. R., Nielsen, P. R., Blümel, E., Rittig, A. H., Celis, P., Herpers, B., Becker, J. C., Stausbol-Gron, B., Wasik, M. A., Gluud, M., Fredholm, S., Buus, T. B., Johansen, C., Nastasi, C., Peiffer, Tags: Lymphoid Neoplasia Source Type: research
Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs
We report the presence in fetal tissues of 2 distinct CD19+ B-progenitors, an adult-type CD10+ve ProB-progenitor and a new CD10-ve PreProB-progenitor, and describe their molecular and functional characteristics. PreProB-progenitors and ProB-progenitors appear early in the first trimester in embryonic liver, followed by a sustained second wave of B-progenitor development in fetal bone marrow (BM), where together they form >40% of the total hematopoietic stem cell/progenitor pool. Almost one-third of fetal B-progenitors are CD10-ve PreProB-progenitors, whereas, by contrast, PreProB-progenitors are almost undetectable (0.5...
Source: Blood - September 25, 2019 Category: Hematology Authors: OByrne, S., Elliott, N., Rice, S., Buck, G., Fordham, N., Garnett, C., Godfrey, L., Crump, N. T., Wright, G., Inglott, S., Hua, P., Psaila, B., Povinelli, B., Knapp, D. J. H. F., Agraz-Doblas, A., Bueno, C., Varela, I., Bennett, P., Koohy, H., Watt, S. M. Tags: Immunobiology and Immunotherapy, Lymphoid Neoplasia Source Type: research
Hematopoietic stem cell response to acute thrombocytopenia requires signaling through distinct receptor tyrosine kinases
Although bone marrow niche cells are essential for hematopoietic stem cell (HSC) maintenance, their interaction in response to stress is not well defined. Here, we used a mouse model of acute thrombocytopenia to investigate the cross talk between HSCs and niche cells during restoration of the thrombocyte pool. This process required membrane-localized stem cell factor (m-SCF) in megakaryocytes, which was regulated, in turn, by vascular endothelial growth factor A (VEGF-A) and platelet-derived growth factor-BB (PDGF-BB). HSCs and multipotent progenitors type 2 (MPP2), but not MPP3/4, were subsequently activated by a dual-rec...
Source: Blood - September 25, 2019 Category: Hematology Authors: Ramasz, B., Krüger, A., Reinhardt, J., Sinha, A., Gerlach, M., Gerbaulet, A., Reinhardt, S., Dahl, A., Chavakis, T., Wielockx, B., Grinenko, T. Tags: Hematopoiesis and Stem Cells, Thrombocytopenia, Platelets and Thrombopoiesis Source Type: research
Reduced ADAMTS13 activity during TTP remission is associated with stroke in TTP survivors
In conclusion, stroke is common after recovery from TTP and is associated with reduced ADAMTS13 activity during remission. (Source: Blood)
Source: Blood - September 25, 2019 Category: Hematology Authors: Upreti, H., Kasmani, J., Dane, K., Braunstein, E. M., Streiff, M. B., Shanbhag, S., Moliterno, A. R., Sperati, C. J., Gottesman, R. F., Brodsky, R. A., Kickler, T. S., Chaturvedi, S. Tags: Thrombosis and Hemostasis, Clinical Trials and Observations Source Type: research
Ibrutinib plus lenalidomide and rituximab has promising activity in relapsed/refractory non-germinal center B-cell-like DLBCL
This study was registered at www.clinicaltrials.gov as #NCT02077166. (Source: Blood)
Source: Blood - September 25, 2019 Category: Hematology Authors: Goy, A., Ramchandren, R., Ghosh, N., Munoz, J., Morgan, D. S., Dang, N. H., Knapp, M., Delioukina, M., Kingsley, E., Ping, J., Beaupre, D. M., Neuenburg, J. K., Ruan, J. Tags: Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research
Amino acid metabolism in hematologic malignancies and the era of targeted therapy
Tumor cells rewire metabolic pathways to adapt to their increased nutritional demands for energy, reducing equivalents, and cellular biosynthesis. Alternations in amino acid metabolism are 1 modality for satisfying those demands. Amino acids are not only components of proteins but also intermediate metabolites fueling multiple biosynthetic pathways. Amino acid–depletion therapies target amino acid uptake and catabolism using heterologous enzymes or recombinant or engineered human enzymes. Notably, such therapies have minimal effect on normal cells due to their lower demand for amino acids compared with tumor cells an...
Source: Blood - September 25, 2019 Category: Hematology Authors: Tabe, Y., Lorenzi, P. L., Konopleva, M. Tags: Myeloid Neoplasia, Review Articles Source Type: research
Effect of donor, component, and recipient characteristics on hemoglobin increments following red blood cell transfusion
Significant research has focused individually on blood donors, product preparation and storage, and optimal transfusion practice. To better understand the interplay between these factors on measures of red blood cell (RBC) transfusion efficacy, we conducted a linked analysis of blood donor and component data with patients who received single-unit RBC transfusions between 2008 and 2016. Hemoglobin levels before and after RBC transfusions and at 24- and 48-hour intervals after transfusion were analyzed. Generalized estimating equation linear regression models were fit to examine hemoglobin increments after RBC transfusion ad...
Source: Blood - September 25, 2019 Category: Hematology Authors: Roubinian, N. H., Plimier, C., Woo, J. P., Lee, C., Bruhn, R., Liu, V. X., Escobar, G. J., Kleinman, S. H., Triulzi, D. J., Murphy, E. L., Busch, M. P. Tags: Transfusion Medicine, Plenary Papers Source Type: research
Antibiotics can improve CTCL
(Source: Blood)
Source: Blood - September 25, 2019 Category: Hematology Authors: Vermeer, M. H. Tags: Free Research Articles COMMENTS Source Type: research
Origins of the human B-cell lineage
(Source: Blood)
Source: Blood - September 25, 2019 Category: Hematology Authors: Müschen, M. Tags: Free Research Articles COMMENTS Source Type: research
Ibrutinib and lenalidomide: when 1+1 = >2
(Source: Blood)
Source: Blood - September 25, 2019 Category: Hematology Authors: Westin, J. Tags: Free Research Articles COMMENTS Source Type: research
A rose is a rose is a rose, or not
(Source: Blood)
Source: Blood - September 25, 2019 Category: Hematology Authors: Spitalnik, S. L. Tags: Free Research Articles COMMENTS Source Type: research
NMDP/CIBMTR donor selection guidelines
(Source: Blood)
Source: Blood - September 18, 2019 Category: Hematology Tags: Free Research Articles, CME article CONTINUING MEDICAL EDUCATION (CME) QUESTIONS Source Type: research
