Nguyen TD, Shaid S, Vakhrusheva O, et al. Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. Blood. 2019;133(2):168-179.
(Source: Blood)
Source: Blood - July 3, 2019 Category: Hematology Tags: Free Research Articles ERRATUM Source Type: research
An unusual cause of lymphadenopathy: when AFB staining is not enough
(Source: Blood)
Source: Blood - July 3, 2019 Category: Hematology Authors: Cassidy, D. P., Chapman, J. Tags: Free Research Articles, BloodWork BLOOD WORK Source Type: research
A population of CD20+CD27+CD43+CD38lo/int B1 cells in PNH are missing GPI-anchored proteins and harbor PIGA mutations
(Source: Blood)
Source: Blood - July 3, 2019 Category: Hematology Authors: Kageyama, Y., Miwa, H., Tawara, I., Ohishi, K., Masuya, M., Katayama, N. Tags: Immunobiology and Immunotherapy, Red Cells, Iron, and Erythropoiesis Letter to Blood Source Type: research
Modeling the safe minimum frequency of molecular monitoring for CML patients attempting treatment-free remission
(Source: Blood)
Source: Blood - July 3, 2019 Category: Hematology Authors: Shanmuganathan, N., Braley, J. A., Yong, A. S. M., Hiwase, D. K., Yeung, D. T., Ross, D. M., Hughes, T. P., Branford, S. Tags: Myeloid Neoplasia, Clinical Trials and Observations Letter to Blood Source Type: research
Osteopontin mediates murine transfusion-related acute lung injury via stimulation of pulmonary neutrophil accumulation
Transfusion-related acute lung injury (TRALI) is one of the leading causes of transfusion-related fatalities and is characterized by the onset of acute respiratory distress within 6 hours upon blood transfusion. Specific therapies are unavailable. Preexisting inflammation is a risk factor for TRALI and neutrophils (polymorphonuclear neutrophils [PMNs]) are considered to be the major pathogenic cells. Osteopontin (OPN) is a multifunctional protein expressed at sites of inflammation and, for example, is involved in pulmonary disorders, can regulate cellular migration, and can function as a PMN chemoattractant. We investigate...
Source: Blood - July 3, 2019 Category: Hematology Authors: Kapur, R., Kasetty, G., Rebetz, J., Egesten, A., Semple, J. W. Tags: Immunobiology and Immunotherapy, Transfusion Medicine Source Type: research
RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1
RUNX1 transcription factor regulates normal and malignant hematopoiesis. Somatic or germline mutant RUNX1 (mtRUNX1) is associated with poorer outcome in acute myeloid leukemia (AML). Knockdown or inhibition of RUNX1 induced more apoptosis of AML expressing mtRUNX1 versus wild-type RUNX1 and improved survival of mice engrafted with mtRUNX1-expressing AML. CRISPR/Cas9-mediated editing-out of RUNX1 enhancer (eR1) within its intragenic super-enhancer, or BET protein BRD4 depletion by short hairpin RNA, repressed RUNX1, inhibited cell growth, and induced cell lethality in AML cells expressing mtRUNX1. Moreover, treatment with B...
Source: Blood - July 3, 2019 Category: Hematology Authors: Mill, C. P., Fiskus, W., DiNardo, C. D., Qian, Y., Raina, K., Rajapakshe, K., Perera, D., Coarfa, C., Kadia, T. M., Khoury, J. D., Saenz, D. T., Saenz, D. N., Illendula, A., Takahashi, K., Kornblau, S. M., Green, M. R., Futreal, A. P., Bushweller, J. H., Tags: Myeloid Neoplasia Source Type: research
Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T-cell efficacy
In chronic lymphocytic leukemia (CLL), acquired T-cell dysfunction impedes development of effective immunotherapeutic strategies, through as-yet unresolved mechanisms. We have previously shown that CD8+ T cells in CLL exhibit impaired activation and reduced glucose uptake after stimulation. CD8+ T cells in CLL patients are chronically exposed to leukemic B cells, which potentially impacts metabolic homeostasis resulting in aberrant metabolic reprogramming upon stimulation. Here, we report that resting CD8+ T cells in CLL have reduced intracellular glucose transporter 1 (GLUT1) reserves, and have an altered mitochondrial me...
Source: Blood - July 3, 2019 Category: Hematology Authors: van Bruggen, J. A. C., Martens, A. W. J., Fraietta, J. A., Hofland, T., Tonino, S. H., Eldering, E., Levin, M.-D., Siska, P. J., Endstra, S., Rathmell, J. C., June, C. H., Porter, D. L., Melenhorst, J. J., Kater, A. P., van der Windt, G. J. W. Tags: Immunobiology and Immunotherapy, Lymphoid Neoplasia Source Type: research
A niche-dependent myeloid transcriptome signature defines dormant myeloma cells
The era of targeted therapies has seen significant improvements in depth of response, progression-free survival, and overall survival for patients with multiple myeloma. Despite these improvements in clinical outcome, patients inevitably relapse and require further treatment. Drug-resistant dormant myeloma cells that reside in specific niches within the skeleton are considered a basis of disease relapse but remain elusive and difficult to study. Here, we developed a method to sequence the transcriptome of individual dormant myeloma cells from the bones of tumor-bearing mice. Our analyses show that dormant myeloma cells exp...
Source: Blood - July 3, 2019 Category: Hematology Authors: Khoo, W. H., Ledergor, G., Weiner, A., Roden, D. L., Terry, R. L., McDonald, M. M., Chai, R. C., De Veirman, K., Owen, K. L., Opperman, K. S., Vandyke, K., Clark, J. R., Seckinger, A., Kovacic, N., Nguyen, A., Mohanty, S. T., Pettitt, J. A., Xiao, Y., Cor Tags: Multiple Myeloma, Lymphoid Neoplasia Source Type: research
PD-1 blockade with pembrolizumab for classical Hodgkin lymphoma after autologous stem cell transplantation
In conclusion, pembrolizumab was successfully administered as post-ASCT consolidation in patients with RR cHL, and resulted in a promising PFS in a high-risk patient cohort, supporting the testing of this strategy in a randomized trial. This trial was registered at www.clinicaltrials.gov as #NCT02362997. (Source: Blood)
Source: Blood - July 3, 2019 Category: Hematology Authors: Armand, P., Chen, Y.-B., Redd, R. A., Joyce, R. M., Bsat, J., Jeter, E., Merryman, R. W., Coleman, K. C., Dahi, P. B., Nieto, Y., LaCasce, A. S., Fisher, D. C., Ng, S. Y., Odejide, O. O., Freedman, A. S., Kim, A. I., Crombie, J. L., Jacobson, C. A., Jacob Tags: Immunobiology and Immunotherapy, Lymphoid Neoplasia, Clinical Trials and Observations Source Type: research
Pediatric Evans syndrome is associated with a high frequency of potentially damaging variants in immune genes
In conclusion, pES was potentially genetically determined in at least 65% of cases. Systematic, wide-ranging genetic screening should be offered in pES; the genetic findings have prognostic significance and may guide the choice of a targeted treatment. (Source: Blood)
Source: Blood - July 3, 2019 Category: Hematology Authors: Hadjadj, J., Aladjidi, N., Fernandes, H., Leverger, G., Magerus-Chatinet, A., Mazerolles, F., Stolzenberg, M.-C., Jacques, S., Picard, C., Rosain, J., Fourrage, C., Hanein, S., Zarhrate, M., Pasquet, M., Abou Chahla, W., Barlogis, V., Bertrand, Y., Pellie Tags: Pediatric Hematology, Immunobiology and Immunotherapy, Platelets and Thrombopoiesis, Red Cells, Iron, and Erythropoiesis, Clinical Trials and Observations Source Type: research
Yet do much less...so much less!
(Source: Blood)
Source: Blood - July 3, 2019 Category: Hematology Authors: Lipton, J. H. Tags: Free Research Articles COMMENTS Source Type: research
Osteopontin makes the bridge in TRALI
(Source: Blood)
Source: Blood - July 3, 2019 Category: Hematology Authors: Boilard, E. Tags: Free Research Articles COMMENTS Source Type: research
Myeloma sleeper agent in myeloid disguise
(Source: Blood)
Source: Blood - July 3, 2019 Category: Hematology Authors: Dhakal, B., Janz, S. Tags: Free Research Articles COMMENTS Source Type: research
Revving up the immune engine in cHL
(Source: Blood)
Source: Blood - July 3, 2019 Category: Hematology Authors: Karmali, R., Gordon, L. I. Tags: Free Research Articles COMMENTS Source Type: research
Striking emperipolesis in megakaryocytes of gray platelet syndrome
(Source: Blood)
Source: Blood - June 26, 2019 Category: Hematology Authors: McGinnis, E., Chipperfield, K. M. Tags: Free Research Articles, BloodWork, Platelets and Thrombopoiesis BLOOD WORK Source Type: research
