Gaucher or pseudo-Gaucher cells
Blood Res. 2024 Feb 28;59(1):7. doi: 10.1007/s44313-024-00005-x.NO ABSTRACTPMID:38485813 | PMC:PMC10917702 | DOI:10.1007/s44313-024-00005-x (Source: Blood Research)
Source: Blood Research - March 15, 2024 Category: Hematology Authors: Gurpreet Kaur Ankur Ahuja Ganesh Kumar Vishwananthan Arijit Sen Source Type: research
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) gene polymorphisms in a cohort of Egyptian patients with immune thrombocytopenia (ITP)
CONCLUSION: CTLA-4 CT 60 A/G may affect the susceptibility of ITP, but both CTLA-4 + 49 A/G and CT60 A/G did not impact the response of patients with ITP to different lines of therapy.PMID:38485815 | PMC:PMC10917709 | DOI:10.1007/s44313-024-00011-z (Source: Blood Research)
Source: Blood Research - March 15, 2024 Category: Hematology Authors: Doaa Mohamed El Demerdash Maha Mohamed Saber Alia Ayad Kareeman Gomaa Mohamed Abdelkader Morad Source Type: research
Peripheral T-cell lymphoma, NOS in bone marrow and heart
Blood Res. 2024 Feb 26;59(1):5. doi: 10.1007/s44313-024-00009-7.NO ABSTRACTPMID:38485820 | PMC:PMC10917705 | DOI:10.1007/s44313-024-00009-7 (Source: Blood Research)
Source: Blood Research - March 15, 2024 Category: Hematology Authors: Hye Won Lee Ja Young Lee Source Type: research
Adding MYC/BCL2 double expression to NCCN-IPI may not improve prognostic value to an acceptable level
CONCLUSIONS: Adding DE to the NCCN-IPI may not improve the prognostic value to an acceptable level in resource-limited settings. Multiple independent confirmatory studies from a large cohort of lymphoma registries have provided additional evidence for the clinical utility of DE.PMID:38485822 | PMC:PMC10903517 | DOI:10.1007/s44313-024-00006-w (Source: Blood Research)
Source: Blood Research - March 15, 2024 Category: Hematology Authors: Naree Warnnissorn Nonglak Kanitsap Pimjai Niparuck Paisarn Boonsakan Prapasri Kulalert Wasithep Limvorapitak Lantarima Bhoopat Supawee Saengboon Chinnawut Suriyonplengsaeng Pichika Chantrathammachart Teeraya Puavilai Suporn Chuncharunee Source Type: research
Comparable outcomes with low-dose and standard-dose horse anti-thymocyte globulin in the treatment of severe aplastic anemia
CONCLUSION: Our study revealed that the response rates of patients with AA and LD were similar to those of patients with SD to hATG combined with cyclosporine in a real-world setting.PMID:38485832 | PMC:PMC10903521 | DOI:10.1007/s44313-024-00003-z (Source: Blood Research)
Source: Blood Research - March 15, 2024 Category: Hematology Authors: Arihant Jain Aditya Jandial Thenmozhi Mani Kamal Kishore Charanpreet Singh Deepesh Lad Gaurav Prakash Alka Khadwal Reena Das Neelam Varma Subhash Varma Pankaj Malhotra Source Type: research
Genomic testing for germline predisposition to hematologic malignancies
Blood Res. 2024 Mar 8;59(1):12. doi: 10.1007/s44313-024-00012-y.ABSTRACTGermline predisposition (GPD) to hematological malignancies has gained interest because of the increased use of genetic testing in this field. Recent studies have suggested that GPD is underrecognized and requires appropriate genomic testing for an accurate diagnosis. Identification of GPD significantly affects patient management and has diverse implications for family members. This review discusses the reasons for testing GPD in hematologic malignancies and explores the considerations necessary for appropriate genomic testing. The aim is to provide in...
Source: Blood Research - March 15, 2024 Category: Hematology Authors: Sang Mee Hwang Source Type: research
Upregulation of lnc-FOXD2-AS1, CDC45, and CDK1 in patients with primary non-M3 AML is associated with a worse prognosis
In this study, we performed an in-silico method to identify antisense RNAs (AS-RNAs) and their related co-expression genes. GSE68172 was selected from the AML database of the Gene Expression Omnibus and compared using the GEO2R tool to find DEGs. Antisense RNAs were selected from all the genes that had significant expression and a survival plot was drawn for them in the GEPIA database, FOXD2-AS1 was chosen for further investigation based on predetermined criteria (logFC ≥|1| and P < 0.05) and its noteworthy association between elevated expression level and a marked reduction in the overall survival (OS) in patients di...
Source: Blood Research - March 15, 2024 Category: Hematology Authors: Saba Manoochehrabadi Morteza Talebi Hossein Pashaiefar Soudeh Ghafouri-Fard Mohammad Vaezi Mir Davood Omrani Mohammad Ahmadvand Source Type: research
Acute erythroid leukemia leading to the diagnosis of Schwachman-Diamond syndrome
Blood Res. 2024 Mar 6;59(1):10. doi: 10.1007/s44313-024-00008-8.NO ABSTRACTPMID:38485850 | PMC:PMC10917704 | DOI:10.1007/s44313-024-00008-8 (Source: Blood Research)
Source: Blood Research - March 15, 2024 Category: Hematology Authors: Bernhard Strasser Sebastian Mustafa Josef Tomasits Alexander Haushofer Source Type: research
Impact of CYP1A1 variants on the risk of acute lymphoblastic leukemia: evidence from an updated meta-analysis
CONCLUSION: Our comprehensive analysis indicates that the T3801 and A2455G polymorphisms of CYP1A1 may increase the risk of ALL depending on ethnicity. Therefore, both variants should be considered promising biomarkers for ALL risk. Further large-scale investigations are necessary to assess other factors, such as gene-gene or gene-environment interactions.PMID:38485870 | PMC:PMC10917727 | DOI:10.1007/s44313-024-00007-9 (Source: Blood Research)
Source: Blood Research - March 15, 2024 Category: Hematology Authors: Imen Frikha Rim Frikha Moez Medhaffer Hanen Charfi Fatma Turki Moez Elloumi Source Type: research
The role of next-generation sequencing in hematologic malignancies
Blood Res. 2024 Mar 6;59(1):11. doi: 10.1007/s44313-024-00010-0.ABSTRACTNext-generation sequencing (NGS) allows high-throughput detection of molecular changes in tumors. Over the past 15 years, NGS has rapidly evolved from a promising research tool to a core component of the clinical laboratory. Sequencing of tumor cells provides an important step in detecting somatic driver mutations that not only characterize the disease but also influence treatment decisions. For patients with hematologic malignancies, NGS has been used for accurate classification and diagnosis based on genetic alterations. The recently revised World He...
Source: Blood Research - March 15, 2024 Category: Hematology Authors: Young-Uk Cho Source Type: research
Genomic technologies for detecting structural variations in hematologic malignancies
Blood Res. 2024 Feb 13;59(1):1. doi: 10.1007/s44313-024-00001-1.ABSTRACTGenomic structural variations in myeloid, lymphoid, and plasma cell neoplasms can provide key diagnostic, prognostic, and therapeutic information while elucidating the underlying disease biology. Several molecular diagnostic approaches play a central role in evaluating hematological malignancies. Traditional cytogenetic diagnostic assays, such as chromosome banding and fluorescence in situ hybridization, are essential components of the current diagnostic workup that guide clinical care for most hematologic malignancies. However, each assay has inherent...
Source: Blood Research - March 15, 2024 Category: Hematology Authors: Mi-Ae Jang Source Type: research
Real-world incidence and risk factors of bortezomib-related cardiovascular adverse events in patients with multiple myeloma
CONCLUSION: Approximately 15% of the Korean patients treated with bortezomib experienced severe CVAEs. Thus, patients, especially those with identified risk factors, should be closely monitored for CVAE symptoms during bortezomib treatment.PMID:38485811 | PMC:PMC10903519 | DOI:10.1007/s44313-024-00004-y (Source: Blood Research)
Source: Blood Research - March 15, 2024 Category: Hematology Authors: Bitna Jang Jonghyun Jeong Kyu-Nam Heo Youngil Koh Ju-Yeun Lee Source Type: research
Gaucher or pseudo-Gaucher cells
Blood Res. 2024 Feb 28;59(1):7. doi: 10.1007/s44313-024-00005-x.NO ABSTRACTPMID:38485813 | PMC:PMC10917702 | DOI:10.1007/s44313-024-00005-x (Source: Blood Research)
Source: Blood Research - March 15, 2024 Category: Hematology Authors: Gurpreet Kaur Ankur Ahuja Ganesh Kumar Vishwananthan Arijit Sen Source Type: research
Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) gene polymorphisms in a cohort of Egyptian patients with immune thrombocytopenia (ITP)
CONCLUSION: CTLA-4 CT 60 A/G may affect the susceptibility of ITP, but both CTLA-4 + 49 A/G and CT60 A/G did not impact the response of patients with ITP to different lines of therapy.PMID:38485815 | PMC:PMC10917709 | DOI:10.1007/s44313-024-00011-z (Source: Blood Research)
Source: Blood Research - March 15, 2024 Category: Hematology Authors: Doaa Mohamed El Demerdash Maha Mohamed Saber Alia Ayad Kareeman Gomaa Mohamed Abdelkader Morad Source Type: research
Peripheral T-cell lymphoma, NOS in bone marrow and heart
Blood Res. 2024 Feb 26;59(1):5. doi: 10.1007/s44313-024-00009-7.NO ABSTRACTPMID:38485820 | PMC:PMC10917705 | DOI:10.1007/s44313-024-00009-7 (Source: Blood Research)
Source: Blood Research - March 15, 2024 Category: Hematology Authors: Hye Won Lee Ja Young Lee Source Type: research
