Marked von Willebrand factor and factor VIII elevations in severe acute respiratory syndrome coronavirus-2-positive, but not severe acute respiratory syndrome coronavirus-2-negative, pneumonia: a case–control study
Patients with novel coronavirus pneumonia show increased thrombotic risk. Although hemostatic alterations have been described in novel coronavirus pneumonia patients, case–control studies of von Willebrand factor (VWF), factor VIII (FVIII), and a disintegrin-like and metalloprotease with thrombospondin type I motif, member 13 (ADAMTS13) are lacking. VWF, ADAMTS13, FVIII, d-dimer, C-reactive protein, and routine blood cells and chemistry were measured in 10 novel coronavirus pneumonia patients and 10 non-novel coronavirus pneumonia controls. Hemostatic factors were measured less than 48 h of hospital admission in patien...
Source: Blood Coagulation and Fibrinolysis - May 20, 2021 Category: Hematology Tags: SHORT COMMUNICATIONS Source Type: research
Screening hemostatic defects in Saudi University students with unexplained menorrhagia: a diagnosis, which could be missed
Bleeding disorders are a common cause of unexplained menorrhagia in adolescents. However, there is lack of information provided on Arab girls. To estimate the prevalence of coagulation factor deficiencies and platelet dysfunction among Saudi university students with unexplained menorrhagia. In this cross sectional study, 463 adolescent girls surveyed for having heavy menses for further evaluation of underlying bleeding tendencies using screening standardized questionnaire. Only 109 girls out of the total 463 girls reported menorrhagia and were included in the evaluation. All girls with menorrhagia were evaluated by Pictori...
Source: Blood Coagulation and Fibrinolysis - May 20, 2021 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research
Soluble thrombomodulin and cardiovascular disease risk factors in Japanese children
This study aimed to establish standard reference values for soluble thrombomodulin in healthy prepubertal school-aged children and elucidate the relationship between soluble thrombomodulin levels and obesity, metabolic syndrome-associated indices, and other markers of vascular endothelial damage. The participants in this study were healthy Japanese children aged 9–10 years (315 boys and 267 girls). Blood tests for soluble thrombomodulin, leptin, fibrinogen, and general biochemical markers were performed, and the mean and 10th, 50th, and 90th percentiles for each marker were determined. Participants were divided into tw...
Source: Blood Coagulation and Fibrinolysis - May 20, 2021 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research
Assessment of endothelial progenitor cells, VEGF-A and SDF-1α in Hodgkin's lymphoma
Recently, there is great interest in vasculogenesis, a process of the formation of new blood vessels from progenitor cells or angioblasts, in the pathogenesis of cancer. To the best of our knowledge, the evaluation of endothelial progenitor cells (EPCs) in Hodgkin's lymphoma has not yet been reported.
The aim of the present study was to assess the number of EPCs and selected cytokines, such as vascular endothelial growth factor (VEGF-A) and stromal cell-derived factor (SDF-1α) involved in vasculogenesis in Hodgkin's lymphoma patients.
The study was conducted in a group of 42 patients with Hodgkin's lymphoma (eight p...
Source: Blood Coagulation and Fibrinolysis - May 20, 2021 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research
Which tests can most effectively indicate the clinical phenotype of paediatric haemophilia patients with prophylaxis?
Patients with haemophilia A who have similar FVIII levels show clinical heterogeneity, and 10–15% of patients with severe haemophilia do not have a severe bleeding phenotype. The aim of this study was to assess whether global haemostasis tests, such as thrombin generation assay (TGA) and thromboelastography (TEG), can predict the bleeding pattern of severe haemophilia better than trough levels and pharmacokinetic profiles, particularly in the prophylactic setting. The study group consisted of 39 patients with haemophilia A and 75 healthy controls. The annual bleeding rate (ABR) and Hemophilia Joint Health Score 2.1 (HJHS...
Source: Blood Coagulation and Fibrinolysis - May 20, 2021 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research
Impact of ABO blood group on bleeding complications after surgery for acute type A aortic dissection
This study could not demonstrate any association between blood group and bleeding after surgery for ATAAD. It cannot be ruled out that potential differences were levelled out by blood group O patients receiving significantly more fibrinogen concentrate. (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - May 20, 2021 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research
Use of fibrin monomer and D-Dimer in assessing overt and nonovert disseminated intravascular coagulation
Introduction
Early diagnosis of disseminated intravascular coagulation (DIC) before its progression to an overt stage is beneficial for its treatment and prognosis.
This retrospective study aimed to evaluate the diagnostic performance of D-dimer and fibrin monomer in the early stage of DIC.
A total of 707 patients suspected of having DIC, 302 healthy people were enrolled and divided into four groups: overt DIC, nonovert DIC, non-DIC based on the International Society of Thrombosis and Hemostasis scoring for overt DIC and the modified nonovert DIC criteria, healthy people as control group. Quantitative determinati...
Source: Blood Coagulation and Fibrinolysis - May 20, 2021 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research
Blood biocompatibility enhancement of biomaterials by heparin immobilization: a review
Blood contacting materials are concerned with biocompatibility including thrombus formation, decrease blood coagulation time, hematology, activation of complement system, platelet aggression. Interestingly, recent research suggests that biocompatibility is increasing by incorporating various materials including heparin using different methods. Basic of heparin including uses and complications was mentioned, in which burst release of heparin is major issue. To minimize the problem of biocompatibility and unpredictable heparin release, present review article potentially reviews the reported work and investigates the various ...
Source: Blood Coagulation and Fibrinolysis - May 20, 2021 Category: Hematology Tags: REVIEW ARTICLE Source Type: research
Recommendations for the treatment of immune thrombocytopenia in adults: a comparison
No abstract available (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - April 1, 2021 Category: Hematology Tags: LETTER TO THE EDITOR Source Type: research
2B or not 2B? A diagnosis of von Willebrand disease a lifetime of 86 years in the making
We present a case of such a patient, expressing a clearly atypical VWF phenotype, but as still associated with enhanced ristocetin-induced platelet aggregation, thrombocytopenia, and a previously undescribed VWF variant (c.4130C>G; p.Ala1377Gly). The patient was misdiagnosed over his lifetime as idiotypic thrombocytopenia – a (mis)diagnosis that took a lifetime of 86 years to redress. (Source: Blood Coagulation and Fibrinolysis)
Source: Blood Coagulation and Fibrinolysis - April 1, 2021 Category: Hematology Tags: CASE REPORT Source Type: research
Viscoelastic hemostasis assays in septic, critically ill coronavirus disease 2019 patients: a practical guide for clinicians
Coronavirus disease 2019 (COVID-19)-associated coagulopathy is unusual, poorly defined and is linked with significant hypercoagulability and microthrombotic and macrothrombotic complications leading to worse outcomes and higher mortality. Conventional coagulation assays do not always actively reflect these derangements and might fail to detect this coagulopathy. Viscoelastic hemostatic assays (VHA) provide a possible tool that adds to conventional coagulation assays in identifying this hypercoagulable state. VHA has been mostly used in surgery and trauma but it's still not well defined in sepsis patients with lack of large...
Source: Blood Coagulation and Fibrinolysis - April 1, 2021 Category: Hematology Tags: SHORT COMMUNICATIONS Source Type: research
Evaluation of the algorithm of Anticlot Assistant: an anticoagulant management system based on mobile health technology
The purpose is to evaluate the algorithm of Anticlot Assistant, a novel anticoagulant management system based on mobile health technology which was developed to facilitate patient self-management. The eligible patients managed warfarin therapy with usual care, following the prescriptions of the doctors. The actual prescriptions of doctors and the virtual recommendations by Anticlot Assistant were compared and analyzed. There were no significant differences between the next test dates recommended by Anticlot Assistant and those prescribed by doctors. The mean warfarin dosage prescribed by doctors was lower than that recomme...
Source: Blood Coagulation and Fibrinolysis - April 1, 2021 Category: Hematology Tags: SHORT COMMUNICATIONS Source Type: research
Isovolemic filter-based therapeutic plasma-exchange with fresh frozen plasma is associated with minimal thromboelastometric changes in noncoagulopathic patients
The aim of this study was to assess the effects of isovolemic therapeutic plasma-exchange using fresh frozen plasma on coagulations parameters assessed by standard coagulation tests and rotational thromboelastometry in noncoagulopathic patients. Twenty patients who underwent isovolemic filter-based therapeutic plasma-exchange of approximately 1.5 plasma volume per session were included in the current study. Standard coagulation tests and rotational thromboelastometry (ExTEM, InTEM, FibTEM and ApTEM) were performed 30 min before and after the procedure. Isovolemic therapeutic plasma-exchange was associated with decreased ...
Source: Blood Coagulation and Fibrinolysis - April 1, 2021 Category: Hematology Tags: SHORT COMMUNICATIONS Source Type: research
Prolongation of clot lysis time by a direct thrombin inhibitor melagatran mediated by paradoxical enhancement of thrombin generation: comparison with a direct factor Xa inhibitor edoxaban
Previously, we reported that a direct thrombin inhibitor melagatran paradoxically increased thrombin generation in human plasma in the presence of thrombomodulin. The aim of this study is to test the hypothesis that melagatran may exert a deleterious effect on tissue-type plasminogen activator (t-PA)-induced fibrinolysis via enhancement of thrombin generation and subsequent activation of thrombin-activatable fibrinolysis inhibitor (TAFI) and factor XIII (FXIII).
Clot formation in human plasma containing t-PA and thrombomodulin was induced by tissue factor. The absorbance at 405 nm was measured to obtain clot lysis tim...
Source: Blood Coagulation and Fibrinolysis - April 1, 2021 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research
Microparticles: a link to increased thrombin generation
Circulating microparticles in human plasma may play a significant role in thrombogenesis because they carry the initiator of blood coagulation, tissue factor. Microparticles in blood are derived from diverse cell types, including erythrocytes, endothelial cells and platelets. Thrombin generation is an important part of the coagulation system and might be influenced by the presence of microparticles in the circulation. With this study, we determined the contribution of microparticles to increased thrombin generation in plasma samples received for thrombophilia workup and compare that with normal plasma. Microparticles were ...
Source: Blood Coagulation and Fibrinolysis - April 1, 2021 Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research
