Extracellular vesicles of Weizmannia coagulans lilac-01 reduced cell death of primary microglia and increased mitochondrial content in dermal fibroblasts in vitro
Biosci Biotechnol Biochem. 2023 Dec 20:zbad175. doi: 10.1093/bbb/zbad175. Online ahead of print.ABSTRACTWe investigated the properties of extracellular vesicles from the probiotic Weizmannia coagulans lilac-01 (Lilac-01EVs). The phospholipids in the Lilac-01EV membrane were phosphatidylglycerol and mitochondria-specific cardiolipin. We found that applying Lilac-01EVs to primary rat microglia in vitro resulted in a reduction in primary microglial cell death (p < 0.05). Lilac-01EVs, which contain cardiolipin and phosphatidylglycerol, may have the potential to inhibit cell death in primary microglia. The addition of Lilac-...
Source: Bioscience, Biotechnology, and Biochemistry - December 21, 2023 Category: Biochemistry Authors: Kimiko Minamida Toshio Taira Masato Sasaki Ohki Higuchi Xian-Ying Meng Yoichi Kamagata Kazunori Miwa Source Type: research

Extracellular vesicles of Weizmannia coagulans lilac-01 reduced cell death of primary microglia and increased mitochondrial content in dermal fibroblasts in vitro
Biosci Biotechnol Biochem. 2023 Dec 20:zbad175. doi: 10.1093/bbb/zbad175. Online ahead of print.ABSTRACTWe investigated the properties of extracellular vesicles from the probiotic Weizmannia coagulans lilac-01 (Lilac-01EVs). The phospholipids in the Lilac-01EV membrane were phosphatidylglycerol and mitochondria-specific cardiolipin. We found that applying Lilac-01EVs to primary rat microglia in vitro resulted in a reduction in primary microglial cell death (p < 0.05). Lilac-01EVs, which contain cardiolipin and phosphatidylglycerol, may have the potential to inhibit cell death in primary microglia. The addition of Lilac-...
Source: Bioscience, Biotechnology, and Biochemistry - December 21, 2023 Category: Biochemistry Authors: Kimiko Minamida Toshio Taira Masato Sasaki Ohki Higuchi Xian-Ying Meng Yoichi Kamagata Kazunori Miwa Source Type: research

Extracellular vesicles of Weizmannia coagulans lilac-01 reduced cell death of primary microglia and increased mitochondrial content in dermal fibroblasts in vitro
Biosci Biotechnol Biochem. 2023 Dec 20:zbad175. doi: 10.1093/bbb/zbad175. Online ahead of print.ABSTRACTWe investigated the properties of extracellular vesicles from the probiotic Weizmannia coagulans lilac-01 (Lilac-01EVs). The phospholipids in the Lilac-01EV membrane were phosphatidylglycerol and mitochondria-specific cardiolipin. We found that applying Lilac-01EVs to primary rat microglia in vitro resulted in a reduction in primary microglial cell death (p < 0.05). Lilac-01EVs, which contain cardiolipin and phosphatidylglycerol, may have the potential to inhibit cell death in primary microglia. The addition of Lilac-...
Source: Bioscience, Biotechnology, and Biochemistry - December 21, 2023 Category: Biochemistry Authors: Kimiko Minamida Toshio Taira Masato Sasaki Ohki Higuchi Xian-Ying Meng Yoichi Kamagata Kazunori Miwa Source Type: research

Extracellular vesicles of Weizmannia coagulans lilac-01 reduced cell death of primary microglia and increased mitochondrial content in dermal fibroblasts in vitro
Biosci Biotechnol Biochem. 2023 Dec 20:zbad175. doi: 10.1093/bbb/zbad175. Online ahead of print.ABSTRACTWe investigated the properties of extracellular vesicles from the probiotic Weizmannia coagulans lilac-01 (Lilac-01EVs). The phospholipids in the Lilac-01EV membrane were phosphatidylglycerol and mitochondria-specific cardiolipin. We found that applying Lilac-01EVs to primary rat microglia in vitro resulted in a reduction in primary microglial cell death (p < 0.05). Lilac-01EVs, which contain cardiolipin and phosphatidylglycerol, may have the potential to inhibit cell death in primary microglia. The addition of Lilac-...
Source: Bioscience, Biotechnology, and Biochemistry - December 21, 2023 Category: Biochemistry Authors: Kimiko Minamida Toshio Taira Masato Sasaki Ohki Higuchi Xian-Ying Meng Yoichi Kamagata Kazunori Miwa Source Type: research

Extracellular vesicles of Weizmannia coagulans lilac-01 reduced cell death of primary microglia and increased mitochondrial content in dermal fibroblasts in vitro
Biosci Biotechnol Biochem. 2023 Dec 20:zbad175. doi: 10.1093/bbb/zbad175. Online ahead of print.ABSTRACTWe investigated the properties of extracellular vesicles from the probiotic Weizmannia coagulans lilac-01 (Lilac-01EVs). The phospholipids in the Lilac-01EV membrane were phosphatidylglycerol and mitochondria-specific cardiolipin. We found that applying Lilac-01EVs to primary rat microglia in vitro resulted in a reduction in primary microglial cell death (p < 0.05). Lilac-01EVs, which contain cardiolipin and phosphatidylglycerol, may have the potential to inhibit cell death in primary microglia. The addition of Lilac-...
Source: Bioscience, Biotechnology, and Biochemistry - December 21, 2023 Category: Biochemistry Authors: Kimiko Minamida Toshio Taira Masato Sasaki Ohki Higuchi Xian-Ying Meng Yoichi Kamagata Kazunori Miwa Source Type: research

Extracellular vesicles of Weizmannia coagulans lilac-01 reduced cell death of primary microglia and increased mitochondrial content in dermal fibroblasts in vitro
Biosci Biotechnol Biochem. 2023 Dec 20:zbad175. doi: 10.1093/bbb/zbad175. Online ahead of print.ABSTRACTWe investigated the properties of extracellular vesicles from the probiotic Weizmannia coagulans lilac-01 (Lilac-01EVs). The phospholipids in the Lilac-01EV membrane were phosphatidylglycerol and mitochondria-specific cardiolipin. We found that applying Lilac-01EVs to primary rat microglia in vitro resulted in a reduction in primary microglial cell death (p < 0.05). Lilac-01EVs, which contain cardiolipin and phosphatidylglycerol, may have the potential to inhibit cell death in primary microglia. The addition of Lilac-...
Source: Bioscience, Biotechnology, and Biochemistry - December 21, 2023 Category: Biochemistry Authors: Kimiko Minamida Toshio Taira Masato Sasaki Ohki Higuchi Xian-Ying Meng Yoichi Kamagata Kazunori Miwa Source Type: research

Extracellular vesicles of Weizmannia coagulans lilac-01 reduced cell death of primary microglia and increased mitochondrial content in dermal fibroblasts in vitro
Biosci Biotechnol Biochem. 2023 Dec 20:zbad175. doi: 10.1093/bbb/zbad175. Online ahead of print.ABSTRACTWe investigated the properties of extracellular vesicles from the probiotic Weizmannia coagulans lilac-01 (Lilac-01EVs). The phospholipids in the Lilac-01EV membrane were phosphatidylglycerol and mitochondria-specific cardiolipin. We found that applying Lilac-01EVs to primary rat microglia in vitro resulted in a reduction in primary microglial cell death (p < 0.05). Lilac-01EVs, which contain cardiolipin and phosphatidylglycerol, may have the potential to inhibit cell death in primary microglia. The addition of Lilac-...
Source: Bioscience, Biotechnology, and Biochemistry - December 21, 2023 Category: Biochemistry Authors: Kimiko Minamida Toshio Taira Masato Sasaki Ohki Higuchi Xian-Ying Meng Yoichi Kamagata Kazunori Miwa Source Type: research

Extracellular vesicles of Weizmannia coagulans lilac-01 reduced cell death of primary microglia and increased mitochondrial content in dermal fibroblasts in vitro
Biosci Biotechnol Biochem. 2023 Dec 20:zbad175. doi: 10.1093/bbb/zbad175. Online ahead of print.ABSTRACTWe investigated the properties of extracellular vesicles from the probiotic Weizmannia coagulans lilac-01 (Lilac-01EVs). The phospholipids in the Lilac-01EV membrane were phosphatidylglycerol and mitochondria-specific cardiolipin. We found that applying Lilac-01EVs to primary rat microglia in vitro resulted in a reduction in primary microglial cell death (p < 0.05). Lilac-01EVs, which contain cardiolipin and phosphatidylglycerol, may have the potential to inhibit cell death in primary microglia. The addition of Lilac-...
Source: Bioscience, Biotechnology, and Biochemistry - December 21, 2023 Category: Biochemistry Authors: Kimiko Minamida Toshio Taira Masato Sasaki Ohki Higuchi Xian-Ying Meng Yoichi Kamagata Kazunori Miwa Source Type: research

Genome-wide identification and expression profiles of the Phytophthora infestans responsive CYPome (Cytochrome P450 complement) in Solanum tuberosum
This study firstly reported the CYPome in S. tuberosum, and characterized the expression patterns of these P450 genes during the infection of P. infestans.PMID:38115610 | DOI:10.1093/bbb/zbad180 (Source: Bioscience, Biotechnology, and Biochemistry)
Source: Bioscience, Biotechnology, and Biochemistry - December 20, 2023 Category: Biochemistry Authors: Yajie Wang Yining Sun Yan Li Huanhuan Shao Xiaojie Cheng Xiaoyang Wang Bin Yong Xiang Tao Source Type: research

Genome-wide identification and expression profiles of the Phytophthora infestans responsive CYPome (Cytochrome P450 complement) in Solanum tuberosum
This study firstly reported the CYPome in S. tuberosum, and characterized the expression patterns of these P450 genes during the infection of P. infestans.PMID:38115610 | DOI:10.1093/bbb/zbad180 (Source: Bioscience, Biotechnology, and Biochemistry)
Source: Bioscience, Biotechnology, and Biochemistry - December 20, 2023 Category: Biochemistry Authors: Yajie Wang Yining Sun Yan Li Huanhuan Shao Xiaojie Cheng Xiaoyang Wang Bin Yong Xiang Tao Source Type: research

Advancement in structure elucidation of natural medium-sized lactones through synthesis and theoretical calculations
Biosci Biotechnol Biochem. 2023 Dec 18:zbad179. doi: 10.1093/bbb/zbad179. Online ahead of print.ABSTRACTMedium-sized lactones are an important class of natural products with diverse biological activities. Unlike conventional organic compounds, these molecules exhibit elevated levels of conformational flexibility. This inherent structural feature occasionally exacerbates the complexities associated with determining their conformation, thereby posing challenges in deciphering their stereochemistry or, in certain instances, leading to incorrect structures. This review highlights specific scenarios in which synthetic studies a...
Source: Bioscience, Biotechnology, and Biochemistry - December 19, 2023 Category: Biochemistry Authors: Ryo Katsuta Source Type: research

Advancement in structure elucidation of natural medium-sized lactones through synthesis and theoretical calculations
Biosci Biotechnol Biochem. 2023 Dec 18:zbad179. doi: 10.1093/bbb/zbad179. Online ahead of print.ABSTRACTMedium-sized lactones are an important class of natural products with diverse biological activities. Unlike conventional organic compounds, these molecules exhibit elevated levels of conformational flexibility. This inherent structural feature occasionally exacerbates the complexities associated with determining their conformation, thereby posing challenges in deciphering their stereochemistry or, in certain instances, leading to incorrect structures. This review highlights specific scenarios in which synthetic studies a...
Source: Bioscience, Biotechnology, and Biochemistry - December 19, 2023 Category: Biochemistry Authors: Ryo Katsuta Source Type: research

Valine improves mitochondrial function and protects against oxidative stress
In conclusion, our findings shed more light on the critical function of valine in protecting mitochondrial function thereby preventing mitochondrial/cellular damage induced by oxidative stress.PMID:38093456 | DOI:10.1093/bbb/zbad169 (Source: Bioscience, Biotechnology, and Biochemistry)
Source: Bioscience, Biotechnology, and Biochemistry - December 14, 2023 Category: Biochemistry Authors: Shakshi Sharma Xiaomin Zhang Gohar Azhar Pankaj Patyal Ambika Verma Grishma Kc Jeanne Y Wei Source Type: research

Valine improves mitochondrial function and protects against oxidative stress
In conclusion, our findings shed more light on the critical function of valine in protecting mitochondrial function thereby preventing mitochondrial/cellular damage induced by oxidative stress.PMID:38093456 | DOI:10.1093/bbb/zbad169 (Source: Bioscience, Biotechnology, and Biochemistry)
Source: Bioscience, Biotechnology, and Biochemistry - December 14, 2023 Category: Biochemistry Authors: Shakshi Sharma Xiaomin Zhang Gohar Azhar Pankaj Patyal Ambika Verma Grishma Kc Jeanne Y Wei Source Type: research

Valine improves mitochondrial function and protects against oxidative stress
In conclusion, our findings shed more light on the critical function of valine in protecting mitochondrial function thereby preventing mitochondrial/cellular damage induced by oxidative stress.PMID:38093456 | DOI:10.1093/bbb/zbad169 (Source: Bioscience, Biotechnology, and Biochemistry)
Source: Bioscience, Biotechnology, and Biochemistry - December 14, 2023 Category: Biochemistry Authors: Shakshi Sharma Xiaomin Zhang Gohar Azhar Pankaj Patyal Ambika Verma Grishma Kc Jeanne Y Wei Source Type: research