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Production of docosahexaenoic acid by a novel isolated Aurantiochytrium sp. 6-2 using fermented defatted soybean as a nitrogen source for sustainable fish feed development
Biosci Biotechnol Biochem. 2024 Mar 22:zbae035. doi: 10.1093/bbb/zbae035. Online ahead of print.ABSTRACTWe focused on the production of DHA-containing microbial lipids by Aurantiochytrium sp. using of defatted soybean (DS) as a nitrogen source. DS is a plant biomass that could provide a sustainable supply at a low cost. Results showed that Aurantiochytrium sp. could not directly assimilate the DS as a nitrogen source but could grow well in a medium containing DS fermented with rice malt. When cultivated in a fermented DS (FDS) medium, Aurantiochytrium sp. showed vigorous growth with the addition of sufficient sulfate and c...
Source: Bioscience, Biotechnology, and Biochemistry - March 23, 2024 Category: Biochemistry Authors: Chi-Hei Ip Hibiki Higuchi Chang-Yu Wu Tomoyo Okuda Shohei Katsuya Jun Ogawa Akinori Ando Source Type: research

Correction to: Sesamin promotes angiogenesis and accelerates wound healing in rats via alleviates TBHP-induced apoptosis in human umbilical vein endothelial cells
Biosci Biotechnol Biochem. 2024 Mar 22:zbab194. doi: 10.1093/bbb/zbab194. Online ahead of print.NO ABSTRACTPMID:38517934 | DOI:10.1093/bbb/zbab194 (Source: Bioscience, Biotechnology, and Biochemistry)
Source: Bioscience, Biotechnology, and Biochemistry - March 22, 2024 Category: Biochemistry Source Type: research

The crude extract obtained from Cinnamomum macrostemon Hayata regulates oxidative stress and mitophagy in keratinocytes
Biosci Biotechnol Biochem. 2024 Mar 20:zbae022. doi: 10.1093/bbb/zbae022. Online ahead of print.ABSTRACTFour ethanol fractionated crude extracts (EFCE. A-D) purified from the leaves of Cinnamomum macrostemon Hayata were screened for anti-oxidative effects and mitochondrial function in HaCaT cells. The higher cell viability indicated that EFCE. C was mildly toxic. Under the treatment of 50 ng/mL EFCE. C, the H2O2-induced cytosolic and mitochondrial ROS levels were reduced as well as the H2O2-impaired cell viability, mitochondrial membrane potential (MMP), ATP production and mitochondrial mass. The conversion of globular mit...
Source: Bioscience, Biotechnology, and Biochemistry - March 20, 2024 Category: Biochemistry Authors: Yung-Shun Su Ming-Jen Cheng Aij-Lie Kwan Shu-Ping Huang Yu-Chang Tyan Chee-Yin Chai Bin Huang Source Type: research

A modified system using macrophage-conditioned medium revealed that the indirect effects of anti-inflammatory food-derived compounds improve inflammation-induced suppression of UCP-1 mRNA expression in 10T1/2 adipocytes
In this study, we developed a modified system to evaluate only the indirect effects of anti-inflammatory food-derived compounds by optimizing the conventional experimental system using conditioned medium. We validated this new system using 6-shogaol and 6-gingerol, which have been reported to show the anti-inflammatory effects and to increase the basal expression of UCP-1 mRNA. In addition, we found that the acetone extract of Sarcodon aspratus, an edible mushroom, showed anti-inflammatory effects and rescued the inflammation-induced suppression of UCP-1 mRNA expression. These findings indicate that the system with CM is v...
Source: Bioscience, Biotechnology, and Biochemistry - March 18, 2024 Category: Biochemistry Authors: Hisako Takahashi Miori Morikawa Emi Ozaki Minami Numasaki Hiromu Morimoto Miori Tanaka Hirofumi Inoue Tsuyoshi Goto Teruo Kawada Fumio Eguchi Mariko Uehara Nobuyuki Takahashi Source Type: research

Pharmacokinetics of soy-derived lysophosphatidylcholine compared with that of glycerophosphocholine: a randomized controlled trial
This study investigated the single-dose pharmacokinetics of 480 mg soy-derived LPC in 12 healthy men compared with that of either soy oil with the same lipid amount (placebo) or GPC with the same choline amount. Both LPC and GPC supplementation increased plasma choline, serum phospholipid, and serum triglyceride concentrations, but neither of them significantly elevated plasma trimethylamine N-oxide concentration. In addition, although the intake of LPC slightly increased plasma LPC16:0, LPC18:2, and total LPC concentrations, their concentrations remained within physiological ranges. No adverse events were attributed to th...
Source: Bioscience, Biotechnology, and Biochemistry - March 15, 2024 Category: Biochemistry Authors: Ryohei Tanaka-Kanegae Hiroyuki Kimura Koichiro Hamada Source Type: research

Substrate profiling of human Transglutaminase 1 using cDNA display and next-generation sequencing
Biosci Biotechnol Biochem. 2024 Mar 13:zbae029. doi: 10.1093/bbb/zbae029. Online ahead of print.ABSTRACTHuman transglutaminase 1 (TG1) modulates skin development while its involvement in diseases remains poorly understood, necessitating comprehensive exploration of its substrate interactions. To study the substrate profile of TG1, an in vitro selection system based on cDNA display technology was used to screen two peptide libraries with mutations at varying distance from the reactive glutamine. Next-generation sequencing and bioinformatics analysis of the selected DNA pools revealed a detailed TG1 substrate profile indicat...
Source: Bioscience, Biotechnology, and Biochemistry - March 13, 2024 Category: Biochemistry Authors: T I K Munaweera Jasmina Damnjanovi ć Maurizio Camagna Moeri Nezu Beixi Jia Kiyotaka Hitomi Naoto Nemoto Hideo Nakano Source Type: research