Incensole acetate prevents beta-amyloid-induced neurotoxicity in human olfactory bulb neural stem cells
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Mohammed A. El-Magd, Sara F. Khalifa, Faisal Abdulrahman A. Alzahrani, Abdelnaser A. Badawy, Eman S. El-Shetry, Lamess M. Dawood, Mohammed M. Alruwaili, Hedib A. Alrawaili, Engi F. Risha, Fathy M. El-Taweel, Hany E. MareiAbstractβ-Amyloid peptide (Aβ) is a potent neurotoxic protein associated with Alzheimer’s disease (AD) which causes oxidative damage to neurons. Incensole acetate (IA) is a major constituent of Boswellia carterii resin, which has anti-inflammatory and protective properties against damage of a lar...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Potent tocolytic activity of ethyl acetate fraction of Ananas comosus on rat and human uteri
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Faezeh Monji, Lang Chu Lau, Abrar Al-Mahmood Siddiquee, Baharudin Bin Said, Lay-Kien Yang, Yoganathan K., Mahesh A. Choolani, P. Ganesan AdaikanAbstractThe aim of this study was to investigate the tocolytic properties of Ananas comosus extract in rat and human uterine tissue in vitro and in the rat in vivo. Organ bath technique was employed to perform functional studies in vitro. The PhysioTel transmitter was implanted in SD rats to measure the changes in intrauterine pressure (IUP) in vivo. Analyses of F2 was performed using LC...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Synergistic effect of glucosamine and vitamin E against experimental rheumatoid arthritis in neonatal rats
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Wei Dai, Chang Qi, Shasha WangAbstractThe effect of glucosamine and vitamin E against rheumatoid arthritis (RA) in a neonatal rat model was investigated. Lipid peroxidation, superoxide dismutase (SOD), catalase, reduced glutathione (GSH), glutathione peroxidase (Gpx), matrix metalloproteinase-3 (MMP-3), prostaglandin E2 (PGE2), ceruloplasmin, copper, zinc, nitric oxide (NO), uric acid, inducible nitric oxide synthase (iNOS), and nuclear factor-kappaB (NF-κB) levels were determined in control and rheumatoid arthritis neonat...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Suppression of SMOC2 reduces bleomycin (BLM)-induced pulmonary fibrosis by inhibition of TGF-β1/SMADs pathway
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Li Luo, Chang-Cheng Wang, Xiao-Ping Song, Hong-Mei Wang, Hui Zhou, Ying Sun, Xiao-Kun Wang, Shuo Hou, Fu-Yang PeiAbstractAlthough the initiation and modulation of lung fibrosis has been widely investigated, the pathogenesis was not well understood. Secreted modular calcium-binding protein 2 (SMOC2) as the secreted protein acidic is enriched in cysteine (SPARC) family of matricellular proteins, which are important in regulating cell-matrix interactions. Here we aimed to calculate the effects and molecular mechanism of SMOC2 on th...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Heterogeneous nuclear ribonucleoprotein M promotes the progression of breast cancer by regulating the axin/β-catenin signaling pathway
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Wen-Hua Yang, Ming-Jian Ding, Guo-Zhong Cui, Meng Yang, Dian-Lu DaiAbstractDespite significant progress in the treatment of breast cancer due to advances in surgery, cytotoxic agents, and endocrine therapy, the prognosis for patients has not improved much. Accumulated evidence indicates that heterogeneous nuclear ribonucleoprotein M (hnRNPM) and Wnt/β-catenin function as tumor oncogenes in the progression of many cancers. The present study aimed to explore whether HnRNPM/β-catenin signaling molecules might serve as a g...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Immunomodulatory effects of Thymol through modulation of redox status and trace element content in experimental model of asthma
The objective of this study was to investigate the thymol effects on oxidative parameters along with trace elements in asthma experimental model. The Balb/c mice were sensitized by intraperitoneal injection of ovalbumin and thymol (8, 16 and 32 mg/kg) and dexamethasone (DEX) (2 mg/kg) were orally administered to sensitized mice. Oxidative stress parameters including protein carbonyl content, malondialdehyde (MDA), 8-hydroxy-2′-deoxyguanosine (8-OHdG) and total antioxidant capacity (TAC) besides trace element levels were evaluated. The protein carbonyl content, MDA and 8-OHdG in treated mice with 32 mg/kg of thy...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Peperomin E (PepE) protects against high fat diet-induced atherosclerosis in Apolipoprotein E deficient (ApoE−/−) mice through reducing inflammation via the suppression of NLRP3 signaling pathway
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Jin Yan, Ming Li, Xiao-Dong Wang, Zi-Ying Lu, Xiao-Long NiAbstractPeperomin E (PepE) is a type of secolignan, a major component of the plant Peperomia dindygulensis. It has been shown to exert anti-inflammatory effects; however, the effects of PepE on human atherosclerosis remain unexplored. In the study, we investigated the role of PepE in high fat diet (HFD) induced atherosclerosis using apolipoprotein E defcient (ApoE−/−) mice. Elevated serum homocyteine, cholesterol, and triglyceride levels, accelerated progressi...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

MicroRNA-519d-3p inhibits cell proliferation and migration by targeting TROAP in colorectal cancer
In conclusion, miR-519d-3p might be a promising therapeutic strategy against human CRC by directly targeting TROAP. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-373-3p enhances the chemosensitivity of gemcitabine through cell cycle pathway by targeting CCND2 in pancreatic carcinoma cells
ConclusionMiR-373-3p inhibited cell propagation, migration and invasion and boosted apoptosis in gemcitabine resistance pancreatic carcinoma cells by targeting CCND2. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Chios mastic gum decreases renin levels and ameliorates vascular remodeling in renovascular hypertensive rats
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Aspasia I. Tzani, Ilias P. Doulamis, Panagiotis S. Konstantopoulos, Ermioni D. Pasiou, Afrodite Daskalopoulou, Dimitrios C. Iliopoulos, Ioannis V. Georgiadis, Nikolaos Kavantzas, Stavros K. Kourkoulis, Despina N. PerreaAbstractChios mastic gum (CMG) exerts robust anti-inflammatory and antioxidant properties and it affects pathways that are implicated in the pathophysiology of endothelial and vascular inflammation. Aim of this study was to test the hypothesis that CMG administration lowers blood pressure (BP) and improves hyperte...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Trehalose prevents sciatic nerve damage to and apoptosis of Schwann cells of streptozotocin-induced diabetic C57BL/6J mice
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Haiyan Pan, Yuanlin Ding, Ning Yan, Yaxin Nie, Mei Li, Linyan TongAbstractType 1 diabetes (T1DM) affects approximately 1 in 500 children. Diabetic peripheral neuropathy (DPN) is the most common form of peripheral neuropathy in diabetes and is a significant risk factor for serious pathological change. It is difficult and costly to treat DPN and although there have been several pivotal trials. The development of new drugs to treat DPN remains a high priority. Trehalose is a naturally occurring disaccharide, which is indicated to p...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Ursolic acid improves diabetic nephropathy via suppression of oxidative stress and inflammation in streptozotocin-induced rats
In conclusion, our data demonstrate that UA could be well used as a protective agent to counter renal dysfunction – through antioxidant and anti-inflammatory effects.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-363-3p suppresses tumor growth and metastasis of colorectal cancer via targeting SphK2
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Jinlang Dong, Jianshan Geng, Weiwei TanAbstractAberrant expression of miR-363-3p is seen in a wide array of cancers. The exact function of miR-363-3p in colorectal cancer (CRC), and the underlying mechanisms remain undefined. In the current study, we observed a down-regulation of miR-363-3p in CRC tissues, along with a strong correlation between low miR-363-3p levels and clinico-pathological parameters like tumor stage and lymph node metastasis. Ectopic overexpression of miR-363-3p in HT29 and HCT116 cell lines effectively inhib...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Angiopoietin 2 promotes angiogenesis in tissue-engineered bone and improves repair of bone defects by inducing autophagy
In conclusion, our study demonstrated that a high concentration of Ang2 promoted angiogenesis in tissue-engineered bone and improved repair of bone defects by inducing autophagy.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

MicroRNA-449a upregulation promotes chondrocyte extracellular matrix degradation in osteoarthritis
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Jianjun Wu, Min Zou, Ansong Ping, Zhouming Deng, Lin CaiAbstractOsteoarthritis (OA) is a highly prevalent chronic and degenerative joint disease characterized by the continuous destruction of the articular cartilage. MicroRNAs (miRNAs) have been reported to be strongly involved in the pathogenesis of OA. The aim of this study was to explore whether miR-449a regulates the expression of growth differentiation factor5 (GDF5), which promotes chondrocyte extracellular matrix (ECM) degradation. We found that miR-449a expression was up...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Role of an indole-thiazolidiene PPAR pan ligand on actions elicited by G-protein coupled receptor activated neutrophils
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): José Roberto Santin, Isabel Daufenback Machado, Carine C. Drewes, Léonard de Vinci Kanda Kupa, Rodrigo Marcondes Soares, Danielle Maia Cavalcanti, Ivan da Rocha Pitta, Sandra H.P. FarskyAbstractNeutrophils are the first line of defence during inflammatory processes; nevertheless, exacerbated influx and actions of neutrophils in terms of uncontrolled inflammation are harmful to the host. Hence, neutrophil activity is the target of drugs seeking to address undesired inflammation. Here, we investigated the mechanisms ...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Comprehensive anti-tumor effect of Brusatol through inhibition of cell viability and promotion of apoptosis caused by autophagy via the PI3K/Akt/mTOR pathway in hepatocellular carcinoma
In this study, we demonstrated that Brusatol inhibited cell viability, proliferation and induced apoptosis in liver cancer lines. Furthermore, Brusatol could activate autophagy in diverse liver cell lines, and the autophagy inhibitor chloroquine (CQ) reversed Brusatol-induced apoptosis in Bel7404 cells. In addition, we found that Brusatol inhibited PI3K/Akt/mTOR. Brusatol may also inhibit invasion, migration and the epithelial-mesenchymal transition (EMT). In a human liver xenograft tumor model in nude mice, immunohistochemistry showed that Brusatol significantly inhibited tumor invasion and proliferation. Taken together, ...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

TGF-β1 modulates podocyte migration by regulating the expression of integrin-β1 and -β3 through different signaling pathways
This study provides a novel mechanism for TGF-β1 signaling in regulating podocyte migration.Graphical abstractTGF-β1 inhibits integrin-β1 maturation through MAP kinases pathway, but increases integrin-β3 expression through Smad2/3 and MAP kinases pathways in podocytes. The increased integrin-β3 promotes podocyte adhesion and migration that may lead to foot process effacement. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Therapeutic efficacy of zingerone against vancomycin-induced oxidative stress, inflammation, apoptosis and aquaporin 1 permeability in rat kidney
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Fatih Mehmet Kandemir, Serkan Yildirim, Sefa Kucukler, Cuneyt Caglayan, Amdia Mahamadu, Muhammet Bahaeddin DortbudakAbstractVancomycin (VCM) is a glycopeptidic broad-spectrum antibiotic against methicillin-resistant Staphylococcus aureus, though it has some adverse effects, including nephrotoxicity, that limit its usefulness. Zingerone (ZO), a component of dry ginger root, has several pharmacological activities due to its antioxidant, anti-inflammatory and antiapoptotic properties. The aim of this study was to determine the ther...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of Monocolin K and COQ10 supplementation in hypertensive and hypercholesterolemic subjects with metabolic syndrome
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Alberto Mazza, Salvatore Lenti, Laura Schiavon, Ezio Di Giacomo, Monica Tomasi, Roberto Manunta, Gioia Torin, Danyelle M. Townsend, Domenico RubelloAbstractIntroductionMetabolic syndrome (MetS) is a world-wide epidemic disease with an increased risk of morbidity and mortality. Treatment strategies of MetS include pharmacologic and non-pharmacologic interventions and in this respect a relevant role has been shown for nutraceutical compounds (NCs). The aim of this study was to investigate the efficacy and safety of NCs incorporate...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Neuroprotective effect of Decalepis hamiltonii aqueous root extract and purified 2-hydroxy-4-methoxy benzaldehyde on 6-OHDA induced neurotoxicity in Caenorhabditis elegans
In this study, we investigated the possible neuroprotective efficacy of Decalepis hamiltonii tuber extract against 6-Hydroxy dopamine (6-OHDA) induced neurotoxicity and associated effects in Caenorhabditis elegans. The major component of flavour rich extract from D. hamiltonii is 2-hydroxy-4-methoxy benzaldehyde (2H4MB) which is an isomer of vanillin. We have conducted preliminary experiments with different types of extracts and subsequently DHFE (D. hamiltonii Fresh Tuber Extract) and DHPF (D. hamiltonii purified 2H4MB fraction) were used for further studies. Here we attempted to enumerate the neuroprotective efficacy of ...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Current advances of pharmacological properties of 7-chloro-4-(phenylselanyl) quinoline: Prevention of cognitive deficit and anxiety in Alzheimer’s disease model
In conclusion, 4-PSQ protected against learning and memory impairment and anxiety in a mouse model of AD induced by Aβ, and anticholinesterase and antioxidant actions are involved in the pharmacological effect of the compound.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Protective effects of Spinacia oleracea seeds extract in an experimental model of schizophrenia: Possible behavior, biochemical, neurochemical and cellular alterations
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Monu Yadav, Milind Parle, Nidhi Sharma, Deepak Kumar Jindal, Aryan Bhidhasra, Mamta Sachdeva Dhingra, Anil Kumar, Sameer DhingraAbstractSchizophrenia is one of the psychotic mental disorders characterized by symptoms of thought, behavior, and social problems. Newer biomedicine and pharmacotherapy has been investigated for the treatment of various neuropsychiatric disorders in the past few decades. Spinacia oleracea is one of these, reported to have beneficial effect against several neurodegenerative disorders. The present study ...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

17-DMAG-loaded nanofibrous scaffold for effective growth inhibition of lung cancer cells through targeting HSP90 gene expression
In conclusion, the findings demonstrated that 17-DMAG-loaded PCL/PEG nanofibers are more effectual than free 17-DMAG against A549 lung cancer cells via modulation of Hsp90 expression and inhibition of telomerase activity. Hence, the implantable 17-DMAG-loaded nanofibrous scaffolds might be an excellent tool for efficiently killing of the lung residual cancer cells and avoid the local cancer recurrence.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Effects of the SGLT2 inhibitor ipragliflozin on food intake, appetite-regulating hormones, and arteriovenous differences in postprandial glucose levels in type 2 diabetic rats
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Atsuo Tahara, Yoshinori Kondo, Toshiyuki Takasu, Hiroshi TomiyamaAbstractAimsThe sodium-glucose cotransporter (SGLT) 2 inhibitor, ipragliflozin, improves not only hyperglycemia but also obesity in type 2 diabetic animals and patients; however, there have been concerns that it may also cause an increase in compensatory food intake. Appetite is regulated by complex mechanisms involving the central nervous system, part of which involves appetite-related hormones and arteriovenous differences in postprandial glucose levels. We evalu...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Tanshinones from Salvia miltiorrhiza Bunge revert chemotherapy-induced neuropathic pain and reduce glioblastoma cells malignancy
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Lorenzo Di Cesare Mannelli, Marialuisa Piccolo, Francesco Maione, Maria Grazia Ferraro, Carlo Irace, Vincenzo De Feo, Carla Ghelardini, Nicola MascoloAbstractMedicinal plants and herbal extracts from traditional Chinese medicine are used increasingly commonly worldwide for their benefits to health and quality of life as dietary supplements or as ingredients in functional foods. Among them, Salvia miltiorrhiza Bunge (a natural strong remedy for the treatment of a variety of conditions) is traditionally used for centuries in Asian...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of simvastatin and microRNA-21 inhibitor on metastasis and progression of human salivary adenoid cystic carcinoma
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Chao Wang, Ting Li, Fei Yan, Wenyan Cai, Jiwei Zheng, Xingyu Jiang, Jinhu SunAbstractSalivary adenoid cystic carcinoma (SACC) is a common malignancy of the salivary glands. Epithelial-mesenchymal transition (EMT) and P53 signaling pathway are associated with SACC metastasis and progression. Although simvastatin (SIM) is effective against the growth of many cancer types, its side effects limit its use. microRNA-21 (miR-21) is highly expressed in a variety of tumors and has a role in promoting tumor development. Therefore, the aim...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Extract of Penicillium sclerotiorum an endophytic fungus isolated from Cassia fistula L. induces cell cycle arrest leading to apoptosis through mitochondrial membrane depolarization in human cervical cancer cells
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Gini C Kuriakose, Divya Lakshmanan M, Arathi BP, Hari Kumar RS, Anantha Krishna TH, Kavya Ananthaswamy, Jayabhaskaran C.AbstractSeventeen endophytic fungi were isolated from various tissues of Cassia fistula and the ethyl acetate extracts obtained from 21-day cultures of all the endophytic fungal isolates were initially screened for their cytotoxicity against HeLa (human cervical carcinoma) cells using MTT assay. Of these, Penicillium sclerotiorum extract (PSE), significantly affected the viability of HeLa cells in a dose-depend...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-129 regulates growth and invasion by targeting MAL2 in papillary thyroid carcinoma
In this study, we investigated the roles and underlying mechanism of MAL2 in the development of papillary thyroid carcinoma (PTC). Up-regulation of MAL2 was found in human PTC tissues and significantly correlated with poor overall survival (OS). Knockdown of MAL2 dramatically suppressed PTC cell proliferation and invasion in vitro and inhibited tumor growth in vivo. We further found that miR-129 suppressed the expression of MLA through directly binding to the 3′ untranslated region (3′ UTR). While forced miR-129 expression suppressed growth and invasion of PTC cells, re-expression of MAL2 rescued these effects....
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Probable mechanisms involved in the antipsychotic-like activity of morin in mice
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Benneth Ben-Azu, Adegbuyi Oladele Aderibigbe, Itivere Adrian Omogbiya, Abayomi Mayowa Ajayi, Olatunde Owoeye, Elizabeth Toyin Olonode, Ezekiel O. IwalewaAbstractEvidence derived from preliminary studies suggests that morin, a neuroactive flavonoid with proven antioxidant and antiinflammatory properties possess antipsychotic-like activity. The present study was designed to evaluate the probable mechanisms involve in the antipsychotic-like activity of morin in ketamine model of schizophrenia. The effects of morin, haloperidol and ...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Modulation of hyperglycemia and dyslipidemia in experimental type 2 diabetes by gallic acid and p-coumaric acid: The role of adipocytokines and PPARγ
In conclusion, gallic acid and p-coumaric acid exhibited marked antidiabetic action that could be mediated via modulation of TNF-α and adipocytokines secretions as well as upregulation of PPARγ mRNA expression.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Morphometric changes and AQP2 expression in kidneys of young male rats exposed to chronic stress and a high-sucrose diet
ConclusionsOur results show that both chronic stress and a high-sucrose diet induce histological changes, but chronic stress may generate an accelerated glomerular hypertrophy associated with functional changes before puberty.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

miR-149 regulates the proliferation and apoptosis of cervical cancer cells by targeting GIT1
In this study, miR-149 expression is decreased in CC tissues and cell lines compare with paired normal tissues and normal epithelial cell, respectively. Moreover, the restoration of miR-149 expression inhibited cell proliferation, migration, invasion and promoted cell apoptosis in vitro. We further proved that miR-149 overexpression suppresse the growth of cervical cancer cells in vivo using a mouse xenograft model. Dual luciferase assays identified the GIT1 as a novel direct target of miR-149. To identify the mechanisms, we investigated the PI3K/AKT/mTOR pathway and found that the expression of PI3K, AKT and mTOR were sup...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Protective aptitude of Periploca hydaspidis Falc against CCl4 induced hepatotoxicity in experimental rats
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Saima Ali, Muhammad Rashid Khan, Sayed Afzal Shah, Riffat Batool, Sonia Maryam, Muhammad Majid, Zartash ZahraAbstractIn the present study the antioxidant capacity of Periploca hydaspidis was assessed through various in vitro assays and by the hepatoprotective potential on CCl4 induced toxicity in rat. Phytochemical analysis of different extracts of P. hydaspidis indicated existence of various phytochemical classes. HPLC-DAD analysis of methanol extract indicated the existence of rutin, gallic acid and caffeic acid. Total phenoli...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Long non-coding RNA HOTTIP is upregulated in renal cell carcinoma and regulates cell growth and apoptosis by epigenetically silencing of LATS2
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Feifei Peng, Xiaoli Shi, Yin Meng, Bo Dong, Guangchi Xu, Tingting Hou, Yang Shi, Tao LiuAbstractRenal cell carcinoma (RCC) is one of the most aggressive malignancies with increasing incidence worldwide and is characterized by dismal prognosis owing to a lack of early detection and prognostic biomarkers for this fatal disease. Accumulating studies demonstrated that abnormally expressed long non-coding RNAs (lncRNAs) are involved in tumorigenesis and progression. Specifically, HOTTIP is upregulated and exerts oncogenic properties ...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Knockdown of CREB1 promotes apoptosis and decreases estradiol synthesis in mouse granulosa cells
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Pengju Zhang, Jun Wang, Hongyan Lang, Weixia Wang, Xiaohui Liu, Haiyan Liu, Chengcheng Tan, Xintao Li, Yumin Zhao, Xinghong WuAbstractCyclic AMP response element-binding protein 1 (CREB1), a member of the CREB family, is known to be involved in follicular growth, ovulation, and ovarian disease. However, the physiological function of CREB1 in mouse granulosa cells (mGCs) remains lagerly unknown. The aim of this study was to determine the role of CREB1 in mGCs by knocking down CREB1 expression. CREB1 knock-down in mGCs at the mRNA...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

microRNA-19a-3p promotes tumor metastasis and chemoresistance through the PTEN/Akt pathway in hepatocellular carcinoma
In conclusion, ectopic expression of miR-19a-3p contributes to HCC metastasis and chemoresistance by modulating PTEN expression and the PTEN-dependent pathways. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Oncogenic miR-663a is associated with cellular function and poor prognosis in renal cell carcinoma
ConclusionsThese results indicate that miR-663a can be used as an independent marker for the poor prognosis of ccRCC, and may also play an important role as a tumor oncogene in the occurrence and development of RCC. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Role of high mobility group A1/nuclear factor-kappa B signaling in coronary microembolization-induced myocardial injury
ConclusionsHMGA1/NF-κB signaling is involved in CME-induced myocardial inflammation. Inhibition of HMGA1/NF-κB signaling attenuated the CME-induced myocardial injury and improved cardiac function, suggesting a new potential target for the prevention and treatment of CME-induced myocardial injury.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Sirt3-mediated mitochondrial fission regulates the colorectal cancer stress response by modulating the Akt/PTEN signalling pathway
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Yan Wang, Xiaohui Sun, Kaihua Ji, Liqing Du, Chang Xu, Ningning He, Jinhan Wang, Yang Liu, Qiang LiuAbstractSirtuin-3 (Sirt3), a sub-family member of the nicotinamide adenine dinucleotide-dependent histone deacetylases, has been reported to be involved in mitochondrial oxidative stress regulation, mitochondrial calcium management, mitophagy activation, and mitochondrial energy metabolism. The aim of our study was to explore the functional role of Sirt3 in colorectal cancer stress, focusing particularly on its effects on mitochon...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

LncRNA H19 functions as an Aquaporin 1 competitive endogenous RNA to regulate microRNA-874 expression in LPS sepsis
ConclusionWe determined that H19 acted as AQP1 ceRNA in regulating miR-874. H19 acted as AQP1 ceRNA in regulating miR-874 and restoring LPS dysregulated inflammatory responses and myocardial dysfunction. H19 expression might be used as a potential therapeutic target for LPS induced sepsis and myocardial dysfunction.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Umbilical cord blood-mesenchymal stem cells and carvedilol reduce doxorubicin- induced cardiotoxicity: Possible role of insulin-like growth factor-1
In this study, we tried to demonstrate the effects of adding human umbilical cord blood mesenchymal stem cells (hUCB-MSCs) to carvedilol in improving the doxorubicin- induced cardiotoxicity in rats. Rats were randomly divided into four groups: group 1: control group, group 2: doxorubicin untreated group, group 3: rats injected with doxorubicin and received carvedilol, and group 4: rats injected with doxorubicin and received carvedilol and stem cell–treated. Electrocardiography (ECG) was performed to assess cardiac function after animals were sacrificed. Cardiac muscle sections were examined histologically using H&...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Therapeutic effect of vitamin B3 on hyperglycemia, oxidative stress and DNA damage in alloxan induced diabetic rat model
This study reports the effects of niacin supplementation in alloxan induced diabetic rats divided into five groups. Diabetes induced rats were further treated with niacin at two doses (10 and 15 mg /kg body weight) and compared with a control set of diabetes without treatment. Niacin treatment showed recovery in almost all parameters in a dose reliant pattern. A notable decline in oxidative stress parameters with reductions in fasting blood glucose levels was observed. Histological studies reveal damage recovery in the liver as well as kidney tissues. A notable amount of recovery was observed in cellular DNA damage. As a...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

LncRNA MEG3 enhances 131I sensitivity in thyroid carcinoma via sponging miR-182
ConclusionsMEG3 enhanced the radiosensitivity of 131I in TC cells via sponging miR-182, indicating that MEG3 may act as a potential biomarker and therapeutic target for TC patients with 131I resistance.Graphical abstractThe flow chart schematic model. 131I-resistant TC cells induce down-regulation of MEG3. Then, decreased MEG3 resulted in an increase of miR-182 expression. Finally, up-regulated miR-182 enhanced 131I resistance of TC cells by facilitating proliferation, as well as suppressing apoptosis and DNA damage. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Protective effect of human umbilical cord mesenchymal stem cell exosomes on preserving the morphology and angiogenesis of placenta in rats with preeclampsia
ConclusionhucMSC-Ex, in a dose-dependent manner, can improve the morphology of placental tissue in rats with PE, by inhibiting cell apoptosis and promoting angiogenesis in placental tissue.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Thyme extract increases mucociliary-beating frequency in primary cell lines from chronic obstructive pulmonary disease patients
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Massimo Nabissi, Oliviero Marinelli, Maria Beatrice Morelli, Giovanna Nicotra, Romilde Iannarelli, Consuelo Amantini, Giorgio Santoni, Filippo MaggiAbstractChronic obstructive pulmonary disease (COPD) is a respiratory disorder characterized by a progressive and irreversible airflow limitation. COPD is associated to a chronic inflammatory response with infiltration of inflammatory cells in the surface epithelium of large airways and abnormalities in structure and functions of cilia. Thyme (Thymus vulgaris L.) is a traditional med...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

LncRNA XIST accelerates cervical cancer progression via upregulating Fus through competitively binding with miR-200a
In this study, we aim to explore the specific mechanism and biological function of XIST in cervical cancer. At first, the expression levels of XIST were examined in both tissues and cell lines with qRT-PCR. XIST was extremely overexpressed in cervical cancer tissues and cell lines. Kaplan Meier method was then applied to analyze the correlation between XIST expression and overall survival of cervical cancer patients. Loss-of- function assays were designed and conducted to verify the oncogenic function of XIST on cervical cancer progression. Additionally, the results of mechanistic experiments indicated that XIST upregulate...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Yes-associated protein enhances proliferation and attenuates sensitivity to cisplatin in human gastric cancer cells
ConclusionYAP enhances gastric cancer cell proliferation and attenuates sensitivity to cisplatin potentially through targeting the EGFR signaling, indicating that YAP/EGFR signaling axis may serve as a potential target for treatment of gastric cancer. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

MicroRNA-34a promotes iNOS secretion from pulmonary macrophages in septic suckling rats through activating STAT3 pathway
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Dong-Liang Cheng, Hong-Xing Fang, Yuan Liang, Yi Zhao, Chang-song ShiAbstractPediatric sepsis is frequently a fatal condition and a major cause of death globally. The mortality rate of sepsis remains high despite that the advanced therapeutic methods have been carried out. Our research aims to investigate the potentials of miR-34a in the treatment of pediatric sepsis. Results indicated that miR-34a was up-regulated in Lipopolysaccharide (LPS)-induced pulmonary macrophages and U937 cell lines. In addition, miR-34a silence reduced...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Apigenin prevents metabolic syndrome in high-fructose diet-fed mice by Keap1-Nrf2 pathway
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Min Yang, Zhen-huan Jiang, Chen-guang Li, Yan-juan Zhu, Zhu Li, Yun-zhao Tang, Chang-lin NiAbstractChronic dietary high fructose leads to various kinds of undesirable metabolic effects. Apigenin, a naturally occurring plant flavone, is plentiful in fruits and vegetables. The aim of this study was to identify the protective effects of apigenin on metabolic syndrome and elucidate potential underlying mechanisms. The animal model was established by 4-weeks high fructose feeding. Insulin resistance was estimated by oral glucose tole...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research