Puerarin attenuates neurological deficits via Bcl-2/Bax/cleaved caspase-3 and Sirt3/SOD2 apoptotic pathways in subarachnoid hemorrhage mice
ConclusionsIn coclusion, puerarin can provide potential neuroprotection from the SAH damages, and can be act as a novel therapy for SAH. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Azadirachta indica inhibits key enzyme linked to type 2 diabetes in vitro, abates oxidative hepatic injury and enhances muscle glucose uptake ex vivo
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Olakunle Sanni, Ochuko L. Erukainure, Chika I. Chukwuma, Neil A. Koorbanally, Collins U. Ibeji, Md. Shahidul IslamAbstractThe progression of secondary complications in type 2 diabetes (T2D) has been linked to oxidative stress caused by hyperglycemia. Therefore, the control of hyperglycemia is the main target in the treatment of diabetes. The present study investigated the scavenging and ameliorative potentials of different fractions of Azadirachta indica (A. indica) ethanol stem bark extract in Fe2+-induced oxidative injury in hep...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Comparison of antidiabetic effects of saponins and polysaccharides from Momordica charantia L. in STZ-induced type 2 diabetic mice
This study was aimed to fully compare the antidiabetic effects and the potential mechanism of saponins (SMC) and polysaccharides (PMC) from M. charantia in STZ-induced type 2 diabetic mice with high-fat diet. Three dosages of SMC (L-SMC: 20 mg/kg, M-SMC: 40 mg/kg, H-SMC: 80 mg/kg) have a certain of therapeutic effect on type 2 diabetic mice, and M-SMC (40 mg/kg) is the optimal dosage for the prevention and treatment of diabetes. The results showed that oral administration of SMC, especially M-SMC (40 mg/kg) compared to PMC (500 mg/kg), could significantly restore the body weight, reduce fasting blood glucose le...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

MicroRNA-384 inhibits the progression of esophageal squamous cell carcinoma through blockade of the LIMK1/cofilin signaling pathway by binding to LIMK1
ConclusionCollectively, based on the key findings of the study, miR-384 could sequester LIMK1, which acts to suppress activation of the LIMK1/cofilin signaling pathway, thus ultimately inhibiting the development and progression of ESCC. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

EG-VEGF silencing inhibits cell proliferation and promotes cell apoptosis in pancreatic carcinoma via PI3K/AKT/mTOR signaling pathway
ConclusionThis study identified the high-expression of EG-VEGF in pancreatic carcinoma tissues and cells, and demonstrated that EG-VEGF silencing inhibits the proliferation of PC cells and promotes apoptosis via regulating PI3K/AKT/mTOR pathway. Thus, EG-VEGF may become an essential target for the therapy of pancreatic cancer in the future.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

In vivo antileishmanial efficacy of a naphthoquinone derivate incorporated into a Pluronic® F127-based polymeric micelle system against Leishmania amazonensis infection
In conclusion, results suggested that the Flau-A/M compound may be considered as a possible therapeutic target to be evaluated against human leishmaniasis.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

ELK1-induced upregulation of long non-coding RNA MIR100HG predicts poor prognosis and promotes the progression of osteosarcoma by epigenetically silencing LATS1 and LATS2
In this study, we investigated the biological function and molecular mechanism of MIR100HG in the progression of osteosarcoma. At first, we measured the high expression of MIR100HG in OS tissues and cell lines by qRT-PCR. Kaplan-Meier method revealed that high expression of MIR100HG is a factor for the poor prognosis of OS patients (P = 0.004). To explore the effect of MIR100HG on the biological processes of OS, loss-of-function assays were conducted in OS cells. Functionally, MIR100HG knockdown suppressed cell proliferation, cell cycle progression while promoted cell apoptosis. Mechanistically, MIR100HG was ...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Knockdown of lncRNA-H19 inhibits cell viability, migration and invasion while promotes apoptosis via microRNA-143/RUNX2 axis in retinoblastoma
ConclusionKnockdown of lncRNA-H19 acted a tumor suppressive role in Y79 cells through up-regulating miR-143. Moreover, miR-143 exerted tumor suppressive effects on Y79 cells by targeting RUNX2, along with inhibition of the PI3K/AKT/mTOR pathways. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Hydroxysafflor yellow A suppresses angiogenesis of hepatocellular carcinoma through inhibition of p38 MAPK phosphorylation
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Jingyu Zhang, Jingmin Li, Haoran Song, Yanlian Xiong, Desheng Liu, Xianyong BaiAbstractThe antitumor effect of hydroxysafflor yellow A (HSYA), an active ingredient of the herb Carthamus tinctorius L. (Asteraceae) (safflower), was investigated in the current work. Researches of HSYA on vasculogenesis inhibition, along with the related molecular mechanisms, including the expression of MMP-2, MMP-9, and p38MAPK (COX-2, ATF-2, p-p38MAPK, and p38MAPK) signaling pathway in H22 tumor-bearing mice or HepG2 cells were performed. The animal...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Taurine rescues the arsenic-induced injury in the pancreas of rat offsprings and in the INS-1 cells
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Qiaoting Zhang, Jie Bai, Xiaofeng Yao, Liping Jiang, Wei Wu, Lei Yang, Ni Gao, Tianming Qiu, Guang Yang, Tesfaldet Habtemariam Hidru, Xiance SunAbstractArsenic was an established carcinogen and toxicant, occurring in drinking water and food. Arsenic was increasingly being blamed as a risk factor for diabetes mellitus. Recent studies have found that arsenic could induce the generation of reactive oxygen species (ROS) and mitochondria were the major targets of ROS. Damage mitochondria could be removed by mitophagy and mitophagy play...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Expression profile of maternal circulating microRNAs as non-invasive biomarkers for prenatal diagnosis of congenital heart defects
This study aims to investigate circulating miRNAs as potential biomarkers in the serum of pregnant women with congenital heart defect (CHD) fetuses.MethodA total of 110 pregnant women including 50 CHD cases and 60 healthy controls were included in this study. miRNA microarray followed by real-time PCR was used to explore miRNA expression. Receiver operating characteristic (ROC) curves were calculated to assess the diagnostic capability of miRNAs for fetal CHDs.Results38 Serum miRNAs were revealed to be differentially expressed in the CHD group as compared to control group via microarray. Among these, nine down-regulated an...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Effects of EIF3B gene downregulation on apoptosis and proliferation of human ovarian cancer SKOV3 and HO-8910 cells
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Lei Wang, Ling OuyangAbstractIn order to investigate the role of EIF3B (eukaryotic translation initiation factor 3B, EIF3B) gene in the proliferation and apoptosis of ovarian cancer cells, a lentiviral vector system and shEIF3B lentiviral vector were constructed to transfect human ovarian cancer cells. SKOV3 and HO-8910 cells were used in this experiment. The cell growth was detected by Celigo cell counting assay, the apoptosis rate was measured by flow cytometry and the cell proliferation ability of lentivirus transfected cells w...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Protective effect of Centella asiatica against D-galactose and aluminium chloride induced rats: Behavioral and ultrastructural approaches
Conclusion: In conclusion the results suggest that CA could protect cognitive impairments and morphological alterations caused by d-gal and AlCl3 toxicity in rats. Biochemical and molecular studies are ongoing to elucidate the probable pharmacodynamics of CA.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

HPLC profiling of Mimosa pudica polyphenols and their non-invasive biophysical investigations for anti-dermatoheliotic and skin reinstating potential
In conclusion, the topical emulgel preparation loaded with MP seed extract could be a great strategy to deal with dematoheliosis.Graphical abstractExtraction and fractionation of Mimosa pudica seeds were carried out using solvents of increasing polarity. Hydro-alcoholic crude extract and three fractions (HAMP, NHMP, CLMP, and NBMP) were subjected to phytochemical analysis to estimate total phenolic contents (TPC), total flavonoid contents (TFC), antioxidant and anti-tyrosinase activity along with HPLC profiling for their polyphenols. Depending upon these results, HAMP found to be appropriate for our in-vivo study made to f...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Polysaccharides from Portulaca oleracea L. regulated insulin secretion in INS-1 cells through voltage-gated Na+ channel
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Qingjuan Hu, Qingchuan Niu, Hao Song, Shanshan Wei, Songhua Wang, Lihua Yao, Yu-Ping LiAbstractThe present study was undertaken to determine the involvement of voltage-gated Na+ channel (VGSC) and other mechanism related to insulin secretion in polysaccharides from Portulaca oleracea L. (POP)-induced secretion of insulin from insulin-secreting β-cell line cells (INS-1) cells. Our results showed that the concentration of insulin both in culture medium and inside INS-1 cells were increased under the existing of different concen...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Piceatannol pretreatment alleviates acute cardiac injury via regulating PI3K-Akt-eNOS signaling in H9c2 cells
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Dapeng Wang, Yufeng Zhang, Chunquan Zhang, Li Gao, Jie LiAbstractPiceatannol (3,3′,4,5′-trans-trihydroxystilbene) is a natural polyphenols compound that occurs hydroxylated analogue of resveratrol showing widely biological activities. Previous studies have demonstrated its functions on anti-cancer, neuroprotection and cardioprotection. However, few studies have clarified the benefits of piceatannol on cardiomyocytes except its anti-oxidative effect based on the original property of polyphenols. Here we apply H9c2 cardi...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Coenzyme Q10 attenuates lung and liver fibrosis via modulation of autophagy in methotrexate treated rat
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Doaa I. Mohamed, Eman Khairy, Sherin Shafik Tawfek, Eman K. Habib, Marwa A. FetouhAbstractThe present study was conducted to investigate the potential protective effects of coenzyme Q 10 (CoQ10) administration on methotrexate induced lung and liver fibrosis in rat model, and to explore our hypothesis regarding its possible mechanism of action through reactivation of autophagy pathway. Methotrexate induced fibrosis was achieved by intraperitoneal injections twice a week for 4 weeks. A combined treatment of CoQ10 and methotrexate we...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-148a suppressed cell invasion and migration via targeting WNT10b and modulating β-catenin signaling in cisplatin-resistant colorectal cancer cells
In conclusion, our study for the first time enriched the cisplatin-resistant CRC cells with enhanced stem cell marker expression from sphere-forming and chemo-resistant SW480-derived tumor xenografts in immune-deficient mice, and miR-148a suppressed the expression of stem cell markers, increased chemo-sensitivity, cell invasion and migration at least partly via regulating WNT10b and β-catenin signaling pathway. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Dapagliflozin attenuates early markers of diabetic nephropathy in fructose-streptozotocin-induced diabetes in rats
This study investigated the effects of dapagliflozin, a sodium glucose co-transporter 2 inhibitor, on some early markers for DN in fructose-streptozotocin (Fr-STZ)-induced diabetes in rats. Fr-STZ rats were treated with either dapagliflozin (1 mg/kg p.o. daily), metformin (350 mg/kg p.o. daily), or their combination for 6 weeks. Fr-STZ rats displayed marked early tubular renal damage and glomerular podocyte injury as evidenced by renal KIM-1, NGAL, cystatin C, and vanin-1 mRNA, as well as urinary NAG elevation and nephrin mRNA suppression, associated with the development of marked renal interstitial fibrosis ...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Histone deacetylase inhibitor MGCD0103 protects the pancreas from streptozotocin-induced oxidative stress and β-cell death
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Hae-Ahm Lee, Eunjo Lee, Ga Young Do, Eun-Kyung Moon, Fu-Shi Quan, Inkyeom KimAbstractInhibition of histone deacetylase (HDAC) suppresses inflammation of pancreatic islets and apoptosis of β-cells. However, the underlying molecular mechanism is unclear. In the present study, we demonstrate that MGCD0103 (MGCD), an HDAC inhibitor, protects the pancreas from streptozotocin (STZ)-induced oxidative stress and cell death. Sprague-Dawley rats were intraperitoneally injected with STZ (40 mg/kg) to induce type I diabetes. MGCD ...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Resistin impairs activation of protein C by suppressing EPCR and increasing SP1 expression
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Pei Zhang, Yu Liu, Jiangli Su, Jie Bai, Shikai Zhao, Shouguo ZhaoAbstractEndothelial cells are vital to blood coagulation and maintain whole body hemostasis. Binding of endothelial cells to endothelial protein C receptor (EPCR) and thrombomodulin (TM) is essential to the formation of activated protein C (APC), one of the key factors regulating blood coagulation. In our study, we showed that resistin, an adipocyte hormone, suppresses thrombin-induced protein C activation in endothelial cells. Resistin treatment results in a reducti...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Involvement of opioid system in behavioral despair induced by social isolation stress in mice
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Arvin Haj-Mirzaian, Rajan Nikbakhsh, Kiana Ramezanzadeh, Mehdi Rezaee, Hossein Amini-Khoei, Arya Haj-Mirzaian, Maria Ghesmati, Khashayar Afshari, Nazgol-Sadat Haddadi, Ahmad Reza DehpourAbstractSocial isolation stress (SIS) as a type of chronic stress could induce depressive- and anxiety-like behaviors. Our study evaluates the role of opioid system on negative behavioral impacts of SIS in male NMRI mice. We investigated effects of morphine, a nonselective opioid receptor (OR) agonist, naltrexone (NLX), an OR antagonist, naltrindol...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro
This study examines the protective mechanisms of SAA on AS in vivo and in vitro. SAA treatment (3 and 10 mg/kg/d) prevented the progression of atherosclerotic lesions and decreased 58.2% and 72.8% of the lipid deposition in the aorta of high fat-diet-induced AS rat. Notably, SAA treatment ameliorated serum lipid abnormalities by decreasing 20.4% and 33.8% of triglyceride, 26.1% and 32.7% of total cholesterol, 36.0% and 57.3% of low-density lipoprotein-cholesterol levels and increasing 183.4% and 337.5% of high-density lipoprotein-cholesterol level in the serum of AS rat (all P 
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Mitophagy protects SH-SY5Y neuroblastoma cells against the TNFα-induced inflammatory injury: Involvement of microRNA-145 and Bnip3
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Huawei Liu, Haitao Huang, Runxin Li, Wenting Bi, Lin Feng, Lingling E, Min Hu, Weisheng WenAbstractInflammatory response is involved in the development of facial neuritis. The aim of our study is to explore the role of mitophagy in facial nerve damage induced by tumor necrosis factor α (TNFα). Our results indicated that TNFα induced SH-SY5Y cell apoptosis in a dose-dependent manner. Besides, TNFα treatment also suppressed mitophagy by reducing the expression of BCL2 interacting protein 3 (Bnip3). Overexpres...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Systems pharmacology uncover the mechanism of anti-non-small cell lung cancer for Hedyotis diffusa Willd
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Xing Su, Yueping Li, Meng Jiang, Jinglin Zhu, Chunli Zheng, Xuetong Chen, Jun Zhou, Yan Li, Wei Xiao, Yonghua WangAbstractNon-small cell lung cancer (NSCLC) has become one of the most general malignancies in the world and has been shown to be the leading cause of cancer-related deaths. Traditional Chinese medicine (TCM) is considered to be a useful medicine for survival, and has been used in Asia for thousands of years. Hedyotis diffusa Willd (HDW) is an important folk herb that is used in clinical treatment of various cancers in ...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Long non-coding RNA DLEU1 exerts an oncogenic function in non-small cell lung cancer
ConclusionsDLEU1 promoted tumorigenesis and progression of NSCLC, and might be a promising therapeutic target for NSCLC.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

miR-532-3p promotes hepatocellular carcinoma progression by targeting PTPRT
ConclusionOur results demonstrate that miR-532-3p, which is frequently up-regulated in HCC, contributes to HCC cells mobility and proliferation through targeting PTPRT.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Ginsenoside Rd contributes the attenuation of cardiac hypertrophy in vivo and in vitro
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Ningning Zhang, Xiangbo An, Pingping Lang, Feng Wang, Yunpeng XieAbstractCardiac hypertrophy are the major health challenges in the whole world. Ginsenoside Rd is an important component of cell growth and tumorigenesis, but the role and mechanism of ginsenoside Rd in pressure overload induced cardiac dysfunction and remodeling are still not fully illuminated. Here, cardiac hypertrophic remodeling and dysfunction were induced by pressure overload in mice. Myocardial histology was detected by Masson's trichrome staining and hematoxy...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

The protective effect of the flavonoid fraction of Abutilon theophrasti Medic. leaves on LPS-induced acute lung injury in mice via the NF-κB and MAPK signalling pathways
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Chunlian Tian, Peng Zhang, Jie Yang, Zehui Zhang, Hong Wang, Yuru Guo, Mingchun LiuAbstractAccompanied by the damages of epithelial and capillary endothelial cell, acute lung injury is diagnosed with the typical pathological symptoms in clinic, including diffusing of pulmonary interstitial, alveolar oedema and hypoxic respiratory insufficiency. Current study focused on the investigation the anti-inflammatory action and mechanisms of total flavonoids extract (TFE) from Abutilon theophrasti Medic. leaves on ALI mice induced by LPSs....
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Neferine inhibits proliferation, migration and invasion of U251 glioma cells by down-regulation of miR-10b
ConclusionsThese results suggested that NEF exerted anti-tumor effect by down-regulation of miR-10b and deactivation of PTEN/PI3K/AKT and p38MAPK signal pathways in glioma cells. These findings might provide a novel therapeutic strategy for glioma. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Tetramethylpyrazine (TMP) ameliorates corneal neovascularization via regulating cell infiltration into cornea after alkali burn
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Yihui Wu, Zhuojun Xu, Ying Yang, Jin Qiu, Meng Yang, Chuangran Wu, Zhipeng Lai, Mingjun Tang, Jian Ge, Keming Yu, Jing ZhuangAbstractIn the present study, we investigated the underlying mechanism of tetramethylpyrazine (TMP)-medicated inhibition of corneal neovascularization (CNV). Our data showed that TMP could effectively downregulate the expression levels of CXCR4 mRNA and protein, as well as inhibit HUVECs, endothelial cells, tubule formation in vitro. In vivo, alkali burn (1 M NaOH) could remarkably upregulate CXCR4 ex...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Protective and reversal actions of a novel peptidomimetic against a pivotal toxin implicated in Alzheimer’s disease
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Giovanni Ferrati, Georgi Bion, Andrew J. Harris, Susan GreenfieldAbstractDespite the many attempts to understand the aetiology of Alzheimer’s disease, the basic mechanisms accounting for the progressive cycle of neuronal loss are still unknown. Previous work has suggested that the pivotal molecule mediating neurodegeneration could be an independently acting peptide cleaved from acetylcholinesterase. This previously unidentified agent acts as a signalling molecule in selectively vulnerable groups of cells where erstwhile deve...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Ailanthone exerts anticancer effect by up-regulating miR-148a expression in MDA-MB-231 breast cancer cells and inhibiting proliferation, migration and invasion
ConclusionsThese data demonstrated that AIL inhibited proliferation, migration and invasion of MDA-MB-231 cells by regulating miR-148a.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Fibroblast growth factor 21 improves glucose homeostasis partially via down-regulation of Na+-d-glucose cotransporter SGLT1 in the small intestine
In conclusion, FGF-21 regulates glucose level in diabetes partially due to inhibiting glucose absorption in the SI via inactivating SGK-1 pathway. These results expand our knowledge about how FGF-21 regulates glucose metabolism.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Preeclampsia: A close look at renal dysfunction
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Hakimeh Moghaddas Sani, Sepideh Zununi Vahed, Mohammadreza ArdalanAbstractPreeclampsia (PE) is a unique pathophysiologic situation that physiologic interests of mother, fetus, and placenta diverge. PE is related to the increased circulating antiangiogenic factors originated from hypoxic placenta. It is simply defined by the new onset of hypertension (≥140/90 mmHg) and proteinuria (≥0.3 g/day) after 20 weeks of gestation. PE is associated with kidney dysfunction due to deficiency in podocyte specific vascular en...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Hyperbaric oxygen therapy: Antimicrobial mechanisms and clinical application for infections
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Mohammad Yousef Memar, Mina Yekani, Naser Alizadeh, Hossein Bannazadeh BaghiAbstractHyperbaric oxygen therapy (HBOT) is a treatment procedure that involves breathing 100% O2 for a certain time and under a certain pressure. HBOT is commonly administrated as a primary or alternative therapy for different diseases such as infections. In this paper, we reviewed the general aspect of HBOT procedures, the mechanisms of antimicrobial effects and the application in the treatment of infections. Parts of the antimicrobial effects of HBOT ar...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Stress-driven discovery in the natural products: A gateway towards new drugs
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Syed Shams ul Hassan, Hui-zi Jin, Tareq Abu-Izneid, Abdur Rauf, Muhammad Ishaq, Hafiz Ansar Rasul SuleriaAbstractElicitation by chemical means including heavy metals is one of a novel technique for drug discoveries. In this review, the effect of heavy metals on animal, plants and microorganisms for the production of novel compounds with the unique structures has been discussed. The number of parameters such as metal concentration, type, dose, treatment schedule, duration of metal exposure, and nutrient composition are significant ...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

NK cells in cerebral ischemia
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Chen Chen, Qi-Di Ai, Shi-Feng Chu, Zhao Zhang, Nai-Hong ChenAbstractAs a vital cell type in immune system and infiltrating cells in ischemic brain, NK cells can bridge the crosstalk between immune system and nervous system in stroke setting. The mechanism of action of NK cells is complicated, involving direct and indirect actions. NK cells are closely associated with poststroke inflammation, immunodepression and infections. The excessive inflammatory response in ischemic brain is one of the important causes for aggravating cerebra...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Hyperbaric oxygen and aerobic exercise in the long-term treatment of fibromyalgia: A narrative review
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Kholoud M. El-Shewy, Ahmad Kunbaz, Mohamed M. Gad, Muneer J. Al-Husseini, Anas M. Saad, Yasser M. Sammour, Mohamed M. Abdel-DaimAbstractChronic pain is one of the most common clinical presentations in the primary care settings. In the US, Fibromyalgia (FM) affects about 1–3% of adults and commonly occurs in adults between the ages of 40–50 years. FM causes widespread muscular pain and tenderness with hyperalgesia and allodynia and may be associated with other somatic complaints.Hyperbaric oxygen therapy (HBOT) has been...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

The renin-angiotensin system as a target to solve the riddle of endocrine pancreas homeostasis
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Francielle Graus-Nunes, Vanessa Souza-MelloAbstractLocal renin-angiotensin system (RAS) in the pancreas is linked to the modulation of glucose-stimulated insulin secretion (GSIS) in beta cells and insulin sensitivity in target tissues, emerging as a promising tool in the prevention and/or treatment of obesity, diabetes, and systemic arterial hypertension. Insulin resistance alters pancreatic islet cell distribution and morphology and hypertrophied islets exhibit upregulated angiotensin II type 1 receptor, which drives oxidative st...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Dietary composition modulates impact of food-added monosodium glutamate on behaviour, metabolic status and cerebral cortical morphology in mice
In conclusion, the findings suggest that possible interactions that may occur between dietary constituents and MSG are determinants of the effects of food-added MSG in mice.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Prevention of pentylenetetrazole-induced kindling and behavioral comorbidities in mice by levetiracetam combined with the GLP-1 agonist liraglutide: Involvement of brain antioxidant and BDNF upregulating properties
In conclusion, our results showed that LIRA can be a promising adjunctive therapy for epilepsy-related neuropsychiatric comorbidities and to improve the management of antiepileptic drug associated behavioral adverse effects.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Cardio-protective and antioxidant properties of caffeic acid and chlorogenic acid: Mechanistic role of angiotensin converting enzyme, cholinesterase and arginase activities in cyclosporine induced hypertensive rats
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Odunayo Michael Agunloye, Ganiyu Oboh, Adedayo Oluwaseun Ademiluyi, Ayokunle Olubode Ademosun, Akintunde Afolabi Akindahunsi, Ademola Adetokunbo Oyagbemi, Temidayo Olutayo Omobowale, Temitayo Olabisi Ajibade, Adeolu Alex AdedapoAbstractCaffeic acid (CAA) and chlorogenic acid (CHA) are important members of hydroxycinnamic acid with natural antioxidant and cardio-protective properties. The present study aimed to determine the effect of CAA and CHA on systolic blood pressure, heart rates (HR) as well as on the activity of the angiote...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Teneligliptin protects against hypoxia/reoxygenation-induced endothelial cell injury
In this study, we investigated the effect of teneligliptin on hypoxia/reoxygenation (H/R)-induced endothelial cell injury in rat cardiac microvascular endothelial cells (CMECs). We showed that teneligliptin pretreatment suppressed H/R-induced production of reactive oxygen species (ROS), NADPH oxidase 4 (NOX4) expression and promoted glutathione production. Teneligliptin pretreatment reduced H/R-induced LDH release and improved cell viability. Teneligliptin significantly relieved the reduction in mitochondrial membrane potential (MMP) induced by H/R. Moreover, teneligliptin suppressed H/R-induced cytokine production and pro...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Ovarian carcinoma biological nanotherapy: Comparison of the advantages and drawbacks of lipid, polymeric, and hybrid nanoparticles for cisplatin delivery
In this study, DDP loaded nanostructured lipid carriers (DDP-NLC), polymeric NPs (DDP-PNP), and lipid–polymer hybrid nanoparticles (DDP-LPN) were prepared for the evaluation in vitro and in vivo. The efficiency of these three kinds of the NPs was compared in terms of in vitro drug release, cellular uptake, in vitro cell growth inhibition, in vivo pharmacokinetics, biodistribution and in vivo antitumor in mice. The size of DDP-PNP (119.8 nm) was smaller than DDP-NLC (132.4 nm) and DDP-LPN (141.2 nm). The release of DDP from DDP-NLC was faster than DDP-PNP. Cellular uptake efficiency of DDP-NLC and...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Triterpenoids from fruits of Sorbus pohuashanensis inhibit acetaminophen-induced acute liver injury in mice
In this study, triterpenoids (Trds) which are mainly composed of ursolic acid and oleanolic acid, were isolated and prepared from fruits of Sorbus pohuashanensis. Further, the effect of Trds against APAP-induced liver injury and the pharmacological mechanism were investigated. The results showed that Trds treatment significantly restrained the increase of serum aspartate transaminase (AST), alanine aminotransferase (ALT), tumor necrosis factor (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6), and hepatic malondialdehyde (MDA) levels, as well as evidently reversed the decrease of hepatic superoxide d...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Baicalein stimulates fibroblast growth factor 21 expression by up-regulating retinoic acid receptor-related orphan receptor α in C2C12 myotubes
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Takao Hirai, Kohei Nomura, Rie Ikai, Ken-ichi Nakashima, Makoto InoueAbstractRetinoic acid receptor-related orphan receptor (ROR) α has been implicated in various physiological functions, including the immune system, inflammation, and circadian rhythms. In the present study, the synthetic RORα/γ agonist SR1078 stimulated the production and gene expression of fibroblast growth factor 21 (FGF21) in C2C12 myotubes. FGF21, a member of the FGF family, plays important roles in the regulation of peripheral glucose toler...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Bile acids elicited endothelium-dependent vasoconstrictor hypo-activity through TRPV4 channels in the thoracic aorta of bile duct ligation rats
In this study, we first determined that bile acids elicited endothelium-dependent vasoconstrictor hypo-activity via TRPV4 channels, which further activated cyclooxygenase 2 (COX2). Myography results demonstrated that the vascular contractile response was attenuated in BDL rats when exposed to 60 mmol/L KCl. Real time PCR and western blotting results showed that bile duct ligation (BDL) induced a time-dependent increase in TRPV4 expression levels. In addition, bile acids upregulated the expression of TRPV4 protein, which proved to be located on the cell surface of endothelial cells, and induced intracellular Ca2+ eve...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Increased expression of LINC01510 predicts poor prognosis and promotes malignant progression in human non-small cell lung cancer
This study aimed to characterize the biological role of LINC01510 in NSCLC and illuminate the molecular mechanisms. Here we found that LINC01510 was highly expressed in NSCLC tissues. Besides, Fisher’s exact test showed that high expression of LINC01510 was associated with larger tumor size, advanced TNM stage and lymph node metastasis. Kaplan-Meier survival analysis showed that patients with high LINC01510 expression had a much lower overall survival rate. Gain- and loss-of-function approaches were employed to investigate the effects of LINC01510 on NSCLC cell phenotypes. Functional studies demonstrated that LINC015...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Possible neuroprotective mechanisms of action involved in the neurobehavioral property of naringin in mice
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Benneth Ben-Azu, Ekene Enekabokom Nwoke, Adegbuyi Oladele Aderibigbe, Itivere Adrian Omogbiya, Abayomi Mayowa Ajayi, Elizabeth Toyin Olonode, Solomon Umukoro, Ezekiel O. IwalewaAbstractFlavonoids are naturally occurring bioactive phytochemical metabolites widely known to prevent and suppress several human diseases, and are important sources of therapeutic compounds from plants. Evidence derived from previous studies suggests that naringin, a neuroactive flavonoid possess functional beneficial neurobehavioral effects including anxi...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research