Clinical and molecular aspects of breast cancer: Targets and therapies
Publication date: October 2018 Source:Biomedicine & Pharmacotherapy, Volume 106 Author(s): R.L.N. Godone, G.M. Leitão, N.B. Araújo, C.H.M. Castelletti, J.L. Lima-Filho, D.B.G. Martins Breast Cancer is a complex disease characterized by the occurrence of multiple molecular alterations. Currently, some molecular markers are in use for breast cancer diagnostic, prognostic, and predictive purposes. Thus, genetic signatures are available for improving the decision-making. The biomarkers are also essential as therapeutic approaches, but many questions remain due to the lack of efficacy on breast cancer tre...
Source: Biomedicine and Pharmacotherapy - June 23, 2018 Category: Drugs & Pharmacology Source Type: research

Neurobiology and consequences of social isolation stress in animal model —A comprehensive review
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Faiza Mumtaz, Muhammad Imran Khan, Muhammad Zubair, Ahmad Reza Dehpour The brain is a vital organ, susceptible to alterations under genetic influences and environmental experiences. Social isolation (SI) acts as a stressor which results in alterations in reactivity to stress, social behavior, function of neurochemical and neuroendocrine system, physiological, anatomical and behavioral changes in both animal and humans. During early stages of life, acute or chronic SIS has been proposed to show signs and symptoms of psychia...
Source: Biomedicine and Pharmacotherapy - June 22, 2018 Category: Drugs & Pharmacology Source Type: research

Erythropoietin: A potential drug in the management of diabetic neuropathy
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Samuel Suarez-Mendez, Carlos Alfonso Tovilla-Zárate, Isela E. Juárez-Rojop, Deysi Y. Bermúdez-Ocaña Erythropoietin (EPO) is required for promoting the progress of erythroid differentiation. However, the discovery of EPO and the EPO receptor (EPOR) in the nervous system may contribute to new treatment strategies for the use of EPO in neurodegenerative disorders. Diabetic neuropathy is a neurodegenerative disease that affects a large proportion of diabetic patients and results in alterations in fu...
Source: Biomedicine and Pharmacotherapy - June 19, 2018 Category: Drugs & Pharmacology Source Type: research

The effects of DMARDs on the expression and function of P-gp, MRPs, BCRP in the treatment of autoimmune diseases
This article reviews the effects of DMARDs on the expression and function of P-gp, MRPs, and BCRP and the related molecular mechanism in the treatment of AID. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - June 18, 2018 Category: Drugs & Pharmacology Source Type: research

Efficacy and safety of immunological adjuvants. Where is the cut-off?
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Alexander Batista-Duharte, Damiana Téllez Martínez, Iracilda Zeppone Carlos Research over the past several decades has provided insight into the mode of action of adjuvants. However, the main focus of attention has been the efficacy in the induction of protective immunogenicity, while less effort has been devoted to the study of toxicity mechanisms. Evidences suggest that several mechanisms that are responsible for the immunostimulating effects are, at the same time, responsible of the adverse effects. In thi...
Source: Biomedicine and Pharmacotherapy - June 10, 2018 Category: Drugs & Pharmacology Source Type: research

A short view on nanohydroxyapatite as coating of dental implants
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Javad Yazdani, Elham Ahmadian, Simin Sharifi, Shahriar Shahi, Solmaz Maleki Dizaj Introduction Titanium based (Ti-based) materials have been used as dental implants due to their high biocompatibility, good mechanical strength and ideal osseointegration properties. Osseointegration of an implant is dependent on surface characteristics such as surface chemistry and topography. Nanotechnology has presented new and interesting applications in dentistry in recent years. The presence of nanoparticles on the implant surface can a...
Source: Biomedicine and Pharmacotherapy - June 8, 2018 Category: Drugs & Pharmacology Source Type: research

Cathepsins: Proteases that are vital for survival but can also be fatal
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Seema Patel, Ahmad Homaei, Hesham R. El-Seedi, Nadeem Akhtar The state of enzymes in the human body determines the normal physiology or pathology, so all the six classes of enzymes are crucial. Proteases, the hydrolases, can be of several types based on the nucleophilic amino acid or the metal cofactor needed for their activity. Cathepsins are proteases with serine, cysteine, or aspartic acid residues as the nucleophiles, which are vital for digestion, coagulation, immune response, adipogenesis, hormone liberation, peptide...
Source: Biomedicine and Pharmacotherapy - June 6, 2018 Category: Drugs & Pharmacology Source Type: research

Treatment targets for M2 microglia polarization in ischemic stroke
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Ji wang, Hongyi xing, Lin wan, Xingjun jiang, Chen wang, Yan wu As the first line of defense in the nervous system, resident microglia are the predominant immune cells in the brain. In diseases of the central nervous system such as stroke, Alzheimer’s disease, and Parkinson’s disease, they often cause inflammation or phagocytosis; however, some studies have found that despite the current controversy over M1, M2 polarization could be beneficial. Ischemic stroke is the third most common cause of death in humans. ...
Source: Biomedicine and Pharmacotherapy - June 6, 2018 Category: Drugs & Pharmacology Source Type: research

Eucalyptus microcorys leaf extract derived HPLC-fraction reduces the viability of MIA PaCa-2 cells by inducing apoptosis and arresting cell cycle
In this study, bioassay-guided fractionation of the aqueous crude E. microcorys extract using RP-HPLC and subsequent assessment of the resultant fractions (F1–F5) for their antioxidant activity and cytotoxicity against pancreatic cancer cell lines were performed. The molecular mechanisms associated with the cytotoxicity was characterised by studying the effects of the most potent fraction-1 (F1) on apoptosis and cell cycle profiles as well as its phytochemical constituents by LC-ESI/MS/MS. F1 displayed significantly greater antioxidant activity in three different assays (p < 0.05). Moreover, F1 exhibited s...
Source: Biomedicine and Pharmacotherapy - June 5, 2018 Category: Drugs & Pharmacology Source Type: research

Biogenic gold nanoparticles synthesis mediated by Mangifera indica seed aqueous extracts exhibits antibacterial, anticancer and anti-angiogenic properties
In this study, AuNP’s was prepared by a simple one step method of employing aqueous Mangifera indica seed extract as a reducing agent. Scanning electron microscopy and transmission electron microscopy revealed spherical shaped nanoparticles and dynamic light scattering analysis indicated the AuNP’s to be approximately 46.8 nm in size. AuNP’s efficiently inhibited the growth of E. coli and S. aureus by its inherent ability to generate reactive oxygen species (ROS) and exhibited detrimental effects towards the tested bacterial species. Biocompatibility assessment indicated the non-toxic nature of AuNP&rsq...
Source: Biomedicine and Pharmacotherapy - June 5, 2018 Category: Drugs & Pharmacology Source Type: research

Portulacaoleraceal extract alleviates trinitrobenzene sulfonic acid-induced colitis in rats
This study examined the effects of POL on trinitrobenzene sulfonic acid (TNBS)-induced colitis via enema administration. Sixty male Sprague–Dawley rats were randomly divided into five groups: untreated, TNBS, TNBS + POL 10 g/kg, TNBS + POL 5 g/kg and TNBS + POL 2.5 g/kg groups. Rats were subjected to enema treatment once a day for 10 consecutive days with POL extract or distilled water after induction of TNBS. The changes of body weight, histological parameters, myeloperoxidase (MPO), superoxide dismutase (SOD), nitric oxide synthase activity (NOS), malondialdehyde (MDA) and nitric oxide (NO) levels...
Source: Biomedicine and Pharmacotherapy - June 5, 2018 Category: Drugs & Pharmacology Source Type: research

Alpha lipoic acid exerts antioxidant effect via Nrf2/HO-1 pathway activation and suppresses hepatic stellate cells activation induced by methotrexate in rats
This study explored the hepatoprotective mechanisms of ALA against MTX-induced hepatic injury in rats. Hepatic injury was induced in MTX group by 20 mg/kg body weight ip. injection of MTX. ALA group was pretreated with ALA 60 mmol/kg body weight ip. for five days followed by a single dose of MTX in the sixth day. Blood samples and liver tissues were then obtained to assess several biochemical parameters as serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), reduced glutathione (GSH), total antioxidant capacity (TAC) and lipid peroxidation. Nuclear factor E2-related factor...
Source: Biomedicine and Pharmacotherapy - June 5, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-129-5p functions as a tumor suppressor in gastric cancer progression through targeting ADAM9
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Qi Liu, Jianwu Jiang, Yang Fu, Tao Liu, Yang Yu, Xiefu Zhang MicroRNAs (miRNAs) are identified as key regulators in cancer initiation, progression and metastasis including gastric cancer (GC). The aim of the study is to explore clinical significance and potential mechanism of miR-129-5p in GC development. In the study, our results found that miR-129-5p expression was significantly downregulated in GC tissues, compared with adjacent normal tissues using qRT-PCR analyses. Furthermore, lower miR-129-5p expression closely asso...
Source: Biomedicine and Pharmacotherapy - June 5, 2018 Category: Drugs & Pharmacology Source Type: research

Downregulation of MiR-1297 predicts poor prognosis and enhances gastric cancer cell growth by targeting CREB1
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Wencang Gao, Ying Cao, Piaoting Guo, Xiaoyan Bao, Hongye Zhu, Jian Zheng, Cheng Yao, Dong Chen, Shenquan Yu, Binhai Chen, Shaoling Zhou, Dexiang Pang, Weijian Chen Dysregulation of mircoRNAs (miRs) that act as tumor suppressors or oncogenes is participated in tumorigenesis and progression. The aim of the study is to investigate the role and mechanism of miR-1297 in gastric cancer (GC). Here, we demonstrated that miR-1297 expression was significantly lower in GC tissue samples compared to adjacent normal tissue samples in 6...
Source: Biomedicine and Pharmacotherapy - June 3, 2018 Category: Drugs & Pharmacology Source Type: research

Xiaokeping-induced autophagy protects pancreatic β-cells against apoptosis under high glucose stress
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Yanyang Wu, Yongquan Hu, Zhou Haiyan, Wei YunLin, Kang Xincong, Liu Dongbo Xiaokeping (XKP), a prescribed Traditional Chinese Medicine (TCM), has been used to treat patients with type Ⅱ diabetes mellitus for many years; however, the molecular mechanism of its effects is unknown. As the only insulin producer, the pancreatic β cell plays an important role in diabetes. Whether XKP influences the viability of pancreatic β cells remains to be substantiated. In the present study, autophagy/apoptosis analyses were use...
Source: Biomedicine and Pharmacotherapy - June 3, 2018 Category: Drugs & Pharmacology Source Type: research

Matrix metalloproteinase-2: A key regulator in coagulation proteases mediated human breast cancer progression through autocrine signaling
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Kaushik Das, Ramesh Prasad, Shabbir Ahmed Ansari, Abhishek Roy, Ashis Mukherjee, Prosenjit Sen Aims Cell invasion is attributed to the synthesis and secretion of proteolytically active matrix-metalloproteinases (MMPs) by tumor cells to degrade extracellular matrix (ECM) and promote metastasis. The role of protease-activated receptor 2 (PAR2) in human breast cancer migration/invasion via MMP-2 up-regulation remains ill-defined; hence we investigated whether TF-FVIIa/trypsin-mediated PAR2 activation induces MMP-2 expression ...
Source: Biomedicine and Pharmacotherapy - June 3, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of yerba mate (Ilex paraguariensis) extract on the metabolism of diabetic rats
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Débora Santos Rocha, Lucas Casagrande, Jorge Felipe Argenta Model, Jordana Tres dos Santos, Ana Lúcia Hoefel, Luiz Carlos Kucharski The relationship between metabolic disturbances and clinical events related to diabetes is well known. Yerba mate has presented a potential use as preventive and therapeutic agent on diabetes. The aim of this study was to evaluate the effect of yerba mate on different tissues of diabetic rats, focusing on energetic metabolism. Diabetes was induced by streptozotocin, followed by d...
Source: Biomedicine and Pharmacotherapy - June 2, 2018 Category: Drugs & Pharmacology Source Type: research

MicroRNA-196b enhances the radiosensitivity of SNU-638 gastric cancer cells by targeting RAD23B
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Yan Nan Shen, In-Seon Bae, Gil Hong Park, Hwa Sik Choi, Kee-Ho Lee, Sang Hoon Kim Gastric cancer is characterized by resistance to ionizing radiation. The development of resistance to radiotherapy in gastric cancer patients is one of the obstacles to effective radiotherapy. MicroRNAs are small well-conserved non-coding RNA species that regulate post-transcriptional activation. Our study aimed to investigate the role of miR-196b in radiation-induced gastric cancer. In the present study, we found that miR-196b expression was...
Source: Biomedicine and Pharmacotherapy - June 2, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-214 promotes cell meastasis and inhibites apoptosis of esophageal squamous cell carcinoma via PI3K/AKT/mTOR signaling pathway
In this study, we observe that the expression of miR-214 is not only increased in human ESCC tissues, but also remarkably increased in cell lines correlates with LZTS1. In addition, the expression of miR-214 inhibited proliferation of ESCC cells in vitro and inhibit the growth of xenograft tumor in vivo. The results show miR-214 serve as a tumor promoter regulating cells migration, invasion and apoptosis in ESCC. Ferthermore, LZTS1 has been proved to as a functional target for miR-214 to regulate cells poliferation and apoptosis. In summary, these results suggest that miR-214 serves as tumor promoter to promote proliferati...
Source: Biomedicine and Pharmacotherapy - June 2, 2018 Category: Drugs & Pharmacology Source Type: research

Proteomics analysis demonstrating rosmarinic acid suppresses cell growth by blocking the glycolytic pathway in human HepG2 cells
This study aimed to investigate the molecular mechanisms of RA in HepG2 cells. RA anti-tumor activity was assessed using 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl-tetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays, and Hoechst 33258 staining. Apoptosis and the cell cycle distribution were evaluated by flow cytometry. A proteomics approach was used to identify differentially expressed proteins following RA treatment in HepG2 cells, and quantitative reverse transcription–quantitative polymerase chain reaction was used to validate the results. Bioinformatics analysis was also implemented to further understa...
Source: Biomedicine and Pharmacotherapy - June 2, 2018 Category: Drugs & Pharmacology Source Type: research

Anticancer and other therapeutic relevance of mushroom polysaccharides: A holistic appraisal
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Damini Kothari, Seema Patel, Soo-Ki Kim The discovery of nutritious dietary supplements and side effect-free therapeutics are a priority in the current scenario of increasing instances of metabolic syndromes. In this direction, mushroom polysaccharides have shown immense promise. Scores of studies have characterized and evaluated their biological relevance, which range from antioxidant, anti-inflammatory, anticancer, antidiabetic, antimicrobial, and antilipemic to immunomodulatory. Hence, it is important to accumulate the ...
Source: Biomedicine and Pharmacotherapy - June 2, 2018 Category: Drugs & Pharmacology Source Type: research

Downregulation of circular RNA hsa_circ_0001649 indicates poor prognosis for retinoblastoma and regulates cell proliferation and apoptosis via AKT/mTOR signaling pathway
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Lichen Xing, Leiming Zhang, Yali Feng, Zhe Cui, Lin Ding Retinoblastoma (RB) is the most common intraocular malignancy in infants and children with high mortality rate in developing countries. Emerging evidence demonstrated that abnormally expressed circular RNAs (circRNAs) are involved in tumorigenesis and progression in several malignancies. However, their clinical values, biological functions and mechanisms in RB has not been reported before. Recently, hsa_circ_0001649 was found to play imperative roles in cholangiocarc...
Source: Biomedicine and Pharmacotherapy - June 1, 2018 Category: Drugs & Pharmacology Source Type: research

L-A03, a dihydroartemisinin derivative, promotes apoptotic cell death of human breast cancer MCF-7 cells by targeting c-Jun N-terminal kinase
This study provides a new insight on the mechanism of L-A03-induced cell death by targeting JNK. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - June 1, 2018 Category: Drugs & Pharmacology Source Type: research

Acylated ghrelin induces but deacylated ghrelin prevents hepatic steatosis and insulin resistance in lean rats: Effects on DAG/ PKC/JNK pathway
In conclusion, while exogenous administration of AG is at high risk of developing steatohepatitis and hepatic IR, co-administration of a balanced dose of UAG reduces this risk and inhibits hepatic lipid accumulation and enhance hepatic insulin signaling. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - June 1, 2018 Category: Drugs & Pharmacology Source Type: research

Simvastatin ameliorates diabetic nephropathy by attenuating oxidative stress and apoptosis in a rat model of streptozotocin-induced type 1 diabetes
In conclusion, SIM can protect against diabetic nephropathy by attenuating oxidative stress and apoptosis. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - June 1, 2018 Category: Drugs & Pharmacology Source Type: research

CXCL10-induced IL-9 promotes liver fibrosis via Raf/MEK/ERK signaling pathway
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Xiaoyun Guo, Yu Cen, Jiaxu Wang, Haixing Jiang Liver fibrosis is a typical complication of chronic liver diseases resulting in cirrhosis that remains a major public health problem. The aim of the present study was to identify the role of interleukin-9 (IL-9), an important regulator of inflammation and autoimmune diseases, in hepatic fibrosis progression. It was found that the expression of IL-9 was significantly increased in liver tissues of liver cirrhosis patients compared with that in healthy controls. Moreover, CXCL10,...
Source: Biomedicine and Pharmacotherapy - June 1, 2018 Category: Drugs & Pharmacology Source Type: research

Curcumin regulates endogenous and exogenous metabolism via Nrf2-FXR-LXR pathway in NAFLD mice
Conclusions These findings indicate that the Nrf2/FXR/LXRα pathway might synergistically regulate both endogenous and exogenous metabolism in NAFLD mice and LXRα may be a novel therapeutic target of curcumin for the prevention and treatment of NAFLD. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - June 1, 2018 Category: Drugs & Pharmacology Source Type: research

A ferutinin analogue with enhanced potency and selectivity against ER-positive breast cancer cells in vitro
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Rémi Safi, Aline Hamade, Najat Bteich, Jamal El Saghir, Mona Diab Assaf, Marwan El-Sabban, Fadia Najjar Estrogen is considered a risk factor for breast cancer since it promotes breast-cell proliferation. The jaesckeanadiol-3-p-hydroxyphenylpropanoate, a hemi-synthetic analogue of the natural phytoestrogen ferutinin (jaesckeanadiol-p-hydroxybenzoate), is designed to be devoid of estrogenic activity. This analogue induces a cytotoxic effect 30 times higher than that of ferutinin towards MCF-7 breast cancer cell line. ...
Source: Biomedicine and Pharmacotherapy - June 1, 2018 Category: Drugs & Pharmacology Source Type: research

Mechanistic considerations in chemotherapeutic activity of caffeine
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Gullanki Naga Venkata Charan Tej, Prasanta Kumar Nayak Caffeine (1,3,7-trimethylxanthine) is one of the most commonly consumed food ingredient throughout the world for thousands of years. It is naturally present in beans, leaves, seeds, and fruits of more than 60 plants and the most common sources are cocoa beans, coffee beans, tea leaves, kola nuts, and guarana berries. Several epidemiological studies suggested that consumption of coffee reduces the risk of different types of cancers. Understanding the chemotherapeutic mo...
Source: Biomedicine and Pharmacotherapy - June 1, 2018 Category: Drugs & Pharmacology Source Type: research

Qing Gan Zi Shen Tang alleviates adipose tissue dysfunction with up-regulation of SIRT1 in spontaneously hypertensive rat
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Yao Zhu, Jing Jing Huang, Xiao Xiao Zhang, Yu Yan, Xiao Wei Yin, Gu Ping, Wei Ming Jiang Qing Gan Zi Shen Tang (QGZST) is a famous traditional Chinese medicine formula in the Jiangsu Province Hospital of Traditional Chinese Medicine for its efficacy in treating hypertension, obesity, hyperlipidemia and insulin resistance. The current study further evaluated the effects and possible mechanisms of QGZST on epididymal white adipose tissue (eWAT) dysfunction in a high-fat-diet (HFD)-fed-spontaneously hypertensive rat (SHR) mod...
Source: Biomedicine and Pharmacotherapy - May 31, 2018 Category: Drugs & Pharmacology Source Type: research

Targeted therapy of chronic liver diseases with the inhibitors of angiogenesis
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Ankita Srivastava, Vanistha Shukla, Deepika Tiwari, Jaya Gupta, Sunil Kumar, Awanish Kumar Angiogenesis appears to be intrinsically associated with the progression of chronic liver diseases, which eventually leads to the development of cirrhosis and related complications, including hepatocellular carcinoma. Several studies have suggested that this association is relevant for chronic liver disease (CLD) progression, with angiogenesis. The fact that angiogenesis plays a pivotal role in CLDs gives rise to new opportunities fo...
Source: Biomedicine and Pharmacotherapy - May 31, 2018 Category: Drugs & Pharmacology Source Type: research

Marine natural products for multi-targeted cancer treatment: A future insight
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Maushmi S. Kumar, Kaveri M. Adki Cancer is world’s second largest alarming disease, which involves abnormal cell growth and have potential to spread to other parts of the body. Most of the available anticancer drugs are designed to act on specific targets by altering the activity of involved transporters and genes. As cancer cells exhibit complex cellular machinery, the regeneration of cancer tissues and chemo resistance towards the therapy has been the main obstacle in cancer treatment. This fact encourages the rese...
Source: Biomedicine and Pharmacotherapy - May 31, 2018 Category: Drugs & Pharmacology Source Type: research

Broad targeting of triptolide to resistance and sensitization for cancer therapy
Publication date: August 2018 Source:Biomedicine & Pharmacotherapy, Volume 104 Author(s): Zhen-yan Hou, Xiao-pei Tong, Yong-bo Peng, Bi-kui Zhang, Miao Yan Cancer cell resistance to current anticancer therapeutics as well as the side effects are still obstacles to successful cancer therapy. Hence, the development of novel anticancer agents or therapeutics is of vital significance, and especially rational adjuvant therapies containing low-cost natural products with multiple targets have attracted great interests. Triptolide, the main biocomponent of Tripterygium wilfordii Hook F, is restricted in clinical applicati...
Source: Biomedicine and Pharmacotherapy - May 30, 2018 Category: Drugs & Pharmacology Source Type: research

Microbiome as therapeutics in vesicular delivery
Publication date: August 2018 Source:Biomedicine & Pharmacotherapy, Volume 104 Author(s): Gautam Singhvi, Vishal Girdhar, Shalini Patil, Gaurav Gupta, Philip M. Hansbro, Kamal Dua Microbiome refers to an ecological community of various symbiotic and pathogenic microorganisms, which plays a crucial role in human health and disease. The concept of novel drug delivery systems particularly the vesicular drug delivery systems is gaining massive attention. This emerging technology has started expanding its horizons in the area of microbiome delivery. This mini-review highlights the role of vesicular systems such as nano...
Source: Biomedicine and Pharmacotherapy - May 30, 2018 Category: Drugs & Pharmacology Source Type: research

Protective effects of zingerone on oxidative stress and inflammation in cisplatin-induced rat nephrotoxicity
In this study, Wistar rats were assigned randomly to 6 groups with 5 animals in each group. The control group; cisplatin group which received 7.5 mg/kg of cisplatin intraperitoneally (i.p.) at the 4th day; zingerone group received 50 mg/kg of zingerone orally for 7 days. Three other groups were pretreated with 10, 20, and 50 mg/kg of zingerone orally for 7 days and cisplatin administered 7.5 mg/kg i.p. at the 4th day, respectively. The animals were sacrificed 72 h after cisplatin injection and blood samples were taken to evaluate the serum factors. Right kidneys were collected for histopathological studies and le...
Source: Biomedicine and Pharmacotherapy - May 30, 2018 Category: Drugs & Pharmacology Source Type: research

Polymeric nano-encapsulation of 5-fluorouracil enhances anti-cancer activity and ameliorates side effects in solid Ehrlich Carcinoma-bearing mice
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Yusuf A. Haggag, Mohamed A. Osman, Sanaa A. El-Gizawy, Ahmed E. Goda, Maha M. Shamloula, Ahmed M. Faheem, Paul A. McCarron Biodegradable PLGA nanoparticles, loaded with 5-fluorouracil (5FU), were prepared using a double emulsion method and characterised in terms of mean diameter, zeta potential, entrapment efficiency and in vitro release. Poly (vinyl alcohol) was used to modify both internal and external aqueous phases and shown have a significant effect on nanoparticulate size, encapsulation efficiency and the initial bur...
Source: Biomedicine and Pharmacotherapy - May 30, 2018 Category: Drugs & Pharmacology Source Type: research

RNA sequencing enables systematic identification of platelet transcriptomic alterations in NSCLC patients
In this study, we performed RNA-seq in platelets from 7 healthy individuals and 15 non-small cell lung cancer (NSCLC) patients. Our data revealed a subset of near universal differently expressed gene (DEG) profiles in platelets of metastatic NSCLC compared to healthy individuals, including 626 up-regulated RNAs (mRNAs and ncRNAs) and 1497 down-regulated genes. The significant over-expressed genes showed enrichment in focal adhesion, platelets activation, gap junction and adherens junction pathways. The DEGs also included previously reported tumor-related genes such as PDGFR, VEGF, EGF, etc., verifying the consistence and s...
Source: Biomedicine and Pharmacotherapy - May 30, 2018 Category: Drugs & Pharmacology Source Type: research

Apoptosis-inducing effects and growth inhibitory of a novel chalcone, in human hepatic cancer cells and lung cancer cells
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Naiwei Dong, Xin Liu, Tong Zhao, Lei Wang, Huimin Li, Shuqian Zhang, Xia Li, Xue Bai, Yong Zhang, Baofeng Yang Apoptosis is an important biological phenomenon, which affects many diseases, such as cancer and Alzheimer’s disease. In the present study, we observed that chalcone 9X, an aromatic ketone, induced apoptosis of human hepatic and lung cancer cells and inhibited cancer cell migration and invasion. This compound strongly suppressed the growth of tumor in a mouse model of xenograft tumors. The anticancer activit...
Source: Biomedicine and Pharmacotherapy - May 30, 2018 Category: Drugs & Pharmacology Source Type: research

Dangguishaoyao-San attenuates LPS-induced neuroinflammation via the TLRs/NF- κB signaling pathway
Conclusion This study demonstrated that DSS has a protective effect on neuroinflammation in LPS-induced BV-2 microglia cells through the TLRs/NF-κB signaling pathway. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 30, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of infliximab and tocilizumab on fructose-induced hyperinsulinemia and hypertension in rats
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Aly M. Abdelrahman, Yousuf M. Al Suleimani, Mohammed Ashique, Priyadarsini Manoj, Badreldin H. Ali Fructose administration can induce hypertension, insulin resistance and hypertriglyceridemia. Here, we investigated the possible protective effect of infliximab (IFX), a tumor necrosis factor alpha (TNF-α) inhibitor, or tocilizumab (TOC), an interleukin-6 (IL6) inhibitor, on fructose-induced increase in blood pressure, insulin resistance and hyperlipidemia in rats. The animals were fed a 60% fructose diet in the absence...
Source: Biomedicine and Pharmacotherapy - May 30, 2018 Category: Drugs & Pharmacology Source Type: research

LncRNA NNT-AS1 promotes the proliferation, and invasion of lung cancer cells via regulating miR-129-5p expression
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Qin Shen, Yongjie Jiang Lung cancer is the leading cause of cancer related-deaths worldwide. Long non-coding RNAs (lncRNAs) are identified as important therapeutic targets in treatment of lung cancer. However, the roles of NNT-AS1 in lung cancer remain unclear. In the present study, we showed that the expression of NNT-AS1 was upregulated in non-small cell lung cancer (NSCLC) tissues and cell lines. High NNT-AS1 expression was associated with advanced tumor stage, and lymph node metastasis of NSCLC patients. In vitro funct...
Source: Biomedicine and Pharmacotherapy - May 29, 2018 Category: Drugs & Pharmacology Source Type: research

Polygonatum sibiricum rhizome promotes sleep by regulating non-rapid eye movement and GABAergic/serotonergic receptors in rodent models
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Kyungae Jo, Hyung Joo Suh, Hyeon-Son Choi The aim of this study is to investigate the sleep-promoting effect of a water extract of the Polygonatum sibiricum rhizome (PSE) in rodent models. PSE contained oleamide (0.10 mg/g extract) and glyceryl monolinoleate (0.17 mg/g extract), which are recognized as sleep-promoting substances. In pentobarbital-induced sleep model at hypnotic level, PSE (160 mg/kg) administration significantly decreased sleep latency time by 29% (2.7 min) and increased sleep duration time by 70% ...
Source: Biomedicine and Pharmacotherapy - May 29, 2018 Category: Drugs & Pharmacology Source Type: research

Network pharmacology-based identification of protective mechanism of Panax Notoginseng Saponins on aspirin induced gastrointestinal injury
Conclusions PNS may have protective function for aspirin-induced gastrointestinal injury through increasing VEGFA expression. Network pharmacology strategy may provide a forceful tool for exploring the mechanism of herb medicine and discovering novel bioactive ingredients. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 29, 2018 Category: Drugs & Pharmacology Source Type: research

Total glucosides of paeony improves the immunomodulatory capacity of MSCs partially via the miR-124/STAT3 pathway in oral lichen planus
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Zhongfang Zhao, Ying Han, Zhihui Zhang, Wenwen Li, Xiaoli Ji, Xiaodan Liu, Jianqiu Jin, Si Xu, Hongmei Cui, Zhe Cheng, Qian Wang, Xing Wang, Xiang Guo, Yixiang Wang, Hongwei Liu Mesenchymal stem cells (MSCs) have been used clinically and experimentally to relieve severe immune-related diseases due to their immunomodulatory properties, but these are impaired by inflammation. Oral lichen planus (OLP) is a T cell-mediated chronic inflammatory mucosal disease. In the present study, we found MSCs from OLP with higher expression...
Source: Biomedicine and Pharmacotherapy - May 29, 2018 Category: Drugs & Pharmacology Source Type: research

Increased hepatic FAT/CD36, PTP1B and decreased HNF4A expression contributes to dyslipidemia associated with ethanol –induced liver dysfunction: Rescue effect of ginger extract
This study aimed to characterize the lipid metabolism alterations and the molecular mediators which are related to lipid metabolism in liver under the heavy ethanol exposure alone or combined with ginger extract. Twenty-four male wistar rats were assigned into three groups, namely control, ethanol, and ginger extract treated ethanol (GETE) groups. Six weeks after the treatment, the ethanol group showed a significant increase in fatty acid translocase (FAT)/CD36, protein tyrosine phosphatase 1B (PTP1B) and decrease hepatocyte nuclear factor 4 Alpha (HNF4A) genes expressions compared to the control group. The ethanol adminis...
Source: Biomedicine and Pharmacotherapy - May 29, 2018 Category: Drugs & Pharmacology Source Type: research

Berberine alleviates adipose tissue fibrosis by inducing AMP-activated kinase signaling in high-fat diet-induced obese mice
The objective of this study was to assess the effects of BBR on adipose tissue fibrosis in high fat diet (HFD)-induced obese mice. The results showed that BBR reduced animal body weight and significantly improved glucose tolerance in HFD mice. In addition, BBR treatment markedly attenuated collagen deposition and reversed the up-regulation of fibrosis associated genes in the adipose tissue of HFD mice. Moreover, BBR treatment activated AMP-activated kinase signaling and reduced TGF-β1 and Smad3 phosphorylation. Of note, the inhibitory effects of BBR on adipose tissue fibrosis were significantly blocked by AMPK inhibit...
Source: Biomedicine and Pharmacotherapy - May 29, 2018 Category: Drugs & Pharmacology Source Type: research

Glucose-regulated protein of 94 kDa contributes to the development of an aggressive phenotype in breast cancer cells
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Pedro Buc Calderon, Anne-Laure Sennesael, Christophe Glorieux Grp94 plays an essential role in protein assembly. We previously suggested that Grp94 overexpression is involved in tumor aggressiveness. However, the underlying mechanisms remain unknown. Since many tumors display high Grp94 levels, we investigated the effects of tumor microenvironment on the regulation of this chaperone expression. First, we found out that hypoxia did not change Grp94 expression in the human tumor cell lines MCF-7 (breast cancer) and HepG2 (li...
Source: Biomedicine and Pharmacotherapy - May 29, 2018 Category: Drugs & Pharmacology Source Type: research

MicroRNA-497 promotes proliferation and inhibits apoptosis of cardiomyocytes through the downregulation of Mfn2 in a mouse model of myocardial ischemia-reperfusion injury
Conclusion The present study provided strong evidence that miR-497 promotes proliferation and inhibits apoptosis of cardiomyocytes by downregulating the expression of Mfn2 in a mouse model of myocardial I/R injury. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 29, 2018 Category: Drugs & Pharmacology Source Type: research

Role of innate immune system in the pathogenesis of ankylosing spondylitis
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Negar Vanaki, Saeed Aslani, Ahmadreza Jamshidi, Mahdi Mahmoudi Ankylosing Spondylitis (AS) is a debilitating rheumatic disease that gives young adults a severe form of arthritis with pain and stiffness in the axial skeleton. After the discovery of Human leukocyte antigen B27 (HLA-B27), several hypotheses have been suggested to uncover the exact etiology of AS. The tendency of HLA-B27 to form unusual structures results in recognition and activation of crucial components in innate immune system. Moreover, cellular and solubl...
Source: Biomedicine and Pharmacotherapy - May 29, 2018 Category: Drugs & Pharmacology Source Type: research

Naringin attenuates liver damage in streptozotocin-induced diabetic rats
In conclusion, NAR protects against the liver damage caused by STZ-induced diabetes and it could be a novel therapeutic strategy to prevent the non alcoholic fatty liver disease associated with the type 1Diabetes mellitus. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 28, 2018 Category: Drugs & Pharmacology Source Type: research