Dexmedetomidine protects against lipopolysaccharide-induced sepsis-associated acute kidney injury via an α7 nAChR-dependent pathway
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Kai Kang, Yang Gao, Si-Cong Wang, Hai-Tao Liu, Wei-Lan Kong, Xing Zhang, Rui Huang, Zhi-Dong Qi, Jun-Bo Zheng, Jing-Dong Qu, Rui-Jin Liu, Yan-Song Liu, Hong-Liang Wang, Kai-Jiang YuAbstractAcute kidney injury (AKI) is a clinical syndrome that results in severe tubular damage with high morbidity and mortality. However, there is a lack of effective therapy strategies. Therefore, it is critical to develop effective drugs for AKI. Dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist, has neuroprotective, anti-infl...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

MiRNA-34a reversed TGF-β-induced epithelial-mesenchymal transition via suppression of SMAD4 in NPC cells
In this study, we found that transforming growth factor-β (TGF-β), which reportedly promotes EMT in multiple cancers, can trigger EMT and increase the invasive and migratory capacities of NPC cells. Conversely, the downregulation of SMAD4, a vital member of the canonical TGF-β pathway, reversed the TGF-β-induced EMT, invasion, and migration. Further experiments revealed that SMAD4 was the target of miRNA-34a, which was downregulated in NPC tissues and suppressed NPC cell metastasis in vivo. miRNA-34a overexpression also antagonized the TGF-β-induced EMT progression, invasion, and migration through ...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Angelica sinensis polysaccharide protects rat cardiomyocytes H9c2 from hypoxia-induced injury by down-regulation of microRNA-22
ConclusionASP pretreatment attenuated hypoxia-induced H9c2 cell injury, possibly through down-regulating miR-22 expression. The PI3K/AKT and JAK1/STAT3 pathways were activated by ASP pretreatment via miR-22 in hypoxia-treated cells.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Role of selenium and vitamin C in mitigating oxidative stress induced by fenitrothion in rat liver
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Marija D. Milošević, Milica G. Paunović, Miloš M. Matić, Branka I. Ognjanović, Zorica S. SaičićAbstractExcessive use of organophosphate insecticides, including fenitrothion (FNT) can cause detrimental consequences in non-target organisms. Selenium (Se) and vitamin C (Vit C) possess protective abilities against various toxic compounds due to their antioxidative properties. Accordingly, the aim of the present study was to examine the possible ameliorative effects of Se and Vit C in hepatotoxicity induced by FNT. ...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Conditioned medium from stimulated macrophages inhibits growth but induces an inflammatory phenotype in breast cancer cells
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Wenzhe Song, Parth Thakor, David A. Vesey, Glenda C. Gobe, Christudas MoraisAbstractDisparate roles exist for tumor-associated macrophages in breast cancer growth and progression. The aim of this study was to explore the influence of induced macrophages on the growth of breast cancer cells. THP-1 monocytes were differentiated to macrophages using phorbol 12-myristate 13-acetate. The effect of the medium from THP-1 monocytes or macrophage-conditioned medium (MφCM) on MCF-7 (estrogen receptor and progesterone-positive positive) ...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Paeoniflorin inhibits Rho kinase activation in joint synovial tissues of rats with collagen-induced rheumatoid arthritis
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Wenjing Zhai, Zhihong Ma, Weijie Wang, Lin Song, Jianfeng YiAbstractPaeoniflorin (PF) has many effects, such as anti-inflammation, immune-regulation, abirritation, and so on. However, the protective mechanisms of PF on rheumatoid arthritis (RA) was not completely known. Thus, we explored deeply the protective mechanisms in a collagen-induced RA (CIA) rat model. CIA was induced in rats by intradermal injection of bovine type II collagen in complete Freund's adjuvant. Later, the CIA rats received oral administration of PF (50 and 10...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Enhanced expression of lncRNA TP73-AS1 predicts adverse phenotypes for cholangiocarcinoma and exerts oncogenic properties in vitro and in vivo
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Yue Yao, Yue Sun, Yuehong Jiang, Lijun Qu, Yi XuAbstractCholangiocarcinoma (CCA) is one of the most aggressive malignancies with increasing incidence worldwide. Various evidence documents that abnormally expressed long non-coding RNAs (lncRNAs) play important roles in tumorigenesis and progression. TP73-AS1 is a novel cancer-related lncRNA that contributes to the development of several malignancies. However, its clinical value and potential effects on CCA remains unknown. RT-qPCR was used to measure the expression levels of TP73-A...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Down-regulated miR-148b increases resistance to CHOP in diffuse large B-cell lymphoma cells by rescuing Ezrin
ConclusionOur data indicated that the high level of HDAC6 inhibited miR-148b via maintaining the low acetylation of histones H3 and H4 in the miR-148b promoter, thus rescuing Ezrin expression and promoting CHOP resistance in DLBCL. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

RGD peptide-modified, paclitaxel prodrug-based, dual-drugs loaded, and redox-sensitive lipid-polymer nanoparticles for the enhanced lung cancer therapy
In this study, RGD peptide-modified, paclitaxel (PTX) prodrug-based, dual-drugs loaded, and redox-sensitive lipid-polymer nanoparticles were developed and the in vitro and in vivo antitumor efficiency was evaluated in lung cancer cells and tumor bearing animal models. RGD-modified PTX and cisplatin (CDDP) loaded LPNs (RGD-ss-PTX/CDDP LPNs) have sizes around 190 nm, and zeta potentials of −35 mV. The half-maximal inhibitory concentration (IC50) values were 26.7 and 75.3 μg/mL for drugs loaded LPNs and free drugs combination, which indicates significantly higher antitumor activity of LPNs than free drugs. RGD-...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Biochemical investigation of gender-specific association between insulin resistance and inflammatory biomarkers in types 2 diabetic patients
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Muhammad Sajid Hamid Akash, Kanwal Rehman, Aamira Liaqat, Muhammad Numan, Qaisar Mahmood, Shagufta KamalAbstractInflammatory mediators play a key role in the pathogenesis of type 2 diabetes mellitus (T2DM) and development of insulin resistance (IR). The purpose of the present study was to investigate the gender-specific association between serum levels of inflammatory biomarkers and development of IR in type 2 diabetic patients. We recruited 90 study participants and collected their blood samples to measure the serum level of inte...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Imidazole bearing chalcones as a new class of monoamine oxidase inhibitors
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Rani Sasidharan, Seung Cheol Baek, Manju Sreedharannair Leelabaiamma, Hoon Kim, Bijo MathewAbstractIn the present study, series of eleven (2E)-1-[4-(1H-imidazol-1-yl)substituted phenyl]-3-phenylprop-2-en-1-one (IM1–IM11) derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The results indicate that (2E)-3-[4-(dimethylamino) phenyl]-1-[4-(1H-imidazol-1-yl) phenyl] prop-2-en-1-one (IM5) is a nonselective and reversible competitive inhibitor of MAO-A and MAO-B with IC50 ...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Magnesium isoglycyrrhizinate ameliorates liver fibrosis and hepatic stellate cell activation by regulating ferroptosis signaling pathway
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Miao Sui, Xiaofei Jiang, Jun Chen, Haiyan Yang, Yan ZhuAbstractFerroptosis is recently reported as a new mode of regulated cell death. It is triggered by disturbed redox homeostasis, overloaded iron and increased lipid peroxidation. Howerver, the role of ferroptosis in hepatic fibrosis remains obscure. In the current study, we attempted to investigate the effect of Magnesium isoglycyrrhizinate (MgIG) on ferroptosis in liver fibrosis, and to further clarify the possible mechanisms. Our data showed that MgIG treatment markedly atten...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Kuijieling regulates the differentiation of Treg and Th17 cells to ameliorate experimental colitis in rats
ConclusionKJL restores the balance between Treg and Th17 cells through regulating the differentiation of them, therefore contributes to the treatment of UC. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

LncRNA XIST accelerates cervical cancer progression via upregulating Fus through competitively binding with miR-200a
In this study, we aim to explore the specific mechanism and biological function of XIST in cervical cancer. At first, the expression levels of XIST were examined in both tissues and cell lines with qRT-PCR. XIST was extremely overexpressed in cervical cancer tissues and cell lines. Kaplan Meier method was then applied to analyze the correlation between XIST expression and overall survival of cervical cancer patients. Loss-of- function assays were designed and conducted to verify the oncogenic function of XIST on cervical cancer progression. Additionally, the results of mechanistic experiments indicated that XIST upregulate...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Tripterine alleviates LPS-induced inflammatory injury by up-regulation of miR-146a in HaCaT cells
ConclusionThese results demonstrated that tripterine could attenuate LPS-induced inflammatory injury and deactivate JNK and NF-κB pathways by up-regulation of miR-146a. This study will provide a theoretical basis for further study of tripterine in CDD.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-22-3p targeting alpha-enolase 1 regulates the proliferation of retinoblastoma cells
This study sought to explore the role of alpha-Enolase 1 (ENO1) in retinoblastoma (RB) which remains uncertain.MethodsThe expression of ENO1 in RB cell lines was examined by RT-qPCR and western blot. The biological function of ENO1 on cell proliferation in RB was determined in vitro. The predicted target of ENO1 was validated by dual-luciferase reporter assay and rescue experiment. The validation of clinical tissue samples was performed by RT-qPCR.ResultsElevated ENO1 could promote the proliferation of RB cells. The dual luciferase reporter assay confirmed that ENO1 is the target for miR-22-3p. In rescue experiment, the re...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Incensole acetate prevents beta-amyloid-induced neurotoxicity in human olfactory bulb neural stem cells
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Mohammed A. El-Magd, Sara F. Khalifa, Faisal Abdulrahman A. Alzahrani, Abdelnaser A. Badawy, Eman S. El-Shetry, Lamess M. Dawood, Mohammed M. Alruwaili, Hedib A. Alrawaili, Engi F. Risha, Fathy M. El-Taweel, Hany E. MareiAbstractβ-Amyloid peptide (Aβ) is a potent neurotoxic protein associated with Alzheimer’s disease (AD) which causes oxidative damage to neurons. Incensole acetate (IA) is a major constituent of Boswellia carterii resin, which has anti-inflammatory and protective properties against damage of a lar...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Potent tocolytic activity of ethyl acetate fraction of Ananas comosus on rat and human uteri
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Faezeh Monji, Lang Chu Lau, Abrar Al-Mahmood Siddiquee, Baharudin Bin Said, Lay-Kien Yang, Yoganathan K., Mahesh A. Choolani, P. Ganesan AdaikanAbstractThe aim of this study was to investigate the tocolytic properties of Ananas comosus extract in rat and human uterine tissue in vitro and in the rat in vivo. Organ bath technique was employed to perform functional studies in vitro. The PhysioTel transmitter was implanted in SD rats to measure the changes in intrauterine pressure (IUP) in vivo. Analyses of F2 was performed using LC...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Synergistic effect of glucosamine and vitamin E against experimental rheumatoid arthritis in neonatal rats
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Wei Dai, Chang Qi, Shasha WangAbstractThe effect of glucosamine and vitamin E against rheumatoid arthritis (RA) in a neonatal rat model was investigated. Lipid peroxidation, superoxide dismutase (SOD), catalase, reduced glutathione (GSH), glutathione peroxidase (Gpx), matrix metalloproteinase-3 (MMP-3), prostaglandin E2 (PGE2), ceruloplasmin, copper, zinc, nitric oxide (NO), uric acid, inducible nitric oxide synthase (iNOS), and nuclear factor-kappaB (NF-κB) levels were determined in control and rheumatoid arthritis neonat...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Suppression of SMOC2 reduces bleomycin (BLM)-induced pulmonary fibrosis by inhibition of TGF-β1/SMADs pathway
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Li Luo, Chang-Cheng Wang, Xiao-Ping Song, Hong-Mei Wang, Hui Zhou, Ying Sun, Xiao-Kun Wang, Shuo Hou, Fu-Yang PeiAbstractAlthough the initiation and modulation of lung fibrosis has been widely investigated, the pathogenesis was not well understood. Secreted modular calcium-binding protein 2 (SMOC2) as the secreted protein acidic is enriched in cysteine (SPARC) family of matricellular proteins, which are important in regulating cell-matrix interactions. Here we aimed to calculate the effects and molecular mechanism of SMOC2 on th...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Heterogeneous nuclear ribonucleoprotein M promotes the progression of breast cancer by regulating the axin/β-catenin signaling pathway
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Wen-Hua Yang, Ming-Jian Ding, Guo-Zhong Cui, Meng Yang, Dian-Lu DaiAbstractDespite significant progress in the treatment of breast cancer due to advances in surgery, cytotoxic agents, and endocrine therapy, the prognosis for patients has not improved much. Accumulated evidence indicates that heterogeneous nuclear ribonucleoprotein M (hnRNPM) and Wnt/β-catenin function as tumor oncogenes in the progression of many cancers. The present study aimed to explore whether HnRNPM/β-catenin signaling molecules might serve as a g...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Immunomodulatory effects of Thymol through modulation of redox status and trace element content in experimental model of asthma
The objective of this study was to investigate the thymol effects on oxidative parameters along with trace elements in asthma experimental model. The Balb/c mice were sensitized by intraperitoneal injection of ovalbumin and thymol (8, 16 and 32 mg/kg) and dexamethasone (DEX) (2 mg/kg) were orally administered to sensitized mice. Oxidative stress parameters including protein carbonyl content, malondialdehyde (MDA), 8-hydroxy-2′-deoxyguanosine (8-OHdG) and total antioxidant capacity (TAC) besides trace element levels were evaluated. The protein carbonyl content, MDA and 8-OHdG in treated mice with 32 mg/kg of thy...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Peperomin E (PepE) protects against high fat diet-induced atherosclerosis in Apolipoprotein E deficient (ApoE−/−) mice through reducing inflammation via the suppression of NLRP3 signaling pathway
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Jin Yan, Ming Li, Xiao-Dong Wang, Zi-Ying Lu, Xiao-Long NiAbstractPeperomin E (PepE) is a type of secolignan, a major component of the plant Peperomia dindygulensis. It has been shown to exert anti-inflammatory effects; however, the effects of PepE on human atherosclerosis remain unexplored. In the study, we investigated the role of PepE in high fat diet (HFD) induced atherosclerosis using apolipoprotein E defcient (ApoE−/−) mice. Elevated serum homocyteine, cholesterol, and triglyceride levels, accelerated progressi...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

MicroRNA-519d-3p inhibits cell proliferation and migration by targeting TROAP in colorectal cancer
In conclusion, miR-519d-3p might be a promising therapeutic strategy against human CRC by directly targeting TROAP. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-373-3p enhances the chemosensitivity of gemcitabine through cell cycle pathway by targeting CCND2 in pancreatic carcinoma cells
ConclusionMiR-373-3p inhibited cell propagation, migration and invasion and boosted apoptosis in gemcitabine resistance pancreatic carcinoma cells by targeting CCND2. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Chios mastic gum decreases renin levels and ameliorates vascular remodeling in renovascular hypertensive rats
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Aspasia I. Tzani, Ilias P. Doulamis, Panagiotis S. Konstantopoulos, Ermioni D. Pasiou, Afrodite Daskalopoulou, Dimitrios C. Iliopoulos, Ioannis V. Georgiadis, Nikolaos Kavantzas, Stavros K. Kourkoulis, Despina N. PerreaAbstractChios mastic gum (CMG) exerts robust anti-inflammatory and antioxidant properties and it affects pathways that are implicated in the pathophysiology of endothelial and vascular inflammation. Aim of this study was to test the hypothesis that CMG administration lowers blood pressure (BP) and improves hyperte...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Trehalose prevents sciatic nerve damage to and apoptosis of Schwann cells of streptozotocin-induced diabetic C57BL/6J mice
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Haiyan Pan, Yuanlin Ding, Ning Yan, Yaxin Nie, Mei Li, Linyan TongAbstractType 1 diabetes (T1DM) affects approximately 1 in 500 children. Diabetic peripheral neuropathy (DPN) is the most common form of peripheral neuropathy in diabetes and is a significant risk factor for serious pathological change. It is difficult and costly to treat DPN and although there have been several pivotal trials. The development of new drugs to treat DPN remains a high priority. Trehalose is a naturally occurring disaccharide, which is indicated to p...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Ursolic acid improves diabetic nephropathy via suppression of oxidative stress and inflammation in streptozotocin-induced rats
In conclusion, our data demonstrate that UA could be well used as a protective agent to counter renal dysfunction – through antioxidant and anti-inflammatory effects.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-363-3p suppresses tumor growth and metastasis of colorectal cancer via targeting SphK2
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Jinlang Dong, Jianshan Geng, Weiwei TanAbstractAberrant expression of miR-363-3p is seen in a wide array of cancers. The exact function of miR-363-3p in colorectal cancer (CRC), and the underlying mechanisms remain undefined. In the current study, we observed a down-regulation of miR-363-3p in CRC tissues, along with a strong correlation between low miR-363-3p levels and clinico-pathological parameters like tumor stage and lymph node metastasis. Ectopic overexpression of miR-363-3p in HT29 and HCT116 cell lines effectively inhib...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Angiopoietin 2 promotes angiogenesis in tissue-engineered bone and improves repair of bone defects by inducing autophagy
In conclusion, our study demonstrated that a high concentration of Ang2 promoted angiogenesis in tissue-engineered bone and improved repair of bone defects by inducing autophagy.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

MicroRNA-449a upregulation promotes chondrocyte extracellular matrix degradation in osteoarthritis
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Jianjun Wu, Min Zou, Ansong Ping, Zhouming Deng, Lin CaiAbstractOsteoarthritis (OA) is a highly prevalent chronic and degenerative joint disease characterized by the continuous destruction of the articular cartilage. MicroRNAs (miRNAs) have been reported to be strongly involved in the pathogenesis of OA. The aim of this study was to explore whether miR-449a regulates the expression of growth differentiation factor5 (GDF5), which promotes chondrocyte extracellular matrix (ECM) degradation. We found that miR-449a expression was up...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Role of an indole-thiazolidiene PPAR pan ligand on actions elicited by G-protein coupled receptor activated neutrophils
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): José Roberto Santin, Isabel Daufenback Machado, Carine C. Drewes, Léonard de Vinci Kanda Kupa, Rodrigo Marcondes Soares, Danielle Maia Cavalcanti, Ivan da Rocha Pitta, Sandra H.P. FarskyAbstractNeutrophils are the first line of defence during inflammatory processes; nevertheless, exacerbated influx and actions of neutrophils in terms of uncontrolled inflammation are harmful to the host. Hence, neutrophil activity is the target of drugs seeking to address undesired inflammation. Here, we investigated the mechanisms ...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Comprehensive anti-tumor effect of Brusatol through inhibition of cell viability and promotion of apoptosis caused by autophagy via the PI3K/Akt/mTOR pathway in hepatocellular carcinoma
In this study, we demonstrated that Brusatol inhibited cell viability, proliferation and induced apoptosis in liver cancer lines. Furthermore, Brusatol could activate autophagy in diverse liver cell lines, and the autophagy inhibitor chloroquine (CQ) reversed Brusatol-induced apoptosis in Bel7404 cells. In addition, we found that Brusatol inhibited PI3K/Akt/mTOR. Brusatol may also inhibit invasion, migration and the epithelial-mesenchymal transition (EMT). In a human liver xenograft tumor model in nude mice, immunohistochemistry showed that Brusatol significantly inhibited tumor invasion and proliferation. Taken together, ...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

TGF-β1 modulates podocyte migration by regulating the expression of integrin-β1 and -β3 through different signaling pathways
This study provides a novel mechanism for TGF-β1 signaling in regulating podocyte migration.Graphical abstractTGF-β1 inhibits integrin-β1 maturation through MAP kinases pathway, but increases integrin-β3 expression through Smad2/3 and MAP kinases pathways in podocytes. The increased integrin-β3 promotes podocyte adhesion and migration that may lead to foot process effacement. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Therapeutic efficacy of zingerone against vancomycin-induced oxidative stress, inflammation, apoptosis and aquaporin 1 permeability in rat kidney
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Fatih Mehmet Kandemir, Serkan Yildirim, Sefa Kucukler, Cuneyt Caglayan, Amdia Mahamadu, Muhammet Bahaeddin DortbudakAbstractVancomycin (VCM) is a glycopeptidic broad-spectrum antibiotic against methicillin-resistant Staphylococcus aureus, though it has some adverse effects, including nephrotoxicity, that limit its usefulness. Zingerone (ZO), a component of dry ginger root, has several pharmacological activities due to its antioxidant, anti-inflammatory and antiapoptotic properties. The aim of this study was to determine the ther...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of Monocolin K and COQ10 supplementation in hypertensive and hypercholesterolemic subjects with metabolic syndrome
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Alberto Mazza, Salvatore Lenti, Laura Schiavon, Ezio Di Giacomo, Monica Tomasi, Roberto Manunta, Gioia Torin, Danyelle M. Townsend, Domenico RubelloAbstractIntroductionMetabolic syndrome (MetS) is a world-wide epidemic disease with an increased risk of morbidity and mortality. Treatment strategies of MetS include pharmacologic and non-pharmacologic interventions and in this respect a relevant role has been shown for nutraceutical compounds (NCs). The aim of this study was to investigate the efficacy and safety of NCs incorporate...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Neuroprotective effect of Decalepis hamiltonii aqueous root extract and purified 2-hydroxy-4-methoxy benzaldehyde on 6-OHDA induced neurotoxicity in Caenorhabditis elegans
In this study, we investigated the possible neuroprotective efficacy of Decalepis hamiltonii tuber extract against 6-Hydroxy dopamine (6-OHDA) induced neurotoxicity and associated effects in Caenorhabditis elegans. The major component of flavour rich extract from D. hamiltonii is 2-hydroxy-4-methoxy benzaldehyde (2H4MB) which is an isomer of vanillin. We have conducted preliminary experiments with different types of extracts and subsequently DHFE (D. hamiltonii Fresh Tuber Extract) and DHPF (D. hamiltonii purified 2H4MB fraction) were used for further studies. Here we attempted to enumerate the neuroprotective efficacy of ...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Current advances of pharmacological properties of 7-chloro-4-(phenylselanyl) quinoline: Prevention of cognitive deficit and anxiety in Alzheimer’s disease model
In conclusion, 4-PSQ protected against learning and memory impairment and anxiety in a mouse model of AD induced by Aβ, and anticholinesterase and antioxidant actions are involved in the pharmacological effect of the compound.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Protective effects of Spinacia oleracea seeds extract in an experimental model of schizophrenia: Possible behavior, biochemical, neurochemical and cellular alterations
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Monu Yadav, Milind Parle, Nidhi Sharma, Deepak Kumar Jindal, Aryan Bhidhasra, Mamta Sachdeva Dhingra, Anil Kumar, Sameer DhingraAbstractSchizophrenia is one of the psychotic mental disorders characterized by symptoms of thought, behavior, and social problems. Newer biomedicine and pharmacotherapy has been investigated for the treatment of various neuropsychiatric disorders in the past few decades. Spinacia oleracea is one of these, reported to have beneficial effect against several neurodegenerative disorders. The present study ...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

17-DMAG-loaded nanofibrous scaffold for effective growth inhibition of lung cancer cells through targeting HSP90 gene expression
In conclusion, the findings demonstrated that 17-DMAG-loaded PCL/PEG nanofibers are more effectual than free 17-DMAG against A549 lung cancer cells via modulation of Hsp90 expression and inhibition of telomerase activity. Hence, the implantable 17-DMAG-loaded nanofibrous scaffolds might be an excellent tool for efficiently killing of the lung residual cancer cells and avoid the local cancer recurrence.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Effects of the SGLT2 inhibitor ipragliflozin on food intake, appetite-regulating hormones, and arteriovenous differences in postprandial glucose levels in type 2 diabetic rats
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Atsuo Tahara, Yoshinori Kondo, Toshiyuki Takasu, Hiroshi TomiyamaAbstractAimsThe sodium-glucose cotransporter (SGLT) 2 inhibitor, ipragliflozin, improves not only hyperglycemia but also obesity in type 2 diabetic animals and patients; however, there have been concerns that it may also cause an increase in compensatory food intake. Appetite is regulated by complex mechanisms involving the central nervous system, part of which involves appetite-related hormones and arteriovenous differences in postprandial glucose levels. We evalu...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Tanshinones from Salvia miltiorrhiza Bunge revert chemotherapy-induced neuropathic pain and reduce glioblastoma cells malignancy
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Lorenzo Di Cesare Mannelli, Marialuisa Piccolo, Francesco Maione, Maria Grazia Ferraro, Carlo Irace, Vincenzo De Feo, Carla Ghelardini, Nicola MascoloAbstractMedicinal plants and herbal extracts from traditional Chinese medicine are used increasingly commonly worldwide for their benefits to health and quality of life as dietary supplements or as ingredients in functional foods. Among them, Salvia miltiorrhiza Bunge (a natural strong remedy for the treatment of a variety of conditions) is traditionally used for centuries in Asian...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of simvastatin and microRNA-21 inhibitor on metastasis and progression of human salivary adenoid cystic carcinoma
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Chao Wang, Ting Li, Fei Yan, Wenyan Cai, Jiwei Zheng, Xingyu Jiang, Jinhu SunAbstractSalivary adenoid cystic carcinoma (SACC) is a common malignancy of the salivary glands. Epithelial-mesenchymal transition (EMT) and P53 signaling pathway are associated with SACC metastasis and progression. Although simvastatin (SIM) is effective against the growth of many cancer types, its side effects limit its use. microRNA-21 (miR-21) is highly expressed in a variety of tumors and has a role in promoting tumor development. Therefore, the aim...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Extract of Penicillium sclerotiorum an endophytic fungus isolated from Cassia fistula L. induces cell cycle arrest leading to apoptosis through mitochondrial membrane depolarization in human cervical cancer cells
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Gini C Kuriakose, Divya Lakshmanan M, Arathi BP, Hari Kumar RS, Anantha Krishna TH, Kavya Ananthaswamy, Jayabhaskaran C.AbstractSeventeen endophytic fungi were isolated from various tissues of Cassia fistula and the ethyl acetate extracts obtained from 21-day cultures of all the endophytic fungal isolates were initially screened for their cytotoxicity against HeLa (human cervical carcinoma) cells using MTT assay. Of these, Penicillium sclerotiorum extract (PSE), significantly affected the viability of HeLa cells in a dose-depend...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-129 regulates growth and invasion by targeting MAL2 in papillary thyroid carcinoma
In this study, we investigated the roles and underlying mechanism of MAL2 in the development of papillary thyroid carcinoma (PTC). Up-regulation of MAL2 was found in human PTC tissues and significantly correlated with poor overall survival (OS). Knockdown of MAL2 dramatically suppressed PTC cell proliferation and invasion in vitro and inhibited tumor growth in vivo. We further found that miR-129 suppressed the expression of MLA through directly binding to the 3′ untranslated region (3′ UTR). While forced miR-129 expression suppressed growth and invasion of PTC cells, re-expression of MAL2 rescued these effects....
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Probable mechanisms involved in the antipsychotic-like activity of morin in mice
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Benneth Ben-Azu, Adegbuyi Oladele Aderibigbe, Itivere Adrian Omogbiya, Abayomi Mayowa Ajayi, Olatunde Owoeye, Elizabeth Toyin Olonode, Ezekiel O. IwalewaAbstractEvidence derived from preliminary studies suggests that morin, a neuroactive flavonoid with proven antioxidant and antiinflammatory properties possess antipsychotic-like activity. The present study was designed to evaluate the probable mechanisms involve in the antipsychotic-like activity of morin in ketamine model of schizophrenia. The effects of morin, haloperidol and ...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Modulation of hyperglycemia and dyslipidemia in experimental type 2 diabetes by gallic acid and p-coumaric acid: The role of adipocytokines and PPARγ
In conclusion, gallic acid and p-coumaric acid exhibited marked antidiabetic action that could be mediated via modulation of TNF-α and adipocytokines secretions as well as upregulation of PPARγ mRNA expression.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Morphometric changes and AQP2 expression in kidneys of young male rats exposed to chronic stress and a high-sucrose diet
ConclusionsOur results show that both chronic stress and a high-sucrose diet induce histological changes, but chronic stress may generate an accelerated glomerular hypertrophy associated with functional changes before puberty.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

miR-149 regulates the proliferation and apoptosis of cervical cancer cells by targeting GIT1
In this study, miR-149 expression is decreased in CC tissues and cell lines compare with paired normal tissues and normal epithelial cell, respectively. Moreover, the restoration of miR-149 expression inhibited cell proliferation, migration, invasion and promoted cell apoptosis in vitro. We further proved that miR-149 overexpression suppresse the growth of cervical cancer cells in vivo using a mouse xenograft model. Dual luciferase assays identified the GIT1 as a novel direct target of miR-149. To identify the mechanisms, we investigated the PI3K/AKT/mTOR pathway and found that the expression of PI3K, AKT and mTOR were sup...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Protective aptitude of Periploca hydaspidis Falc against CCl4 induced hepatotoxicity in experimental rats
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Saima Ali, Muhammad Rashid Khan, Sayed Afzal Shah, Riffat Batool, Sonia Maryam, Muhammad Majid, Zartash ZahraAbstractIn the present study the antioxidant capacity of Periploca hydaspidis was assessed through various in vitro assays and by the hepatoprotective potential on CCl4 induced toxicity in rat. Phytochemical analysis of different extracts of P. hydaspidis indicated existence of various phytochemical classes. HPLC-DAD analysis of methanol extract indicated the existence of rutin, gallic acid and caffeic acid. Total phenoli...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research