MicroRNA-575 regulates development of gastric cancer by targeting PTEN
Publication date: May 2019Source: Biomedicine & Pharmacotherapy, Volume 113Author(s): Ya-nan Wang, Fang Xu, Pei Zhang, Pan Wang, Ya-ning Wei, Chen Wu, Shu-jie ChengAbstractMicroRNA-575 (miR-575) is oncogene in many tumors. However, the role of miR-575 in the progression of gastric cancer (GC) is still unknown. The aim of this study was to identify whether miR-575 play a role in the development of GC. We obtained GC cell lines, GC tissues from 40 patients to measure the levels of miR-575 and its predicted target PTEN by using RT‑PCR, immunohistochemistry or western blot analysis. MGC-803 cells were transfected with mi...
Source: Biomedicine and Pharmacotherapy - March 6, 2019 Category: Drugs & Pharmacology Source Type: research

Therapeutic effect of Parmotrema tinctorum against complete Freund’s adjuvant-induced arthritis in rats and identification of novel Isophthalic ester derivative
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Khader Syed Zameer Ahmed, Sidhra Syed Zameer Ahmed, Arunachalam Thangakumar, Radhakrishnan KrishnaveniAbstractThe present study reveals the anti-arthritic potential of traditionally used Parmotrema tinctorum (Pt) on experimental rats and purification of novel Isophthalic ester derivative. Arthritis was induced in rats using Freund’s complete adjuvant (CFA) and subsequently treated with Pt extract (100 & 200 mg/kg.b.w). Assessment of antiarthritic activity was carried out using paw volume, arthritic score, haematolog...
Source: Biomedicine and Pharmacotherapy - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

Extracellular HMGB1 prevents necroptosis in acute myeloid leukemia cells
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Yingting Liu, Pan Chen, Linyong Xu, Meifei Ouyang, Dan Wang, Daolin Tang, Liangchun Yang, Min Xie, Lizhi Cao, Minghua YangAbstractChanges in the expression and subcellular localization of high mobility group box 1 (HMGB1), a damage-associated molecular pattern (DAMP) molecule, have been implicated in tumorigenesis and tumor cell death in response to cancer therapy. Specifically, HMGB1 release has been shown to occur with a specific form of induced cell death known as necroptosis. In the present study, we examined the role of HMGB1 i...
Source: Biomedicine and Pharmacotherapy - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

Long noncoding RNA GAS5 modulates α-Solanine-induced radiosensitivity by negatively regulating miR-18a in human prostate cancer cells
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Jinhui Yang, Tongtong Hao, Jiantao Sun, Pengtao Wei, Han ZhangAbstractRadiotherapy is an adjuvant treatment of surgery in prostate cancer, while radioresistance has been the challenge of treatment. It has been reported that α-Solanine exhibits anti-cancer activity and enhances the chemo- and radio-sensitivity in several human cancers, whereas the role of α-Solanine on radiosensitivity to PCa remains to be uncovered yet. We found α-Solanine decreased cell viability in human PCa cells rather than normal prostate epit...
Source: Biomedicine and Pharmacotherapy - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

Etanercept improved anemia and decreased hepcidin gene expression in a rat model of rheumatoid arthritis
ConclusionEtanercept improved anemia in this animal model of RA, which could be explained in part by the reduction in hepcidin gene expression. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

Arbutin attenuates hydrogen peroxide-induced oxidative injury through regulation of microRNA-29a in retinal ganglion cells
ConclusionsThese data demonstrated that ARB protected RGCs against oxidative injury induced by H2O2 through blocking MEK/ERK and p38MAPK signaling pathways by up-regulation of miR-29a.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

Circular RNA circ_0026134 regulates non-small cell lung cancer cell proliferation and invasion via sponging miR-1256 and miR-1287
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Hao Chang, Junfeng Qu, Ju Wang, Xipeng Liang, Wei SunAbstractNon-small cell lung cancer (NSCLC) is the major type of lung malignancy with increasing incidence worldwide. Despite progression in diagnosis and management of NSCLC, the patients’ survival rate is still unfavorable. Accumulating data have shown that circular RNAs (circRNAs) act as key roles in oncogenesis. In this project, circ_0026134 expression in NSCLC tissue specimens and cells was measured by RT-qPCR. The functional roles (cell growth, apoptosis, migration, and...
Source: Biomedicine and Pharmacotherapy - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

Polydatin promotes the osteogenic differentiation of human bone mesenchymal stem cells by activating the BMP2-Wnt/β-catenin signaling pathway
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Xiao-Jun Chen, Ying-Shan Shen, Min-Cong He, Fan Yang, Peng Yang, Feng-Xiang Pang, Wei He, Yan-ming Cao, Qiu-Shi WeiAbstractSteroid-induced osteonecrosis of the femoral head (SONFH) is a refractory disease induced by glucocorticoids. Marrow mesenchymal stem cells (MSCs) differentiate into multiple bone matrix cells and have been used as cell-based therapies to treat ONFH. However, the osteogenesis of MSCs isolated from patients with SONFH is significantly decreased. Polydatin has been widely used in traditional Chinese remedies due t...
Source: Biomedicine and Pharmacotherapy - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

Inhibitory effect of polysaccharide of Sargassum weizhouense on PCV2 induced inflammation in mice by suppressing histone acetylation
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Chen Hai-lan, Tan Hong-lian, Yang Jian, Song Manling, Feng Heyu, Kuang Na, Huc Wenyue, Chen Si-yu, Wei Ying-yi, Hu Ting-junAbstractSeaweeds are excellent source of bioactive compounds and seaweed-derived polysaccharides have demonstrated an array of biological effects. Here, we investigated the effect of polysaccharide of Sargassum weizhouense (PSW) on the inflammatory response in porcine circovirus type 2 (PCV2) infected mice and the underlying mechanism was studied according to the histone acetylation. After PCV2 infection, the le...
Source: Biomedicine and Pharmacotherapy - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

Effects of Centella asiatica on skeletal muscle structure and key enzymes of glucose and glycogen metabolism in type 2 diabetic rats
ConclusionOur findings strongly suggest that the anti-diabetic effects of CA in part target muscle glucose and glycogen metabolism and hence supporting its folkloric medical use as an anti-diabetic remedy.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

Finite element analysis of different internal fixation methods for the treatment of Pauwels type III femoral neck fracture
ConclusionThe “F” shaped cannulated screw technique is capable of eliminating the torsional stress and shear stress while maintaining the axial compressive stress at the fracture end. Besides, the medial support plate can effectively resist the shearing force of the Pauwels III femoral neck fracture and create an excellent mechanical environment for fracture healing. Thus, for the Pauwels III femoral neck fracture, the use of “F” shaped cannulated screws combined with medial plate internal fixation are recommended.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

Analysis of inline-filter blockage with trastuzumab formulation using scanning-electron microscopy
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Chiaki OgawaAbstractThe instability of pharmaceutical monoclonal antibodies are affected by physical stimuli including, temperature, denaturant, surfactant, stirring, solid phase adsorption, oxidation, and ultraviolet rays. Clinically, we frequently experience precipitation during preparation of several pharmaceutical monoclonal antibodies for cancer. Although it is possible to remove precipitates in the injection solution during the preparation procedure, potential filter blockade during administration remains a problem with advers...
Source: Biomedicine and Pharmacotherapy - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

Identification of plasma secreted phosphoprotein 1 as a novel biomarker for upper tract urothelial carcinomas
In conclusion, plasma SPP1 is a novel biomarker for UTUC. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

ADAM10 in Alzheimer's disease: Pharmacological modulation by natural compounds and its role as a peripheral marker
Publication date: May 2019Source: Biomedicine & Pharmacotherapy, Volume 113Author(s): Patricia Regina Manzine, Miren Ettcheto, Amanda Cano, Oriol Busquets, Elena Marcello, Silvia Pelucchi, Monica Di Luca, Kristina Endres, Jordi Olloquequi, Antoni Camins, Márcia Regina CominettiAbstractAlzheimer’s disease (AD) represents a global burden in the economics of healthcare systems. Amyloid-β (Aβ) peptides are formed by amyloid-β precursor protein (AβPP) cleavage, which can be processed by two pathways. The cleavage by the α-secretase A Disintegrin And Metalloprotease 10 (ADAM10) releases...
Source: Biomedicine and Pharmacotherapy - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

Quercetin promotes antipromastigote effect by increasing the ROS production and anti-amastigote by upregulating Nrf2/HO-1 expression, affecting iron availability
Publication date: May 2019Source: Biomedicine & Pharmacotherapy, Volume 113Author(s): Allan Henrique Depieri Cataneo, Fernanda Tomiotto-Pellissier, Milena Menegazzo Miranda-Sapla, João Paulo Assolini, Carolina Panis, Danielle Kian, Lucy Megumi Yamauchi, Andrea Name Colado Simão, Rubia Casagrande, Phileno Pinge-Filho, Idessania Nazareth Costa, Waldiceu Ap. Verri, Ivete Conchon-Costa, Wander Rogério PavanelliAbstractAmerican cutaneous leishmaniasis is a zoonotic disease caused by protozoans of the genus Leishmania. The treatment of cutaneous leishmaniasis is unsatisfactory, thus, much research effort...
Source: Biomedicine and Pharmacotherapy - March 4, 2019 Category: Drugs & Pharmacology Source Type: research

Immunomodulatory effects exerted by Poria Cocos polysaccharides via TLR4/TRAF6/NF-κB signaling in vitro and in vivo
ConclusionThese results support the concept that PCP may exhibit immunomodulatory activity through TLR4/TRAF6/NF-κB signaling both in vitro and in vivo. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 1, 2019 Category: Drugs & Pharmacology Source Type: research

Apoptosis repressor with caspase recruitment domain deficiency accelerates ischemia/reperfusion (I/R)-induced acute kidney injury by suppressing inflammation and apoptosis: The role of AKT/mTOR signaling
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Ke Yingjie, Yan Haihong, Chen Lingwei, Zhong Sen, Dai Yuanting, Cai Shasha, Pan Liutong, Wang Ying, Zhou MinAbstractAcute kidney injury (AKI) is a significant medical problem worldwide. Ischemia-reperfusion (I/R) injury of the kidney is a major cause of AKI. However, the pathogenesis that contributes to renal I/R injury is still unclear. Apoptosis repressor with caspase recruitment domain (ARC) is abundantly expressed in various tissues, and has been reported to play a strong protective role during pathological processes. Our result...
Source: Biomedicine and Pharmacotherapy - March 1, 2019 Category: Drugs & Pharmacology Source Type: research

Production of “biobetter” variants of glucarpidase with enhanced enzyme activity
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Alanod D. Al-Qahtani, Sara S. Bashraheel, Fatma B. Rashidi, C. David O’Connor, Atilio Reyes Romero, Alexander Domling, Sayed K. GodaAbstractGlucarpidase, also known as carboxypeptidase G2, is a Food and Drug Administration-approved enzyme used in targeted cancer strategies such as antibody-directed enzyme prodrug therapy (ADEPT). It is also used in drug detoxification when cancer patients have excessive levels of the anti-cancer agent methotrexate. The application of glucarpidase is limited by its potential immunogenicity and ...
Source: Biomedicine and Pharmacotherapy - March 1, 2019 Category: Drugs & Pharmacology Source Type: research

Growth arrest specific transcript 5 in tumorigenesis process: An update on the expression pattern and genomic variants
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Soudeh Ghaforui-Fard, Mohammad TaheriAbstractGrowth arrest-specific 5 (GAS5) is a long non-coding RNA (lncRNA) with diverse functions in regulation of gene expression. Most studies have reported a role for this lncRNA in induction of cell apoptosis and suppression of tumorigenesis process. Although few studies demonstrated up-regulation of this lncRNA in tumor tissues compared to non-tumor tissues of the same origin, the results of in vitro functional studies mostly support the tumor suppressor role for GAS5. A number of recent stud...
Source: Biomedicine and Pharmacotherapy - February 28, 2019 Category: Drugs & Pharmacology Source Type: research

Limonin attenuates the stemness of breast cancer cells via suppressing MIR216A methylation
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Zhou Su, Caihong Wang, Deyu Chang, Xiuna Zhu, Chunmei Sai, Jian PeiAbstractLimonin has been shown to exert anti-inflammatory effects, however, its roles in tumor progression remain unclear. This work aims to investigate the roles and related mechanism of limonin in the stemness of breast cancer cells. Here, we found that limonin attenuated the stemness of breast cancer cells in a concentration-dependent manner, evident by the decreasing the capacity of cell spheroid formation, expression of stemness markers and ALDH1 activity, where...
Source: Biomedicine and Pharmacotherapy - February 28, 2019 Category: Drugs & Pharmacology Source Type: research

Ketamine-induced antidepressant like effects in mice: A possible involvement of cannabinoid system
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Fatemeh Khakpai, Mohaddeseh Ebrahimi-Ghiri, Sakineh Alijanpour, Mohammad-Reza ZarrindastAbstractThe purpose of this study was to explore the possible interaction between ketamine and cannabinoid system in the modulation of depression-related responses using the forced swimming test (FST), tail suspension test (TST) and open-field test (OFT) in mice. Our results revealed that intra-peritoneal (i.p.) injection of ketamine (5 and 10 mg/kg), a non-competitive NMDA antagonist, dose-dependently produced antidepressant-like effect i...
Source: Biomedicine and Pharmacotherapy - February 28, 2019 Category: Drugs & Pharmacology Source Type: research

Fenofibrate improves vascular endothelial function in diabetic mice
This study tested the hypothesis that fenofibrate could ameliorate endothelium-dependent vasodilation in diabetic mice and relieve high glucose-induced endothelial dysfunction via activating endothelial nitric oxide synthase (eNOS) and adenosine monophosphate-activated protein kinase (AMPK) phosphorylation. A streptozotocin (STZ)-induced diabetic model was established by intraperitoneal injection of STZ (dissolved in sodium citrate buffer) at a dose of 60 mg/kg for 5 consecutive days. Mice were administered fenofibrate (100 mg/kg/d, i.g.) for 14 days. The endothelial function of extracted mouse aortae was exa...
Source: Biomedicine and Pharmacotherapy - February 28, 2019 Category: Drugs & Pharmacology Source Type: research

The interaction between CSE/H2S and the iNOS/NO-mediated resveratrol/poly(ethylene glycol)-poly(phenylalanine) complex alleviates intestinal ischemia/reperfusion injuries in diabetic rats
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Zhongchao Wang, Ying Yan, Yini Wang, Fei TongAbstractIntroductionThe purpose of the experiment was to survey the therapeutic function of resveratrol (RES)-loaded poly(ethylene glycol)-poly(phenylalanine) (PEG-PPhe) on intestinal ischemia/reperfusion injury (II/RI) via the interaction between CSE/H2S and iNOS/NO compared to free RES in diabetic rats.MethodsDiabetic rats were pretreated with 20 mg/kg of RES or the RES/PEG-PPhe complex and then subjected to 1 h of ischemia and 3 h of reperfusion. Blood and intestin...
Source: Biomedicine and Pharmacotherapy - February 28, 2019 Category: Drugs & Pharmacology Source Type: research

LncRNA ADAMTS9-AS2 promotes tongue squamous cell carcinoma proliferation, migration and EMT via the miR-600/EZH2 axis
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Yingru Li, Quan Wan, Weiwei Wang, Lianxi Mai, Liujuan Sha, Mubarak Mashrah, Zhaoyu Lin, Chaobin PanAbstractLong noncoding RNAs (lncRNAs) are a type of noncoding RNA transcript that are characterized by lack of protein-coding capacity. The vital role of lncRNAs in tongue squamous cell carcinoma (TSCC) is attracting increasing attention. In the present study, we identify a key lncRNA regulating TSCC metastasis and investigated the underlying mechanism. Our results indicate that the lncRNA ADAMTS9-AS2 is most significantly upregulated ...
Source: Biomedicine and Pharmacotherapy - February 28, 2019 Category: Drugs & Pharmacology Source Type: research

Sodium ferulate inhibits myocardial hypertrophy induced by abdominal coarctation in rats: Involvement of cardiac PKC and MAPK signaling pathways
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Min Luo, Pan-pan Chen, Lu Yang, Peng Wang, Yan-liu Lu, Fu-guo Shi, Yang Gao, Shang-fu Xu, Qi-hai Gong, Rui-xia Xu, Jiang DengAbstractSodium ferulate (SF) is the sodium salt of ferulic acid which is an active ingredient of Radix Angelica Sinensis and Ligusticum chuanxiong hort. Here, we investigated SF inhibition in a rat model of myocardial hypertrophy induced by coarctation of the abdominal aorta. Following coarctation, rats were given SF (20, 40, and 80 mg/kg/day) for 25 consecutive days. We characterized myocardial hypertr...
Source: Biomedicine and Pharmacotherapy - February 28, 2019 Category: Drugs & Pharmacology Source Type: research

MALAT1 knockdown inhibits proliferation and enhances cytarabine chemosensitivity by upregulating miR-96 in acute myeloid leukemia cells
In conclusion, MALAT1 knockdown inhibited proliferation, promoted apoptosis and enhanced Ara-C sensitivity in AML cells by upregulating miR-96, providing novel insights into the critical role of MALAT1 as a miRNA sponge in AML. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - February 27, 2019 Category: Drugs & Pharmacology Source Type: research

Human telomerase reverse transcriptase recruits the β-catenin/TCF-4 complex to transactivate chemokine (C-C motif) ligand 2 expression in colorectal cancer
ConclusionshTERT may promote CRC by recruiting β-catenin/TCF-4 complex to transactivate CCL2 expression, which is a novel crosstalk mechanism likely involved in the pathogenesis of CRC. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - February 27, 2019 Category: Drugs & Pharmacology Source Type: research

Synthesis of coumarin analogs appended with quinoline and thiazole moiety and their apoptogenic role against murine ascitic carcinoma
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): T. Prashanth, B.R. Vijay Avin, Prabhu Thirusangu, V. Lakshmi Ranganatha, B.T. Prabhakar, J.N. Narendra Sharath Chandra, Shaukath Ara KhanumAbstractThe synthesis and antiproliferative effect of a series of quinoline and thiazole containing coumarin analogs 12a-d and 13a-f respectively, on mice leukemic cells was performed. The chemical structures of newly synthesized compounds were confirmed by IR, 1H NMR, 13C NMR and mass spectral analysis. The result indicates that, 7-methoxy-2-oxo-2H-chromene-3-carboxylic acid [4-(4-methoxy-phenyl...
Source: Biomedicine and Pharmacotherapy - February 27, 2019 Category: Drugs & Pharmacology Source Type: research

Protective effect of cultured bear bile powder against dimethylnitrosamine-induced hepatic fibrosis in rats
In conclusion, CBBP has the potential to attenuate liver fibrosis and its mechanism involves the promotion of the liver expression of PPARα and PPARγ. Our results may help in the development of a novel substitute for bear bile and therapeutic strategies for fibrotic liver diseases. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - February 26, 2019 Category: Drugs & Pharmacology Source Type: research

The potential effect of Bruton’s tyrosine kinase in refractory periapical periodontitis
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Ming Dong, Haiwei Jin, Meina Zuo, Hua Bai, Lina Wang, Chun Shi, Weidong NiuAbstractTo determine the expression of Bruton’s tyrosine kinase (BTK) in refractory periapical periodontitis and analyze the relationship between BTK and bone resorption in refractory periapical periodontitis. The mechanism of bone resorption is also discussed. The OneArray Plus expression microarray was used to screen for genes related to refractory periapical periodontitis. Real-time PCR was used to detect the expression of BTK in refractory periapica...
Source: Biomedicine and Pharmacotherapy - February 26, 2019 Category: Drugs & Pharmacology Source Type: research

Molecular basis of neurophysiological and antioxidant roles of Szechuan pepper
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Shun Deng, Haibo Rong, He Tu, Bingxin Zheng, Xiaoyuan Mu, Liyang Zhu, Xu Zhou, Wei Peng, Mingquan Wu, Enming Zhang, Xia Li, Hai ShenAbstractThe balance between anti- and pro-oxidant activities is of great important to maintain the biochemical and physiological homeostasis in the human body. Developing new therapeutic strategies to reduce health risks caused by free radicals has always been research focus over the past decades. Szechuan pepper, a characteristic pungent-flavored spice in Sichuanese cuisine, recently attracts the atten...
Source: Biomedicine and Pharmacotherapy - February 25, 2019 Category: Drugs & Pharmacology Source Type: research

Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation
This study indicated that shikonin attenuated APAP-induced acute liver injury via inhibiting oxidative stress and inflammatory responses in vivo and in vitro. These findings offer new insights into the potential therapy for APAP hepatotoxicity. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - February 25, 2019 Category: Drugs & Pharmacology Source Type: research

Polypeptides extracted from Eupolyphaga sinensis walker via enzymic digestion alleviate UV radiation-induced skin photoaging
In this study, Eupolyphaga sinensis walker were identified to include fifteen amino acids, of which hydrophobic amino acids accounted for 46.7%. Eupolyphaga sinensis walker polypeptides (EPs) were extracted by sequentially hydrolyzing with pepsin and trypsin. EPs could effectively scavenge 1,1-diphenyl-2-picrylhydrazyl radical (DPPH·), superoxide anion radical (O2−), and hydroxyl radical (OH-), and reduce ferric solution in vitro. EPs also enhanced the activities of Ssuperoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPH-Px), increased the contents of hydroxyproline (HYP), and reduced the c...
Source: Biomedicine and Pharmacotherapy - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

Luteolin protects PC-12 cells from H2O2-induced injury by up-regulation of microRNA-21
ConclusionOur research revealed the protective effects of luteolin on H2O2-induced ICVD cell oxidative injury. Luteolin protected PC-12 cells from H2O2-induced oxidative injury by up-regulating miR-21, activating PI3K/AKT pathway and inactivating PDCD4/p21 pathway.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

Bu-Shen-Yi-Qi formula ameliorates airway remodeling in murine chronic asthma by modulating airway inflammation and oxidative stress in the lung
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Jie Cui, Fei Xu, Zhao Tang, Wenqian Wang, Ling li Hu, Chen Yan, Qingli Luo, Hongjian Gao, Ying Wei, Jingcheng DongAbstractBu-Shen-Yi-Qi formula (BSYQF) could suppress chronic airway inflammation according to previous studies. However, there is relatively little direct experimental evidence to evaluate the effects of BSYQF treatment on airway remodeling in chronic asthma. Recent evidence suggests that oxidative stress is involved in airway inflammation and airway remodeling in chronic asthma. BSYQF which includes various of chemical ...
Source: Biomedicine and Pharmacotherapy - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

Protective effect of down-regulated microRNA-27a mediating high thoracic epidural block on myocardial ischemia-reperfusion injury in mice through regulating ABCA1 and NF-κB signaling pathway
ConclusionCollectively, our study indicates that inhibition of miR-27a could induce HTEB to protect mice against MI/RI by regulating ABCA1 and NF-κB signaling pathway. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

Depletion of the lncRNA RP11-567G11.1 inhibits pancreatic cancer progression
ConclusionRP11-567G11.1 plays a crucial role in pancreatic cancer. Importantly, depletion of RP11-567G11.1 boosts the sensitivity of pancreatic cancer cells to gemcitabine, suggesting that this lncRNA is a promising target for pancreatic cancer treatment. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

Experimental study of blood pressure and its impact on spontaneous hypertension in rats with Xin Mai Jia
ConclusionXMJ had satisfactory hypotensive action on the SHR in this study. Its mechanism may be associated with inhibiting RAAS activity and improving RAAS function, inhibiting hypertensive-induced vascular diastolic dysfunction, and improving vascular endothelial function.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

Cancer cells change their glucose metabolism to overcome increased ROS: One step from cancer cell to cancer stem cell?
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Zahra Ghanbari Movahed, Mohsen Rastegari-Pouyani, Mohammad hossein Mohammadi, Kamran MansouriAbstractCancer cells can adapt to low energy sources in the face of ATP depletion as well as to their high levels of ROS by altering their metabolism and energy production networks which might also have a role in determining cell fate and developing drug resistance. Cancer cells are generally characterized by increased glycolysis. This is while; cancer stem cells (CSCs) exhibit an enhanced pentose phosphate pathway (PPP) metabolism. Based on...
Source: Biomedicine and Pharmacotherapy - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

Male sexual dysfunction: A review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Lei Chen, Guang-rui Shi, Dan-dan Huang, Yang Li, Chen-chao Ma, Min Shi, Bin-xiao Su, Guang-jiang ShiAbstractSexual dysfunction (SD) is a disorder of sexual behavior and sexual sensation that appears as an abnormality or absence of sexual psychology and physiological reaction. It is a general term for many different symptoms includes several aspects, erectile dysfunction (ED), failure of sexual intercourse and loss of libido/desire. According to statistics, 52% of 40˜70 year old men suffer from varying degrees of SD. And...
Source: Biomedicine and Pharmacotherapy - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

Luteolin, a flavonoid, as an anticancer agent: A review
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Muhammad Imran, Abdur Rauf, Tareq Abu-Izneid, Muhammad Nadeem, Mohammad Ali Shariati, Imtiaz Ali Khan, Ali Imran, Ilkay Erdogan Orhan, Muhammad Rizwan, Muhammad Atif, Tanweer Aslam Gondal, Mohammad S. MubarakAbstractMany food-derived phytochemicals and their derivatives represent a cornucopia of new anti-cancer compounds. Luteolin (3,4,5,7-tetrahydroxy flavone) is a flavonoid found in different plants such as vegetables, medicinal herbs, and fruits. It acts as an anticancer agent against various types of human malignancies such as l...
Source: Biomedicine and Pharmacotherapy - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

Development of a recombinant human IL-15·sIL-15Rα/Fc superagonist with improved half-life and its antitumor activity alone or in combination with PD-1 blockade in mouse model
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Meiqi Zhao, Manyu Luo, Yueqing Xie, Hua Jiang, Cedric Cagliero, Ninghuan Li, Hao Ye, Mingyuan Wu, Shuai Hao, Tianyuan Sun, Hui Yang, Mengxiao Zhang, Tong Lin, Huili Lu, Jianwei ZhuAbstractRecombinant human interleukin-15 (IL-15) is a potent cancer immunotherapeutic candidate due to its excellent immune stimulating effects. Previous work demonstrated that IL-15 appeared with short half-life in circulation system, while the complex with its receptor can prolong the half-life as well as benefit its activities in vivo. Therefore, IL-15 ...
Source: Biomedicine and Pharmacotherapy - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

Moringa concanensis Nimmo extracts ameliorates hyperglycemia-mediated oxidative stress and upregulates PPARγ and GLUT4 gene expression in liver and pancreas of streptozotocin-nicotinamide induced diabetic rats
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Brindha Banu Balakrishnan, Kalaivani Krishnasamy, Vijayakumar Mayakrishnan, Arokiyaraj SelvarajAbstractThe current study investigates the effects of ethanolic extract of M. concanensis Nimmo leaves (EEMCNL) with respect to its potent protective tissue damage, antioxidant properties in serum, liver and kidney, histopathological evaluation, and PPARγ and GLUT4 gene expression in liver and pancreatic tissue of Streptozotocin-Nicotinamide (STZ-NA) induced diabetic rats. Animals were divided into five groups (n = 5): control; d...
Source: Biomedicine and Pharmacotherapy - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

Attenuation of reproductive dysfunction in diabetic male rats with timber cultured Antrodia cinnamomea ethanol extract
This study was aimed to investigate the anti-oxidative and the ameliorative effects of Antrodia cinnamomea ethanol extract (ACEE) on reproduction dysfunction in male diabetic rats. The diabetic condition was induced by administrating the combination of streptozotocin (STZ) (65 mg/kg) and nicotinamide (NA) (230 mg/kg). Three different doses of ACEE were tested (385, 770, 1540 mg/kg) for 5 weeks. The results indicated that the ACEE improved STZ-NA induced hyperglycemia, oxidative stress, and insulin resistance. In addition to this, ACEE reduced the degree of lipid peroxidation, recovered the abnormal str...
Source: Biomedicine and Pharmacotherapy - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

Galangin loaded galactosylated pluronic F68 polymeric micelles for liver targeting
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Sharvil Patil, Vinayak Ujalambkar, Atul Rathore, Supada Rojatkar, Varsha PokharkarAbstractGalangin possess wide range of pharmacological activities including antiarthritic, hepatoprotective, anti-inflammatory, antibacterial, and anticancer especially in hepatocellular carcinoma. However, its biological use has been limited owing to its poor aqueous solubility, P-gp efflux and rapid in vivo metabolism by cytochrome enzymes. In order to address the drawbacks of galangin, the current work was designed with an objective to prepare liver...
Source: Biomedicine and Pharmacotherapy - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

Trametenolic acid B protects against cerebral ischemia and reperfusion injury through modulation of microRNA-10a and PI3K/Akt/mTOR signaling pathways
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Junzhi Wang, Ailing Wang, Haibo He, Xinxin She, Yumin He, Shi Li, Lanqing Liu, Tao Luo, Nianyu Huang, Huajun Luo, Kun ZouAbstractTrametenolic acid B (TAB) was a lanostane-type triterpenoid isolated from the trametes lactinea (Berk.) Pat. We have previously reported that extract from trametes lactinea (Berk.) Pat and TAB could efficiently improve learning and memory ability of the cerebral ischemia injury rats and suppress mitochondrial-mediated apoptosis in hydrogen peroxide damaged SH-SY5Y cells. However, the potential mechanisms h...
Source: Biomedicine and Pharmacotherapy - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

Immunostimulatory activity of Y-shaped DNA nanostructures mediated through the activation of TLR9
In this study, we developed two kinds of Y-shaped double-stranded DNA nanostructures (Y-DNAs), including a single unit composed of three DNA strands (YS-DNA) and a ligated multiunit complex formed by crosslinking each YS-DNA (YL-DNA), and investigated whether they have immunostimulatory activity in innate immune cells. YS-DNA and YL-DNA induced the production of immune cytokines such as IL-12 and TNF-α and the expression of costimulatory molecules such as CD80 and CD86 in primary mouse dendritic cells and macrophage cells (RAW264.7 cells). A Coprecipitation study demonstrated that YL-DNA was directly associated with ...
Source: Biomedicine and Pharmacotherapy - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

Pterodon pubescens and Cordia verbenacea association promotes a synergistic response in antinociceptive model and improves the anti-inflammatory results in animal models
This study evaluated the pharmacological effect of the association of crude extract from the fruits of Pterodon pubescens (Pp) with the essential oil of Cordia verbenacea (Cv) in antinociception and anti-inflammatory experimental models. The effective doses of each extract and the combinations used in the associations of extracts were defined by acetic acid-induced writhing test. The separate extracts were also evaluated on formalin test. Interaction between extracts was assessed by isobologram method. The effects of different concentrations of associations (A50, A100 and A200) were evaluated on formalin test, tail flick a...
Source: Biomedicine and Pharmacotherapy - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

The effect of white tea on serum TNF-α/NF-κB and immunohistochemical parameters in cisplatin-related renal dysfunction in female rats
ConclusionWhite tea infusions reduced significantly the nephrotoxicity of CP. The anti-nephrotoxic feature of the infusion may be attributed primarily to its anti-inflammatory and anti-apoptotic characteristics. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - February 23, 2019 Category: Drugs & Pharmacology Source Type: research

Alpha-lipoic acid attenuates p-cresyl sulfate-induced renal tubular injury through suppression of apoptosis and autophagy in human proximal tubular epithelial cells
Publication date: April 2019Source: Biomedicine & Pharmacotherapy, Volume 112Author(s): Jung Sun Park, Hoon In Choi, Dong-Hyun Kim, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan KimAbstractThe p-cresyl sulfate accumulates in kidney disease and may be involved in renal injury. α-Lipoic acid (α-LA) acts as an antioxidant in cell injury. We investigated the effects of α-LA treatment on p-cresyl sulfate-induced renal tubular injury. p-Cresyl sulfate induced cell death, and increased Bax/Bcl-2, cleaved caspase-3, Beclin-1, and LC3BII/LC3BI in human renal proximal tubular epithelial (HK-2) cells, whi...
Source: Biomedicine and Pharmacotherapy - February 23, 2019 Category: Drugs & Pharmacology Source Type: research