Differential consequences of neurokinin receptor 1 and 2 antagonists in metastatic breast carcinoma cells; Effects independent of Substance P
ConclusionsIncreased sensitivity of metastatic breast carcinoma cells to NK1R and NK2R antagonists suggest potential therapeutic value of antagonists in metastatic disease. NK1R and NK2R in metastatic breast carcinoma cells react differently to agonists and antagonists. These findings together with previously published data demonstrate that differential consequences of receptor antagonists and SP may inhibit breast cancer growth and metastasis. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - September 15, 2018 Category: Drugs & Pharmacology Source Type: research

microRNA-300/NAMPT regulates inflammatory responses through activation of AMPK/mTOR signaling pathway in neonatal sepsis
ConclusionsOur study provides evidence indicating that overexpressedmiR-300 enhances autophagy by targeting NAMPT through activation of the AMPK/mTOR signaling pathway in septic mouse models, indicating it may serve as a potential therapeutic target for sepsis. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - September 15, 2018 Category: Drugs & Pharmacology Source Type: research

Possible therapeutic potential of berberine in the treatment of STZ plus HFD-induced diabetic osteoporosis
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Huanguang Xie, Qingqing Wang, Xinyue Zhang, Te Wang, Wei Hu, Theasha Manicum, Hua Chen, Liaojun SunAbstractDiabetic osteoporosis is a complication of diabetes mellitus, and can result in an increased incidence of bone fractures and a delay in fracture healing. Berberine is one of the most widely distributed isoquinoline alkaloid in plants and possesses antioxidant properties. These properties can reduce the high glucose mediated in the dysfunction of human bone marrow stem cells. Therefore, the present study was designed to inves...
Source: Biomedicine and Pharmacotherapy - September 15, 2018 Category: Drugs & Pharmacology Source Type: research

Imbalance between T helper 17 and regulatory T cell subsets plays a significant role in the pathogenesis of systemic sclerosis
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Cuiling Mo, Zhuotong Zeng, Qiancheng Deng, Yan Ding, Rong XiaoAbstractSystemic sclerosis (SSc) is a rare autoimmune disease that is characterized by fibrosis, inflammation, and vasculopathy of the skin and internal organs. The etiopathogenesis of SSc remains unclear. However, the pivotal role of T lymphocytes with an aberrant immune response in SSc is well established. Among T cells, IL-17-producing helper T (Th17) cell and regulatory T (Treg) cell subsets have recently been found to play crucial roles in SSc pathogenesis. Genera...
Source: Biomedicine and Pharmacotherapy - September 14, 2018 Category: Drugs & Pharmacology Source Type: research

Therapeutic effects of honokiol on motor impairment in hemiparkinsonian mice are associated with reversing neurodegeneration and targeting PPARγ regulation
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Hwei-Hsien Chen, Pei-Chi Chang, Shiaw-Pyng Wey, Pei-Mei Chen, Chinpiao Chen, Ming-Huan ChanAbstractParkinson’s disease (PD) is a profound neurodegenerative disorder with gradual loss of dopamine nigrostriatal neurons linked to serious behavioral symptoms. While the current treatment strategies present limitations on halting the progression of PD, this study aimed to investigate the therapeutic potential of honokiol, as a partial peroxisome proliferator-activated receptor-gamma (PPARγ) mimic, on the proceeding behavior...
Source: Biomedicine and Pharmacotherapy - September 14, 2018 Category: Drugs & Pharmacology Source Type: research

Novel circular RNA, hsa_circ_0025039 promotes cell growth, invasion and glucose metabolism in malignant melanoma via the miR-198/CDK4 axis
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Donghui Bian, Yan Wu, Guodong SongAbstractMalignant melanoma, a tumor derived from melanocytes, shows severe drug resistance and prompt metastasis, causing a serious threat to human health. Circular RNAs (circRNAs) are widely expressed in mammals and have been indicated to play important roles in tumorigenesis. In the present study, we analyzed the variability of circRNAs in malignant melanoma by microarray and identified six differentially expressed circRNAs. In particular, we found that hsa_circ_0025039, which is formed by FOXM...
Source: Biomedicine and Pharmacotherapy - September 14, 2018 Category: Drugs & Pharmacology Source Type: research

The influence of gut microbiota dysbiosis to the efficacy of 5-Fluorouracil treatment on colorectal cancer
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Lu Yuan, Siruo Zhang, Huan Li, Fan Yang, Noosheen Mushtaq, Shakir Ullah, Yi Shi, Cuihong An, Jiru XuAbstractColorectal cancer is one of the most frequently diagnosed cancers worldwide. Gut flora can modulate the host response to chemotherapeutic drugs. However, the understanding regarding the relationship between the gut microbiota and the antitumor efficacy of 5- Fluorouracil (5-FU) treatment is limited. Therefore, we compared the tumor size and profiled the gut microbiota of mice treated with 5-FU, combined with probiotics or A...
Source: Biomedicine and Pharmacotherapy - September 14, 2018 Category: Drugs & Pharmacology Source Type: research

PTBP1 knockdown overcomes the resistance to vincristine and oxaliplatin in drug-resistant colon cancer cells through regulation of glycolysis
In conclusion, PTBP1 knockdown enhanced the sensitivity of drug-resistant colon cancer cells to vincristine and oxaliplatin through repression of glycolysis. Our study provided a promising therapeutic strategy to overcome drug resistance in colon cancer cells. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - September 14, 2018 Category: Drugs & Pharmacology Source Type: research

Xin-Jia-Xiang-Ru-Yin alleviated H1N1-induced acute lung injury and inhibited the IFN-γ-related regulatory pathway in summer flu
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Qiulu Li, Peng Pang, Ke Zheng, Li Sun, Jing Wang, Xiaoyin ChenAbstractSeasonal influenza is an acute viral infection caused by influenza virus, which is often prevalent in summer and winter. In contrast to the prevalent focus on winter flu, summer flu is often ignored by epidemiological researchers. However, summer flu should be studied because of the special immune status and the influenza spread mechanism in the hot and humid environment. Moreover, people are more likely to catch a summertime cold upon suddenly entering relativ...
Source: Biomedicine and Pharmacotherapy - September 14, 2018 Category: Drugs & Pharmacology Source Type: research

Metabolism of liver CYP450 and ultrastructural changes after long-term administration of aspirin and ibuprofen
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Congcong Wen, Zaishou Zhuang, Huanchun Song, Shuhua Tong, Xianchuan Wang, Yijing Lin, Haichao Zhan, Zhibin Chen, Lufeng HuAbstractWorldwide, aspirin and ibuprofen are the most commonly used non-steroidal anti-inflammatory drugs (NSAIDs). Some adverse reactions, including gastrointestinal reactions, have been concerned extensively. Nevertheless, the mechanism of liver injury remains unclear. In the present study, we focused on the metabolism of liver cytochrome P450 (CYP450) and ultrastructural morphology of liver cells. A total o...
Source: Biomedicine and Pharmacotherapy - September 14, 2018 Category: Drugs & Pharmacology Source Type: research

Culture filtrate ether extracted metabolites from Streptomyces levis ABRIINW111 increased apoptosis and reduced proliferation in acute lymphoblastic leukemia
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Behnaz Valipour, Seyede Momeneh Mohammadi, Ali Abedelahi, Behnaz Faramarzian Azimi Maragheh, Elahe Naderali, Alireza Dehnad, Hojjatollah Nozad CharoudehAbstractDespite the advances in the discovery of various types of anticancer drugs for curing acute lymphoblastic leukemia (ALL), their toxicity and unfavorable side effects remained as big limitations for therapeutical applications. In this regard, natural products such as Streptomyces -derived agents have shown potential applications as anticancer drugs. The present study deals ...
Source: Biomedicine and Pharmacotherapy - September 14, 2018 Category: Drugs & Pharmacology Source Type: research

Sinapic acid ameliorates bleomycin-induced lung fibrosis in rats
ConclusionThe present results showed the ability of SA to restore the antioxidant system and to inhibit oxidative stress, proinflammatory cytokines, extracellular matrix, and TGF-β. This is first report demonstrating that SA amoleriates BLM induced lung injuries through inhibition of apoptosis and induction of Nrf2 and HO-1 mediated antioxidant enzyme via NF-κB inhibition. The histopathological finding reveals that SA treatment (10 and 20 mg/kg) significantly ameliorates BLM induced lung injuries.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - September 14, 2018 Category: Drugs & Pharmacology Source Type: research

Effects of silymarin on angiogenesis and oxidative stress in streptozotocin-induced diabetes in mice
In conclusion, treatment with silymarin red uced oxidative stress and inflammation that were induced in the model of streptozotocin-induced diabetes in several organs, without apparent toxicity. Silymarin may be a promising drug for controlling diabetic complications. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - September 14, 2018 Category: Drugs & Pharmacology Source Type: research

Lipocalin-2 protects against renal ischemia/reperfusion injury in mice through autophagy activation mediated by HIF1α and NF-κb crosstalk
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Shujuan Qiu, Xuexun Chen, Yunyan Pang, Zhaoguang ZhangAbstractRenal ischemia/reperfusion injury is a main cause of acute kidney injury (AKI) triggering an inflammatory response associated with infiltrating macrophages. Lipocalin-2 (Lcn2) levels correlate positively and protect against renal ischemia/reperfusion injury. However, the mechanisms remain unclear. The aim of study was to investigate the protective mechanisms of Lcn2 on renal ischemia/reperfusion injury. We found that Lcn2 deficiency significantly aggravated renal injur...
Source: Biomedicine and Pharmacotherapy - September 14, 2018 Category: Drugs & Pharmacology Source Type: research

Cardioprotective and anti-inflammatory effects of G-protein coupled receptor 30 (GPR30) on postmenopausal type 2 diabetic rats
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Hossein Azizian, Mohammad Khaksari, Gholamreza Asadi karam, Mansour Esmailidehaj, Zeinab FarhadiAbstractDiabetic cardiomyopathy is the most common chronic disease in postmenopausal women, but the mechanism(s) is unclear. G-protein coupled receptor 30 (GPR30) is one of the receptors that binds to 17-β Estradiol (E2). To date, there is little information on GPR30 and its expression in postmenopausal type 2 diabetes (T2D) in the heart. The current study hypothesized that GPR30 mediated cardioprotective effects of E2 in ovariect...
Source: Biomedicine and Pharmacotherapy - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

FABP7 promotes cell proliferation and survival in colon cancer through MEK/ERK signaling pathway
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Ran Ma, Lan Wang, Fang Yuan, Shaoxuan Wang, Yingping Liu, Tingting Fan, Fulai WangAbstractColon cancer (CC), one of the most frequently diagnosed malignancies deriving from the digestive system, has greatly threatened human health and life. Fatty acid binding protein 7 (FABP7), an intracellular protein with the tissue-specific expression pattern, has been reported to be implicated in diverse types of human tumors. However, the biological role of FABP7 in CC is still poorly understood. The current study aimed to investigate the ro...
Source: Biomedicine and Pharmacotherapy - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Polydatin suppresses proliferation and metastasis of non-small cell lung cancer cells by inhibiting NLRP3 inflammasome activation via NF-κB pathway
In conclusion, our data showed that polydatin acted as an anti-tumor agent to suppress proliferation and metastasis of NSCLC cells. The anti-tumor effect of polydatin was possibly related to the inhibition of NLRP3 inflammation via the NF-κB pathway. Our finding suggested that polydatin might be a potential therapeutic candidate in the treatment of NSCLC.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Neuro-protective effects of aloperine in an Alzheimer’s disease cellular model
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Jing Zhao, Ge Zhang, Min Li, Qinghua Luo, Yu Leng, Xu LiuAbstractExcessive production of amyloid β (Aβ) induced by familial mutations in amyloid precursor protein (APP) and presenilin 1 (PS1) results in neuronal oxidative insults, mitochondrial dysfunction, and apoptosis, which play an essential role in the pathological development of Alzheimer’s disease (AD). Aloperine, a quinolizidine alkaloid derived from the leaves of the Sophora plant, has displayed multiple pharmacological functions in several chronic diseas...
Source: Biomedicine and Pharmacotherapy - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of Hypericum humifusum aqueous and methanolic leaf extracts on biochemical and histological parameters in adult rats
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Afef Nahdi, Imen Hammami, Ridha Ben Ali, Olfa Kallech-Ziri, Ahmed El May, Michèle Véronique El MayAbstractHypericum genus is traditionally known for its medicinal use and its therapeutic and antioxidant effects. However, the toxic effect of this plant has not been much explored. Our study aimed at investigating the effect of Hypericum humifusum (Hh) leaf extracts on oxidative stress parameters in male rats. For it, we first focused on the phytochemical analysis of the aqueous and methanolic extracts of Hh leaves. He...
Source: Biomedicine and Pharmacotherapy - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Molecules derived from tRNA and snoRNA: Entering the degradome pool
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Witold Światowy, Paweł P. JagodzińśkiAbstractMolecules built of RNA have been the subjects of numerous studies, which have made known new functions and structures that these molecules can create. In recent years, thanks to next-generation sequencing, it is possible to observe very small RNAs and the number of newly discovered RNA molecules is rapidly increasing. Among other small oligonucleotides, structures derived from tRNA and snoRNA molecules have been observed, and these molecules were determined to not be precursors of ...
Source: Biomedicine and Pharmacotherapy - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Uptake-release by MSCs of a cationic platinum(II) complex active in vitro on human malignant cancer cell lines
In this study, the in vitro stability of cisplatin (CisPt) and cationic platinum(II)-complex (caPt(II)-complex) and their in vitro activity (antiproliferative and anti-angiogenic properties) were investigated against three aggressive human tumor cell lines. caPt(II)-complex shown a high stability until 9 days of treatment and displayed a significant and higher activity than CisPt against both NCI-H28 mesothelioma (19.37 ± 9.57 μM versus 34.66 ± 7.65 μM for CisPt) and U87 MG glioblastoma (19.85 ± 0.97 μM versus 54.14 ± 3.19 for CisP...
Source: Biomedicine and Pharmacotherapy - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Bortezomib inhibited the progression of diffuse large B-cell lymphoma via targeting miR-198
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Ruihuan Wang, Jie Shen, Qing Wang, Minjuan ZhangAbstractDiffuse large B-cell lymphoma (DLBCL) is the most common subtype of non-Hodgkin lymphoma, which is an aggressive malignancy with high variance of clinical features and response to the treatment. The proteasome inhibitor bortezomib (BTZ) has been demonstrated to suppress the progression of DLBCL, however, the underlying molecular mechanisms by which BTZ regulates the growth of DLBCL cells remain largely unknown. Increasing evidence has suggested that microRNAs (miRNAs) are no...
Source: Biomedicine and Pharmacotherapy - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

SRT1720 ameliorates sodium taurocholate-induced severe acute pancreatitis in rats by suppressing NF-κB signalling
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Chenyuan Shi, Chaoqun Hou, Xiaole Zhu, Dongya Huang, Yunpeng Peng, Min Tu, Qiang Li, Yi MiaoAbstractSevere acute pancreatitis (SAP) is a medical emergency that is often associated with multiple organ failure and high mortality. Although an SAP diagnosis requires prompt treatment, therapeutic options remain limited. SRT1720 is a newly formulatedSIRT1 activator that exerts multiple pharmacological activities with beneficial health effects. However, its potential as an SAP treatment has not been explored. The current study assessed ...
Source: Biomedicine and Pharmacotherapy - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

The impact of proton pump inhibitors on the pharmacokinetics of voriconazole in vitro and in vivo
The objectives of the study are to evaluate the impact of PPIs on the pharmacokinetics of VRC. Human liver microsomes model was applied to assess the inhibitory effects of PPIs on the metabolism of VRC in vitro. A retrospective study was also carried out to explore the relationship between the plasma VRC trough concentrations and PPIs uses. Patients were divided into six groups: control (n = 166), lansoprazole (LAN, n = 38), esomeprazole (ESO, n = 19), omeprazole (OME, n = 45), pantoprazole (PAN, n = 43), and ilaprazole (ILA, n = 38) groups...
Source: Biomedicine and Pharmacotherapy - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Chemopreventive and antitumor effects of benzyl isothiocynate on HCC models: A possible role of HGF /pAkt/ STAT3 axis and VEGF
ConclusionThe effect of BITC on HGF /pAkt/ STAT3 axis has a potential role in both chemopreventive and chemotherapeutic effects of BITC.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Cinobufacini protects against paclitaxel-induced peripheral neuropathic pain and suppresses TRPV1 up-regulation and spinal astrocyte activation in rats
In this study, the effects of cinobufacini were investigated in a rat model of paclitaxel-induced peripheral neuropathic pain (PIPNP) to better understand and expand its clinical application. A single injection of cinobufacini (2.5 g/kg, i.p.) alleviated pre-established PIPNP, as indicated by decreased mechanical and thermal hypersensitivity compared with paclitaxel-treated rats. Repeated cinobufacini (1.25 and 2.5 g/kg, i.p.), given during the induction of PIPNP, prevented the establishment of paclitaxel-induced mechanical and thermal hypersensitivity. This preventative effect was associated with suppressed ...
Source: Biomedicine and Pharmacotherapy - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Sedative–hypnotic like effect of 5–methoxyflavone in mice and investigation on possible mechanisms by in vivo and in silico methods
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Jaikumar Shanmugasundaram, Viswanathan Subramanian, Jagan S. Nadipelly, Parimala Kathirvelu, Vijaykumar Sayeli, Binoy Varghese CheriyanAbstractFlavonoids have been shown to possess central nervous system (CNS) depressant effect mediated through the ionotropic GABAA receptors. In the present study, 5-methoxyflavone was evaluated for sedative-hypnotic like activity in mice and the mechanisms involved by employing a battery of tests including molecular docking studies. In the open field test, 5–methoxyflavone in various doses ...
Source: Biomedicine and Pharmacotherapy - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Xiao Tan He Wei Decoction reverses MNNG-induced precancerous lesions of gastric carcinoma in vivo and vitro: Regulation of apoptosis through NF-κB pathway
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Jingyu Xu, Wei Shen, Bei Pei, Xiaowei Wang, Dazhi Sun, Yongjin Li, LiJuan Xiu, Xuan Liu, Ye Lu, Xuan Zhang, XiaoQiang YueAbstractIn recent years, Chinese medicine has played an important role in the prognosis of gastric cancer. Precancerous lesions of gastric carcinoma (PLGC) is a class of gastric cancer which is closely related to the gastric mucosal pathology changes in the role of carcinogenic incentives, and plays key role in the progression of normal gastric mucosal cells into gastric cancerous cells. In current experiment, ...
Source: Biomedicine and Pharmacotherapy - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Protective effect of enzymatic hydrolysates from seahorse (Hippocampus abdominalis) against H2O2-mediated human umbilical vein endothelial cell injury
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Yunok Oh, Chang-Bum Ahn, Na Young Yoon, Ki Ho Nam, Yeon-Kye Kim, Jae-Young JeAbstractOxidative stress-mediated endothelial dysfunction and LDL oxidation have been implicated in the pathogenesis of atherosclerosis. Thus, the protection of the endothelial cells against oxidative stress-mediated injury and the inhibition of LDL oxidation by the use of antioxidants are a good strategy against atherosclerosis development. Here, we investigated the protective effect and the inhibition of LDL oxidation of seahorse H. abdominalia hydroly...
Source: Biomedicine and Pharmacotherapy - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Letter to the editor regarding the article by Chen et al. entitled “Protective effects of echinacoside against anoxia/reperfusion injury in H9c2 cells via up-regulating p-AKT and SLC8A3”
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Vincenzo Lariccia, Salvatore Amoroso (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - September 13, 2018 Category: Drugs & Pharmacology Source Type: research

Corrigendum to “Incretin hormones receptor signaling plays the key role in antidiabetic potential of PTY-2 against STZ-induced pancreatitis” [Biomed. Pharmacother. 97 (330–338) 330–338]
Publication date: Available online 14 August 2018Source: Biomedicine & PharmacotherapyAuthor(s): Shivani Srivastava, Priya Shree, Harsh Pandey, Yamini Bhusan Tripathi (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - September 11, 2018 Category: Drugs & Pharmacology Source Type: research

Amelioration of oxidative stress in differentiated neuronal cells by rutin regulated by a concentration switch
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Banudevi Sivanantham, UmaMaheswari Krishnan, Vignesh RajendiranAbstractIncreasing studies have implicated superfluous production of reactive oxygen species (ROS) as a significant factor in the progress of neurodegenerative disorders ranging from ischemic stroke to amyotrophic lateral sclerosis. The possible mechanisms relating to oxidative stress and neurodegeneration are yet to be thoroughly understood. Rutin, a flavonoid, has been well documented for its beneficial and pharmacological activities against diverse targets. However...
Source: Biomedicine and Pharmacotherapy - September 11, 2018 Category: Drugs & Pharmacology Source Type: research

RIPK4 promoted the tumorigenicity of nasopharyngeal carcinoma cells
In this study, we have shown that the expression of RIPK4 was up-regulated in NPC tissues. RIPK4 promoted the growth and anchorage-independent growth of NPC cells, and down-regulation of RIPK4 inhibited the growth of NPC cells both in the plate-based culture and on the soft agar. Moreover, RIPK4 promoted the expression of VEGF in the NPC cells and induced the tube formation of HUVEC, and Axitinib (the inhibitor for VEGF receptor) inhibited the tumorigenesis driven by RIPK4. In the molecular mechanism study, RIPK4 was found to enhance the interaction between IKKα and IKKβ, and activated NF-kB signaling. Taken tog...
Source: Biomedicine and Pharmacotherapy - September 11, 2018 Category: Drugs & Pharmacology Source Type: research

Down-regulation of microRNA-21 reduces inflammation and podocyte apoptosis in diabetic nephropathy by relieving the repression of TIMP3 expression
ConclusionThe down-regulation of miR-21 inhibited the progression of DN by targeting TIMP3 in STZ-induced DN rats and HG-treated podocytes, elucidating a novel regulatory mechanism of miR-21 in DN progression and offering a potential target for DN therapy. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - September 11, 2018 Category: Drugs & Pharmacology Source Type: research

miR-217 represses TGF-β1-induced airway smooth muscle cell proliferation and migration through targeting ZEB1
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Ying Gao, Botao Wang, Huanan Luo, Qing Zhang, Min XuAbstractAberrant proliferation and migration of airway smooth muscle cells (ASMCs) contribute to the pathogenesis of airway remodeling during asthma development. Here, the potential function of microRNA-217 (miR-217) on the cell proliferation and migration of TGF-β1-induced ASMCs and the involved mechanisms were investigated in this study. We found that miR-217 expression was apparently downregulated in a time and dose dependent characteristic in ASMCs exposed to transformi...
Source: Biomedicine and Pharmacotherapy - September 11, 2018 Category: Drugs & Pharmacology Source Type: research

Preventive measures in oral cancer: An overview
Publication date: November 2018Source: Biomedicine & Pharmacotherapy, Volume 107Author(s): Sharon D’souza, Veeranjaneyulu AddepalliAbstractWorldwide oral cancer is creating an alarming situation and it’s a matter of global concern as it is the 11th most common carcinoma around the globe. After cardiovascular ailments, cancer is the next biggest killer. Approximately 90% of the total oral malignancies are squamous cell carcinomas. The etiological base of oral cancer is tobacco intake, smoking, smokeless tobacco (snuff or chewing tobacco), alcohol and areca nut intake, excessive sunlight exposure, reverse end...
Source: Biomedicine and Pharmacotherapy - August 3, 2018 Category: Drugs & Pharmacology Source Type: research

Advances of circular RNAs in carcinoma
Publication date: November 2018Source: Biomedicine & Pharmacotherapy, Volume 107Author(s): Xiao-yue Xu, Lei-lei Zhou, Chen Yu, Bo Shen, Ji-feng Feng, Shao-rong YuAbstractCircular RNAs (circRNAs) are a type of non-coding RNAs with single-stranded closed structure. The rapid development of high-throughput sequencing technology has allowed for the widespread presence of circRNAs in transcriptomes. Moreover, increasing studies have identified a correlation between circRNAs and different cancers. In addition, most circRNAs are dysregulated in various cancers, and some of them have been reported be vital in the occurrence an...
Source: Biomedicine and Pharmacotherapy - August 3, 2018 Category: Drugs & Pharmacology Source Type: research

Moringa oleifera stem extract protect skin keratinocytes against oxidative stress injury by enhancement of antioxidant defense systems and activation of PPARα
Publication date: November 2018Source: Biomedicine & Pharmacotherapy, Volume 107Author(s): Yu Zhou, Wushuang Yang, Zhiqun Li, Doudou Luo, Weijie Li, Yali Zhang, Xuan Wang, Meijuan Fang, Qing Chen, Xin JinAbstractOxidative stress is an important cause of skin injury induced by UVB radiation. Moringa oleifera also known as horseradish tree or drumstick tree, have multiple nutraceutical or pharmacological functions. However, whether Moringa oleifera protects skin against oxidative stress injury remains unknown. To investigate the effects of the ethanol extract of Moringa oleifera stem (MSE) on skin oxidative stress injury...
Source: Biomedicine and Pharmacotherapy - August 3, 2018 Category: Drugs & Pharmacology Source Type: research

Ionic gradient liposomes: Recent advances in the stable entrapment and prolonged released of local anesthetics and anticancer drugs
Publication date: November 2018Source: Biomedicine & Pharmacotherapy, Volume 107Author(s): Munazza Tamkeen Fatima, Zeyaul Islam, Ejaj Ahmad, George E. Barreto, Ghulam Md AshrafAbstractLiposomes have established themselves as great pharmaceutical carriers over the past three decades. These phospholipid vesicular systems have undergone great technical advances including remote drug loading, targeted delivery, and combinatorial drug therapy. Ionic gradient liposomes (IGL) necessitates active loading of the drug in preformed vesicles exhibiting a transmembrane pH or ion gradient, with a low intra liposome pH (∼ 4-5), a...
Source: Biomedicine and Pharmacotherapy - August 2, 2018 Category: Drugs & Pharmacology Source Type: research

Cytoprotective effects of paeoniflorin are associated with translocator protein 18 kDa
Publication date: November 2018Source: Biomedicine & Pharmacotherapy, Volume 107Author(s): Zhi-Kun Qiu, Xu Liu, Dan Tang, Zhe Zhang, Qing-Hong Fan, Yun-Yun Pan, Ying-Yu Chen, Mei-Yan Huang, Tao Zhu, Yu-Lu Wang, Xiao-Fang Cheng, Ji-Sheng ChenAbstractPaeoniflorin (PF) is one of the important active components in peony that are known to produce the neuroprotective effects. However, the involved cytoprotective factors on brain astrocytes are remain unclear. Translocator protein 18 kDa (TSPO) and its downstream neurosteroids biosynthesis play a significant role in cytoprotection. Based on these, the role of TSPO and neuro...
Source: Biomedicine and Pharmacotherapy - August 1, 2018 Category: Drugs & Pharmacology Source Type: research

Inhibition of miR-31a-5p decreases inflammation by down-regulating IL-25 expression in human dermal fibroblast cells (CC-2511 cells) under hyperthermic stress via Wnt/β-catenin pathway
ConclusionsThese results demonstrated that miR-31a-5p inhibition could decrease inflammation and improve cell survival of CC-2511 cells under hyperthermic stress via regulation Wnt/β-catenin signal pathway.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - August 1, 2018 Category: Drugs & Pharmacology Source Type: research

Reduction of cisplatin-induced renal and hepatic side effects in rat through antioxidative and anti-inflammatory properties of Malva sylvestris L. extract
ConclusionResults showed that mallow supplement protects the kidneys and liver against side effects of cisplatin, and reduces the resultant oxidative stress and inflammation.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - August 1, 2018 Category: Drugs & Pharmacology Source Type: research

miR-208b targets Bax to protect H9c2 cells against hypoxia-induced apoptosis
ConclusionmiR-208b is highly expressed during MI, and miR-208b protects H9c2 cells against hypoxia-induced apoptosis. miR-208b exerts myocardioprotective effect via targeting Bax and activating PI3K/AKT pathway.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 31, 2018 Category: Drugs & Pharmacology Source Type: research

Involvement of organic cation transporter 2 in the metformin-associated increased lactate levels caused by contrast-induced nephropathy
In this study, iohexol injection was used as a model drug. The contrast agent acute kidney injury rat model, in vivo rat pharmacokinetic study, kidney slices and HK-2 cells were performed to elucidate the pharmacokinetic molecular mechanism of accumulation of metformin caused by contrast-induced nephropathy (CIN). Plasma exposure of metformin was increased significantly in the CIN group compared with that in the normal and control groups. The AUC of metformin was from 2791 ± 382 μg min mL−1 to 4784 ± 767 μg min mL−1. The cumulative urinary excretion of metformin was also ...
Source: Biomedicine and Pharmacotherapy - July 31, 2018 Category: Drugs & Pharmacology Source Type: research

Gold nanoparticles: A plausible tool to combat neurological bacterial infections in humans
Publication date: November 2018Source: Biomedicine & Pharmacotherapy, Volume 107Author(s): Syed Mohd Danish Rizvi, Talib Hussain, Abo Bakr Fathy Ahmed, Thamir M. Alshammari, Afrasim Moin, Mohammed Qumani Ahmed, George E. Barreto, Mohammad Ajmal Kamal, Ghulam Md AshrafAbstractManagement of bacterial infections of central nervous system is a major challenge for the scientists all over the world. Despite the development of various potential drugs, the issue of central nervous system infections persists in the society. The main constraint is the delivery of drugs across the blood brain barrier and only a few drugs after me...
Source: Biomedicine and Pharmacotherapy - July 31, 2018 Category: Drugs & Pharmacology Source Type: research

A comparison of the effects of thymoquinone, silymarin and N-acetylcysteine in an experimental hepatotoxicity
This study investigated the effects of thymoquinone, silymarin, and N-acetylcysteine in a rat model with carbon tetrachloride (CCl4)-induced hepatotoxicity. Although numerous similar studies are available, we aimed to compare the efficacy of these agents by considering N-acetylcysteine as a reference compound. A total of 50 male Wistar albino rats were randomly designated as 5 groups: Group I, CCl4; group II, thymoquinone and CCl4; group III, silymarin and CCl4; group IV, N-acetylcysteine and CCl4; group V, control group. CCl4 was administered intraperitoneally at a dose of 1.5 mL/kg (a mixture of CCl4: olive...
Source: Biomedicine and Pharmacotherapy - July 31, 2018 Category: Drugs & Pharmacology Source Type: research

Activation of the bile acid receptor GPBAR1 (TGR5) ameliorates interleukin-1β (IL-1β)- induced chondrocytes senescence
In this study, we show that the bile acid receptor GPBAR1 (TGR5), a G protein couples bile acid receptor, plays important roles in protecting chondrocytes from interleukin 1β (IL-1β)- caused senescence. TGR5 is fairly expressed in cultured chondrocytes. Its expression is reduced in isolated chondrocytes from osteoarthritis patients, and IL-1β treatment suppresses TGR5 expression. Activation of TGR5 by its synthetic agonist, INT-777, dramatically reduces senescence associated β galactosidase activity by IL-1β. Mechanistically, the action of INT-777 ameliorates IL-1β- induced chondrocytes entry ...
Source: Biomedicine and Pharmacotherapy - July 31, 2018 Category: Drugs & Pharmacology Source Type: research

Oxidized low density lipoprotein induces endothelial-to-mesenchymal transition by stabilizing Snail in human aortic endothelial cells
We report here that ox-LDL treatment is able to induce EndMT in human aortic endothelial cells (HAECs), and that the ox-LDL-induced EndMT is strictly dependent on the presence of its innate receptor, ox-LDL Receptor-1 (LOX-1). In addition, ox-LDL specifically upregulates EndMT transcriptional factor Snail, and knockdown of Snail completely attenuates ox-LDL-induced EndMT, indicating an essential role of Snail in mediating this effect. Mechanically, ox-LDL induces Snail stabilization by inhibiting its ubiquitination, which is in part attributed to inhibited GSK-3β activity. Hence, our findings suggest that inducing End...
Source: Biomedicine and Pharmacotherapy - July 31, 2018 Category: Drugs & Pharmacology Source Type: research

Inhibition of EP300 and DDR1 synergistically alleviates pulmonary fibrosis in vitro and in vivo
ConclusionsThe EP300 siRNA and inhibitors sensitized DDR1 inhibitors in our pulmonary fibrosis models in vitro and in vivo, implicating a combined inhibition of DDR1 with EP300 as potential therapies for IPF.Graphical abstractThe EP300 siRNA and inhibitors sensitized DDR1 inhibitors in pulmonary fibrosis models in vitro and in vivo, implicating a combined inhibition of DDR1 with EP300 as potential therapies for IPF. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 31, 2018 Category: Drugs & Pharmacology Source Type: research

The protective effects of a novel synthetic β-elemene derivative on human umbilical vein endothelial cells against oxidative stress-induced injury: Involvement of antioxidation and PI3k/Akt/eNOS/NO signaling pathways
In conclusion, the present study demonstrated that BEG has antioxidant activity. Furthermore, BEG reduced H2O2-induced endothelial cells injury by the involvement of antioxidation and PI3K/Akt/eNOS/NO signaling pathways.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 31, 2018 Category: Drugs & Pharmacology Source Type: research