Potential role of propolis in wound healing: Biological properties and therapeutic activities
In this study, the clinical trials have been combined and the results were provided as meta-analysis. Propolis is a non-toxic natural product; however some cases of allergy and contact dermatitis to this compound have been described mainly among beekeepers. An important factor in impaired wound healing is biofilm formation; propolis as an anti-microbial agent can reduce biofilm generation and result in accelerated healing processes. Most of the in vivo studies on various wound models suggested the beneficial roles of propolis on experimental wound healing and this has also been approved in the clinical trial studies. Howev...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Adipokines in neurovascular diseases
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Radka Opatrilova, Martin Caprnda, Peter Kubatka, Vanda Valentova, Sona Uramova, Vladimir Nosal, Ludovit Gaspar, Lukas Zachar, Ioana Mozos, Daniel Petrovic, Jozef Dragasek, Slavomira Filipova, Dietrich Büsselberg, Anthony Zulli, Luis Rodrigo, Peter Kruzliak, Vladimir Krasnik Adipose tissue is now described as an endocrine organ secreting a number of adipokines contributing to the development of inflammation and metabolic imbalance, but also endothelial dysfunction, vascular remodeling, atherosclerosis, and ischemic strok...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Recent advances in the neurobiology and neuropharmacology of Alzheimer ’s disease
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Kushal Kumar, Ashwani Kumar, Richard M. Keegan, Rahul Deshmukh Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by progressive deterioration of cognitive functions. The pathological hallmarks are extracellular deposits of amyloid plaques and intracellular neurofibrillary tangles of tau protein. The cognitive deficits seen are thought to be due to synaptic dysfunction and neurochemical deficiencies. Various neurochemical abnormalities have been observed during progressive ageing, and are lin...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Orphan G protein-coupled receptors: The role in CNS disorders
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Mohaddeseh Sadat Alavi, Ali Shamsizadeh, Hassan Azhdari-Zarmehri, Ali Roohbakhsh There are various types of receptors in the central nervous system (CNS). G protein-coupled receptors (GPCRs) have the highest expression with a wide range of physiological functions. A newer sub group of these receptors namely orphan GPCRs have been discovered. GPR3, GPR6, GPR17, GPR26, GPR37, GPR39, GPR40, GPR50, GPR52, GPR54, GPR55, GPR85, GPR88, GPR103, and GPR139 are the selected orphan GPCRs for this article. Their roles in the central ner...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

A review on exudates detection methods for diabetic retinopathy
Publication date: January 2018 Source:Biomedicine & Pharmacotherapy, Volume 97 Author(s): Shilpa Joshi, P.T. Karule The presence of exudates on the retina is the most characteristic symptom of diabetic retinopathy. As exudates are among early clinical signs of DR, their detection would be an essential asset to the mass screening task and serve as an important step towards automatic grading and monitoring of the disease. Reliable identification and classification of exudates are of inherent interest in an automated diabetic retinopathy screening system. Here we review the numerous early studies that used for automa...
Source: Biomedicine and Pharmacotherapy - December 14, 2017 Category: Drugs & Pharmacology Source Type: research

HDACis (class I), cancer stem cell, and phytochemicals: Cancer therapy and prevention implications
Publication date: January 2018 Source:Biomedicine & Pharmacotherapy, Volume 97 Author(s): Sahar Bayat, Mahmoud Shekari Khaniani, Jalal Choupani, Mohammad Reza Alivand, Sima Mansoori Derakhshan Epigenetics is independent of the sequence events that physically affect the condensing of chromatin and genes expression. The unique epigenetic memories of various cells trigger exclusive gene expression profiling. According to different studies, the aberrant epigenetic signatures and impaired gene expression profiles are master occurrences in cancer cells in which oncogene and tumor suppressor genes are affected. Owing to ...
Source: Biomedicine and Pharmacotherapy - December 14, 2017 Category: Drugs & Pharmacology Source Type: research

Baicalin attenuates diet induced nonalcoholic steatohepatitis by inhibiting inflammation and oxidative stress via suppressing JNK signaling pathways
This study aimed to investigate the effect of BC on the development of diet induced NASH and the possible mechanisms involved. Mice were fed with high fat and high cholesterol (HFC) diet to establish a NASH model, BC (0.5% w/w) was added into the diet to evaluate its effect on NASH. Mice fed an HFC diet developed NASH in 12 weeks. BC administration attenuated hepatic steatosis, inflammation and fibrosis induced by HFC diet. The NALFD activity score (NAS) was sharply decreased by BC. Mice serum ALT and AST were decreased in the BC group. BC decreased hepatic inflammatory cell infiltration, inflammatory genes (MCP-1, TNF&a...
Source: Biomedicine and Pharmacotherapy - December 14, 2017 Category: Drugs & Pharmacology Source Type: research

Long non-coding RNA OIP5-AS1 functions as an oncogene in lung adenocarcinoma through targeting miR-448/Bcl-2
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Jun Deng, Huan Deng, Chunfeng Liu, Yujia Liang, Songping Wang LncRNAs are increasingly verified to be aberrantly expressed in cancers. The abnormal expression of lncRNAs has turned out to be closely related to tumorigenesis or tumor progression. It has been reported that lncRNA OPI5-AS1 serves as a crucial regulator in tumors. However, the specific function of OIP5-AS1 on the progression of lung adenocarcinoma is still uncertain. In this paper, we mainly elucidated that OIP5-AS1 exerts oncogenic functions in human lung adeno...
Source: Biomedicine and Pharmacotherapy - December 14, 2017 Category: Drugs & Pharmacology Source Type: research

Overexpressed miR-195 attenuated immune escape of diffuse large B-cell lymphoma by targeting PD-L1
Conclusion MiR-195 regulated immune response of DLBCL through targeting PD-L1. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 13, 2017 Category: Drugs & Pharmacology Source Type: research

Long non-coding RNA XLOC_008466 acts as an oncogenic molecular in cervical cancer tumorigenesis
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Fang Guo, Yun-Zhi Chen, Liu Li, Cong Chen, Jian-Hua Jin, Jie Yang, Jing-Jing Chen, Xin-Yan Chen, Min Guo, Yu-Mei Chen Cervical cancer is one of the most common malignant carcinomas in the female reproductive system. Long non-coding RNAs (lncRNAs) have been verified to participate in the tumorigenesis of cervical cancer. In present study, we investigate the role of lncRNA XLOC_008466 in the occurrence and progression of cervical cancer. Results showed that XLOC_008466 expression was up-regulated in cervical cancer tissue and ...
Source: Biomedicine and Pharmacotherapy - December 13, 2017 Category: Drugs & Pharmacology Source Type: research

Aqueous extract of Triphala inhibits cancer cell proliferation through perturbation of microtubule assembly dynamics
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Sanith Cheriyamundath, Tejashree Mahaddalkar, Shreyada N. Save, Sinjan Choudhary, Ramakrishna V. Hosur, Manu Lopus Triphala (Trl) is an ayurvedic formulation used for treating disorders of the digestive, respiratory, and nervous systems. Its anticancer properties have also been documented. We studied effects of Trl on tubulin, a target protein for several anticancer drugs, and systematically elucidated a possible antiproliferative mechanism of action of Trl. Trl inhibited proliferation of HeLa (cervical adenocarcinoma), PANC...
Source: Biomedicine and Pharmacotherapy - December 13, 2017 Category: Drugs & Pharmacology Source Type: research

Overexpression of microRNA-375 impedes platelet-derived growth factor-induced proliferation and migration of human fetal airway smooth muscle cells by targeting Janus kinase 2
In this study, we aimed to investigate the potential role of miR-375 in the regulation of platelet-derived growth factor (PDGF)-induced fetal ASM cell proliferation and migration. Our results showed that miR-375 expression was significantly decreased in fetal ASM cells that were treated with PDGF. Functional data showed that overexpression of miR-375 inhibited the proliferation and migration of fetal ASM cells, whereas inhibition of miR-375 enhanced the proliferation and migration of fetal ASM cells. The results of bioinformatics analysis and a dual-luciferase reporter assay showed that miR-375 binds directly to the 3&prim...
Source: Biomedicine and Pharmacotherapy - December 13, 2017 Category: Drugs & Pharmacology Source Type: research

Lin28a functionally modulates bupivacaine-induced dorsal root ganglion neuron apoptosis through TrkA activation
Conclusion Lin28a is a potent regulator in BUP-induced neuronal apoptosis in DRGNs. The apoptotic protection by Lin28a inhibition is likely through the activation of TrkA signaling pathway. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

Immuno-biological comparison of hepatic stellate cells in a reverted and activated state
In conclusion, the immunologic profile of HSCs is significantly modulated by their activation state and inflammation and is important for the development of novel HSC liver cell-based therapy. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

Diclofenac-induced renal toxicity in female Wistar albino rats is protected by the pre-treatment of aqueous leaves extract of Madhuca longifolia through suppression of inflammation, oxidative stress and cytokine formation
Conclusion The significant result of the aqueous leaf extract ofMadhuca longifolia was due to its ability in restoring renal function by restoring antioxidants and preventing cellular damages. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

Resveratrol inhibits proliferation, migration and invasion via Akt and ERK1/2 signaling pathways in renal cell carcinoma cells
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Yuwan Zhao, Huancheng Tang, Xin Zeng, Dongcai Ye, Jianjun Liu Recent studies have shown that resveratrol (RES) inhibits cancer cell growth, migration and invasion. Here, we evaluated RES in two human renal cell carcinoma (RCC) cell lines, ACHN and A498. We investigated the effects of RES on proliferation, cell morphology, colony formation, migration, and invasion. We used a proliferation assay to demonstrate that RES inhibited cell growth with IC50 values 132.9±1.064μM in ACHN, and 112.8±1.191μM in A498, ...
Source: Biomedicine and Pharmacotherapy - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

Combined efficacy of oseltamivir, isoprinosine and ellagic acid in influenza A(H3N2)-infected mice
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Elitsa L. Pavlova, Lora S. Simeonova, Galina A. Gegova Influenza pathogenesis comprises a complex cascade of impaired cellular processes resulting from the viral replication and exaggerated immune response accompanied by reactive oxygen species (ROS) burst and oxidative stress, destructing membranous structures and tissues. By classical virological and biochemical methods we compared and evaluated the therapeutic effects of 2.5mg/kg/day of the antiviral drug – oseltamivir (OS), 500mg/kg/day of the immune modulator &nda...
Source: Biomedicine and Pharmacotherapy - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

Insights on ornithine decarboxylase silencing as a potential strategy for targeting retinoblastoma
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Sivashanmugam Muthukumaran, Renganathan Bhuvanasundar, Vetrivel Umashankar, K.N. Sulochana Ornithine Decarboxylase (ODC) is a key enzyme involved in polyamine synthesis and is reported to be up regulated in several cancers. However, the effect of ODC gene silencing in retinoblastoma is to be understood for utilization in therapeutic applications. Hence, in this study, a novel siRNA (small interference RNA) targeting ODC was designed and validated in Human Y79 retinoblastoma cells for its effects on intracellular polyamine le...
Source: Biomedicine and Pharmacotherapy - December 12, 2017 Category: Drugs & Pharmacology Source Type: research

Protocatechuic acid ameliorates high glucose-induced extracellular matrix accumulation in diabetic nephropathy
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Yali Ma, Fang Chen, Suxia Yang, Baoping Chen, Jun Shi Protocatechuic acid (PCA), a phenolic compound of anthocyanins, was reported to possess various pharmacologic properties, including anti-oxidant, anti-inflammatory, anti-apoptosis, anti-diabetic and anti-tumor activities. However, the role of PCA in diabetic nephropathy remains elusive. The present study was conducted to evaluate the effects of PCA on extracellular matrix (ECM) accumulation in high glucose (HG)-induced human mesangial cells (MCs) and explore the possible ...
Source: Biomedicine and Pharmacotherapy - December 11, 2017 Category: Drugs & Pharmacology Source Type: research

SALL4 promotes osteoblast differentiation by deactivating NOTCH2 signaling
Conclusions Our study found that SALL4 played very important roles in the process of osteoblast differentiation by deactivating NOTCH2 signaling. These findings might provide a new insight for treatment of osteoporosis. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 11, 2017 Category: Drugs & Pharmacology Source Type: research

MiR-208a-3p aggravates autophagy through the PDCD4-ATG5 pathway in Ang II-induced H9c2 cardiomyoblasts
In this study, we characterized the regulatory role of miR-208a-3p in autophagy in H9c2 cardiomyoblasts induced by Angiotensin II (Ang II). We found that miR-208a-3p was up-regulated in Ang II-induced H9c2 cardiomyoblasts and in starvation-induced autophagy. The overexpression of miR-208a-3p increased Ang II-induced autophagy, and this was accompanied by the inhibition of programmed cell death protein (PDCD4) and upregulation of autophagy protein 5 (ATG5). A dual-luciferase report assay confirmed the direct binding between miR-208a-3p and PDCD4. PDCD4 knockdown up-regulated autophagy, and its overexpression down-regulated ...
Source: Biomedicine and Pharmacotherapy - December 11, 2017 Category: Drugs & Pharmacology Source Type: research

Nanotherapeutics: An insight into healthcare and multi-dimensional applications in medical sector of the modern world
Publication date: January 2018 Source:Biomedicine & Pharmacotherapy, Volume 97 Author(s): Minakshi Prasad, Upendra P. Lambe, Basanti Brar, Ikbal Shah, Manimegalai J, Koushlesh Ranjan, Rekha Rao, Sunil Kumar, Sheefali Mahant, Sandip Kumar Khurana, Hafiz M.N. Iqbal, Kuldeep Dhama, Jyoti Misri, Gaya Prasad In recent years nanotechnology has revolutionized the healthcare strategies and envisioned to have a tremendous impact to offer better health facilities. In this context, medical nanotechnology involves design, fabrication, regulation, and application of therapeutic drugs and devices having a size in nano-range (1&...
Source: Biomedicine and Pharmacotherapy - November 21, 2017 Category: Drugs & Pharmacology Source Type: research

Aberrant DNA methylation of key genes and Acute Lymphoblastic Leukemia
Publication date: January 2018 Source:Biomedicine & Pharmacotherapy, Volume 97 Author(s): Mina Rahmani, Mehdi Talebi, Majid Farshdousti Hagh, Abbas A.Hosseinpour Feizi, Saeed Solali DNA methylation is a dynamic process influencing gene expression by altering either coding or non-coding loci. Despite advances in treatment of Acute Lymphoblastic Leukemia (ALL); relapse occurs in approximately 20% of patients. Nowadays, epigenetic factors are considered as one of the most effective mechanisms in pathogenesis of malignancies. These factors are reversible elements which can be potentially regarded as therapy targets an...
Source: Biomedicine and Pharmacotherapy - November 21, 2017 Category: Drugs & Pharmacology Source Type: research

MicroRNAs as novel biomarkers for colorectal cancer: New outlooks
Publication date: January 2018 Source:Biomedicine & Pharmacotherapy, Volume 97 Author(s): Naghmeh Shirafkan, Behzad Mansoori, Ali Mohammadi, Navid Shomali, Mehri Ghasbi, Behzad Baradaran Colorectal cancer is one of the most prevalent cancers with high mortality in the world. MicroRNAs are a class of small non-coding RNAs that regulate gene expression through targeting mRNAs. MicroRNAs involve in many biological and pathological processes such as cell growth, differentiation, apoptosis. etc. Dysregulation of miRNAs expression patterns have been reported in many tumors including Colorectal Cancer. Various studies in...
Source: Biomedicine and Pharmacotherapy - November 15, 2017 Category: Drugs & Pharmacology Source Type: research

An overview of neuroprotective and cognitive enhancement properties of lignans from Schisandra chinensis
Publication date: January 2018 Source:Biomedicine & Pharmacotherapy, Volume 97 Author(s): Kandhasamy Sowndhararajan, Ponnuvel Deepa, Minju Kim, Se Jin Park, Songmun Kim Schisandra chinensis fruits have been traditionally used for thousands of years in Korea, China and Japan to treat various ailments. The fruits contain a variety of bioactive metabolites, especially lignan components have been reported to have various biological activities and have potential in the treatment of numerous neurodegenerative diseases. The lignans from S. chinensis are mainly grouped under dibenzocyclooctadiene lignans. Previous studies...
Source: Biomedicine and Pharmacotherapy - November 8, 2017 Category: Drugs & Pharmacology Source Type: research

The potential use of melatonin to treat protozoan parasitic infections: A review
Publication date: January 2018 Source:Biomedicine & Pharmacotherapy, Volume 97 Author(s): Ahmad Daryani, Mahbobeh Montazeri, Abdol Satar Pagheh, Mehdi Sharif, Shahabeddin Sarvi, Azam Hosseinzadeh, Russel J. Reiter, Ramtin Hadighi, Mohammad Taghi Joghataei, Habib Ghaznavi, Saeed Mehrzadi Melatonin (N-acetyl-5-methoxytryptamine) is a circadian hormone produced in vertebrates by the pineal gland and other organs. Melatonin is believed to influence immune cells leading to modulation of the proliferative response of stimulated lymphocytes as well as cytokine production. Due to the antioxidant and immunomodulatory effec...
Source: Biomedicine and Pharmacotherapy - November 8, 2017 Category: Drugs & Pharmacology Source Type: research

A review on the chemotherapeutic potential of fisetin: In vitro evidences
Publication date: January 2018 Source:Biomedicine & Pharmacotherapy, Volume 97 Author(s): Kiruthika Sundarraj, Azhwar Raghunath, Ekambaram Perumal During the past five decades, cancer cell lines are being successfully used as an in vitro model to discover the anti-cancer potential of plant secondary metabolites. Fisetin – the most popular polyphenol from fruits and vegetables, exhibits a repertoire of promising pharmacological features. Such versatile properties make fisetin an excellent anticancer agent and its efficacy as a chemotherapeutic agent against tumor heterogeneity from in vitro studies are encour...
Source: Biomedicine and Pharmacotherapy - November 7, 2017 Category: Drugs & Pharmacology Source Type: research

Downregulation of p300 alleviates LPS-induced inflammatory injuries through regulation of RhoA/ROCK/NF- κB pathways in A549 cells
In conclusion, p300 might be involved in progression of cell inflammatory response and could serve as a novel therapeutic target for clinical treatment of infantile pneumonia. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Lipid rafts disruption induces apoptosis by attenuating expression of LRP6 and survivin in triple negative breast cancer
This study explores the effect of lipid rafts disruption by cholesterol depleting agent, MβCD on induction of apoptosis and expression of WNT receptor LRP6, survivin and common apoptotic markers in TNBC cell lines. The in vitro effect of lipid rafts disruption on viability, single cell reproductive ability, proliferation and migration were evaluated by MTT, clonogenic, BrdU incorporation and wound scratch assays, respectively. The morphological changes were assessed by tryphan blue, Wright and Giemsa staining; nuclear changes by Hoechst staining. The induction of apoptosis was evaluated by AO/EtBr staining, DNA damage...
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Incretin hormones receptor signaling plays the key role in antidiabetic potential of PTY-2 against STZ-induced pancreatitis
Conclusions In addition to previously studied DPPIV inhibitor, PTY-2 also acts as incretin receptors agonist and protects against STZ-induced diabetes by down regulating β cells apoptosis. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Phytochemical profile and mechanisms involved in the anti-nociception caused by the hydroethanolic extract obtained from Tocoyena formosa (Cham. & amp; Schltdl.) K. Schum (Jenipapo-bravo) leaves in mice
Publication date: January 2018 Source:Biomedicine & Pharmacotherapy, Volume 97 Author(s): Francisco Rafael Alves Santana Cesário, Thaís Rodrigues de Albuquerque, Giovana Mendes de Lacerda, Maria Rayane Correia de Oliveira, Lindaiane Bezerra Rodrigues, Anita Oliveira Brito Pereira Bezerra Martins, Aline Augusti Boligon, Lucindo José Quintans Júnior, Adriano Antunes de Souza Araújo, Mariana Lima Vale, Henrique Douglas Melo Coutinho, Irwin Rose Alencar de Menezes Tocoyena formosa, a small ornamental tree growing in the dry regions of central Brazil, is commonly known as ‘genip...
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Central and peripheral anti-hyperalgesic effects of diosmin in a neuropathic pain model in rats
In conclusion, our results provide evidence that diosmin produces significant anti-hyperalgesic effects acting at central level by an opioid and D2 dopaminergic receptors participation, and at peripheral level by reducing proinflammatory cytokines. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Protective effect of the hydroalcoholic extract of Tripodanthus acutifolius in hypercholesterolemic Wistar rats
Publication date: January 2018 Source:Biomedicine & Pharmacotherapy, Volume 97 Author(s): Ritiéle Pinto Coelho, Denise Lima Feksa, Patrícia Martinez Oliveira, Angélica Aparecida da Costa Güllich, Bruna Cocco Pilar, Jacqueline da Costa Escobar Piccoli, Vanusa Manfredini Cardiovascular disease (CVD) are a major public health problem, as they are among the leading causes of mortality worldwide. Tripodanthus acutifolius (TA) is a hemiparasite plant used for medicinal purposes with great antioxidant capacity. However, little is known about its hypolipemic effect. Thus, the aim of this study wa...
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Nrf2 overexpression is associated with P-glycoprotein upregulation in gastric cancer
Publication date: January 2018 Source:Biomedicine & Pharmacotherapy, Volume 97 Author(s): Farhad Jeddi, Narges Soozangar, Mohammad Reza Sadeghi, Mohammad Hossein Somi, Masoud Shirmohamadi, Amir-Taher Eftekhar-Sadat, Nasser Samadi The efficacy of chemotherapeutic agents remains very poor in gastric cancer (GC) patients due to the development of multidrug resistance (MDR) phenotype. The nuclear factor erythroid 2-related factor 2 (Nrf2), is a pivotal transcriptional factor that regulates phase II detoxifying enzymes, antioxidants and efflux transporters including P-glycoprotein (P-gp). The aim of this study was to i...
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

CTRP6 inhibits cell proliferation and ECM expression in rat mesangial cells cultured under TGF- β1
In conclusion, we have demonstrated that CTRP6 suppressed ECM expression in renal fibroblasts induced by TGF-β1 through the ERK signaling pathway. Therefore, CTRP6 may be a potential therapeutic target for the treatment of renal fibrosis. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Role of endogenous hydrogen sulfide in cardiac mitochondrial preservation during ischemia reperfusion injury
Publication date: January 2018 Source:Biomedicine & Pharmacotherapy, Volume 97 Author(s): Sanhitha Nandi, Sriram Ravindran, Gino A. Kurian Cardio-protective effect of hydrogen sulfide (H2S) against myocardial ischemia reperfusion injury (I/R) via preservation of mitochondria is well documented. But the distinct role of exogenous and endogenous H2S in cardio-protection and its dependency on functional cardiac mitochondria is not understood. The present study was designed to investigate the role of exogenous H2S preconditioning on cardiac mitochondrial subpopulation namely interfibrillar (IFM) and subsarcolemmal (SS...
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Aqueous extract of Codium fragile alleviates osteoarthritis through the MAPK/NF- κB pathways in IL-1β-induced rat primary chondrocytes and a rat osteoarthritis model
Conclusions These results suggested that AECF is a potential therapeutic agent for the alleviation of osteoarthritis progression. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Autophagy participates in isoliquiritigenin –induced melanin degradation in human epidermal keratinocytes through PI3K/AKT/mTOR signaling
Publication date: January 2018 Source:Biomedicine & Pharmacotherapy, Volume 97 Author(s): Zhibo Yang, Biyun Zeng, Yi Pan, Pan Huang, Chang Wang Melanin is the pigment responsible for the color of human skin and hair. Melanin serves as a double-edge sword which can exert both protective and spot-causing effects on skin. Although melanin has an important role in protecting the skin against UV damage, an excessive or uneven melanin production can lead to the formation of freckles and age spots. Isoliquiritigenin (ISL) has been reported to inhibit melanin synthesis; however, its role in melanin degradation remains unc...
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats
In this study, the effect of BBR on MTX-induced hepatotoxicity was studied. A total number of 28 male Wistar rats were randomly divided into four experimental groups. Rats were pretreated with BBR orally with dose of 100mg/kg for 10 consecutive days and MTX (20mg/kg, intraperitoneally) was administrated on the 9th day. Then on day 11, blood samples were collected to determine serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP). The extracted livers were used for histological examination, biochemical assays and real time PCR studies. Malondialdehyde (MDA), glutathi...
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Galangin (GG) combined with cisplatin (DDP) to suppress human lung cancer by inhibition of STAT3-regulated NF- κB and Bcl-2/Bax signaling pathways
Publication date: January 2018 Source:Biomedicine & Pharmacotherapy, Volume 97 Author(s): Shuo Yu, Lian-sheng Gong, Nian-feng Li, Yi-feng Pan, Lun Zhang Lung cancer represents a significant problem for public health worldwide. Galangin (GG), a natural active compound 3, 5, 7-trihydroxyflavone, is a type of bioflavonoid, which is isolated from the Alpinia galangal root and suggested to induce apoptosis in various cancers. We investigated the ability of Galangin (GG) to attenuate the drug resistance of human lung cancer cells, resistant to treatment of cisplatin (DDP). DDP is a pyrimidine analog, widely used in canc...
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

LncRNATCF7 promotes the growth and self-renewal of glioma cells via suppressing the miR-200c-EpCAM axis
Publication date: January 2018 Source:Biomedicine & Pharmacotherapy, Volume 97 Author(s): Jian Zhao, Lianglong Zhang, Lizhi Zheng, Youbo Hong, Lizhi Zhao Accumulating evidence has demonstrated that long non-coding RNAs (lncRNAs) are involved in tumor initiation and development. Recent studies illustrated that lncRNATCF7 was highly expressed in lung cancer and liver cancer, however, the expression pattern and function of lncRNATCF7 in glioma remains to be elucidated. Here, we found that lncTCF7 was highly expressed in glioma tissues and cell lines. Overexpression of lncTCF7 promoted the proliferation and migration ...
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Combination of ULK1 and LC3B improve prognosis assessment of hepatocellular carcinoma
Conclusion ULK1 were demonstrated to be an important prognostic factor for HCC patient, and it combined LC3B would improve prognosis assessment of the patients. Combined autophagic biomarkers would better represent dynamic stage of autophagy and It might provide a potential therapeutic way that how to interfere autophagy in HCC. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Taurine enhances spermatogenic function and antioxidant defense mechanisms in testes and epididymis of L-NAME-induced hypertensive rats
Publication date: January 2018 Source:Biomedicine & Pharmacotherapy, Volume 97 Author(s): Isaac A. Adedara, Sanmi E. Alake, Mercy O. Adeyemo, Laide O. Olajide, Temitayo O. Ajibade, Ebenezer O. Farombi The beneficial health effects of taurine on hypertension have been demonstrated previously in both experimental and epidemiological studies. However, the role of taurine in reproductive dysfunction associated with hypertension has not been investigated. The present study evaluated the therapeutic efficacy of taurine on reproductive deficits in N-nitro-l-arginine methyl ester (L-NAME)-induced hypertensive rats. Sixty ...
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Hepatoprotective evaluation and isolation of the major secondary metabolites from the ethyl acetate extract of liquid culture filtrate of Chaetomium globosum
In conclusion, the extract recorded hepatoprotective effect by ameliorating the biochemical parameters under investigation. The liver histopathological pictures confirmed our results. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

The anti-hyperuricemic effect of epigallocatechin-3-gallate (EGCG) on hyperuricemic mice
This study aimed to evaluate the antihyperuricemic activity of EGCG on hyperuricemic mice. We demonstrated that serum uric acid (UA) level was decreased significantly with dose-dependence by EGCG treated with 10, 20, and 50mg/kg. Compared with the model, data on blood urea nitrogen (BUN) supported that there was significance with high dose of EGCG (50mg/kg). Levels of serum creatinine (Cr) in each EGCG-treated group were decreased but not significant; the activities of hepatic xanthine oxidase (XOD) and adenosine deaminase (ADA) in high dose groups' EGCG were notably lower than those of model group. EGCG could downregulate...
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

MicroRNA-574-5p promotes cell growth of vascular smooth muscle cells in the progression of coronary artery disease
In conclusion, our findings indicate that miR-574-5p promotes cell proliferation and inhibits apoptosis by inhibiting ZDHHC14 gene expression, suggesting that miR-574-5p is a CAD-related factor that may serve as a potential molecular target for CAD treatment. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Eclalbasaponin I from Aralia elata (Miq.) Seem. reduces oxidative stress-induced neural cell death by autophagy activation
In this study, six known triterpene saponins were isolated from the buds of A. elata, a well-known medicinal and edible plant in Northeast China. Subsequently, the anti-oxidative effects of all six triterpene saponins were screened by H2O2-induced damage in human neuronblastoma SH-SY5Y cells. Compound 6, also known as Eclalbasaponin I (EcI), was the most potent. Furthermore, the mechanism by which EcI combats H2O2-induced oxidative stress was investigated. The data suggested that EcI could down-regulate apoptosis induction and the generation of reactive oxygen species (ROS) induced by 200μM H2O2 in SH-SY5Y cells. Moreov...
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Vitexin inhibits inflammation in murine ovalbumin-induced allergic asthma
Publication date: January 2018 Source:Biomedicine & Pharmacotherapy, Volume 97 Author(s): Cláudio Luís Venturini, Antonio Macho, Karuppusamy Arunachalam, Danielle Ayr Tavares de Almeida, Suellen Iara Guirra Rosa, Eduarda Pavan, Sikiru Olaitan Balogun, Amílcar Sabino Damazo, Domingos Tabajara de Oliveira Martins Vitexin is an important component of various medicinal plants frequently used to treat asthma, such as Crataegus spp., Vitex spp., Passiflora spp., and Echinodorus spp. However, there is no information about the vitexin potential as anti-asthmatic. The aim of the present work was to eva...
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

LncRNA GACAT3 promotes gastric cancer progression by negatively regulating miR-497 expression
Publication date: January 2018 Source:Biomedicine & Pharmacotherapy, Volume 97 Author(s): Li Feng, Yonggang Zhu, Yunxin Zhang, Min Rao Accumulating evidence indicates that long noncoding RNAs (LncRNAs) are involved in tumorigenesis and tumor development. LncRNA GACAT3 (GACAT3) has been reported to be upregulated in gastric cancer (GC); however, the biological function and underlying mechanisms of GACAT3 remain largely unknown. Here, we found that GACAT3 showed a higher expression in GC tissues and cell lines. Increased GACAT3 level was significantly associated with a shorter overall survival of patients with GC. F...
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research

Ameliorating effect of Alpinia oxyphylla —Schisandra chinensis herb pair on cognitive impairment in a mouse model of Alzheimer’s disease
This study provided an experimental basis for further study of Alpinia oxyphylla − Schisandra chinensis herb pair in AD therapy. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2017 Category: Drugs & Pharmacology Source Type: research