CTRP6 inhibits PDGF-BB-induced vascular smooth muscle cell proliferation and migration
In conclusion, these findings showed that CTRP6 inhibits PDGF-BB-induced VSMC proliferation and migration, at least in part, through suppressing the PI3K/Akt/mTOR signaling pathway. Therefore, CTRP6 may be a potential target for the treatment of atherosclerosis. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

Nobiletin (NOB) suppresses autophagic degradation via over-expressing AKT pathway and enhances apoptosis in multidrug-resistant SKOV3/TAX ovarian cancer cells
In conclusion, the findings here supplied the illustration that NOB could overcome multidrug resistance in human ovarian cancer cells through AKT-regulated suppression of autophagic degradation. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

Osteoblast response to Vitamin D3 loaded cellulose enriched hydroxyapatite Mesoporous silica nanoparticles composite
In this study we synthesizd a Cholecalciferol (VD3) loaded, cellulose functionalized hydroxyapatite nanocomposites with different concentration of Mesoporous silica nanoparticles (MSNs). VD3 plays an important role in the bone formation by regulating extracellular levels of calcium and phosphorus. FTIR, SEM, TEM, and X-ray diffraction techniques were used for the characterization of the prepared composites. VD3 releases from the VD3/C/HAP/MSN scaffold were observed by using UV–vis spectroscopy. The nanocomposites C/HAP/MSN, VD3/C/HAP/MSN showed higher viability compared with pure HAP and in-vitro studies revealed tha...
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

Microrna-145 accelerates the inflammatory reaction through activation of NF- κB signaling in atherosclerosis cells and mice
In conclusion, our study demonstrated that miR-145 accelerated the inflammatory reaction through activation of NF-κB signaling in AS. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

Emodin attenuates apoptosis and inflammation induced by LPS through up-regulating lncRNA TUG1 in murine chondrogenic ATDC5 cells
Conclusion Emodin mitigated the LPS-induced apoptosis and inflammation in ATDC5 cells. Emodin might function through inhibiting the Notch and NF-κB pathways via up-regulating TUG1. Our findings might furnish a prospective therapeutic strategy using emodin for OA. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

The ameliorative effect of Homalium nepalense on carbon tetrachloride-induced hepatocellular injury in rats
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Satish Kanhar, Atish Kumar Sahoo, Ajay Kumar Mahapatra The purpose of this study was to evaluate ameliorative effects of Homalium nepalense Benth. (Flacourtiaceae) on CCl4-induced hepatocellular injury in rats. Oxygen-radical absorbance-capacity (ORAC) and cell-based-antioxidant-protection-in-erythrocytes (CAP-e) were performed and found that the ethyl acetate fractions of bark (HNEB) and leaf (HNEL) showed a remarkable degree of antioxidant activities in a dose dependent manner. Antioxidant potential HNEB was higher than HNEL ...
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

Long non-coding RNA NNT-AS1 affects progression of breast cancer through miR-142-3p/ZEB1 axis
This study aims to detect the expression pattern and functional effects of NNT-AS1 in breast cancer. qRT-PCR analysis was applied to detect the expression of NNT-AS1 in both BC tissues and matched normal tissues. Loss of function assay was carried out to detect the effects of silenced NNT-AS1 on proliferation, metastasis and EMT process of BC cells. To understand the functional mechanism of NNT-AS1, mechanism assays were designed and performed in BC cells. Subcellular fractionation assay demonstrated that NNT-AS1 was located in the cytoplasm of BC cells. Therefore, NNT-AS1 might exert ceRNA functions in BC cells. To valida...
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

Puerarin improves methotrexate-induced renal damage by up-regulating renal expression of Oat1 and Oat3 in vivo and in vitro
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Qi Liu, Zhihao Liu, Xiaokui Huo, Changyuan Wang, Qiang Meng, Huijun Sun, Pengyuan Sun, Jinyong Peng, Xiaodong Ma, Kexin Liu The regulation of renal transporters such as organic anion transporter (OATs) is a new target for treatment of acute renal failure. The purpose of this study was to investigate whether the effect of puerarin (Pur) on renal damage induced by methotrexate (MTX) is related to the expression of renal Oat1/3 in vivo and in vitro, and to explore the related mechanisms. Effect of Pur on the renal damage caused by...
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

Piperine alleviates lipopolysaccharide-induced inflammatory injury by down-regulating microRNA-127 in murine chondrogenic ATDC5 cells
Conclusion This study demonstrates the anti-inflammatory effects of piperine on LPS-stimulated ATDC5 cells. The anti-inflammatory properties of piperine are mediated by down-regulating miR-127 and MyD88 expression and then inhibiting NF-κB and p38MAPK signaling pathways activation. Our findings may provide a theoretical basis for further research the clinical treatment of osteoarthritis (OA) by using piperine. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

Bene ficial health effects of lupenone triterpene: A review
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Feng Xu, Xulong Huang, Hongmei Wu, Xiangpei Wang There are a large number of new structure compounds with good pharmacological activity in the natural plants, can be applied to the treatment of human diseases. Finding active ingredients from the plants is one of the important ways to develop new drugs. Triterpenes are widespread in plants, and lupenone belongs to lupane type triterpenoids. Lupenone is very common natural ingredient distributed in multi-family plants including Asteraceae, Balanophoraceae, Cactaceae, Iridaceae, M...
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

A review of FGF signaling in palate development
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Mengjia Weng, Zhengxi Chen, Qian Xiao, Ruomei Li, Zhenqi Chen The fibroblast growth factors (FGFs) play a critical role during palatogenesis by mediating a variety of cellular responses. Extensive epidemiological and genetic studies over several decades in humans have revealed members of the FGF family function as candidate genes for syndromic and nonsyndromic cleft lip and cleft palate. The findings that FGFs signaling work delicately in the development of palate have been confirmed in mice carrying targeted mutations. Here we...
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

Nanostructured lipid carriers for site-specific drug delivery
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Archana Khosa, Satish Reddi, Ranendra N. Saha Nanostructured lipid carriers (NLC), comprises of a blend of solid and liquid lipids which results in a partially crystallized lipid system and imparts many advantages over solid lipid nanoparticles such as enhanced drug loading capacity, drug release modulation flexibility and improved stability. NLC have found numerous applications in both pharmaceutical and cosmetic industry due to ease of preparation, the feasibility of scale-up, biocompatibility, non-toxicity, enhanced targetin...
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

DNA gyrase inhibitors: Progress and synthesis of potent compounds as antibacterial agents
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Tabassum Khan, Kaksha Sankhe, Vasanti Suvarna, Atul Sherje, Kavitkumar Patel, Bhushan Dravyakar DNA gyrase is classified as topoisomerase II, an ATP-dependent enzyme that is vital in the transcription, replication of DNA and chromosome segregation processes. It plays a crucial role in all bacteria except higher eukaryotes and this makes it a desirable and viable therapeutic target for development of new antibacterial agents. Fluoroquinolones are commonly used effective antibacterial agents that target DNA gyrase, however the sp...
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

Bioenergetics mechanisms regulating muscle stem cell self-renewal commitment and function
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Phablo Abreu Muscle stem cells or satellite cells are crucial for muscle maintenance and repair. These cells are mitotically quiescent and uniformly express the transcription factor Pax7, intermittently entering the cell cycle to give rise to daughter myogenic precursors cells and fuse with neighboring myofibers or self-renew, replenishing the stem cell pool in adult skeletal muscle. Pivotal roles of muscle stem cells in muscle repair have been uncovered, but it still remains unclear how muscle stem cell self-renewal is molecul...
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

The potential of herb medicines in the treatment of esophageal cancer
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Jie Ying, Miaomiao Zhang, Xiaoyan Qiu, Yu Lu Esophageal cancer (EC) is one of common malignant neoplasms in the world. Due to dietary habits, environmental factors, stress and so on, larger numbers of person are diagnose with EC every year. Currently, the clinical treatment of EC mainly includes radiotherapy, chemotherapy, surgical resection alone or combined strategy. These treatment options are insufficient and often associated with a number of side effects. Medicinal herbs containing Traditional Chinese Medicine (TCM) have b...
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

Recent advances in colony stimulating factor-1 receptor/c-FMS as an emerging target for various therapeutic implications
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Archana Kumari, Om Silakari, Rajesh K. Singh Colony stimulating factor-1 (CSF-1) is one of the most common proinflammatory cytokine responsible for various inflammatory disorders. It has a remarkable role in the development and progression of osteoarthritis, cancer and other autoimmune disease conditions. The CSF-1 acts by binding to the receptor, called colony stimulating factor-1 receptor (CSF-1R) also known as c-FMS resulting in the cascade of signalling pathway causing cell proliferation and differentiation. Interleukin-34 ...
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

Fibromyalgia and nutrition: Therapeutic possibilities?
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Geir Bjørklund, Maryam Dadar, Salvatore Chirumbolo, Jan Aaseth Fibromyalgia (FM) is a complex chronic condition of unknown etiology, characterized by deep and widespread pain, sleep problems, cognitive impairment, fatigue, and other well-known functional symptoms. Recently, it has been proposed that an imbalance of nutritive components, including essential metal ions and vitamins, might play a critical role in the development of FM. Muscle pain has been associated with deficiencies in amino acids, magnesium, selenium, vi...
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

Peptide based therapeutics and their use for the treatment of neurodegenerative and other diseases
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Mohammad Hassan Baig, Khurshid Ahmad, Mohd Saeed, Ahmed M Alharbi, George E. Barreto, Ghulam Md Ashraf, Inho Choi Bioactive peptides are actively involved in different biological functions and importantly contribute to human health, and the use of peptides as therapeutics has a long successful history in disease management. A number of peptides have wide-ranging therapeutic effects, such as antioxidant, antimicrobial, and antithrombotic effects. Neurodegenerative diseases are typically caused by abnormal aggregations of protein...
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

Molecular Landscape in Alveolar Soft Part Sarcoma: Implications for Molecular Targeted Therapy
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Mohammad Hasan Soheilifar, Ramezan Ali Taheri, Reza Zolfaghari Emameh, Abdolvahab Moshtaghian, Hamid Kooshki, Mohammad Reza Motie Alveolar soft part sarcoma (ASPS) is a highly aggressive rare soft tissue sarcoma (STS) with poor prognosis especially in the metastatic form. ASPS is resistant to standard chemotherapy. Although, early diagnosis and surgical resection of operable tumor could lead to improved patient survival but novel treatment options are needed for advanced (metastatic) ASPS. This malignancy exhibits highly angiog...
Source: Biomedicine and Pharmacotherapy - April 25, 2018 Category: Drugs & Pharmacology Source Type: research

Hinokiflavone induces apoptosis in melanoma cells through the ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Shuping Yang, Yange Zhang, Yi Luo, Bocheng Xu, Yuqin Yao, Yuanle Deng, Fangfang Yang, Tinghong Ye, Gang Wang, Zhiqiang Cheng, Yu Zheng, Yongmei Xie Melanoma, the highest degree of malignancy, is one of the most common skin tumors. However, there is no effective strategy to treat melanoma in current clinical practice. Therefore, it is urgent to find an efficient drug to overcome melanoma. Here, the in vitro anticancer effects of a natural product named hinokiflavone on three melanoma carcinoma cell lines (human melanoma A375 and...
Source: Biomedicine and Pharmacotherapy - April 8, 2018 Category: Drugs & Pharmacology Source Type: research

The long non-coding RNA-DANCR exerts oncogenic functions in non-small cell lung cancer via miR-758-3p
In this study, we investigated the role of the lncRNA DANCR in the development of non-small cell lung cancer (NSCLC). First, we found that DANCR was markedly upregulated in NSCLC tumor tissues and cell lines compared with related normal controls. The ectopic expression of DANCR significantly increased the proliferation, migration and invasion of SPC-A1 and NCL-H1299 cells. Furthermore, we investigated whether DANCR regulates NSCLC tumor formation in vivo. Subsequently, we concluded that DANCR promotes NSCLC cell proliferation, migration and invasion by regulating the tumor suppressor miR-758-3p. These results indicated tha...
Source: Biomedicine and Pharmacotherapy - April 8, 2018 Category: Drugs & Pharmacology Source Type: research

Bombesin attenuated ischemia-induced spatial cognitive and synaptic plasticity impairment associated with oxidative damage
In conclusion, bombesin could protect the oxidative stress and expression of proteins, which were important for synaptic plasticity and cognitive function impairment induced by chronic cerebral ischemia. Our study is presented to provide novel insights into the effects of bombesin on spatial learning and memory, which should be further explored as a potential drug in disorders involving deficits in cognitive function. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 8, 2018 Category: Drugs & Pharmacology Source Type: research

Betaine treatment protects liver through regulating mitochondrial function and counteracting oxidative stress in acute and chronic animal models of hepatic injury
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Reza Heidari, Hossein Niknahad, Ala Sadeghi, Hamidreza Mohammadi, Vahid Ghanbarinejad, Mohammad Mehdi Ommati, Arghavan Hosseini, Negar Azarpira, Forouzan Khodaei, Omid Farshad, Elaheh Rashidi, Asma Siavashpour, Asma Najibi, Asrin Ahmadi, Akram Jamshidzadeh Betaine is a derivative of the amino acid glycine widely investigated for its hepatoprotective properties against alcoholism. The protective properties of betaine in different other experimental models also have been documented. On the other hand, the exact cellular mechanism...
Source: Biomedicine and Pharmacotherapy - April 8, 2018 Category: Drugs & Pharmacology Source Type: research

Avicularin reversed multidrug-resistance in human gastric cancer through enhancing Bax and BOK expressions
In this study, we explored the hypothesis by which AL reversed 5-Fu or DDP resistance in gastric cancer and the underlying molecular mechanism. Here, in vitro, the drug-resistant cancer cells were incubated to AL or DDP alone or the combination of AL and DDP. Then, MTT, colony formation, Hoechst 33258, flow cytometry and western blot analysis were used to investigate the effects of AL in the regulation of drug-resistance gastric cancer cells. The results indicated that AL treatment markedly re-sensitizes the drug resistant cells (SGC-7901/5-Fu and SGC-7901/DDP) to cytotoxicity of 5-Fu or DDP. Molecular mechanism analysis i...
Source: Biomedicine and Pharmacotherapy - April 8, 2018 Category: Drugs & Pharmacology Source Type: research

Renal protective effect of SGLT2 inhibitor dapagliflozin alone and in combination with irbesartan in a rat model of diabetic nephropathy
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Ali F. Abdel-Wahab, Ghazi A. Bamagous, Randa M. Al-Harizy, Naser A. ElSawy, Naiyer Shahzad, Ibrahim A. Ibrahim, Saeed S. Al Ghamdi Considering the complementary mechanisms of SGLT2 inhibitors and angiotensin inhibitors on kidney, it is postulated that combination of both agents could afford greater protection against diabetic renal injury. So, we investigated renal protective effects of SGLT2 inhibitor, dapagliflozin, alone and in combination with irbesartan in a rat model of diabetic nephropathy. Diabetic rats, injected with n...
Source: Biomedicine and Pharmacotherapy - April 8, 2018 Category: Drugs & Pharmacology Source Type: research

Naringin attenuates MLC phosphorylation and NF- κB activation to protect sepsis-induced intestinal injury via RhoA/ROCK pathway
Conclusion Naringin improved sepsis-induced intestinal injury via RhoA/ROCK/NF-κB/MLCK/MLC signaling pathway in vivo and in vitro. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 8, 2018 Category: Drugs & Pharmacology Source Type: research

MHC class I chain-related A: Polymorphism, regulation and therapeutic value in cancer
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Xi Yang, Shuzhen Kuang, Liangjiang Wang, Yanzhang Wei MICA and MICB are stress-induced molecules recognized by NKG2D, one of major activation receptors of natural killer (NK) cells. Upon binding to NKG2D, NKG2D-mediated cytolytic immune response of immune effector cells will be activated against virally infected and tumor cells expressing MICA. In the early oncogenic development, membrane-bound MICA serves as a key signal to recruit anti-tumor immune effectors. Nevertheless, both MICA polymorphic features and its dysregulated e...
Source: Biomedicine and Pharmacotherapy - April 8, 2018 Category: Drugs & Pharmacology Source Type: research

Impact of stress on female reproductive health disorders: Possible beneficial effects of shatavari (Asparagus racemosus)
Publication date: July 2018 Source:Biomedicine & Pharmacotherapy, Volume 103 Author(s): Ajai K Pandey, Anumegha Gupta, Meenakshi Tiwari, Shilpa Prasad, Ashutosh N. Pandey, Pramod K. Yadav, Alka Sharma, Kankshi Sahu, Syed Asrafuzzaman, Doyil T. Vengayil, Tulsidas G. Shrivastav, Shail K Chaube Stress is deeply rooted in the society and women are frequently exposed to psychological, physical and physiological stressors. Psychological stress disturbs reproductive health by inducing generation of reactive oxygen species (ROS) and thereby oxidative stress (OS). The increased OS may affect physiology of ovary, oocyte qua...
Source: Biomedicine and Pharmacotherapy - April 8, 2018 Category: Drugs & Pharmacology Source Type: research

Tumor-derived extracellular vesicles in angiogenesis
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Wei Song, Dong Yan, Tianshu Wei, Qiang Liu, Xia Zhou, Ju Liu Angiogenesis is crucial for tumor growth and metastasis. Recent studies revealed that tumor cells promote angiogenesis by secreting extracellular vesicles, which can be captured by endothelial cells. These tumor-derived extracellular vesicles carry microRNAs, long non-coding RNAs, and proteins, which activate pro-angiogenic signaling in endothelial cells. In this review, we will summarize the roles of tumor-derived extracellular vesicles in angiogenesis and the underl...
Source: Biomedicine and Pharmacotherapy - April 7, 2018 Category: Drugs & Pharmacology Source Type: research

The role of bevacizumab on tumour angiogenesis and in the management of gynaecological cancers: A review
Conclusion Bevacizumab possess less documented adverse effects when compared to other chemotherapeutic agents. The manifestation and severity of adverse effects reported varied according to the chemotherapeutic agent(s) that were used with bevacizumab in combination therapy. Overall, bevacizumab effectively improved the survival rate in patients with several gynaecological cancers. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 5, 2018 Category: Drugs & Pharmacology Source Type: research

Cancer chemotherapeutics in rheumatoid arthritis: A convoluted connection
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): S. Jayashree, K. Nirekshana, Gunjan Guha, Dipita Bhakta-Guha Chemotherapy is one of the most popular therapeutic strategies to treat cancer. However, cancer chemotherapeutics have often been associated with impairment of the immune system, which might consequently lead to an augmented risk of autoimmune disorders, such as rheumatoid arthritis. Though the accurate mechanistic facets of rheumatoid arthritis induction have not been interpreted yet, a conglomeration of genetic and environmental factors might promote its etiology. W...
Source: Biomedicine and Pharmacotherapy - April 5, 2018 Category: Drugs & Pharmacology Source Type: research

Antioxidant effects and mechanism of silymarin in oxidative stress induced cardiovascular diseases
We present a comprehensive review regarding the oxidative stress and protective effects of silymarin in CVDs management. We also aim to provide mechanistic insight of the mechanisms of silymarin action in oxidative stress-induced CVDs. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 5, 2018 Category: Drugs & Pharmacology Source Type: research

Oncogenic long noncoding RNA MALAT1 and HCV-related hepatocellular carcinoma
In conclusion, circulatory MALAT1 might represent a putative non-invasive prognostic biomarker indicating worse liver failure score in HCV-related HCC patients with traditional markers. Large-scale verification is warranted in future studies. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 5, 2018 Category: Drugs & Pharmacology Source Type: research

Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor: Overview and current state of the art
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Hassan Mellatyar, Sona Talaei, Younes Pilehvar-Soltanahmadi, Abolfazl Barzegar, Abolfazl Akbarzadeh, Arman Shahabi, Mazyar Barekati-Mowahed, Nosratollah Zarghami Heat shock protein 90 (Hsp90) is an evolutionary preserved molecular chaperone which mediates many cellular processes such as cell transformation, proliferation, and survival in normal and stress conditions. Hsp90 plays an important role in folding, maturation, stabilization and activation of Hsp90 client proteins which all contribute to the development, and proliferat...
Source: Biomedicine and Pharmacotherapy - April 5, 2018 Category: Drugs & Pharmacology Source Type: research

Arginine: Challenges and opportunities of this two-faced molecule in cancer therapy
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Mozhgan Jahani, Fatemeh Noroznezhad, Kamran Mansouri Numerous antitumor therapies have been developed based on the differences in cells’ metabolisms. Regarding the important role of arginine (Arg) in the regulation of multiple metabolic and signaling pathways, its deprivation has been proposed as a good strategy for tumor regression in tumors with defected Arg metabolic enzymes like argininosuccinate synthase 1 (ASS1). However, modulatory effect of Arg on various cancers is also a controversial issue. Therefore, this revi...
Source: Biomedicine and Pharmacotherapy - April 5, 2018 Category: Drugs & Pharmacology Source Type: research

A review on phytochemistry and therapeutic uses of Hibiscus sabdariffa L.
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Ghazala Riaz, Rajni Chopra Hibiscus sabdariffa L. (roselle) belonging to the Malvaceae family is widely grown in many countries. This plant is often used in the traditional medicine being rich in phytochemicals like polyphenols especially anthocyanins, polysaccharides and organic acids thus having enormous prospective in modern therapeutic uses. The study aimed to review and document all the available evidence and information about the calyces of Hibiscus sabdariffa (roselle) with the special focus on their nutritional composit...
Source: Biomedicine and Pharmacotherapy - April 5, 2018 Category: Drugs & Pharmacology Source Type: research

Chitooligosaccharide: An evaluation of physicochemical and biological properties with the proposition for determination of thermal degradation products
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Lucas Phil, Muhammad Naveed, Imran Shair Mohammad, Li Bo, Di Bin Being the most versatile biopolymer, chitooligosaccharide/chitosan oligosaccharide (COS) has been extensively studied for a range of exceptional biological activities and potential developments of novel medical devices and systems in biomedical and pharmaceutical fields. While possessing intrinsic biocompatibility, mucoadhesiveness, and non-toxicity it gained more interests in the biomedical development of novel systems, devices, and pharmaceutical formulations. T...
Source: Biomedicine and Pharmacotherapy - April 5, 2018 Category: Drugs & Pharmacology Source Type: research

Sesquiterpenoids from the root of Panax Ginseng protect CCl4 –induced acute liver injury by anti-inflammatory and anti-oxidative capabilities in mice
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Weidong Wang, Shijie Wang, Jinping Liu, Enbo Cai, Hongyan Zhu, Zhongmei He, Yugang Gao, Pingya Li, Yan Zhao The oxidative stress and inflammatory response play an important role in carbon tetracholoride (CCl4)-induced acute liver injury. In this work, sesquiterpenoids from the root of Panax Ginseng (SPG) were prepared, and then the hepatoprotective effects of SPG against CCl4-induced acute liver injury were investigated and the underlying mechanism was explored in mice. All mice were divided into four groups: the control, CCl4 ...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Umbelliferone prevents oxidative stress, inflammation and hematological alterations, and modulates glutamate-nitric oxide-cGMP signaling in hyperammonemic rats
In conclusion, this study provides evidence that UMB protects against hyperammonemia via attenuation of oxidative stress and inflammation. UMB prevents hyperammonemia associated hematological alterations and therefore represents a promising protective agent against the deleterious effects of excess ammonia. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-arrhythmogenic and anti-inflammatory effects of troxerutin in ischemia/reperfusion injury of diabetic myocardium
Conclusion Preconditioning with TXR could provide cardioprotection by anti-arrhythmic and anti-inflammatory effects against I/R injury in rat hearts. This effect of TXR can introduce this material as a protective agent in cardiovascular diseases. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Pretreatment with taurine prevented brain injury and exploratory behaviour associated with administration of anticancer drug cisplatin in rats
In conclusion, taurine may be a possible protective supplement to reduce cisplatin-induced side-effects including neurotoxicity in patients undergoing cisplatin treatment. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

TNF- α contributes to postmenopausal osteoporosis by synergistically promoting RANKL-induced osteoclast formation
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Li Zha, Li He, Yijian Liang, Hui Qin, Bin Yu, Linli Chang, Li Xue Previous studies showed that inflammatory cytokines promote osteoclast formation, characterized by the function of bone resorption. However, it remains unclear whether inflammatory factors contribute to osteoporosis syndrome in postmenopausal women. Here, we found that postmenopausal women with osteoporosis (PO) had increased levels of TNF-α, compared with those without osteoporosis. TNF-α is highly correlated with the RANK and estrogen levels in PO p...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Linalyl acetate prevents olmesartan-induced intestinal hypermotility mediated by interference of the sympathetic inhibitory pathway in hypertensive rat
In this study, interference with this inhibitory pathway was analyzed in a model of olmesartan-induced intestinal hypermotility (OIH) in rats with nicotine-induced hypertension exposed to chronic immobilizing stress. The effects of the potent inhibitory neurotransmitters norepinephrine (NE) and sodium nitroprusside (SNP), which act via different pathways, were assessed ex vivo, with only NE-modulated frequency and amplitude of spontaneous contractions found to be elevated in OIH rat jejunum. Clinical symptoms frequent in OAE, including atrophy of the intestinal epithelium and weight loss, were observed in these rats. Inter...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Experimental diabetes induced by streptozotocin in the desert gerbil, Gerbillus gerbillus, and the effects of short-term 20-hydroxyecdysone administration
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Aicha Mallek, Jamileh Movassat, Souad Ameddah, Junjun Liu, Nesrine Semiane, Ali Khalkhal, Yasmina Dahmani The present work was aimed at studying the effects of streptozotocin (STZ; 130 mg/kg) in the desert gerbil, Gerbillus gerbillus, and at evaluating the impact of the short-term administration of 20-hydroxyecdysone (20E; 5 mg/kg). We observed that administration of streptozotocin caused a significant increase in plasmatic glucose and a decrease in insulin levels. The plasma lipid profile and liver glycogen content were al...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Involvement of estrogen receptors in silibinin protection of pancreatic β-cells from TNFα- or IL-1β-induced cytotoxicity
This study reports the effect of silibinin on the rat pancreatic β-cell line, INS-1, damaged with pro-inflammatory cytokine, TNFα or IL-1β. Exposure to TNFα or IL-1β for 48 h caused INS-1 cells to reduce the production of insulin as well as cell viability. These actions of TNFα or IL-1β are associated with suppression of the expression of estrogen receptors (ERs). Further study revealed that silibinin protected the suppression in the expression of both ERα and ERβ that were involved in insulin synthesis and release, respectively. Furthermore, evidence is obtained that sili...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Long noncoding RNA SNHG7 accelerates prostate cancer proliferation and cycle progression through cyclin D1 by sponging miR-503
In conclusion, results present that SNHG7 regulates the cycle progression and acts as an oncogenic gene in the prostate cancer tumorigenesis via miR-503/Cyclin D1 pathway, revealing the vital role of lncRNA/miRNA/mRNA axis in prostate cancer carcinogenesis. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Enhanced lipoxygenase/LTD4 signaling accounts for the exaggerated hypertensive and nephrotoxic effects of cyclosporine plus indomethacin in rats
We examined whether these influences relate to the arachidonate/5-lipoxygenase (LOX) pathway. Rats were treated with CSA (20 mg kg−1 day−1), indomethacin (5 mg kg−1 day−1), or their combination for 10 days. Changes in SBP and renal biochemical/histopathological characteristics along with leukotriene levels were determined in rats treated with or without LT receptor antagonists. CSA or indomethacin caused: (i) renal tubular atrophy and interstitial fibrosis, (ii) increases in serum creatinine, blood urea nitrogen (BUN), and renal LTD4, LTB4, TNF-α, TGF-β1, and caspase-3, and (i...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Sanguinarine inhibits epithelial ovarian cancer development via regulating long non-coding RNA CASC2-EIF4A3 axis and/or inhibiting NF- κB signaling or PI3K/AKT/mTOR pathway
Conclusions Our findings reveal that sanguinarine exhibits antitumor effects in epithelial ovarian cancer cells possible via regulating CASC2-EIF4A3 axis and/or inhibiting NF-κB signaling or PI3K/AKT/mTOR pathway. Sanguinarine may serve as a potential therapeutic reagent for epithelial ovarian cancer. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Astragalus polysaccharide protects hypoxia-induced injury by up-regulation of miR-138 in rat neural stem cells
In conclusion, this study demonstrated a protective effect of APS on hypoxia-induced NSC injury. The regulatory mechanism might be mediated by up-regulation of miR-138 and inhibition of the JNK and p38MAPK pathways. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

MicroRNA-132 and microRNA-212 mediate doxorubicin resistance by down-regulating the PTEN-AKT/NF- κB signaling pathway in breast cancer
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Manxin Xie, Ziyi Fu, Jianxiang Cao, Yuan Liu, Jie Wu, Qing Li, Yun Chen Breast cancer is a serious health problem worldwide. Acquisition of multi-drug resistance (MDR) during the treatment of breast cancer is still considered a major clinical obstacle. Despite the biological functions of miRNAs becoming increasingly apparent, the function of miRNAs in regulating drug resistance of breast cancer remains under investigation. Quantitative real-time PCR (qRT-PCR) was used to quantify the expression of miR-132/-212 (miR-132 and miR-...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research