Over-expression of miR-15a-3p enhances the radiosensitivity of cervical cancer by targeting tumor protein D52
ConclusionIn conclusion, our findings suggested that miR-15a-3p enhanced radiosensitivity in cervical cancer by targeting tumor protein D52, suggesting that miR-15a-3p may be a potential therapeutic target for cervical cancer patients.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Hesperidin, piperine and bee venom synergistically potentiate the anticancer effect of tamoxifen against breast cancer cells
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Abeer A.A. Khamis, Ehab M.M. Ali, Mohamed A. Abd El-Moneim, Mohammad M. Abd-Alhaseeb, Mohammed Abu El-Magd, Elsayed I. SalimAbstractDespite advances in cancer treatment, breast cancer remains one of the main life threatening diseases in women. Most anti-breast cancer drugs cause severe health complications and multidrug resistance. Although, some natural products, such as hesperidin (Hes), piperine (Pip) and bee venom (BV), showed anti-breast cancer effect when used separately, their combined effect together or with the anti-can...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Comparison of three different extracts of Centella asiatica for anti-amnesic, antioxidant and anticholinergic activities: in vitro and in vivo study
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Renu Arora, Ritesh Kumar, Amit Agarwal, K.H. Reeta, Y.K. GuptaAbstractCentella asiatica (CA) has been used by Ayurvedic medical practitioners in India for almost 3000 years. The neuropharmacological properties of CA and its constituents have been studied extensively. Anti-oxidant, free radical scavenging and cholinergic modulatory activities are the reported mechanisms of action for its efficacy in memory disorders. Its medicinal values are mainly attributed to the presence of several triterpenes, namely asiatic acid, madecassic...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Effects of chronic systemic low-impact ampakine treatment on neurotrophin expression in rat brain
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Daniel P. Radin, Steven Johnson, Richard Purcell, Arnold S. LippaAbstractNeurotrophin dysregulation has been implicated in a large number of neurodegenerative and neuropsychiatric diseases. Unfortunately, neurotrophins cannot cross the blood brain barrier thus, novel means of up regulating their expression are greatly needed. It has been demonstrated previously that neurotrophins are up regulated in response to increases in brain activity. Therefore, molecules that act as cognitive enhancers may provide a clinical means of up re...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Berberine promoted myocardial protection of postoperative patients through regulating myocardial autophagy
ConclusionIt was concluded that berberine therapy reduced myocardial injury partly by reducing myocardial autophagy and apoptosis through the AMPK/mTOR pathway. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Corrigendum to “Noscapinoids bearing silver nanocrystals augmented drug delivery, cytotoxicity, apoptosis and cellular uptake in B16F1, mouse melanoma skin cancer cells” [Biomed. Pharmacother. 90 (2017) 906–913]
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Naina Soni, Kiran Jyoti, Upendra Kumar Jain, Anju Katyal, Ramesh Chandra, Jitender Madan (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of interleukin-6 on myocardial regeneration in mice after cardiac injury
In conclusion, IL-6 overexpression could enhance cardiomyocyte proliferation and relevant protein expression in mice myocardium, thus promoting cardiac regeneration. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Clinical and molecular aspects of breast cancer: Targets and therapies
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): R.L.N. Godone, G.M. Leitão, N.B. Araújo, C.H.M. Castelletti, J.L. Lima-Filho, D.B.G. MartinsAbstractBreast Cancer is a complex disease characterized by the occurrence of multiple molecular alterations. Currently, some molecular markers are in use for breast cancer diagnostic, prognostic, and predictive purposes. Thus, genetic signatures are available for improving the decision-making. The biomarkers are also essential as therapeutic approaches, but many questions remain due to the lack of efficacy on breast cancer tr...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Signification of protein p-53 isoforms and immune therapeutic success in chronic lymphocytic leukemia
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Aurelian Udristioiu, Delia Nica-BadeaAbstractIn the past few years has used thetechnique for analyzing deletions of genes, its rearrangements, cross-reactivity or multiplications in human genome affected of genetic diseases. Was proved that, the best techniques in the investigation of malignant lymphocytes are the Flow Cytometry, Elisa, ICT and Fluorescence in situ hybridization (FISH). Last method, FISH is used as an alternative to chromosomal banding, a conventional application in molecular medicine and can detect the chromosoma...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

The unique DEK oncoprotein in women’s health: A potential novel biomarker
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Ana Cecília de Albuquerque Oliveira, Ferdinand Kappes, Danyelly Bruneska Gondim Martins, José Luiz de Lima FilhoAbstractBreast and cervical cancer are the first and fourth cancer types with the highest prevalence in women, respectively. The developmental profiles of cancer in women can vary by genetic markers and cellular events. In turn, age and lifestyle influence in the cellular response and also on the cancer progression and relapse. The human DEK protein, a histone chaperone, belongs to a specific subclass of ch...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Endometriosis: Perspective, lights, and shadows of etiology
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Samira Asghari, Amir Valizadeh, Leili Aghebati-Maleki, Mohammad Nouri, Mehdi YousefiAbstractEndometriosis refers to the growth of ectopic endometrial tissue outside the uterine cavity. About 10–15% of female in reproductive age suffer from endometriosis. Several etiologies – such as oxidative stress, inflammatory factors and cytokines, genetic etiology, and hormone role – have been reported for endometriosis. Indeed, oxidative stress leads to abnormalities by the production of ROS and RNS. The mechanism of endome...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Application of sesquiterpene lactone: A new promising way for cancer therapy based on anticancer activity
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Ghader babaei, Azadeh Aliarab, Sina Abroon, Yusof Rasmi, Shiva Gholizadeh- Ghaleh AzizAbstractCancer is one of the most dangerous diseases that are rapidly increasing globally. After heart disease, it is the second leading cause of death, accounting for seven million deaths each year. Chemotherapy is the use of cytotoxic drugs on cancer cells. But the use of common chemotherapy drugs poses a problem due their high side effects and low efficacy. As a result, efforts are on to find new potent compounds with low side effects. The com...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

CPT1A regulates breast cancer-associated lymphangiogenesis via VEGF signaling
ConclusionsIn present study, we revealed the mechanism by which CPT1A regulates breast cancer-associated invasion and lymphangiogenesis. Our findings provide insights into CPT1A -promoted breast tumor metastasis and provide rationale for understanding breast cancer metastasis. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

The down-regulation of microRNA-137 contributes to the up-regulation of retinoblastoma cell proliferation and invasion by regulating COX-2/PGE2 signaling
In this study, we aimed to investigate the functional significance and molecular mechanisms of miR-137 in RB. We reported that miR-137 was frequently down-regulated in RB tissues and cell lines. The overexpression of miR-137 inhibited RB cell proliferation and invasion, while the suppression of miR-137 promoted RB cell proliferation and invasion. Bioinformatic analysis predicted that cyclooxygenase-2 (COX-2) was a potential target gene of miR-137, which was validated by a dual-luciferase reporter assay. Moreover, our results showed that miR-137 negatively regulated the expression of COX-2 and the production of prostaglandi...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Antitumor and immune-modulatory efficacy of dual-treatment based on levamisole and/or taurine in Ehrlich ascites carcinoma-bearing mice
In conclusion, dual-treatments based on Lms and/or Tau are promising therapies for cancer, not only due to its abilities to induce apoptosis in the tumor cells and modulate the immune response against them, but also due to its capabilities to potentiate the chemotherapy anticancer efficacy and minimize its adverse effects.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

The intervention effect of zuogui pill on chronic kidney disease-mineral and bone disorder regulatory factor
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Xiaohong Ma, Liqun HeAbstractChronic kidney disease-mineral and bone disorder (CKD-MBD) play a critical role in the pathogenesis of cardiovascular complications in patients with chronic kidney disease (CKD). Zuogui pill as a traditional Chinese herbal drug has been used for nourish kidney essence improve bone malnutrition of renal bone disease by regulating the metabolism of calcium and phosphorus and participating in osteoblast metabolism. In the present study, 5/6 nephrectomy rat model was used to reveal the mechanism of zuogui ...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Long non-coding RNA PVT1 promotes cell proliferation and invasion through regulating miR-133a in ovarian cancer
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Qi Yang, Yang Yu, Ziqian Sun, Yuan PanAbstractThe long non-coding RNA, plasmacytoma variant translocation 1 (PVT1), was reportedly to be highly expressed in a variety of tumors including ovarian cancer (OC). However, the role and mechanism of action of PVT1 in the carcinogenesis and progression of OC remains largely unknown. PVT1 and miR-133a expression were detected by quantitative real time PCR(qRT-PCR) assays in OC tissues and cell lines. Cell Counting Kit-8 (CCK-8), flow cytometer, wound healing and transwell invasion assays w...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Fatty acid binding protein 5 promotes tumor angiogenesis and activates the IL6/STAT3/VEGFA pathway in hepatocellular carcinoma
ConclusionFABP5 was shown to promote angiogenesis and activate the IL6/STAT3/VEGFA pathway in HCC. FABP5 may be a potential antiangiogenic target in the treatment of HCC.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Valproic acid attenuates Aβ25-35-induced neurotoxicity in PC12 cells through suppression of mitochondria-mediated apoptotic pathway
In conclusion, our results suggested that VPA might serve as a novel protective agent against Aβ25–35-induced cytotoxicity in AD. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

The inhibition of Hippo/Yap signaling pathway is required for magnesium isoglycyrrhizinate to ameliorate hepatic stellate cell inflammation and activation
This study was to investigate the effect of Magnesium isoglycyrrhizinate (MgIG) on liver fibrosis and inflammation, and to further clarify molecular mechanism. We found that MgIG treatment significantly alleviated carbon tetrachloride (CCl4)-induced liver fibrosis and HSC activation by regulating TGF-β signaling and MMP/TIMP systems. In addition, MgIG treatment significantly inhibited the inflammatory response of liver fibrosis in mice characterized by reduced pro-inflammatory factors expression and increased anti-inflammatory factors expression. Interestingly, experiments in vitro also showed that MgIG treatment sign...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Neuroprotective effect of 1-Deoxynojirimycin on cognitive impairment, β-amyloid deposition, and neuroinflammation in the SAMP8 mice
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Weike Chen, Tingting Liang, Wenwen Zuo, Xin Wu, Zibo Shen, Fang Wang, Cunyu Li, Yunfeng Zheng, Guoping PengAbstractβ-amyloid deposition and neuroinflammation play a crucial part in Alzheimer’s disease. Therefore, this study was designed to find the effects of 1-deoxynojirimycin (DNJ) purified from mulberry leaves on pathological deposition of Aβ peptides and neuroinflammation in senescence-accelerated-prone mouse 8 (SAMP8) mice. Compared to senescence-accelerated-resistant mouse 1 (SAMR1) mice, SAMP8 mice exhibited...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Antioxidant and anti-inflammatory properties of marmelosin from Bael (Aegle marmelos L.); Inhibition of TNF-α mediated inflammatory/tumor markers
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Hasitha Pynam, Shylaja M. DharmeshAbstractOxidative stress and inflammation are important critical factors that are implicated in almost all life style disorders such as diabetes, cardiovascular disease, ulcer and cancer. Current study aimed at isolation and characterization of a furanocoumarin from Bael (Aegle marmelos L.) fruit that can modulate both oxidative stress and inflammation effectively. Ethyl acetate extract of Bael fruit (EAFB) was subjected to HPLC for identification, purified and characterized using FTIR, NMR and ES...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling
In conclusion, the present study confirms that SIRT6 functions as a tumor suppressor gene in colon cancer by modulating PTEN/AKT signaling, which may provide a novel target for the treatment of colon cancer. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Matrine inhibits hypoxia/reoxygenation-induced apoptosis of cardiac microvascular endothelial cells in rats via the JAK2/STAT3 signaling pathway
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Xue-Bin Zhao, Yi Qin, Yu-Ling Niu, Jun YangAbstractHypoxia/reoxygenation (H/R) often results in cellular oxidative stress and the subsequent apoptosis of cardiac microvascular endothelial cells (CMECs). More recently, studies have highlighted the therapeutic effects of matrine on various cardiovascular diseases. Thus, the aim of the present study was to investigate the underlying mechanism and effects of matrine on hypoxia/reoxygenation (H/R)-induced apoptosis of CMECs in rats. CMECs from Sprague Dawley (SD) rats were primarily tr...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Anticancer effect of the water extract of a commercial Spirulina (Arthrospira platensis) product on the human lung cancer A549 cell line
In conclusion, the results obtained provide evidence of the anti-cancer activity of the commercial Spirulina product against lung cancer cells and strongly support the knowledge of the chemopreventive properties of Spirulina.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Long non-coding RNA FEZF1-AS1 promotes cell invasion and epithelial-mesenchymal transition through JAK2/STAT3 signaling pathway in human hepatocellular carcinoma
In conclusion, the present study for the first time demonstrated that FEZF1-AS1 serves as an oncogenic lncRNA in human HCC and implicated FEZF1-AS1 as a valuable therapeutic target for HCC treatment. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

1,25(OH)2D3 promotes chondrocyte apoptosis and restores physical function in rheumatoid arthritis through the NF-κB signal pathway
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Run Tian, Xiaofang Li, Yue Li, Kunzheng Wang, Chunsheng Wang, Pei YangAbstractWe explored the modulatory effect of 1,25(OH)2D3 on chondrocytes and physical function in rats with RA and its mechanism underlying the regulation of NF-κB signal pathway. RA patients and healthy volunteers were selected. Sprague-Dawley (SD) rats were used to establish RA models. The paw volume of rats was estimated. Chondrocytes were isolated from RA rats. The protein levels in both cartilage tissues and chondrocytes were determined using western ...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Long noncoding RNA HOXD-AS1 promotes non-small cell lung cancer migration and invasion through regulating miR-133b/MMP9 axis
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Huan Xia, Hongyu Jing, Yang Li, Xiaohong LvAbstractHOXD antisense growth associated long noncoding RNA (HOXD-AS1) was reported to be dysregulated and exert crucial roles in tumorigenesis and progression of multiple malignancies. However, the role and mechanism of action of HOXD-AS1 in the carcinogenesis and progression of non-small lung cell cancers (NSCLC) remains largely unknown. HOXD-AS1, miR-133a and Matrix metallopeptidase 9 (MMP-9) mRNA expression were detected by quantitative real-time polymerase chain reaction assays in NS...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Oridonin enhances the cytotoxicity of 5-FU in renal carcinoma cells by inducting necroptotic death
ConclusionOridonin enhances the cytotoxicity of 5-FU in renal cancer cells partially through inducing necroptosis, providing evidence of using necroptosis inducers in combination with chemotherapeutic agents for cancer treatment.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Lavatera critica controls systemic insulin resistance by ameliorating adipose tissue inflammation and oxidative stress using bioactive compounds identified by GC–MS
ConclusionsThese findings prove that LCE improves the insulin-sensitizing activity in the mouse model of HGFD-caused IR, probably due to the amelioration of adipose tissue inflammation and oxidative damage. Hence, the LCE could serve as a useful anti-diabetic agent.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Aucubin protects against lipopolysaccharide-induced acute pulmonary injury through regulating Nrf2 and AMPK pathways
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Yan-Ling Qiu, Xiao-Ning Cheng, Feng Bai, Li-Yun Fang, Hui-Zhong Hu, Da-Qing SunAbstractAucubin (Ai), a natural compound isolated from plants, including Aucuba japonica and Eucommia ulmoides, shows significant anti-inflammatory and anti-oxidative bioactivities. Here, we attempted to explore the protect effects of Ai on LPS-induced acute lung injury (ALI). Our results indicated that Ai increased the survival rate and ameliorated pathogenic processes in lipopolysaccharide (LPS)-induced mice. However, nuclear factor erythroid 2-relate...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

ROS mediated ER stress induces Bax-Bak dependent and independent apoptosis in response to Thioridazine
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Mahendra Seervi, Ankita Rani, Abhay K. Sharma, T.R. Santhosh KumarAbstractA dopamine receptor antagonist, Thioridazine (TDZ) is known for its cytotoxic activity against various cancers and its role in combinational chemotherapy is being actively investigated. Several molecular targets of TDZ have been studied to delineate its anticancer activities, with contrasting findings in different cancer types. Moreover, the underlying mechanism of cell death from TDZ treatment is not well defined. In the current study, we studied TDZ mediat...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Dexmedetomidine protects against lipopolysaccharide-induced sepsis-associated acute kidney injury via an α7 nAChR-dependent pathway
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Kai Kang, Yang Gao, Si-Cong Wang, Hai-Tao Liu, Wei-Lan Kong, Xing Zhang, Rui Huang, Zhi-Dong Qi, Jun-Bo Zheng, Jing-Dong Qu, Rui-Jin Liu, Yan-Song Liu, Hong-Liang Wang, Kai-Jiang YuAbstractAcute kidney injury (AKI) is a clinical syndrome that results in severe tubular damage with high morbidity and mortality. However, there is a lack of effective therapy strategies. Therefore, it is critical to develop effective drugs for AKI. Dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist, has neuroprotective, anti-infl...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

MiRNA-34a reversed TGF-β-induced epithelial-mesenchymal transition via suppression of SMAD4 in NPC cells
In this study, we found that transforming growth factor-β (TGF-β), which reportedly promotes EMT in multiple cancers, can trigger EMT and increase the invasive and migratory capacities of NPC cells. Conversely, the downregulation of SMAD4, a vital member of the canonical TGF-β pathway, reversed the TGF-β-induced EMT, invasion, and migration. Further experiments revealed that SMAD4 was the target of miRNA-34a, which was downregulated in NPC tissues and suppressed NPC cell metastasis in vivo. miRNA-34a overexpression also antagonized the TGF-β-induced EMT progression, invasion, and migration through ...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Angelica sinensis polysaccharide protects rat cardiomyocytes H9c2 from hypoxia-induced injury by down-regulation of microRNA-22
ConclusionASP pretreatment attenuated hypoxia-induced H9c2 cell injury, possibly through down-regulating miR-22 expression. The PI3K/AKT and JAK1/STAT3 pathways were activated by ASP pretreatment via miR-22 in hypoxia-treated cells.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Role of selenium and vitamin C in mitigating oxidative stress induced by fenitrothion in rat liver
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Marija D. Milošević, Milica G. Paunović, Miloš M. Matić, Branka I. Ognjanović, Zorica S. SaičićAbstractExcessive use of organophosphate insecticides, including fenitrothion (FNT) can cause detrimental consequences in non-target organisms. Selenium (Se) and vitamin C (Vit C) possess protective abilities against various toxic compounds due to their antioxidative properties. Accordingly, the aim of the present study was to examine the possible ameliorative effects of Se and Vit C in hepatotoxicity induced by FNT. ...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Conditioned medium from stimulated macrophages inhibits growth but induces an inflammatory phenotype in breast cancer cells
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Wenzhe Song, Parth Thakor, David A. Vesey, Glenda C. Gobe, Christudas MoraisAbstractDisparate roles exist for tumor-associated macrophages in breast cancer growth and progression. The aim of this study was to explore the influence of induced macrophages on the growth of breast cancer cells. THP-1 monocytes were differentiated to macrophages using phorbol 12-myristate 13-acetate. The effect of the medium from THP-1 monocytes or macrophage-conditioned medium (MφCM) on MCF-7 (estrogen receptor and progesterone-positive positive) ...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Paeoniflorin inhibits Rho kinase activation in joint synovial tissues of rats with collagen-induced rheumatoid arthritis
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Wenjing Zhai, Zhihong Ma, Weijie Wang, Lin Song, Jianfeng YiAbstractPaeoniflorin (PF) has many effects, such as anti-inflammation, immune-regulation, abirritation, and so on. However, the protective mechanisms of PF on rheumatoid arthritis (RA) was not completely known. Thus, we explored deeply the protective mechanisms in a collagen-induced RA (CIA) rat model. CIA was induced in rats by intradermal injection of bovine type II collagen in complete Freund's adjuvant. Later, the CIA rats received oral administration of PF (50 and 10...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Enhanced expression of lncRNA TP73-AS1 predicts adverse phenotypes for cholangiocarcinoma and exerts oncogenic properties in vitro and in vivo
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Yue Yao, Yue Sun, Yuehong Jiang, Lijun Qu, Yi XuAbstractCholangiocarcinoma (CCA) is one of the most aggressive malignancies with increasing incidence worldwide. Various evidence documents that abnormally expressed long non-coding RNAs (lncRNAs) play important roles in tumorigenesis and progression. TP73-AS1 is a novel cancer-related lncRNA that contributes to the development of several malignancies. However, its clinical value and potential effects on CCA remains unknown. RT-qPCR was used to measure the expression levels of TP73-A...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Down-regulated miR-148b increases resistance to CHOP in diffuse large B-cell lymphoma cells by rescuing Ezrin
ConclusionOur data indicated that the high level of HDAC6 inhibited miR-148b via maintaining the low acetylation of histones H3 and H4 in the miR-148b promoter, thus rescuing Ezrin expression and promoting CHOP resistance in DLBCL. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

RGD peptide-modified, paclitaxel prodrug-based, dual-drugs loaded, and redox-sensitive lipid-polymer nanoparticles for the enhanced lung cancer therapy
In this study, RGD peptide-modified, paclitaxel (PTX) prodrug-based, dual-drugs loaded, and redox-sensitive lipid-polymer nanoparticles were developed and the in vitro and in vivo antitumor efficiency was evaluated in lung cancer cells and tumor bearing animal models. RGD-modified PTX and cisplatin (CDDP) loaded LPNs (RGD-ss-PTX/CDDP LPNs) have sizes around 190 nm, and zeta potentials of −35 mV. The half-maximal inhibitory concentration (IC50) values were 26.7 and 75.3 μg/mL for drugs loaded LPNs and free drugs combination, which indicates significantly higher antitumor activity of LPNs than free drugs. RGD-...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Biochemical investigation of gender-specific association between insulin resistance and inflammatory biomarkers in types 2 diabetic patients
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Muhammad Sajid Hamid Akash, Kanwal Rehman, Aamira Liaqat, Muhammad Numan, Qaisar Mahmood, Shagufta KamalAbstractInflammatory mediators play a key role in the pathogenesis of type 2 diabetes mellitus (T2DM) and development of insulin resistance (IR). The purpose of the present study was to investigate the gender-specific association between serum levels of inflammatory biomarkers and development of IR in type 2 diabetic patients. We recruited 90 study participants and collected their blood samples to measure the serum level of inte...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Imidazole bearing chalcones as a new class of monoamine oxidase inhibitors
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Rani Sasidharan, Seung Cheol Baek, Manju Sreedharannair Leelabaiamma, Hoon Kim, Bijo MathewAbstractIn the present study, series of eleven (2E)-1-[4-(1H-imidazol-1-yl)substituted phenyl]-3-phenylprop-2-en-1-one (IM1–IM11) derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The results indicate that (2E)-3-[4-(dimethylamino) phenyl]-1-[4-(1H-imidazol-1-yl) phenyl] prop-2-en-1-one (IM5) is a nonselective and reversible competitive inhibitor of MAO-A and MAO-B with IC50 ...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Magnesium isoglycyrrhizinate ameliorates liver fibrosis and hepatic stellate cell activation by regulating ferroptosis signaling pathway
Publication date: October 2018Source: Biomedicine & Pharmacotherapy, Volume 106Author(s): Miao Sui, Xiaofei Jiang, Jun Chen, Haiyan Yang, Yan ZhuAbstractFerroptosis is recently reported as a new mode of regulated cell death. It is triggered by disturbed redox homeostasis, overloaded iron and increased lipid peroxidation. Howerver, the role of ferroptosis in hepatic fibrosis remains obscure. In the current study, we attempted to investigate the effect of Magnesium isoglycyrrhizinate (MgIG) on ferroptosis in liver fibrosis, and to further clarify the possible mechanisms. Our data showed that MgIG treatment markedly atten...
Source: Biomedicine and Pharmacotherapy - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Kuijieling regulates the differentiation of Treg and Th17 cells to ameliorate experimental colitis in rats
ConclusionKJL restores the balance between Treg and Th17 cells through regulating the differentiation of them, therefore contributes to the treatment of UC. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

LncRNA XIST accelerates cervical cancer progression via upregulating Fus through competitively binding with miR-200a
In this study, we aim to explore the specific mechanism and biological function of XIST in cervical cancer. At first, the expression levels of XIST were examined in both tissues and cell lines with qRT-PCR. XIST was extremely overexpressed in cervical cancer tissues and cell lines. Kaplan Meier method was then applied to analyze the correlation between XIST expression and overall survival of cervical cancer patients. Loss-of- function assays were designed and conducted to verify the oncogenic function of XIST on cervical cancer progression. Additionally, the results of mechanistic experiments indicated that XIST upregulate...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Tripterine alleviates LPS-induced inflammatory injury by up-regulation of miR-146a in HaCaT cells
ConclusionThese results demonstrated that tripterine could attenuate LPS-induced inflammatory injury and deactivate JNK and NF-κB pathways by up-regulation of miR-146a. This study will provide a theoretical basis for further study of tripterine in CDD.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-22-3p targeting alpha-enolase 1 regulates the proliferation of retinoblastoma cells
This study sought to explore the role of alpha-Enolase 1 (ENO1) in retinoblastoma (RB) which remains uncertain.MethodsThe expression of ENO1 in RB cell lines was examined by RT-qPCR and western blot. The biological function of ENO1 on cell proliferation in RB was determined in vitro. The predicted target of ENO1 was validated by dual-luciferase reporter assay and rescue experiment. The validation of clinical tissue samples was performed by RT-qPCR.ResultsElevated ENO1 could promote the proliferation of RB cells. The dual luciferase reporter assay confirmed that ENO1 is the target for miR-22-3p. In rescue experiment, the re...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Incensole acetate prevents beta-amyloid-induced neurotoxicity in human olfactory bulb neural stem cells
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Mohammed A. El-Magd, Sara F. Khalifa, Faisal Abdulrahman A. Alzahrani, Abdelnaser A. Badawy, Eman S. El-Shetry, Lamess M. Dawood, Mohammed M. Alruwaili, Hedib A. Alrawaili, Engi F. Risha, Fathy M. El-Taweel, Hany E. MareiAbstractβ-Amyloid peptide (Aβ) is a potent neurotoxic protein associated with Alzheimer’s disease (AD) which causes oxidative damage to neurons. Incensole acetate (IA) is a major constituent of Boswellia carterii resin, which has anti-inflammatory and protective properties against damage of a lar...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research

Potent tocolytic activity of ethyl acetate fraction of Ananas comosus on rat and human uteri
Publication date: September 2018Source: Biomedicine & Pharmacotherapy, Volume 105Author(s): Faezeh Monji, Lang Chu Lau, Abrar Al-Mahmood Siddiquee, Baharudin Bin Said, Lay-Kien Yang, Yoganathan K., Mahesh A. Choolani, P. Ganesan AdaikanAbstractThe aim of this study was to investigate the tocolytic properties of Ananas comosus extract in rat and human uterine tissue in vitro and in the rat in vivo. Organ bath technique was employed to perform functional studies in vitro. The PhysioTel transmitter was implanted in SD rats to measure the changes in intrauterine pressure (IUP) in vivo. Analyses of F2 was performed using LC...
Source: Biomedicine and Pharmacotherapy - July 5, 2018 Category: Drugs & Pharmacology Source Type: research