Pyrazole ring-containing isolongifolanone derivatives as potential CDK2 inhibitors: Evaluation of anticancer activity and investigation of action mechanism
Publication date: July 2021Source: Biomedicine & Pharmacotherapy, Volume 139Author(s): Yunyun Wang, Wei Shi, Chenliang Wu, Lin Wan, Yuxun Zhao, Chenglong Zhang, Wen Gu, Shifa Wang (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 10, 2021 Category: Drugs & Pharmacology Source Type: research

Therapeutic advancement of simvastatin-loaded solid lipid nanoparticles (SV-SLNs) in treatment of hyperlipidemia and attenuating hepatotoxicity, myopathy and apoptosis: Comprehensive study
Publication date: July 2021Source: Biomedicine & Pharmacotherapy, Volume 139Author(s): Hagar B. Abo-zalam, Ezzeldein S. El-Denshary, Rania M. Abdelsalam, Islam A. Khalil, Mahmoud M. Khattab, Mohamed A. Hamzawy (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 10, 2021 Category: Drugs & Pharmacology Source Type: research

The molecular mechanism of LRP1 in physiological vascular homeostasis and signal transduction pathways
Publication date: July 2021Source: Biomedicine & Pharmacotherapy, Volume 139Author(s): Zhaohui He, Gang Wang, Jianbo Wu, Zonghao Tang, Mao Luo (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 8, 2021 Category: Drugs & Pharmacology Source Type: research

Metformin and insulin-resistant related diseases: Emphasis on the role of microRNAs
Publication date: July 2021Source: Biomedicine & Pharmacotherapy, Volume 139Author(s): Nahid Alimoradi, Negar Firouzabadi, Reihaneh Fatehi (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 8, 2021 Category: Drugs & Pharmacology Source Type: research

The smoking estrogens – a potential synergy between estradiol and benzo(a)pyrene
Publication date: July 2021Source: Biomedicine & Pharmacotherapy, Volume 139Author(s): Bartosz Kazimierz Słowikowski, Maurycy Jankowski, Paweł Piotr Jagodziński (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 8, 2021 Category: Drugs & Pharmacology Source Type: research

Role of microbiota-derived short-chain fatty acids in nervous system disorders
Publication date: July 2021Source: Biomedicine & Pharmacotherapy, Volume 139Author(s): Rasoul Mirzaei, Behnaz Bouzari, Seyed Reza Hosseini-Fard, Maryam Mazaheri, Yaghoub Ahmadyousefi, Milad Abdi, Saba Jalalifar, Zahra Karimitabar, Ali Teimoori, Hossein Keyvani, Farhad Zamani, Rasoul Yousefimashouf, Sajad Karampoor (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 8, 2021 Category: Drugs & Pharmacology Source Type: research

Pharmacokinetics/pharmacometabolomics-pharmacodynamics reveals the synergistic mechanism of a multicomponent herbal formula, Baoyuan decoction against cardiac hypertrophy
Publication date: July 2021Source: Biomedicine & Pharmacotherapy, Volume 139Author(s): Zhiyong Du, Yingyuan Lu, Jiaxu Sun, Kun Chang, Mengqiu Lu, Meng Fang, Xiangrui Zeng, Wenxin Zhang, Jinyang Song, Xiaoyu Guo, Pengfei Tu, Yong Jiang (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 8, 2021 Category: Drugs & Pharmacology Source Type: research

Polysaccharide from Potentilla anserina L ameliorate pulmonary edema induced by hypobaric hypoxia in rats
Publication date: July 2021Source: Biomedicine & Pharmacotherapy, Volume 139Author(s): Jipeng Shi, Zhao Liu, Maoxing Li, Jie Guo, Lele Chen, Ling Ding, Xu Ding, Tao Zhou, Ji Zhang (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 8, 2021 Category: Drugs & Pharmacology Source Type: research

Comparative evaluation of the protective effects of oral administration of auraptene and umbelliprenin against CFA-induced chronic inflammation with polyarthritis in rats
Publication date: July 2021Source: Biomedicine & Pharmacotherapy, Volume 139Author(s): Kobra Shirani, Mehrdad Iranshahi, Vahid Reza Askari, Zahra Gholizadeh, Armin Attaran Zadeh, Majid Zeinali, Faezeh Vahdati Hassani, Zhila Taherzadeh (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 8, 2021 Category: Drugs & Pharmacology Source Type: research

A spontaneously hypertensive diet-induced atherosclerosis-prone mouse model of metabolic syndrome
Publication date: July 2021Source: Biomedicine & Pharmacotherapy, Volume 139Author(s): Dragana Dragoljevic, Camilla Bertuzzo Veiga, Danielle L. Michell, Waled A. Shihata, Annas Al-Sharea, Geoffrey A. Head, Andrew J. Murphy, Michael J. Kraakman, Man K.S. Lee (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 8, 2021 Category: Drugs & Pharmacology Source Type: research

Coronary hypercontractility to acidosis owes to the greater activity of TMEM16A/ANO1 in the arterial smooth muscle cells
Publication date: July 2021Source: Biomedicine & Pharmacotherapy, Volume 139Author(s): Pengmei Guo, Yu Liu, Xiaojia Xu, Guijin Ma, Xiaomin Hou, Yanying Fan, Mingsheng Zhang (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 8, 2021 Category: Drugs & Pharmacology Source Type: research

Tetrahydrocurcumin ameliorates Alzheimer's pathological phenotypes by inhibition of microglial cell cycle arrest and apoptosis via Ras/ERK signaling
Publication date: July 2021Source: Biomedicine & Pharmacotherapy, Volume 139Author(s): Yu Xiao, Ying Dai, Li Li, Fang Geng, Yisha Xu, Jinqiu Wang, Shu Wang, Junning Zhao (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 8, 2021 Category: Drugs & Pharmacology Source Type: research

Osteopontin silencing attenuates bleomycin-induced murine pulmonary fibrosis by regulating epithelial–mesenchymal transition
Publication date: July 2021Source: Biomedicine & Pharmacotherapy, Volume 139Author(s): Omer Faruk Hatipoglu, Eyyup Uctepe, Gabriel Opoku, Hidenori Wake, Kentaro Ikemura, Takashi Ohtsuki, Junko Inagaki, Mehmet Gunduz, Esra Gunduz, Shogo Watanabe, Takashi Nishinaka, Hideo Takahashi, Satoshi Hirohata (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 8, 2021 Category: Drugs & Pharmacology Source Type: research

Vascular normalization in immunotherapy: A promising mechanisms combined with radiotherapy
Publication date: July 2021Source: Biomedicine & Pharmacotherapy, Volume 139Author(s): Zijing Liu, Qin Zhao, Zhuangzhuang Zheng, Shiyu Liu, Lingbin Meng, Lihua Dong, Xin Jiang (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 7, 2021 Category: Drugs & Pharmacology Source Type: research

Leveraging hallmark Alzheimer’s molecular targets using phytoconstituents: Current perspective and emerging trends
Publication date: July 2021Source: Biomedicine & Pharmacotherapy, Volume 139Author(s): Prajakta A. Dhage, Archana A. Sharbidre, Sarada P. Dakua, Shidin Balakrishnan (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - May 7, 2021 Category: Drugs & Pharmacology Source Type: research