Piceatannol pretreatment alleviates acute cardiac injury via regulating PI3K-Akt-eNOS signaling in H9c2 cells
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Dapeng Wang, Yufeng Zhang, Chunquan Zhang, Li Gao, Jie LiAbstractPiceatannol (3,3′,4,5′-trans-trihydroxystilbene) is a natural polyphenols compound that occurs hydroxylated analogue of resveratrol showing widely biological activities. Previous studies have demonstrated its functions on anti-cancer, neuroprotection and cardioprotection. However, few studies have clarified the benefits of piceatannol on cardiomyocytes except its anti-oxidative effect based on the original property of polyphenols. Here we apply H9c2 cardi...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Coenzyme Q10 attenuates lung and liver fibrosis via modulation of autophagy in methotrexate treated rat
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Doaa I. Mohamed, Eman Khairy, Sherin Shafik Tawfek, Eman K. Habib, Marwa A. FetouhAbstractThe present study was conducted to investigate the potential protective effects of coenzyme Q 10 (CoQ10) administration on methotrexate induced lung and liver fibrosis in rat model, and to explore our hypothesis regarding its possible mechanism of action through reactivation of autophagy pathway. Methotrexate induced fibrosis was achieved by intraperitoneal injections twice a week for 4 weeks. A combined treatment of CoQ10 and methotrexate we...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-148a suppressed cell invasion and migration via targeting WNT10b and modulating β-catenin signaling in cisplatin-resistant colorectal cancer cells
In conclusion, our study for the first time enriched the cisplatin-resistant CRC cells with enhanced stem cell marker expression from sphere-forming and chemo-resistant SW480-derived tumor xenografts in immune-deficient mice, and miR-148a suppressed the expression of stem cell markers, increased chemo-sensitivity, cell invasion and migration at least partly via regulating WNT10b and β-catenin signaling pathway. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Dapagliflozin attenuates early markers of diabetic nephropathy in fructose-streptozotocin-induced diabetes in rats
This study investigated the effects of dapagliflozin, a sodium glucose co-transporter 2 inhibitor, on some early markers for DN in fructose-streptozotocin (Fr-STZ)-induced diabetes in rats. Fr-STZ rats were treated with either dapagliflozin (1 mg/kg p.o. daily), metformin (350 mg/kg p.o. daily), or their combination for 6 weeks. Fr-STZ rats displayed marked early tubular renal damage and glomerular podocyte injury as evidenced by renal KIM-1, NGAL, cystatin C, and vanin-1 mRNA, as well as urinary NAG elevation and nephrin mRNA suppression, associated with the development of marked renal interstitial fibrosis ...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Histone deacetylase inhibitor MGCD0103 protects the pancreas from streptozotocin-induced oxidative stress and β-cell death
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Hae-Ahm Lee, Eunjo Lee, Ga Young Do, Eun-Kyung Moon, Fu-Shi Quan, Inkyeom KimAbstractInhibition of histone deacetylase (HDAC) suppresses inflammation of pancreatic islets and apoptosis of β-cells. However, the underlying molecular mechanism is unclear. In the present study, we demonstrate that MGCD0103 (MGCD), an HDAC inhibitor, protects the pancreas from streptozotocin (STZ)-induced oxidative stress and cell death. Sprague-Dawley rats were intraperitoneally injected with STZ (40 mg/kg) to induce type I diabetes. MGCD ...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Resistin impairs activation of protein C by suppressing EPCR and increasing SP1 expression
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Pei Zhang, Yu Liu, Jiangli Su, Jie Bai, Shikai Zhao, Shouguo ZhaoAbstractEndothelial cells are vital to blood coagulation and maintain whole body hemostasis. Binding of endothelial cells to endothelial protein C receptor (EPCR) and thrombomodulin (TM) is essential to the formation of activated protein C (APC), one of the key factors regulating blood coagulation. In our study, we showed that resistin, an adipocyte hormone, suppresses thrombin-induced protein C activation in endothelial cells. Resistin treatment results in a reducti...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Involvement of opioid system in behavioral despair induced by social isolation stress in mice
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Arvin Haj-Mirzaian, Rajan Nikbakhsh, Kiana Ramezanzadeh, Mehdi Rezaee, Hossein Amini-Khoei, Arya Haj-Mirzaian, Maria Ghesmati, Khashayar Afshari, Nazgol-Sadat Haddadi, Ahmad Reza DehpourAbstractSocial isolation stress (SIS) as a type of chronic stress could induce depressive- and anxiety-like behaviors. Our study evaluates the role of opioid system on negative behavioral impacts of SIS in male NMRI mice. We investigated effects of morphine, a nonselective opioid receptor (OR) agonist, naltrexone (NLX), an OR antagonist, naltrindol...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Potential mechanisms underlying the protective effects of salvianic acid A against atherosclerosis in vivo and vitro
This study examines the protective mechanisms of SAA on AS in vivo and in vitro. SAA treatment (3 and 10 mg/kg/d) prevented the progression of atherosclerotic lesions and decreased 58.2% and 72.8% of the lipid deposition in the aorta of high fat-diet-induced AS rat. Notably, SAA treatment ameliorated serum lipid abnormalities by decreasing 20.4% and 33.8% of triglyceride, 26.1% and 32.7% of total cholesterol, 36.0% and 57.3% of low-density lipoprotein-cholesterol levels and increasing 183.4% and 337.5% of high-density lipoprotein-cholesterol level in the serum of AS rat (all P 
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Mitophagy protects SH-SY5Y neuroblastoma cells against the TNFα-induced inflammatory injury: Involvement of microRNA-145 and Bnip3
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Huawei Liu, Haitao Huang, Runxin Li, Wenting Bi, Lin Feng, Lingling E, Min Hu, Weisheng WenAbstractInflammatory response is involved in the development of facial neuritis. The aim of our study is to explore the role of mitophagy in facial nerve damage induced by tumor necrosis factor α (TNFα). Our results indicated that TNFα induced SH-SY5Y cell apoptosis in a dose-dependent manner. Besides, TNFα treatment also suppressed mitophagy by reducing the expression of BCL2 interacting protein 3 (Bnip3). Overexpres...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Systems pharmacology uncover the mechanism of anti-non-small cell lung cancer for Hedyotis diffusa Willd
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Xing Su, Yueping Li, Meng Jiang, Jinglin Zhu, Chunli Zheng, Xuetong Chen, Jun Zhou, Yan Li, Wei Xiao, Yonghua WangAbstractNon-small cell lung cancer (NSCLC) has become one of the most general malignancies in the world and has been shown to be the leading cause of cancer-related deaths. Traditional Chinese medicine (TCM) is considered to be a useful medicine for survival, and has been used in Asia for thousands of years. Hedyotis diffusa Willd (HDW) is an important folk herb that is used in clinical treatment of various cancers in ...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Long non-coding RNA DLEU1 exerts an oncogenic function in non-small cell lung cancer
ConclusionsDLEU1 promoted tumorigenesis and progression of NSCLC, and might be a promising therapeutic target for NSCLC.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

miR-532-3p promotes hepatocellular carcinoma progression by targeting PTPRT
ConclusionOur results demonstrate that miR-532-3p, which is frequently up-regulated in HCC, contributes to HCC cells mobility and proliferation through targeting PTPRT.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Ginsenoside Rd contributes the attenuation of cardiac hypertrophy in vivo and in vitro
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Ningning Zhang, Xiangbo An, Pingping Lang, Feng Wang, Yunpeng XieAbstractCardiac hypertrophy are the major health challenges in the whole world. Ginsenoside Rd is an important component of cell growth and tumorigenesis, but the role and mechanism of ginsenoside Rd in pressure overload induced cardiac dysfunction and remodeling are still not fully illuminated. Here, cardiac hypertrophic remodeling and dysfunction were induced by pressure overload in mice. Myocardial histology was detected by Masson's trichrome staining and hematoxy...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

The protective effect of the flavonoid fraction of Abutilon theophrasti Medic. leaves on LPS-induced acute lung injury in mice via the NF-κB and MAPK signalling pathways
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Chunlian Tian, Peng Zhang, Jie Yang, Zehui Zhang, Hong Wang, Yuru Guo, Mingchun LiuAbstractAccompanied by the damages of epithelial and capillary endothelial cell, acute lung injury is diagnosed with the typical pathological symptoms in clinic, including diffusing of pulmonary interstitial, alveolar oedema and hypoxic respiratory insufficiency. Current study focused on the investigation the anti-inflammatory action and mechanisms of total flavonoids extract (TFE) from Abutilon theophrasti Medic. leaves on ALI mice induced by LPSs....
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Neferine inhibits proliferation, migration and invasion of U251 glioma cells by down-regulation of miR-10b
ConclusionsThese results suggested that NEF exerted anti-tumor effect by down-regulation of miR-10b and deactivation of PTEN/PI3K/AKT and p38MAPK signal pathways in glioma cells. These findings might provide a novel therapeutic strategy for glioma. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Tetramethylpyrazine (TMP) ameliorates corneal neovascularization via regulating cell infiltration into cornea after alkali burn
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Yihui Wu, Zhuojun Xu, Ying Yang, Jin Qiu, Meng Yang, Chuangran Wu, Zhipeng Lai, Mingjun Tang, Jian Ge, Keming Yu, Jing ZhuangAbstractIn the present study, we investigated the underlying mechanism of tetramethylpyrazine (TMP)-medicated inhibition of corneal neovascularization (CNV). Our data showed that TMP could effectively downregulate the expression levels of CXCR4 mRNA and protein, as well as inhibit HUVECs, endothelial cells, tubule formation in vitro. In vivo, alkali burn (1 M NaOH) could remarkably upregulate CXCR4 ex...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Protective and reversal actions of a novel peptidomimetic against a pivotal toxin implicated in Alzheimer’s disease
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Giovanni Ferrati, Georgi Bion, Andrew J. Harris, Susan GreenfieldAbstractDespite the many attempts to understand the aetiology of Alzheimer’s disease, the basic mechanisms accounting for the progressive cycle of neuronal loss are still unknown. Previous work has suggested that the pivotal molecule mediating neurodegeneration could be an independently acting peptide cleaved from acetylcholinesterase. This previously unidentified agent acts as a signalling molecule in selectively vulnerable groups of cells where erstwhile deve...
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Ailanthone exerts anticancer effect by up-regulating miR-148a expression in MDA-MB-231 breast cancer cells and inhibiting proliferation, migration and invasion
ConclusionsThese data demonstrated that AIL inhibited proliferation, migration and invasion of MDA-MB-231 cells by regulating miR-148a.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Fibroblast growth factor 21 improves glucose homeostasis partially via down-regulation of Na+-d-glucose cotransporter SGLT1 in the small intestine
In conclusion, FGF-21 regulates glucose level in diabetes partially due to inhibiting glucose absorption in the SI via inactivating SGK-1 pathway. These results expand our knowledge about how FGF-21 regulates glucose metabolism.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 6, 2018 Category: Drugs & Pharmacology Source Type: research

Preeclampsia: A close look at renal dysfunction
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Hakimeh Moghaddas Sani, Sepideh Zununi Vahed, Mohammadreza ArdalanAbstractPreeclampsia (PE) is a unique pathophysiologic situation that physiologic interests of mother, fetus, and placenta diverge. PE is related to the increased circulating antiangiogenic factors originated from hypoxic placenta. It is simply defined by the new onset of hypertension (≥140/90 mmHg) and proteinuria (≥0.3 g/day) after 20 weeks of gestation. PE is associated with kidney dysfunction due to deficiency in podocyte specific vascular en...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Hyperbaric oxygen therapy: Antimicrobial mechanisms and clinical application for infections
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Mohammad Yousef Memar, Mina Yekani, Naser Alizadeh, Hossein Bannazadeh BaghiAbstractHyperbaric oxygen therapy (HBOT) is a treatment procedure that involves breathing 100% O2 for a certain time and under a certain pressure. HBOT is commonly administrated as a primary or alternative therapy for different diseases such as infections. In this paper, we reviewed the general aspect of HBOT procedures, the mechanisms of antimicrobial effects and the application in the treatment of infections. Parts of the antimicrobial effects of HBOT ar...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Stress-driven discovery in the natural products: A gateway towards new drugs
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Syed Shams ul Hassan, Hui-zi Jin, Tareq Abu-Izneid, Abdur Rauf, Muhammad Ishaq, Hafiz Ansar Rasul SuleriaAbstractElicitation by chemical means including heavy metals is one of a novel technique for drug discoveries. In this review, the effect of heavy metals on animal, plants and microorganisms for the production of novel compounds with the unique structures has been discussed. The number of parameters such as metal concentration, type, dose, treatment schedule, duration of metal exposure, and nutrient composition are significant ...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

NK cells in cerebral ischemia
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Chen Chen, Qi-Di Ai, Shi-Feng Chu, Zhao Zhang, Nai-Hong ChenAbstractAs a vital cell type in immune system and infiltrating cells in ischemic brain, NK cells can bridge the crosstalk between immune system and nervous system in stroke setting. The mechanism of action of NK cells is complicated, involving direct and indirect actions. NK cells are closely associated with poststroke inflammation, immunodepression and infections. The excessive inflammatory response in ischemic brain is one of the important causes for aggravating cerebra...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Hyperbaric oxygen and aerobic exercise in the long-term treatment of fibromyalgia: A narrative review
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Kholoud M. El-Shewy, Ahmad Kunbaz, Mohamed M. Gad, Muneer J. Al-Husseini, Anas M. Saad, Yasser M. Sammour, Mohamed M. Abdel-DaimAbstractChronic pain is one of the most common clinical presentations in the primary care settings. In the US, Fibromyalgia (FM) affects about 1–3% of adults and commonly occurs in adults between the ages of 40–50 years. FM causes widespread muscular pain and tenderness with hyperalgesia and allodynia and may be associated with other somatic complaints.Hyperbaric oxygen therapy (HBOT) has been...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

The renin-angiotensin system as a target to solve the riddle of endocrine pancreas homeostasis
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Francielle Graus-Nunes, Vanessa Souza-MelloAbstractLocal renin-angiotensin system (RAS) in the pancreas is linked to the modulation of glucose-stimulated insulin secretion (GSIS) in beta cells and insulin sensitivity in target tissues, emerging as a promising tool in the prevention and/or treatment of obesity, diabetes, and systemic arterial hypertension. Insulin resistance alters pancreatic islet cell distribution and morphology and hypertrophied islets exhibit upregulated angiotensin II type 1 receptor, which drives oxidative st...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Dietary composition modulates impact of food-added monosodium glutamate on behaviour, metabolic status and cerebral cortical morphology in mice
In conclusion, the findings suggest that possible interactions that may occur between dietary constituents and MSG are determinants of the effects of food-added MSG in mice.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Prevention of pentylenetetrazole-induced kindling and behavioral comorbidities in mice by levetiracetam combined with the GLP-1 agonist liraglutide: Involvement of brain antioxidant and BDNF upregulating properties
In conclusion, our results showed that LIRA can be a promising adjunctive therapy for epilepsy-related neuropsychiatric comorbidities and to improve the management of antiepileptic drug associated behavioral adverse effects.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Cardio-protective and antioxidant properties of caffeic acid and chlorogenic acid: Mechanistic role of angiotensin converting enzyme, cholinesterase and arginase activities in cyclosporine induced hypertensive rats
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Odunayo Michael Agunloye, Ganiyu Oboh, Adedayo Oluwaseun Ademiluyi, Ayokunle Olubode Ademosun, Akintunde Afolabi Akindahunsi, Ademola Adetokunbo Oyagbemi, Temidayo Olutayo Omobowale, Temitayo Olabisi Ajibade, Adeolu Alex AdedapoAbstractCaffeic acid (CAA) and chlorogenic acid (CHA) are important members of hydroxycinnamic acid with natural antioxidant and cardio-protective properties. The present study aimed to determine the effect of CAA and CHA on systolic blood pressure, heart rates (HR) as well as on the activity of the angiote...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Teneligliptin protects against hypoxia/reoxygenation-induced endothelial cell injury
In this study, we investigated the effect of teneligliptin on hypoxia/reoxygenation (H/R)-induced endothelial cell injury in rat cardiac microvascular endothelial cells (CMECs). We showed that teneligliptin pretreatment suppressed H/R-induced production of reactive oxygen species (ROS), NADPH oxidase 4 (NOX4) expression and promoted glutathione production. Teneligliptin pretreatment reduced H/R-induced LDH release and improved cell viability. Teneligliptin significantly relieved the reduction in mitochondrial membrane potential (MMP) induced by H/R. Moreover, teneligliptin suppressed H/R-induced cytokine production and pro...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Ovarian carcinoma biological nanotherapy: Comparison of the advantages and drawbacks of lipid, polymeric, and hybrid nanoparticles for cisplatin delivery
In this study, DDP loaded nanostructured lipid carriers (DDP-NLC), polymeric NPs (DDP-PNP), and lipid–polymer hybrid nanoparticles (DDP-LPN) were prepared for the evaluation in vitro and in vivo. The efficiency of these three kinds of the NPs was compared in terms of in vitro drug release, cellular uptake, in vitro cell growth inhibition, in vivo pharmacokinetics, biodistribution and in vivo antitumor in mice. The size of DDP-PNP (119.8 nm) was smaller than DDP-NLC (132.4 nm) and DDP-LPN (141.2 nm). The release of DDP from DDP-NLC was faster than DDP-PNP. Cellular uptake efficiency of DDP-NLC and...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Triterpenoids from fruits of Sorbus pohuashanensis inhibit acetaminophen-induced acute liver injury in mice
In this study, triterpenoids (Trds) which are mainly composed of ursolic acid and oleanolic acid, were isolated and prepared from fruits of Sorbus pohuashanensis. Further, the effect of Trds against APAP-induced liver injury and the pharmacological mechanism were investigated. The results showed that Trds treatment significantly restrained the increase of serum aspartate transaminase (AST), alanine aminotransferase (ALT), tumor necrosis factor (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6), and hepatic malondialdehyde (MDA) levels, as well as evidently reversed the decrease of hepatic superoxide d...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Baicalein stimulates fibroblast growth factor 21 expression by up-regulating retinoic acid receptor-related orphan receptor α in C2C12 myotubes
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Takao Hirai, Kohei Nomura, Rie Ikai, Ken-ichi Nakashima, Makoto InoueAbstractRetinoic acid receptor-related orphan receptor (ROR) α has been implicated in various physiological functions, including the immune system, inflammation, and circadian rhythms. In the present study, the synthetic RORα/γ agonist SR1078 stimulated the production and gene expression of fibroblast growth factor 21 (FGF21) in C2C12 myotubes. FGF21, a member of the FGF family, plays important roles in the regulation of peripheral glucose toler...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Bile acids elicited endothelium-dependent vasoconstrictor hypo-activity through TRPV4 channels in the thoracic aorta of bile duct ligation rats
In this study, we first determined that bile acids elicited endothelium-dependent vasoconstrictor hypo-activity via TRPV4 channels, which further activated cyclooxygenase 2 (COX2). Myography results demonstrated that the vascular contractile response was attenuated in BDL rats when exposed to 60 mmol/L KCl. Real time PCR and western blotting results showed that bile duct ligation (BDL) induced a time-dependent increase in TRPV4 expression levels. In addition, bile acids upregulated the expression of TRPV4 protein, which proved to be located on the cell surface of endothelial cells, and induced intracellular Ca2+ eve...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Increased expression of LINC01510 predicts poor prognosis and promotes malignant progression in human non-small cell lung cancer
This study aimed to characterize the biological role of LINC01510 in NSCLC and illuminate the molecular mechanisms. Here we found that LINC01510 was highly expressed in NSCLC tissues. Besides, Fisher’s exact test showed that high expression of LINC01510 was associated with larger tumor size, advanced TNM stage and lymph node metastasis. Kaplan-Meier survival analysis showed that patients with high LINC01510 expression had a much lower overall survival rate. Gain- and loss-of-function approaches were employed to investigate the effects of LINC01510 on NSCLC cell phenotypes. Functional studies demonstrated that LINC015...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Possible neuroprotective mechanisms of action involved in the neurobehavioral property of naringin in mice
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Benneth Ben-Azu, Ekene Enekabokom Nwoke, Adegbuyi Oladele Aderibigbe, Itivere Adrian Omogbiya, Abayomi Mayowa Ajayi, Elizabeth Toyin Olonode, Solomon Umukoro, Ezekiel O. IwalewaAbstractFlavonoids are naturally occurring bioactive phytochemical metabolites widely known to prevent and suppress several human diseases, and are important sources of therapeutic compounds from plants. Evidence derived from previous studies suggests that naringin, a neuroactive flavonoid possess functional beneficial neurobehavioral effects including anxi...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Gambogic acid induces heme oxygenase-1 through Nrf2 signaling pathway and inhibits NF-κB and MAPK activation to reduce inflammation in LPS-activated RAW264.7 cells
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Jie Ren, Lixia Li, Yue Wang, Jingchen Zhai, Guangtong Chen, Kun HuAbstractGambogic acid (GA), a natural product with a xanthone structure, was previously demonstrated to exert anti-inflammatory effects. The aim of this study was to evaluate the anti-inflammatory activity of GA on LPS-stimulated mouse macrophage RAW264.7 and its anti-inflammatory mechanism. Pretreatment with GA inhibited LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2) through reducing the expressions of inducible nitric oxide synthase (iNOS)...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Ginkgolide B enhances gemcitabine sensitivity in pancreatic cancer cell lines via inhibiting PAFR/NF-кB pathway
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Changjie Lou, Haibo Lu, Zhigang Ma, Chao Liu, Yanqiao ZhangAbstractGemcitabine resistance will occur by time after the initial response in pancreatic cancer. Ginkgolide B (GB), a major terpene lactone component of Ginkgo biloba leaves, is a highly selective and competitive inhibitor for platelet-activating factor (PAF) receptor. In the present study, we evaluated the effect of GB on gemcitabine sensitivity in pancreatic cancer cell lines in vitro and in vivo. Cell viability assay, flow cytometry, dual luciferase reporter assay and...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Combined treatment with Cinnamaldehyde and β-TCP had an additive effect on bone formation and angiogenesis in critical size calvarial defect in ovariectomized rats
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): She-Ji Weng, De-Yi Yan, Jia-Hao Tang, Zi-Jian Shen, Zong-Yi Wu, Zhong-Jie Xie, Jia-Yi Yang, Bing-Li Bai, Liang Chen, Viraj Boodhun, Lin Yang, Xiang Da (Eric) Dong, Lei YangAbstractAccumulating evidence suggests that improvements in osteogenesis and angiogenesis play an important role in repairing osteoporotic bone defects. Cinnamomum cassia (C. cassia), a traditional Chinese medicinal herb, is reported to show anabolic effects on osteoblasts. However, whether C. cassia could actually repair bone defects in osteoporotic conditions ...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Extracellular calcium influx through L-type calcium channels, intracellular calcium currents and extracellular signal-regulated kinase signaling are involved in the abscisic acid-induced precognitive and anti-anxiety effects
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Reyhaneh Naderi, Saeed Esmaeili-Mahani, Mehdi AbbasnejadAbstractAbscisic acid (ABA), a critical phytohormone, is also produced in animal tissues. It has been reported that ABA has pro-cognitive and anti-anxiety effects in rats. However, its detailed mechanism has not yet been clarified. Here, the possible roles of extracellular and intracellular calcium store and ERK signaling were evaluated in pro-cognitive and anti-anxiety effects of ABA. Morris water maze (MWM) and plus maze tests were used to evaluate the learning and memory a...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Co-administration of the low dose of orexin and nitrergic antagonists induces an antidepressant-like effect in mice
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Sahar Alijanpour, Fatemeh Khakpai, Mohaddeseh Ebrahimi-Ghiri, Mohammad-Reza ZarrindastAbstractIt is now well-established that orexins (OXs) and their receptors are involved in the pathophysiology of depression. Considering the evidence indicating the importance of nitric oxide (NO) system in the mood modulation, this study investigated the effect of intraperitoneal (i.p.) administration of orexin 1 (OX1) receptor antagonist -SB334867- alone or in combination with NO agents on depression using the forced swimming test (FST), tail s...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Up-regulation of miR-383-5p suppresses proliferation and enhances chemosensitivity in ovarian cancer cells by targeting TRIM27
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Jing Jiang, Chuanmei Xie, Yujuan Liu, Qi Shi, Yan ChenAbstractMicroRNAs are small non-coding RNAs which play important roles in tumor progression. MiR-383-5p has been characterized as a cancer suppressor in several cancers. The aim of theses present study was to explore the role of miR-383-5p in the proliferation and chemosensitivity of ovarian cancer cells. MiR-383-5p expression was down-regulated while the expression of TRIM27 was up-regulated in ovarian cancer tissues and cell lines. We came up with the hypothesis that miR-383-...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Atorvastatin alleviates early hypertensive renal damage in spontaneously hypertensive rats
This study aimed to examine the effects of atorvastatin on early hypertensive renal damage and explored the underlying mechanisms. 12-week-old salt-loaded spontaneous hypertensive rats (SHRs) were divided into four groups: atorvastatin (AVT), losartan potassium (LP), atorvastatin combined with peroxisome proliferators-activated receptor γ (PPAR-γ) inhibitor (AVT + GW9662), and saline. During 10 weeks administration blood pressure and urea albumin creatinine ratio were determined. We also examined the renal function, pathological changes of kidney, inflammatory cytokines in the serum and the associ...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Hydroalcoholic extract of Brazilian green propolis modulates inflammatory process in mice submitted to a low protein diet
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Marina Barcelos de Miranda, Mariana Ferreira Lanna, Ana Luiza Barros Nascimento, Carmen Aparecida de Paula, Marcelo Eustáquio de Souza, Mariane Felipetto, Lucíola da Silva Barcelos, Sandra Aparecida Lima de MouraAbstractThe occurrence of inflammation and protein malnutrition is an aggravating risk factor for morbidity and mortality in the clinical setting. The green propolis, a natural product made by Apis mellifera bees from Baccharis dracunculifolia resin, has therapeutic potential to modulate chronic inflammation....
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Aminophenols increase proliferation of thyroid tumor cells by inducing the transcription factor activity of estrogen receptor α
In this study, the transcription factor activity of ERα in BHP10-3 cells (a thyroid tumor cell line) was examined using luciferase assays. The promoter recruitment of ERα was examined using chromatin co-precipitation (ChIP). Additionally, in an in vivo study, BHP10-3 cells were transplanted into nude mice. Upon administration of aminophenols, the transcription factor activity of ERα was significantly increased in BHP10-3 cells, and the recruitment of ERα to the promoter of its target gene was increased. Aminophenols enhanced the in vitro and in vivo proliferation of BHP10-3 cells. By discovering tha...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Tabernaemontana catharinensis leaves effectively reduce the irritant contact dermatitis by glucocorticoid receptor-dependent pathway in mice
ConclusionThe results confirm the topical popular use ofT.catharinensis leaves in the treatment of skin inflammation and demonstrate the TcE’ potential for the development of a promising topical anti-inflammatory agent to treat inflammatory disorders.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Early administration of empagliflozin preserved heart function in cardiorenal syndrome in rat
This study tested the hypothesis that early administration of empagliflozin (Empa), an inhibitor of glucose recycling in renal tubules, could preserve heart function in cardiorenal syndrome (CRS) in rat. Chronic kidney disease (CKD) was caused by 5/6 subtotal nephrectomy and dilated cardiomyopathy (DCM) by doxorubicin (DOX) treatment. In vitro results showed that protein expressions of cleaved-caspase3 and autophagy activity at 24 h/48 h in NRK-52P cells were significantly upregulated by para-Creso treatment; these were significantly downregulated by Empa treatment. Flow cytometric analysis showed that annexi...
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Response to “Effect of monacolin K and COQ10 supplementation in hypertensive and hypercholesterolemic subjects with metabolic syndrome”
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Marilyn K. Schoenle, Stephanie L. Ballard (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 4, 2018 Category: Drugs & Pharmacology Source Type: research

Occurrence, chemical composition, biological activities and analytical methods on Copaifera genus—A review
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Caroline Arruda, Jennyfer Andrea Aldana Mejía, Victor Pena Ribeiro, Carly Henrique Gambeta Borges, Carlos Henrique Gomes Martins, Rodrigo Cássio Sola Veneziani, Sérgio Ricardo Ambrósio, Jairo Kenupp BastosAbstractCopaifera is a genus of large trees found in Brazil, mainly in Amazon forest, but also in Atlantic forest and cerrado biomes. It has also been found in other countries in South America. In Africa, it is found mainly in Congo, Cameroon, Guinea and Angola. Its oleoresin has been used in folk medi...
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Targeting gap junction in epilepsy: Perspectives and challenges
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Qin Li, Qiu-Qi Li, Ji-Ning Jia, Zhao-Qian Liu, Hong-Hao Zhou, Xiao-Yuan MaoAbstractGap junctions (GJs) are multiple cellular intercellular connections that allow ions to pass directly into the cytoplasm of neighboring cells. Electrical coupling mediated by GJs plays a role in the generation of highly synchronous electrical activity. Accumulative investigations show that GJs in the brain are involved in the generation, synchronization and maintenance of seizure events. At the same time, GJ blockers exert potent curative potential o...
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

The SUMO-specific protease family regulates cancer cell radiosensitivity
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Chenxi Hu, Xiaodong JiangAbstractAbnormalities in the small ubiquitin-related modifier (SUMO) pathway and the SUMO-specific proteases (SENPs) pathway are frequently observed in cancer. SUMOylation and deSUMOylation are dynamic processes in cells. SUMOylation of cancer-associated proteins may serve as a biomarker for cancer diagnosis and a target for cancer therapy. In recent years, an increasing number of studies have focused on the role of SENPs in the radiosensitivity of cancer cells. SENPs regulate cancer cell radiosensitivity ...
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research