Targeting expression of adenosine receptors during hypoxia induced angiogenesis – A study using zebrafish model
Publication date: March 2018 Source:Biomedicine & Pharmacotherapy, Volume 99 Author(s): Navina Panneerselvan, Malathi Ragunathan Hypoxia is known to be a major player during pathological angiogenesis and adenosine as a negative feedback signaling to maintain oxygen delivery in pathological ischemic condition. We mimicked hypoxic condition and studied angiogenesis by inducing adenosine receptors using forskolin, a plant compound and NECA analogue of adenosine using zebrafish model. Vascular endothelial growth factor (VEGF) is known to play a key role during pathological angiogenesis and regulated by the factors HIF...
Source: Biomedicine and Pharmacotherapy - January 9, 2018 Category: Drugs & Pharmacology Source Type: research

Crocin improves the proliferation and cytotoxic function of T cells in children with acute lymphoblastic leukemia
Conclusions Crocin could improve the proliferation and cytotoxic function of T cells, and reduce DNA damage caused by Ara-C. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - January 9, 2018 Category: Drugs & Pharmacology Source Type: research

Down-regulation of miR-133a/b in patients with myocardial infarction correlates with the presence of ventricular fibrillation
Publication date: March 2018 Source:Biomedicine & Pharmacotherapy, Volume 99 Author(s): Emanuela Boštjančič, Tanisa Brandner, Nina Zidar, Damjan Glavač, Dušan Štajer MicroRNAs (miRNAs) are important regulators of physiologic and pathologic conditions of the heart. Animal models of heart diseases have shown that miRNAs may contribute to the development of arrhythmias. However, little is known about the expression of muscle- and cardiac-specific miRNAs in patients with myocardial infarction (MI) who have developed ventricular fibrillation (VF). Our study included 47 patients who had died from...
Source: Biomedicine and Pharmacotherapy - January 9, 2018 Category: Drugs & Pharmacology Source Type: research

Esterification of trans-aconitic acid improves its anti-inflammatory activity in LPS-induced acute arthritis
Publication date: March 2018 Source:Biomedicine & Pharmacotherapy, Volume 99 Author(s): Diego Pinto de Oliveira, Thales do Valle Moreira, Nathália Vieira Batista, José Dias de Souza Filho, Flávio Almeida Amaral, Mauro Martins Teixeira, Rodrigo Maia de Pádua, Fernão Castro Braga trans-Aconitic acid (TAA) is an abundant constituent in the leaves of Echinodorus grandiflorus, a medicinal plant used to treat rheumatoid arthritis in Brazil. Esterification was explored as a strategy to increase lipophilicity and biopharmaceutical properties of TAA, a highly polar tricarboxylic acid. We ...
Source: Biomedicine and Pharmacotherapy - January 9, 2018 Category: Drugs & Pharmacology Source Type: research

MicroRNA-145 alleviates high glucose-induced proliferation and migration of vascular smooth muscle cells through targeting ROCK1
Publication date: March 2018 Source:Biomedicine & Pharmacotherapy, Volume 99 Author(s): Mantian Chen, Yi Zhang, Wei Li, Jieying Yang The excessive proliferation and migration of vascular smooth muscle cells (VSMCs) are important steps in atherosclerosis. The present study aimed to investigate whether the high glucose-induced changes of VSCMs are mediated by miR-145 and the potential molecular mechanism involved. We found that loss of miR-145 accompanied with increased proliferation and migration was observed in cultured human VSMCs exposed to high glucose. Exogenous overexpression of miR-145 effectively suppressed...
Source: Biomedicine and Pharmacotherapy - January 9, 2018 Category: Drugs & Pharmacology Source Type: research

Histone demethylase KDM5A inhibits glioma cells migration and invasion by down regulating ZEB1
In this study, we found that compared with primary glioma, metastasis glioma had low KDM5A levels. Besides, lower KDM5A levels were linked to poor survival in glioma cancer patients, indicating that KDM5A is a new prognostic marker for glioma cancer. KDM5A knockdown increases the invasive abilities of glioma cancer cells and changes the EMT markers. A mechanism, KDM5A suppressing the expression of ZEB1, and its catalytic activity is indispensable for anti-invasive function. Our study revealed that histone demethylase KDM5A exerts anti-invasiveness function partly through repressing oncogenic ZEB1 expression by mediating H3...
Source: Biomedicine and Pharmacotherapy - January 9, 2018 Category: Drugs & Pharmacology Source Type: research

Knockdown of TRIM37 suppresses the proliferation, migration and invasion of glioma cells through the inactivation of PI3K/Akt signaling pathway
Publication date: March 2018 Source:Biomedicine & Pharmacotherapy, Volume 99 Author(s): Shi-lei Tang, Yuan-lin Gao, Hu Wen-zhong Tripartite motif 37 (TRIM37), a member of the TRIM protein family, was involved in the tumorigenesis of several types of cancer. However, the expression pattern and role of TRIM37 in glioma remain unclear. Therefore, the aim of the present study was to investigate the role of TRIM37 in glioma, and to determine the molecular mechanisms. Our results demonstrated that TRIM37 was highly expressed in human glioma tissues and cell liens. Additionally, knockdown of TRIM37 dramatically inhibited...
Source: Biomedicine and Pharmacotherapy - January 9, 2018 Category: Drugs & Pharmacology Source Type: research

25-Hydroxyl-protopanaxatriol protects against H2O2-induced H9c2 cardiomyocytes injury via PI3K/Akt pathway and apoptotic protein down-regulation
In this study, we explored whether 25-OH-PTT plays a role in antioxidant stress injury and anti-apoptosis in cardiomyocytes. We also explored the mechanisms in order to provide a theoretical basis to develop 25-OH-PPT as a new drug for treatment of MI/RI. First, we used H2O2 to induce H9c2 cardiomyocytes in vitro resulting in an oxidative stress injury model and pretreated with 25-OH-PPT. Secondly, we examined the viability of H9c2 cells by MTT assay, the reactive oxygen species (ROS) content and mitochondrial membrane potential by flow cytometry as well as cell apoptosis by flow cytometry Annexin-FITC/PI and Hoechst 33258...
Source: Biomedicine and Pharmacotherapy - January 9, 2018 Category: Drugs & Pharmacology Source Type: research

The hypoxia-responsive long non-coding RNAs may impact on the tumor biology and subsequent management of breast cancer
Publication date: March 2018 Source:Biomedicine & Pharmacotherapy, Volume 99 Author(s): Andrea Kapinova, Peter Kubatka, Pavol Zubor, Olga Golubnitschaja, Zuzana Dankova, Sona Uramova, Ivana Pilchova, Martin Caprnda, Radka Opatrilova, Jan Richnavsky, Peter Kruzliak, Jan Danko Long non-coding RNAs (lncRNAs) are DNA transcripts longer than 200 nucleotides without protein-coding potential. As they are key regulators of gene expression at chromatic, transcriptional and posttranscriptional level, they play important role in various biological and pathological processes. Dysregulation of lncRNAs has been observed in seve...
Source: Biomedicine and Pharmacotherapy - January 9, 2018 Category: Drugs & Pharmacology Source Type: research

Antacids ’ side effect hyperuricaemia could be alleviated by long-term aerobic exercise via accelerating ATP turnover rate
Publication date: March 2018 Source:Biomedicine & Pharmacotherapy, Volume 99 Author(s): Shu Yuan, Zhong-Wei Zhang, Zi-Lin Li Hyperuricemia is the term for an abnormally high serum uric acid level. Many factors contribute to hyperuricemia, however no definite correlation between proton pump inhibitors (PPIs) and hyperuricemia has been reported before. Physical exercise also decreases serum uric acid levels. However, the detailed biochemical-regulatory mechanisms remain unknown. Here we found that adenylate deaminase activities are much higher in hyperuricemia patients than in the healthy people. Therefore, the pati...
Source: Biomedicine and Pharmacotherapy - January 9, 2018 Category: Drugs & Pharmacology Source Type: research

TINCR suppresses proliferation and invasion through regulating miR-544a/FBXW7 axis in lung cancer
Conclusion TINCR suppressed proliferation and invasion through regulating miR-544a/FBXW7 axis in lung cancer, indicating that it might be a potential target for the therapy of lung cancer. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - January 9, 2018 Category: Drugs & Pharmacology Source Type: research

Corilagin, a promising medicinal herbal agent
Publication date: March 2018 Source:Biomedicine & Pharmacotherapy, Volume 99 Author(s): Xuan Li, Yuan Deng, Zhizhong Zheng, Wen Huang, Lianghua Chen, Qingxuan Tong, Yanlin Ming Corilagin, a gallotannin, is one of the major active components of many ethnopharmacological plants. It was isolated from Caesalpinia coriaria (Jacq.) Willd. (dividivi) by Schmidt in 1951 for the first time. In the past few decades, corilagin was reported to exhibit anti-tumor, anti-inflammatory and hepatoprotective activities, etc. However, little attention was paid to its pharmacological properties due to the complicated and inefficient e...
Source: Biomedicine and Pharmacotherapy - January 9, 2018 Category: Drugs & Pharmacology Source Type: research

The promising future of ventricular restraint therapy for the management of end-stage heart failure
Publication date: March 2018 Source:Biomedicine & Pharmacotherapy, Volume 99 Author(s): Muhammad Naveed, Imran Shair Mohammad, Li Xue, Sara Khan, Wang Gang, Yanfang Cao, Yijie Cheng, Xingxing Cui, Chen DingDing, Yu Feng, Wang Zhijie, Zhou Xiaohui Complicated pathophysiological syndrome associated with irregular functioning of the heart leading to insufficient blood supply to the organs is linked to congestive heart failure (CHF) which is the leading cause of death in developed countries. Numerous factors can add to heart failure (HF) pathogenesis, including myocardial infarction (MI), genetic factors, coronary art...
Source: Biomedicine and Pharmacotherapy - January 9, 2018 Category: Drugs & Pharmacology Source Type: research

Genomic stability and telomere regulation in skeletal muscle tissue
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Larissa Alexsandra da Silva Neto Trajano, Eduardo Tavares Lima Trajano, Marco Aurélio dos Santos Silva, Ana Carolina Stumbo, Andre Luiz Mencalha, Adenilson de Souza da Fonseca Muscle injuries are common, especially in sports and cumulative trauma disorder, and their repair is influenced by free radical formation, which causes damages in lipids, proteins and DNA. Oxidative DNA damages are repaired by base excision repair and nucleotide excision repair, ensuring telomeric and genomic stability. There are few studies on ...
Source: Biomedicine and Pharmacotherapy - January 8, 2018 Category: Drugs & Pharmacology Source Type: research

Integrin alpha5beta1 suppresses rBMSCs anoikis and promotes nitric oxide production
Conclusion Transduction of rat rBMSCs with ITGA5B1 lentivirus could prevent cell anoikis and increase NO production. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - January 8, 2018 Category: Drugs & Pharmacology Source Type: research

Diversity and functional evolution of the plasminogen activator system
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Rishi Kumar Jaiswal, Akhil Kumar Varshney, Pramod Kumar Yadava The urokinase plasminogen activator system is a family of serine proteases which consists of uPA (urokinase plasminogen activator), uPAR (urokinase type plasminogen activator receptor) and PAI-1 (plasminogen activator inhibitor 1). In addition to their significant roles in activation, these proteases act as key regulators of the tumor microenvironment and are involved in the metastatic process in many cancers. High levels of uPA system proteases in many human can...
Source: Biomedicine and Pharmacotherapy - January 7, 2018 Category: Drugs & Pharmacology Source Type: research

A comprehensive review of the pharmacological potential of Crocus sativus and its bioactive apocarotenoids
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Syed Imran Bukhari, Mahreen Manzoor, M.K. Dhar Crocus sativus is an herbaceous plant that belongs to family Iridaceae. It is commonly known as saffron and has been used for medicinal purposes since many centuries in India and other parts of the world. Saffron of commercial importance comprises of dried stigmas of the plant and is rich in flavonoids, vitamins, and carotenoids. Carotenoids represent the main components of saffron and their cleavage results in the formation of apocarotenoids such as crocin, picrocrocin, and saf...
Source: Biomedicine and Pharmacotherapy - January 4, 2018 Category: Drugs & Pharmacology Source Type: research

Ghrelin prevents articular cartilage matrix destruction in human chondrocytes
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Jie liu, Lie Cao, Xueming Gao, Zhixin Chen, Shifang Guo, Zongru He, Yaowen Qian, Yongzhi Yu, Gang Wang Osteoarthritis (OA) is the most common form of arthritis worldwide. Excessive production of pro-inflammatory cytokines such as interleukin-1β (IL-1β) plays a key role in the pathogenesis of OA. OA is generally characterized by degradation of extracellular matrixes such as type II collagen and aggrecans mediated by matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (...
Source: Biomedicine and Pharmacotherapy - January 4, 2018 Category: Drugs & Pharmacology Source Type: research

Double sword role of EZH2 in leukemia
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Sahar Safaei, Behzad Baradaran, Majid Farshdousti Hagh, Mohammad Reza Alivand, Mehdi Talebi, Tohid Gharibi, Saeed Solali Enhancer of zeste homolog 2 (EZH2), the core component of the polycomb group complex, plays a major role in normal hematopoiesis. The molecular function of EZH2 is to establish H3K27me3 mark on specific genes by which promotes transcriptional repression of target genes. The activity of EZH2 affects the balance between self-renewal and differentiation of hematopoietic stem cells. In addition, EZH2 contribut...
Source: Biomedicine and Pharmacotherapy - December 29, 2017 Category: Drugs & Pharmacology Source Type: research

Haemato-protective influence of dietary fenugreek (Trigonella foenum-graecum L.) seeds is potentiated by onion (Allium cepa L.) in streptozotocin-induced diabetic rats
This study also evaluated the altered erythrocyte membrane lipid profile and beneficial countering of increased lipid peroxidation, osmotic fragility, along with reduced membrane fluidity and deformability, nitric oxide production and echinocyte formation. Dietary fenugreek seeds and onion appeared to counter the deformity and fragility of erythrocytes partially in diabetic rats by their antioxidant potential and hypocholesterolemic property. The antisickling potency of these spices was accomplished by a substantial decrease in echinocyte population and AGEs in diabetic rats. Further insight into the factors that might hav...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Central administration of coagonist of GLP-1 and glucagon receptors improves dyslipidemia
In this study, we have investigated the role of central GLP-1 receptor (GLP-1R) and glucagon receptor (GCGR) activation in regulation of lipid metabolism in cholesterol-fed hamsters. Hamsters were treated with coagonist alone (0.3 μg) or in combination with either GLP-1R antagonist (0.15 μg) or GCGR antagonist (0.3 μg) for 4 weeks by intracerebroventricular route (icv). A pair-fed control to coagonist was included in the experiment. In a separate experiment, vagotomized hamsters were treated with coagonist (0.3 μg) for four weeks. At the end of the treatment, plasma and hepatic lipids, bile homeostasis,...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Synergistic therapeutic effect of diethylstilbestrol and CX-4945 in human acute T-lymphocytic leukemia cells
In this study, we investigated the immunosuppressive and anti-proliferative effects of the synthetic estrogen diethylstilbestrol (DES), both alone and combined with the casein kinase 2 (CK2) inhibitor CX-4945. Our results indicated that DES induced caspase-dependent apoptosis in a human T-ALL cell line (Jurkat cells), while exerting no significant cytotoxicity in normal peripheral blood mononuclear cells (PBMCs). Phytohaemagglutinin and phorbol 12-myristate 13-acetate induced interleukin (IL)-2 production and activation of NF-κB signaling pathways, which were both inhibited by DES. Moreover, DES exerted synergistic e...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

CXCL16/ROCK1 signaling pathway exacerbates acute kidney injury induced by ischemia-reperfusion
In this study, we examined the role of the CXCL16/ Rho Associated Coiled-Coil Containing Protein Kinase-1 (ROCK1) signaling pathway in AKI induced by IRI. In vivo, CXCL16 was induced markedly after IRI. Mice treated with anti-CXCL16 antibody displayed less severe renal dysfunction and tubular injury in response to IRI compared with vehicle-treated mice. Inhibition of CXCL16 substantially reduced apoptotic cells and suppresses caspase-3 activation in the kidneys of mice following IRI. Additionally, CXCL16 inhibition profoundly decreased the production of TNF-α, IL-1β and IL-6 in the kidneys of mice post IRI. Furt...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Extract of Citrus maxima (pummelo) leaves improve hepatoprotective activity in Wistar rats submitted to the induction of non-alcoholic hepatic steatosis
The objective of this study was to evaluate the n vitro antioxidant potential of the CM leaves extract and on Wistar rats submitted to hepatic steatosis induction by fructose-associated hyperlipid diet (FHD). For the evaluation of in vivo effects, the animals were distributed in G1 (normal diet - ND), G2 (FHD), G3 (ND + extract 50mg/kg) and G4 (FHD + extract 50 mg/kg). All the parameters were determined through classical methodologies. The extract showed a significant antioxidant potential in vitro. In the in vivo analysis, the diet used was able to induce the development of metabolic abnormalities that favored t...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Crocin potentiates antioxidant defense system and improves oxidative damage in liver tissue in diabetic rats
Conclusion Crocin maybe a potential therapeutic candidate against diabetes-induced hepatic dysfunction by attenuating oxidative damage in the hepatic tissue. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Exogenous VEGF introduced by bioceramic composite materials promotes the restoration of bone defect in rabbits
This study aimed to investigate the effect of exogenous vascular endothelial growth factor (VEGF) introduced by bioceramic composite materials on jawbone defect. Rabbits were randomly divided into four groups: control, sham, model, and stent. In the model group, holes of jawbone defect were created through surgery. In the stent group, rabbits with jawbone defect were treated with polyether ketone (PEK)/biphasic bioceramic ((PEK-BBC)) composite materials encapsulating VEGF. At 4, 8, and 16 weeks post-operation, HE and Van Gieson staining of jawbones were performed to characterize the repair status of the bone defect. For al...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

α-asarone reduce proteinuria by restoring antioxidant enzymes activities and regulating necrosis factor κB signaling pathway in doxorubicin-induced nephrotic syndrome
In conclusion, α-asarone has an anti-nephritic effect that might be attributed to its antioxidant, hypolipidaemic and anti-inflammatory activities. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Cardioprotective effects of total flavonoids from Jinhe Yangxin prescription by activating the PI3K/Akt signaling pathway in myocardial ischemia injury
In conclusion, these observations indicated that JHTF has cardioprotective effects against MI, and these effects seem to be related to the activation of PI3K/Akt signaling pathway in the myocardium. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Knockdown of the long non-coding RNA HOTTIP inhibits colorectal cancer cell proliferation and migration and induces apoptosis by targeting SGK1
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Tianyou Liu, Tao Yu, Haiying Hu, Keping He More and more long non-coding RNA (lncRNA) might be serve as molecular biomarkers for tumor cell progression. HOTTIP has been recently revealed as oncogenic regulator in several cancers. However, it remains unclear about whether and how HOTTIP regulates Colorectal cancer (CRC). In the present study, we assayed the expression of HOTTIP in CRC tissues and cell lines, and detected CRC cells (HCT-116 and SW620) proliferation, migration, and apoptosis when HOTTIP was knocked down. Furthe...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

The protective effects of triptolide on age-related bone loss in old male rats
Conclusion These results suggested that triptolide had a protective effect on age-related bone loss at least in part by reducing osteoclast number in elder rats. Therefore, triptolide might be a feasible therapeutic approach for senile osteoporosis. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Combination of novel DR5 targeting agonistic scFv antibody TR2-3 with cisplatin shows enhanced synergistic antitumor activity in vitro and in vivo
Conclusions Our findings suggest that cisplatin enhanced the antitumor activity of TR2-3 in COLO205 and MDA-MB-231 cancer cells through up-regulation of DR5 expression. The TR2-3 combined with cisplatin may be a promising treatment for cancer therapy. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Overexpression of ING5 inhibits HGF-induced proliferation, invasion and EMT in thyroid cancer cells via regulation of the c-Met/PI3K/Akt signaling pathway
In this study, we found that the expression of ING5 was significantly down-regulated in human thyroid cancer tissues and cell lines. In addition, overexpression of ING5 markedly inhibited hepatocyte growth factor (HGF)-induced proliferation, invasion and epithelial-mesenchymal transition (EMT) of thyroid cancer cells as well as suppressed the tumor growth and metastasis in vivo. Furthermore, our data showed that the c-Met/PI3K/Akt signaling pathway was responsible for the inhibitory effect of ING5 on the thyroid cancer. Taken together, these findings provided an essential basis for the tumor-suppression role of ING5 in thy...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Autophagy enhanced antitumor effect in K562 and K562/ADM cells using realgar transforming solution
In conclusion, our findings demonstrated that RTS could serve as a promising arsenic candidate for anti-CML/MDR-CML by inducing apoptosis and autophagy and is more potent than ATO and realgar. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Ameliorative effect of pumpkin seed oil against emamectin induced toxicity in mice
In conclusion, pumpkin seed oil has valuable value in ameliorating the toxic insult produced by emamectin in mice. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Peanut testa extracts possessing histone deacetylase inhibitory activity induce apoptosis in cholangiocarcinoma cells
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Somprasong Saenglee, Gulsiri Senawong, Sanun Jogloy, Banchob Sripa, Thanaset Senawong Previous studies demonstrated that peanut testa extracts (KK4 and ICG15042) containing natural histone deacetylase (HDAC) inhibitors inhibited the growth of several human cancer cell lines via apoptosis induction. The aims of this study were to investigate the anti-proliferative effects and the mechanism(s) responsible for apoptosis induction mediated by these peanut testa extracts in human cholangiocarcinoma cell lines (KKU-M214 and KKU-10...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

STAT3 aggravates TGF- β1-induced hepatic epithelial-to-mesenchymal transition and migration
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Bin Wang, Ting Liu, Jun-Cheng Wu, Sheng-Zheng Luo, Rong Chen, Lun-Gen Lu, Ming-Yi Xu Signal transducer and activator of transcription 3 (STAT3) has been shown to affect epithelial-to-mesenchymal transition (EMT) in cancers. We investigated the underlying molecular mechanisms of STAT3 crosstalk with Snail-Smad3/transforming growth factor (TGF)-β1 signaling pathways during the EMT in hepatocellular carcinoma (HCC). STAT3 and TGF-β1 expressions are examined in liver tissues of HCC patients and rats. The effect of IL-6...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Potential effect of spermidine on GABA, dopamine, acetylcholinesterase, oxidative stress and proinflammatory cytokines to diminish ketamine-induced psychotic symptoms in rats
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Monu Yadav, Milind Parle, Deepak Kumar Jindal, Nidhi Sharma Ketamine, N-methyl-d-aspartate receptor antagonist has been implanted in such behavioural and biochemical alterations in animals similar to human psychosis. Spermidine, a biogenic polyamine, involved in various cellular functions in living organisms, on the contrary possess NMDA receptor agonistic effect. Therefore, we aimed to study the effect of spermidine (10 and 20 mg/kg, i.p.) in ketamine (50 mg/kg, i.p.) induced psychotic symptoms using various behavioural...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

UBE2C is involved in the functions of ECRG4 on esophageal squamous cell carcinoma
Conclusions ECRG4 down-regulated UBE2C expression in ESCC cells via NF-κB signaling. UBE2C was involved in the anti-proliferative and pro-apoptotic functions of ECRG4 in ESCC cells. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Osteoporosis is associated with metabolic syndrome induced by high-carbohydrate high-fat diet in a rat model
In conclusion, HCHF diet-induced MetS can cause adverse effects on the bone. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Protective effect of Coptisine from Rhizoma Coptidis on LPS/D-GalN-induced acute liver failure in mice through up-regulating expression of miR-122
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Fang-Ni Chai, Jiang Zhang, Hong-Mei Xiang, He-Shan Xu, Yuan-Feng Li, Wen-Yu Ma, Xue-Gang Li, Xiao-Li Ye Coptisine (COP), one of the main active ingredients of Rhizoma Coptidis, reportedly has anti-inflammatory, anti-colon cancer properties, but it remains elusive whether COP owns hepatoprotective activity. Mice were pretreated with COP for 7d prior to lipopolysaccharide/d-galactosamine (LPS/D-GalN) administration to detect the hepatic protective effects of COP. The mechanism was explored in using HepG2 cells with low level o...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Glucose-dependent growth arrest of leukemia cells by MCT1 inhibition: Feeding Warburg ’s sweet tooth and blocking acid export as an anticancer strategy
This study aims to investigate the utilization of The Warburg Effect, cancer’s “sweet tooth” and natural greed for glucose to enhance the effect of monocarboxylate transporter inhibition on cellular acidification. By simulating hyperglycemia with high glucose we may increase the effectiveness of inhibition of lactate and proton export on the dysregulation of cell pH homeostasis causing cell death or disruption of growth in cancer cells. MCT1 and MCT4 expression was determined in MCF7 and K562 cell lines using RT-PCR. Cell viability, growth, intracellular pH and cell cycle analysis was measured in the cell...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

The role of MCM5 expression in cervical cancer: Correlation with progression and prognosis
In conclusion, MCM5 is associated with the malignant status and poor prognosis in cervical adenocarcinoma patients, and modulates cervical adenocarcinoma cells proliferation. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Synthesis, characterization and inhibitory effects of crocetin derivative compounds in cancer and inflammation
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Yang Chu, Jin Gao, Jie Niu, Yan-Fen Huang, Ming Chen, Mao-Ze Wang, Qiang Shang, Wen-Qi Lu, Li-Hua Peng, Zhi-Hong Jiang Crocetin is a natural product possessing extraordinary therapeutic effects for various diseases. However, its extremely low solubility limits its application greatly. Conjugation of organic compounds containing heteroatoms such as N to poor soluble molecules can help the synthesized derivative to form stable hydrogen bonds by lowering the salvation energy, which will improve the solubility of the synthesized...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Metformin treatment decreases nitroxidative stress, restores nitric oxide bioavailability and endothelial function beyond glucose control
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Takehiko Sambe, R. Preston Mason, Hazem Dawoud, Deepak L. Bhatt, Tadeusz Malinski Reduction of nitric oxide (NO), a potent vasodilator, and an increase in cytotoxic peroxynitrite (ONOO−) may be associated with the uncoupling of NO synthase (eNOS) and endothelial cell (EC) dysfunction. In addition to its effect on glucose control, metformin, may also directly benefit in the restoration of the function of eNOS and EC. Obese Zucker rats were administered vehicle or 300 mg/kg/day metformin for 4 weeks. NO concentration [...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Diminazene aceturate alleviated lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Pu Ge, Xin Yao, Jing Li, Rong Jiang, Jie Dai, Li Zhang Diminazene aceturate (DIZE) has been widely used as an antiprotozoal agent, but recent studies have revealed its anti-inflammatory activities. In the present study, the potential effects of DIZE on lethal inflammatory disorder were investigated in a mouse model with lipopolysaccharide (LPS)/D-galactosamine (D-Gal)-induced fulminant hepatitis. The results indicated that treatment with DIZE suppressed LPS/D-Gal-induced elevation of plasma alanine aminotransferase (ALT) and...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Artemisia capillaris extract AC68 induces apoptosis of hepatocellular carcinoma by blocking the PI3K/AKT pathway
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Honghua Yan, Kyung Hee Jung, Juyoung Kim, Marufa Rumman, Myung Sook Oh, Soon-Sun Hong Artemisia capillaris Thunberg (AC) has been widely used to treat various diseases including hepatitis and is known to affect many cellular events such as cell proliferation and apoptosis. Herein a potent ethyl acetate fraction (AC68) was newly extracted from AC, and was assessed for its anti-cancer efficacy in progression and growth of hepatocellular carcinoma (HCC). AC68 dose-dependently inhibited the growth and proliferation of two HCC ce...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Polyphenol-rich ethyl acetate fraction isolated from Molineria latifolia ameliorates insulin resistance in experimental diabetic rats via IRS1/AKT activation
This study aimed to evaluate the effect of ethyl acetate fraction (EAF) isolated from Molineria latifolia rhizome as dietary interventions for type 2 diabetes mellitus (T2DM) and its underlying molecular mechanisms in vivo. Experimental rats were induced by high fat diet feeding coupled with combined exposure to streptozotocin and nicotinamide. Treatment with EAF improved glucose tolerance and lipid profiles, but the insulin secretion was unaltered. Gene expression analyses on insulin/adipocytokine signalling-related genes demonstrated tissue-specific transcriptional responses. In skeletal muscle and liver tissues, Socs1, ...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Blood-brain barrier permeability and neuroprotective effects of three main alkaloids from the fruits of Euodia rutaecarpa with MDCK-pHaMDR cell monolayer and PC12 cell line
This study predicted the permeability of EDM, RCP and DEDM through BBB and discovered the neuroprotective substance basis of EF as a potential encephalopathy drug. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

TNF-related apoptosis-inducing ligand (TRAIL) as the potential therapeutic target in hematological malignancies
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Adel Naimi, Ali Akbar Movassaghpour, Majid Farshdousti Hagh, Mehdi Talebi, Atefeh Entezari, Farhad Jadidi-Niaragh, Saeed Solali Despite numerous attempts to find the treatment strategies that can selectively target the cancer cells, cancer still remains a major public health problem. Conventional cancer treatments such as chemo- and radio-therapies are associated with systemic toxicity and the risk of recurrence. Additionally, acquired or pre-existing resistance is the main problem of most therapies. TNF-related apoptosis-in...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research

Breast cancer: Lesser-known facets and hypotheses
Publication date: February 2018 Source:Biomedicine & Pharmacotherapy, Volume 98 Author(s): Seema Patel Breast cancer is the most common cancer in females. The deteriorating environment, and lifestyle flaws are raising the frequency of this cancer. Existing therapies are not universally-effective, and they cause side effects, relapses, and high mortality rate. Alternative medications may be milder, but are less effective or are inadequate for a complex disease like the breast cancer. So, it requires the understanding that drugs are not the solution of this cancer, but prevention is the sustainable solution. In the ...
Source: Biomedicine and Pharmacotherapy - December 27, 2017 Category: Drugs & Pharmacology Source Type: research