MiRNA-34a reversed TGF- β-induced epithelial-mesenchymal transition via suppression of SMAD4 in NPC cells
In this study, we found that transforming growth factor-β (TGF-β), which reportedly promotes EMT in multiple cancers, can trigger EMT and increase the invasive and migratory capacities of NPC cells. Conversely, the downregulation of SMAD4, a vital member of the canonical TGF-β pathway, reversed the TGF-β-induced EMT, invasion, and migration. Further experiments revealed that SMAD4 was the target of miRNA-34a, which was downregulated in NPC tissues and suppressed NPC cell metastasis in vivo. miRNA-34a overexpression also antagonized the TGF-β-induced EMT progression, invasion, and migration through ...
Source: Biomedicine and Pharmacotherapy - June 29, 2018 Category: Drugs & Pharmacology Source Type: research

Application of sesquiterpene lactone: A new promising way for cancer therapy based on anticancer activity
Publication date: October 2018 Source:Biomedicine & Pharmacotherapy, Volume 106 Author(s): Ghader babaei, Azadeh Aliarab, Sina Abroon, Yusof Rasmi, Shiva Gholizadeh- Ghaleh Aziz Cancer is one of the most dangerous diseases that are rapidly increasing globally. After heart disease, it is the second leading cause of death, accounting for seven million deaths each year. Chemotherapy is the use of cytotoxic drugs on cancer cells. But the use of common chemotherapy drugs poses a problem due their high side effects and low efficacy. As a result, efforts are on to find new potent compounds with low side effects. The comp...
Source: Biomedicine and Pharmacotherapy - June 29, 2018 Category: Drugs & Pharmacology Source Type: research

Dexmedetomidine protects against lipopolysaccharide-induced sepsis-associated acute kidney injury via an α7 nAChR-dependent pathway
Publication date: October 2018 Source:Biomedicine & Pharmacotherapy, Volume 106 Author(s): Kai Kang, Yang Gao, Si-Cong Wang, Hai-Tao Liu, Wei-Lan Kong, Xing Zhang, Rui Huang, Zhi-Dong Qi, Jun-Bo Zheng, Jing-Dong Qu, Rui-Jin Liu, Yan-Song Liu, Hong-Liang Wang, Kai-Jiang Yu Acute kidney injury (AKI) is a clinical syndrome that results in severe tubular damage with high morbidity and mortality. However, there is a lack of effective therapy strategies. Therefore, it is critical to develop effective drugs for AKI. Dexmedetomidine (DEX), a highly selective α2-adrenoreceptor agonist, has neuroprotective, anti-infla...
Source: Biomedicine and Pharmacotherapy - June 28, 2018 Category: Drugs & Pharmacology Source Type: research

ROS mediated ER stress induces Bax-Bak dependent and independent apoptosis in response to Thioridazine
Publication date: October 2018 Source:Biomedicine & Pharmacotherapy, Volume 106 Author(s): Mahendra Seervi, Ankita Rani, Abhay K. Sharma, T.R. Santhosh Kumar A dopamine receptor antagonist, Thioridazine (TDZ) is known for its cytotoxic activity against various cancers and its role in combinational chemotherapy is being actively investigated. Several molecular targets of TDZ have been studied to delineate its anticancer activities, with contrasting findings in different cancer types. Moreover, the underlying mechanism of cell death from TDZ treatment is not well defined. In the current study, we studied TDZ mediate...
Source: Biomedicine and Pharmacotherapy - June 28, 2018 Category: Drugs & Pharmacology Source Type: research

Aucubin protects against lipopolysaccharide-induced acute pulmonary injury through regulating Nrf2 and AMPK pathways
Publication date: October 2018 Source:Biomedicine & Pharmacotherapy, Volume 106 Author(s): Yan-Ling Qiu, Xiao-Ning Cheng, Feng Bai, Li-Yun Fang, Hui-Zhong Hu, Da-Qing Sun Aucubin (Ai), a natural compound isolated from plants, including Aucuba japonica and Eucommia ulmoides, shows significant anti-inflammatory and anti-oxidative bioactivities. Here, we attempted to explore the protect effects of Ai on LPS-induced acute lung injury (ALI). Our results indicated that Ai increased the survival rate and ameliorated pathogenic processes in lipopolysaccharide (LPS)-induced mice. However, nuclear factor erythroid 2-related...
Source: Biomedicine and Pharmacotherapy - June 28, 2018 Category: Drugs & Pharmacology Source Type: research

Lavatera critica controls systemic insulin resistance by ameliorating adipose tissue inflammation and oxidative stress using bioactive compounds identified by GC –MS
Conclusions These findings prove that LCE improves the insulin-sensitizing activity in the mouse model of HGFD-caused IR, probably due to the amelioration of adipose tissue inflammation and oxidative damage. Hence, the LCE could serve as a useful anti-diabetic agent. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - June 28, 2018 Category: Drugs & Pharmacology Source Type: research

Oridonin enhances the cytotoxicity of 5-FU in renal carcinoma cells by inducting necroptotic death
Conclusion Oridonin enhances the cytotoxicity of 5-FU in renal cancer cells partially through inducing necroptosis, providing evidence of using necroptosis inducers in combination with chemotherapeutic agents for cancer treatment. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - June 28, 2018 Category: Drugs & Pharmacology Source Type: research

Long noncoding RNA HOXD-AS1 promotes non-small cell lung cancer migration and invasion through regulating miR-133b/MMP9 axis
Publication date: October 2018 Source:Biomedicine & Pharmacotherapy, Volume 106 Author(s): Huan Xia, Hongyu Jing, Yang Li, Xiaohong Lv HOXD antisense growth associated long noncoding RNA (HOXD-AS1) was reported to be dysregulated and exert crucial roles in tumorigenesis and progression of multiple malignancies. However, the role and mechanism of action of HOXD-AS1 in the carcinogenesis and progression of non-small lung cell cancers (NSCLC) remains largely unknown. HOXD-AS1, miR-133a and Matrix metallopeptidase 9 (MMP-9) mRNA expression were detected by quantitative real-time polymerase chain reaction assays in NSC...
Source: Biomedicine and Pharmacotherapy - June 28, 2018 Category: Drugs & Pharmacology Source Type: research

1,25(OH)2D3 promotes chondrocyte apoptosis and restores physical function in rheumatoid arthritis through the NF- κB signal pathway
Publication date: October 2018 Source:Biomedicine & Pharmacotherapy, Volume 106 Author(s): Run Tian, Xiaofang Li, Yue Li, Kunzheng Wang, Chunsheng Wang, Pei Yang We explored the modulatory effect of 1,25(OH)2D3 on chondrocytes and physical function in rats with RA and its mechanism underlying the regulation of NF-κB signal pathway. RA patients and healthy volunteers were selected. Sprague-Dawley (SD) rats were used to establish RA models. The paw volume of rats was estimated. Chondrocytes were isolated from RA rats. The protein levels in both cartilage tissues and chondrocytes were determined using western b...
Source: Biomedicine and Pharmacotherapy - June 28, 2018 Category: Drugs & Pharmacology Source Type: research

Antioxidant and anti-inflammatory properties of marmelosin from Bael (Aegle marmelos L.); Inhibition of TNF- α mediated inflammatory/tumor markers
Publication date: October 2018 Source:Biomedicine & Pharmacotherapy, Volume 106 Author(s): Hasitha Pynam, Shylaja M. Dharmesh Oxidative stress and inflammation are important critical factors that are implicated in almost all life style disorders such as diabetes, cardiovascular disease, ulcer and cancer. Current study aimed at isolation and characterization of a furanocoumarin from Bael (Aegle marmelos L.) fruit that can modulate both oxidative stress and inflammation effectively. Ethyl acetate extract of Bael fruit (EAFB) was subjected to HPLC for identification, purified and characterized using FTIR, NMR and ESI...
Source: Biomedicine and Pharmacotherapy - June 28, 2018 Category: Drugs & Pharmacology Source Type: research

Endometriosis: Perspective, lights, and shadows of etiology
Publication date: October 2018 Source:Biomedicine & Pharmacotherapy, Volume 106 Author(s): Samira Asghari, Amir Valizadeh, Leili Aghebati-Maleki, Mohammad Nouri, Mehdi Yousefi Endometriosis refers to the growth of ectopic endometrial tissue outside the uterine cavity. About 10–15% of female in reproductive age suffer from endometriosis. Several etiologies – such as oxidative stress, inflammatory factors and cytokines, genetic etiology, and hormone role – have been reported for endometriosis. Indeed, oxidative stress leads to abnormalities by the production of ROS and RNS. The mechanism of endomet...
Source: Biomedicine and Pharmacotherapy - June 28, 2018 Category: Drugs & Pharmacology Source Type: research

Long non-coding RNA FEZF1-AS1 promotes cell invasion and epithelial-mesenchymal transition through JAK2/STAT3 signaling pathway in human hepatocellular carcinoma
In conclusion, the present study for the first time demonstrated that FEZF1-AS1 serves as an oncogenic lncRNA in human HCC and implicated FEZF1-AS1 as a valuable therapeutic target for HCC treatment. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - June 27, 2018 Category: Drugs & Pharmacology Source Type: research

Magnesium isoglycyrrhizinate ameliorates liver fibrosis and hepatic stellate cell activation by regulating ferroptosis signaling pathway
Publication date: October 2018 Source:Biomedicine & Pharmacotherapy, Volume 106 Author(s): Miao Sui, Xiaofei Jiang, Jun Chen, Haiyan Yang, Yan Zhu Ferroptosis is recently reported as a new mode of regulated cell death. It is triggered by disturbed redox homeostasis, overloaded iron and increased lipid peroxidation. Howerver, the role of ferroptosis in hepatic fibrosis remains obscure. In the current study, we attempted to investigate the effect of Magnesium isoglycyrrhizinate (MgIG) on ferroptosis in liver fibrosis, and to further clarify the possible mechanisms. Our data showed that MgIG treatment markedly attenu...
Source: Biomedicine and Pharmacotherapy - June 27, 2018 Category: Drugs & Pharmacology Source Type: research

Matrine inhibits hypoxia/reoxygenation-induced apoptosis of cardiac microvascular endothelial cells in rats via the JAK2/STAT3 signaling pathway
Publication date: October 2018 Source:Biomedicine & Pharmacotherapy, Volume 106 Author(s): Xue-Bin Zhao, Yi Qin, Yu-Ling Niu, Jun Yang Hypoxia/reoxygenation (H/R) often results in cellular oxidative stress and the subsequent apoptosis of cardiac microvascular endothelial cells (CMECs). More recently, studies have highlighted the therapeutic effects of matrine on various cardiovascular diseases. Thus, the aim of the present study was to investigate the underlying mechanism and effects of matrine on hypoxia/reoxygenation (H/R)-induced apoptosis of CMECs in rats. CMECs from Sprague Dawley (SD) rats were primarily tre...
Source: Biomedicine and Pharmacotherapy - June 27, 2018 Category: Drugs & Pharmacology Source Type: research

Sirtuin 6 inhibits colon cancer progression by modulating PTEN/AKT signaling
In conclusion, the present study confirms that SIRT6 functions as a tumor suppressor gene in colon cancer by modulating PTEN/AKT signaling, which may provide a novel target for the treatment of colon cancer. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - June 27, 2018 Category: Drugs & Pharmacology Source Type: research

Neuroprotective effect of 1-Deoxynojirimycin on cognitive impairment, β-amyloid deposition, and neuroinflammation in the SAMP8 mice
Publication date: October 2018 Source:Biomedicine & Pharmacotherapy, Volume 106 Author(s): Weike Chen, Tingting Liang, Wenwen Zuo, Xin Wu, Zibo Shen, Fang Wang, Cunyu Li, Yunfeng Zheng, Guoping Peng β-amyloid deposition and neuroinflammation play a crucial part in Alzheimer’s disease. Therefore, this study was designed to find the effects of 1-deoxynojirimycin (DNJ) purified from mulberry leaves on pathological deposition of Aβ peptides and neuroinflammation in senescence-accelerated-prone mouse 8 (SAMP8) mice. Compared to senescence-accelerated-resistant mouse 1 (SAMR1) mice, SAMP8 mice exhibited ...
Source: Biomedicine and Pharmacotherapy - June 27, 2018 Category: Drugs & Pharmacology Source Type: research

The inhibition of Hippo/Yap signaling pathway is required for magnesium isoglycyrrhizinate to ameliorate hepatic stellate cell inflammation and activation
This study was to investigate the effect of Magnesium isoglycyrrhizinate (MgIG) on liver fibrosis and inflammation, and to further clarify molecular mechanism. We found that MgIG treatment significantly alleviated carbon tetrachloride (CCl4)-induced liver fibrosis and HSC activation by regulating TGF-β signaling and MMP/TIMP systems. In addition, MgIG treatment significantly inhibited the inflammatory response of liver fibrosis in mice characterized by reduced pro-inflammatory factors expression and increased anti-inflammatory factors expression. Interestingly, experiments in vitro also showed that MgIG treatment sign...
Source: Biomedicine and Pharmacotherapy - June 27, 2018 Category: Drugs & Pharmacology Source Type: research

Valproic acid attenuates A β25-35-induced neurotoxicity in PC12 cells through suppression of mitochondria-mediated apoptotic pathway
In conclusion, our results suggested that VPA might serve as a novel protective agent against Aβ25–35-induced cytotoxicity in AD. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - June 27, 2018 Category: Drugs & Pharmacology Source Type: research

Fatty acid binding protein 5 promotes tumor angiogenesis and activates the IL6/STAT3/VEGFA pathway in hepatocellular carcinoma
Conclusion FABP5 was shown to promote angiogenesis and activate the IL6/STAT3/VEGFA pathway in HCC. FABP5 may be a potential antiangiogenic target in the treatment of HCC. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - June 27, 2018 Category: Drugs & Pharmacology Source Type: research

Long non-coding RNA PVT1 promotes cell proliferation and invasion through regulating miR-133a in ovarian cancer
Publication date: October 2018 Source:Biomedicine & Pharmacotherapy, Volume 106 Author(s): Qi Yang, Yang Yu, Ziqian Sun, Yuan Pan The long non-coding RNA, plasmacytoma variant translocation 1 (PVT1), was reportedly to be highly expressed in a variety of tumors including ovarian cancer (OC). However, the role and mechanism of action of PVT1 in the carcinogenesis and progression of OC remains largely unknown. PVT1 and miR-133a expression were detected by quantitative real time PCR(qRT-PCR) assays in OC tissues and cell lines. Cell Counting Kit-8 (CCK-8), flow cytometer, wound healing and transwell invasion assays we...
Source: Biomedicine and Pharmacotherapy - June 27, 2018 Category: Drugs & Pharmacology Source Type: research

The unique DEK oncoprotein in women ’s health: A potential novel biomarker
Publication date: October 2018 Source:Biomedicine & Pharmacotherapy, Volume 106 Author(s): Ana Cecília de Albuquerque Oliveira, Ferdinand Kappes, Danyelly Bruneska Gondim Martins, José Luiz de Lima Filho Breast and cervical cancer are the first and fourth cancer types with the highest prevalence in women, respectively. The developmental profiles of cancer in women can vary by genetic markers and cellular events. In turn, age and lifestyle influence in the cellular response and also on the cancer progression and relapse. The human DEK protein, a histone chaperone, belongs to a specific subclass of chr...
Source: Biomedicine and Pharmacotherapy - June 27, 2018 Category: Drugs & Pharmacology Source Type: research

The intervention effect of zuogui pill on chronic kidney disease-mineral and bone disorder regulatory factor
Publication date: October 2018 Source:Biomedicine & Pharmacotherapy, Volume 106 Author(s): Xiaohong Ma, Liqun He Chronic kidney disease-mineral and bone disorder (CKD-MBD) play a critical role in the pathogenesis of cardiovascular complications in patients with chronic kidney disease (CKD). Zuogui pill as a traditional Chinese herbal drug has been used for nourish kidney essence improve bone malnutrition of renal bone disease by regulating the metabolism of calcium and phosphorus and participating in osteoblast metabolism. In the present study, 5/6 nephrectomy rat model was used to reveal the mechanism of zuogui p...
Source: Biomedicine and Pharmacotherapy - June 24, 2018 Category: Drugs & Pharmacology Source Type: research

Antitumor and immune-modulatory efficacy of dual-treatment based on levamisole and/or taurine in Ehrlich ascites carcinoma-bearing mice
In conclusion, dual-treatments based on Lms and/or Tau are promising therapies for cancer, not only due to its abilities to induce apoptosis in the tumor cells and modulate the immune response against them, but also due to its capabilities to potentiate the chemotherapy anticancer efficacy and minimize its adverse effects. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - June 24, 2018 Category: Drugs & Pharmacology Source Type: research

The down-regulation of microRNA-137 contributes to the up-regulation of retinoblastoma cell proliferation and invasion by regulating COX-2/PGE2 signaling
In this study, we aimed to investigate the functional significance and molecular mechanisms of miR-137 in RB. We reported that miR-137 was frequently down-regulated in RB tissues and cell lines. The overexpression of miR-137 inhibited RB cell proliferation and invasion, while the suppression of miR-137 promoted RB cell proliferation and invasion. Bioinformatic analysis predicted that cyclooxygenase-2 (COX-2) was a potential target gene of miR-137, which was validated by a dual-luciferase reporter assay. Moreover, our results showed that miR-137 negatively regulated the expression of COX-2 and the production of prostaglandi...
Source: Biomedicine and Pharmacotherapy - June 24, 2018 Category: Drugs & Pharmacology Source Type: research

Signification of protein p-53 isoforms and immune therapeutic success in chronic lymphocytic leukemia
Publication date: October 2018 Source:Biomedicine & Pharmacotherapy, Volume 106 Author(s): Aurelian Udristioiu, Delia Nica-Badea In the past few years has used thetechnique for analyzing deletions of genes, its rearrangements, cross-reactivity or multiplications in human genome affected of genetic diseases. Was proved that, the best techniques in the investigation of malignant lymphocytes are the Flow Cytometry, Elisa, ICT and Fluorescence in situ hybridization (FISH). Last method, FISH is used as an alternative to chromosomal banding, a conventional application in molecular medicine and can detect the chromosomal...
Source: Biomedicine and Pharmacotherapy - June 24, 2018 Category: Drugs & Pharmacology Source Type: research

Scutellaria: Debates on the anticancer property
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Samira EghbaliFeriz, Akram Taleghani, Zahra Tayarani-Najaran The widespread use of plants as accessible anticancer agents leads to the identification of many natural source chemotherapeutic agents. Scutellaria one of the popular genus of flowering plants has been used for various human illnesses for thousands of years. Scutellaria has anti-metastatic, anti-proliferative, anti-invasion, anti-angiogenic and apoptosis effects in vitro as well as in vivo. Despite numerous reports on the cytotoxic-antitumor activity of the plan...
Source: Biomedicine and Pharmacotherapy - June 23, 2018 Category: Drugs & Pharmacology Source Type: research

Imidazole bearing chalcones as a new class of monoamine oxidase inhibitors
Publication date: October 2018 Source:Biomedicine & Pharmacotherapy, Volume 106 Author(s): Rani Sasidharan, Seung Cheol Baek, Manju Sreedharannair Leelabaiamma, Hoon Kim, Mathew Bijo In the present study, series of eleven (2E)-1-[4-(1H-imidazol-1-yl)substituted phenyl]-3-phenylprop-2-en-1-one (IM1–IM11) derivatives were synthesized and evaluated as inhibitors of recombinant human monoamine oxidase (MAO) A and B. The results indicate that (2E)-3-[4-(dimethylamino) phenyl]-1-[4-(1H-imidazol-1-yl) phenyl] prop-2-en-1-one (IM5) is a nonselective and reversible competitive inhibitor of MAO-A and MAO-B with IC50 v...
Source: Biomedicine and Pharmacotherapy - June 23, 2018 Category: Drugs & Pharmacology Source Type: research

CPT1A regulates breast cancer-associated lymphangiogenesis via VEGF signaling
Conclusions In present study, we revealed the mechanism by which CPT1A regulates breast cancer-associated invasion and lymphangiogenesis. Our findings provide insights into CPT1A -promoted breast tumor metastasis and provide rationale for understanding breast cancer metastasis. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - June 23, 2018 Category: Drugs & Pharmacology Source Type: research

Clinical and molecular aspects of breast cancer: Targets and therapies
Publication date: October 2018 Source:Biomedicine & Pharmacotherapy, Volume 106 Author(s): R.L.N. Godone, G.M. Leitão, N.B. Araújo, C.H.M. Castelletti, J.L. Lima-Filho, D.B.G. Martins Breast Cancer is a complex disease characterized by the occurrence of multiple molecular alterations. Currently, some molecular markers are in use for breast cancer diagnostic, prognostic, and predictive purposes. Thus, genetic signatures are available for improving the decision-making. The biomarkers are also essential as therapeutic approaches, but many questions remain due to the lack of efficacy on breast cancer tre...
Source: Biomedicine and Pharmacotherapy - June 23, 2018 Category: Drugs & Pharmacology Source Type: research

Neurobiology and consequences of social isolation stress in animal model —A comprehensive review
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Faiza Mumtaz, Muhammad Imran Khan, Muhammad Zubair, Ahmad Reza Dehpour The brain is a vital organ, susceptible to alterations under genetic influences and environmental experiences. Social isolation (SI) acts as a stressor which results in alterations in reactivity to stress, social behavior, function of neurochemical and neuroendocrine system, physiological, anatomical and behavioral changes in both animal and humans. During early stages of life, acute or chronic SIS has been proposed to show signs and symptoms of psychia...
Source: Biomedicine and Pharmacotherapy - June 22, 2018 Category: Drugs & Pharmacology Source Type: research

Erythropoietin: A potential drug in the management of diabetic neuropathy
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Samuel Suarez-Mendez, Carlos Alfonso Tovilla-Zárate, Isela E. Juárez-Rojop, Deysi Y. Bermúdez-Ocaña Erythropoietin (EPO) is required for promoting the progress of erythroid differentiation. However, the discovery of EPO and the EPO receptor (EPOR) in the nervous system may contribute to new treatment strategies for the use of EPO in neurodegenerative disorders. Diabetic neuropathy is a neurodegenerative disease that affects a large proportion of diabetic patients and results in alterations in fu...
Source: Biomedicine and Pharmacotherapy - June 19, 2018 Category: Drugs & Pharmacology Source Type: research

The effects of DMARDs on the expression and function of P-gp, MRPs, BCRP in the treatment of autoimmune diseases
This article reviews the effects of DMARDs on the expression and function of P-gp, MRPs, and BCRP and the related molecular mechanism in the treatment of AID. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - June 18, 2018 Category: Drugs & Pharmacology Source Type: research

Efficacy and safety of immunological adjuvants. Where is the cut-off?
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Alexander Batista-Duharte, Damiana Téllez Martínez, Iracilda Zeppone Carlos Research over the past several decades has provided insight into the mode of action of adjuvants. However, the main focus of attention has been the efficacy in the induction of protective immunogenicity, while less effort has been devoted to the study of toxicity mechanisms. Evidences suggest that several mechanisms that are responsible for the immunostimulating effects are, at the same time, responsible of the adverse effects. In thi...
Source: Biomedicine and Pharmacotherapy - June 10, 2018 Category: Drugs & Pharmacology Source Type: research

A short view on nanohydroxyapatite as coating of dental implants
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Javad Yazdani, Elham Ahmadian, Simin Sharifi, Shahriar Shahi, Solmaz Maleki Dizaj Introduction Titanium based (Ti-based) materials have been used as dental implants due to their high biocompatibility, good mechanical strength and ideal osseointegration properties. Osseointegration of an implant is dependent on surface characteristics such as surface chemistry and topography. Nanotechnology has presented new and interesting applications in dentistry in recent years. The presence of nanoparticles on the implant surface can a...
Source: Biomedicine and Pharmacotherapy - June 8, 2018 Category: Drugs & Pharmacology Source Type: research

Cathepsins: Proteases that are vital for survival but can also be fatal
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Seema Patel, Ahmad Homaei, Hesham R. El-Seedi, Nadeem Akhtar The state of enzymes in the human body determines the normal physiology or pathology, so all the six classes of enzymes are crucial. Proteases, the hydrolases, can be of several types based on the nucleophilic amino acid or the metal cofactor needed for their activity. Cathepsins are proteases with serine, cysteine, or aspartic acid residues as the nucleophiles, which are vital for digestion, coagulation, immune response, adipogenesis, hormone liberation, peptide...
Source: Biomedicine and Pharmacotherapy - June 6, 2018 Category: Drugs & Pharmacology Source Type: research

Treatment targets for M2 microglia polarization in ischemic stroke
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Ji wang, Hongyi xing, Lin wan, Xingjun jiang, Chen wang, Yan wu As the first line of defense in the nervous system, resident microglia are the predominant immune cells in the brain. In diseases of the central nervous system such as stroke, Alzheimer’s disease, and Parkinson’s disease, they often cause inflammation or phagocytosis; however, some studies have found that despite the current controversy over M1, M2 polarization could be beneficial. Ischemic stroke is the third most common cause of death in humans. ...
Source: Biomedicine and Pharmacotherapy - June 6, 2018 Category: Drugs & Pharmacology Source Type: research

Eucalyptus microcorys leaf extract derived HPLC-fraction reduces the viability of MIA PaCa-2 cells by inducing apoptosis and arresting cell cycle
In this study, bioassay-guided fractionation of the aqueous crude E. microcorys extract using RP-HPLC and subsequent assessment of the resultant fractions (F1–F5) for their antioxidant activity and cytotoxicity against pancreatic cancer cell lines were performed. The molecular mechanisms associated with the cytotoxicity was characterised by studying the effects of the most potent fraction-1 (F1) on apoptosis and cell cycle profiles as well as its phytochemical constituents by LC-ESI/MS/MS. F1 displayed significantly greater antioxidant activity in three different assays (p < 0.05). Moreover, F1 exhibited s...
Source: Biomedicine and Pharmacotherapy - June 5, 2018 Category: Drugs & Pharmacology Source Type: research

Biogenic gold nanoparticles synthesis mediated by Mangifera indica seed aqueous extracts exhibits antibacterial, anticancer and anti-angiogenic properties
In this study, AuNP’s was prepared by a simple one step method of employing aqueous Mangifera indica seed extract as a reducing agent. Scanning electron microscopy and transmission electron microscopy revealed spherical shaped nanoparticles and dynamic light scattering analysis indicated the AuNP’s to be approximately 46.8 nm in size. AuNP’s efficiently inhibited the growth of E. coli and S. aureus by its inherent ability to generate reactive oxygen species (ROS) and exhibited detrimental effects towards the tested bacterial species. Biocompatibility assessment indicated the non-toxic nature of AuNP&rsq...
Source: Biomedicine and Pharmacotherapy - June 5, 2018 Category: Drugs & Pharmacology Source Type: research

Portulacaoleraceal extract alleviates trinitrobenzene sulfonic acid-induced colitis in rats
This study examined the effects of POL on trinitrobenzene sulfonic acid (TNBS)-induced colitis via enema administration. Sixty male Sprague–Dawley rats were randomly divided into five groups: untreated, TNBS, TNBS + POL 10 g/kg, TNBS + POL 5 g/kg and TNBS + POL 2.5 g/kg groups. Rats were subjected to enema treatment once a day for 10 consecutive days with POL extract or distilled water after induction of TNBS. The changes of body weight, histological parameters, myeloperoxidase (MPO), superoxide dismutase (SOD), nitric oxide synthase activity (NOS), malondialdehyde (MDA) and nitric oxide (NO) levels...
Source: Biomedicine and Pharmacotherapy - June 5, 2018 Category: Drugs & Pharmacology Source Type: research

Alpha lipoic acid exerts antioxidant effect via Nrf2/HO-1 pathway activation and suppresses hepatic stellate cells activation induced by methotrexate in rats
This study explored the hepatoprotective mechanisms of ALA against MTX-induced hepatic injury in rats. Hepatic injury was induced in MTX group by 20 mg/kg body weight ip. injection of MTX. ALA group was pretreated with ALA 60 mmol/kg body weight ip. for five days followed by a single dose of MTX in the sixth day. Blood samples and liver tissues were then obtained to assess several biochemical parameters as serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), reduced glutathione (GSH), total antioxidant capacity (TAC) and lipid peroxidation. Nuclear factor E2-related factor...
Source: Biomedicine and Pharmacotherapy - June 5, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-129-5p functions as a tumor suppressor in gastric cancer progression through targeting ADAM9
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Qi Liu, Jianwu Jiang, Yang Fu, Tao Liu, Yang Yu, Xiefu Zhang MicroRNAs (miRNAs) are identified as key regulators in cancer initiation, progression and metastasis including gastric cancer (GC). The aim of the study is to explore clinical significance and potential mechanism of miR-129-5p in GC development. In the study, our results found that miR-129-5p expression was significantly downregulated in GC tissues, compared with adjacent normal tissues using qRT-PCR analyses. Furthermore, lower miR-129-5p expression closely asso...
Source: Biomedicine and Pharmacotherapy - June 5, 2018 Category: Drugs & Pharmacology Source Type: research

Downregulation of MiR-1297 predicts poor prognosis and enhances gastric cancer cell growth by targeting CREB1
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Wencang Gao, Ying Cao, Piaoting Guo, Xiaoyan Bao, Hongye Zhu, Jian Zheng, Cheng Yao, Dong Chen, Shenquan Yu, Binhai Chen, Shaoling Zhou, Dexiang Pang, Weijian Chen Dysregulation of mircoRNAs (miRs) that act as tumor suppressors or oncogenes is participated in tumorigenesis and progression. The aim of the study is to investigate the role and mechanism of miR-1297 in gastric cancer (GC). Here, we demonstrated that miR-1297 expression was significantly lower in GC tissue samples compared to adjacent normal tissue samples in 6...
Source: Biomedicine and Pharmacotherapy - June 3, 2018 Category: Drugs & Pharmacology Source Type: research

Xiaokeping-induced autophagy protects pancreatic β-cells against apoptosis under high glucose stress
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Yanyang Wu, Yongquan Hu, Zhou Haiyan, Wei YunLin, Kang Xincong, Liu Dongbo Xiaokeping (XKP), a prescribed Traditional Chinese Medicine (TCM), has been used to treat patients with type Ⅱ diabetes mellitus for many years; however, the molecular mechanism of its effects is unknown. As the only insulin producer, the pancreatic β cell plays an important role in diabetes. Whether XKP influences the viability of pancreatic β cells remains to be substantiated. In the present study, autophagy/apoptosis analyses were use...
Source: Biomedicine and Pharmacotherapy - June 3, 2018 Category: Drugs & Pharmacology Source Type: research

Matrix metalloproteinase-2: A key regulator in coagulation proteases mediated human breast cancer progression through autocrine signaling
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Kaushik Das, Ramesh Prasad, Shabbir Ahmed Ansari, Abhishek Roy, Ashis Mukherjee, Prosenjit Sen Aims Cell invasion is attributed to the synthesis and secretion of proteolytically active matrix-metalloproteinases (MMPs) by tumor cells to degrade extracellular matrix (ECM) and promote metastasis. The role of protease-activated receptor 2 (PAR2) in human breast cancer migration/invasion via MMP-2 up-regulation remains ill-defined; hence we investigated whether TF-FVIIa/trypsin-mediated PAR2 activation induces MMP-2 expression ...
Source: Biomedicine and Pharmacotherapy - June 3, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of yerba mate (Ilex paraguariensis) extract on the metabolism of diabetic rats
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Débora Santos Rocha, Lucas Casagrande, Jorge Felipe Argenta Model, Jordana Tres dos Santos, Ana Lúcia Hoefel, Luiz Carlos Kucharski The relationship between metabolic disturbances and clinical events related to diabetes is well known. Yerba mate has presented a potential use as preventive and therapeutic agent on diabetes. The aim of this study was to evaluate the effect of yerba mate on different tissues of diabetic rats, focusing on energetic metabolism. Diabetes was induced by streptozotocin, followed by d...
Source: Biomedicine and Pharmacotherapy - June 2, 2018 Category: Drugs & Pharmacology Source Type: research

MicroRNA-196b enhances the radiosensitivity of SNU-638 gastric cancer cells by targeting RAD23B
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Yan Nan Shen, In-Seon Bae, Gil Hong Park, Hwa Sik Choi, Kee-Ho Lee, Sang Hoon Kim Gastric cancer is characterized by resistance to ionizing radiation. The development of resistance to radiotherapy in gastric cancer patients is one of the obstacles to effective radiotherapy. MicroRNAs are small well-conserved non-coding RNA species that regulate post-transcriptional activation. Our study aimed to investigate the role of miR-196b in radiation-induced gastric cancer. In the present study, we found that miR-196b expression was...
Source: Biomedicine and Pharmacotherapy - June 2, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-214 promotes cell meastasis and inhibites apoptosis of esophageal squamous cell carcinoma via PI3K/AKT/mTOR signaling pathway
In this study, we observe that the expression of miR-214 is not only increased in human ESCC tissues, but also remarkably increased in cell lines correlates with LZTS1. In addition, the expression of miR-214 inhibited proliferation of ESCC cells in vitro and inhibit the growth of xenograft tumor in vivo. The results show miR-214 serve as a tumor promoter regulating cells migration, invasion and apoptosis in ESCC. Ferthermore, LZTS1 has been proved to as a functional target for miR-214 to regulate cells poliferation and apoptosis. In summary, these results suggest that miR-214 serves as tumor promoter to promote proliferati...
Source: Biomedicine and Pharmacotherapy - June 2, 2018 Category: Drugs & Pharmacology Source Type: research

Proteomics analysis demonstrating rosmarinic acid suppresses cell growth by blocking the glycolytic pathway in human HepG2 cells
This study aimed to investigate the molecular mechanisms of RA in HepG2 cells. RA anti-tumor activity was assessed using 3-(4,5-dimethylthiazol-2-yl)2,5-diphenyl-tetrazolium bromide (MTT) and lactate dehydrogenase (LDH) assays, and Hoechst 33258 staining. Apoptosis and the cell cycle distribution were evaluated by flow cytometry. A proteomics approach was used to identify differentially expressed proteins following RA treatment in HepG2 cells, and quantitative reverse transcription–quantitative polymerase chain reaction was used to validate the results. Bioinformatics analysis was also implemented to further understa...
Source: Biomedicine and Pharmacotherapy - June 2, 2018 Category: Drugs & Pharmacology Source Type: research

Anticancer and other therapeutic relevance of mushroom polysaccharides: A holistic appraisal
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Damini Kothari, Seema Patel, Soo-Ki Kim The discovery of nutritious dietary supplements and side effect-free therapeutics are a priority in the current scenario of increasing instances of metabolic syndromes. In this direction, mushroom polysaccharides have shown immense promise. Scores of studies have characterized and evaluated their biological relevance, which range from antioxidant, anti-inflammatory, anticancer, antidiabetic, antimicrobial, and antilipemic to immunomodulatory. Hence, it is important to accumulate the ...
Source: Biomedicine and Pharmacotherapy - June 2, 2018 Category: Drugs & Pharmacology Source Type: research

Downregulation of circular RNA hsa_circ_0001649 indicates poor prognosis for retinoblastoma and regulates cell proliferation and apoptosis via AKT/mTOR signaling pathway
Publication date: September 2018 Source:Biomedicine & Pharmacotherapy, Volume 105 Author(s): Lichen Xing, Leiming Zhang, Yali Feng, Zhe Cui, Lin Ding Retinoblastoma (RB) is the most common intraocular malignancy in infants and children with high mortality rate in developing countries. Emerging evidence demonstrated that abnormally expressed circular RNAs (circRNAs) are involved in tumorigenesis and progression in several malignancies. However, their clinical values, biological functions and mechanisms in RB has not been reported before. Recently, hsa_circ_0001649 was found to play imperative roles in cholangiocarc...
Source: Biomedicine and Pharmacotherapy - June 1, 2018 Category: Drugs & Pharmacology Source Type: research