Association between catatonia and levels of hair and serum trace elements and minerals in autism spectrum disorder
The objective of the study was to investigate the association between catatonia in autism spectrum disorder (ASD) and the levels of hair and serum trace elements and minerals in children with ASD. The levels of hair and serum trace elements and minerals of boys suffering from ASD with (n = 30) and without (n = 30) catatonia, as well as 30 age- and sex-matched neurotypical controls were assessed using ICP-MS. Hair calcium (Ca) and selenium (Se) levels were lower in ASD patients as compared to the controls. Hair mercury (Hg) levels in ASD patients were more than 3-fold and 2-fold higher as compare...
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

The neurovascular protective effect of alogliptin in murine MCAO model and brain endothelial cells
In this study, we investigated the neurovascular protective effects of alogliptin both in vivo and in vitro. In a murine middle cerebral artery occlusion (MCAO) stroke model, administration of alogliptin ameliorated cerebral infarction and disruption of brain vascular permeability, and restored expression of the endothelial tight junction proteins occludin and zona occludens 1 (ZO-1). In brain vascular endothelial cells exposed to oxygen and glucose deprivation/reperfusion (OGD/R), alogliptin prevented OGD/R-induced high permeability of the endothelial monolayer. Alogliptin treatment recovered the reduction in occludin and...
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Involvement of AMPK activation in the inhibition of hepatic gluconeogenesis by Ficus carica leaf extract in diabetic mice and HepG2 cells
In conclusion, FCL extract inhibits hepatic gluconeogenesis via activation of AMPK and down-regulation of gluconeogenic enzymes.Graphical abstractAMP-activated protein kinase (AMPK) plays pivotal roles in insulin sensitivity and glucose homeostasis. PEPCK, G6pase, PGC-1α, FOXO1, HNF4α are the key enzymes and transcription factors in gluconeogenesis. PGC-1α, FOXO1, HNF4α can regulate G6Pase and PEPCK enzymes gene expression. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-31-5p promotes the cell growth, migration and invasion of colorectal cancer cells by targeting NUMB
In conclusion, miR-31-5p promoted the cell growth, migration and invasion by targeting NUMB in colorectal cancer cells. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Effects of ADAM2 silencing on isoflurane-induced cognitive dysfunction via the P13K/Akt signaling pathway in immature rats
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Bao-Juan Zhang, Chang-Xiu YuanAbstractVolatile anesthetics, including isoflurane, have been reported to have negative effects on cognitive dysfunction characterized by cognitive deficits following anesthesia. The aim of the current study was to investigate the effects involved with disintegrin and metallopeptidase domain 2 (ADAM2) silencing on isoflurane-induced cognitive dysfunction via the P13 K/Akt signaling pathway in immature rats. One week old healthy Sprague-Dawley (SD) rats were recruited and administered isoflurane...
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Upregulation of circular RNA circ_0001721 predicts unfavorable prognosis in osteosarcoma and facilitates cell progression via sponging miR-569 and miR-599
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Liandi Li, Ling Guo, Guohua Yin, Guanghao Yu, Yanjing Zhao, Yanming PanAbstractOsteosarcoma (OS) is the most frequent bone malignancy in human. Growing evidence suggests that circular RNAs (circRNAs) play a significant role in regulating tumorigenesis and progression. Previously, circ_0001721 was identified upregulated in OS tissues screened by circRNA microarrays. In the current study, circ_0001721 expression in OS tissue samples and cells were measured by qRT-PCR. Its clinical value was also explored. For the part of functional ...
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Docosahexaenoic acid-flurbiprofen combination ameliorates metaflammation in rats fed on high-carbohydrate high-fat diet
ConclusionsDocosahexaenoic acid-flurbiprofen combination showed an ameliorative effect on obesity-associated metaflammation and its consequences in rats.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

DPP-4 inhibitor impedes lipopolysaccharide-induced osteoclast formation and bone resorption in vivo
In this study, we investigated in vivo effects of DPP-4 inhibition on LPS-induced osteoclast formation and bone resorption, as well as in vitro effects of DPP-4 inhibition on RANKL-induced osteoclastogenesis and TNF-α-induced osteoclastogenesis.MethodsLPS with or without a DPP-4 inhibitor was subcutaneously injected into mouse calvaria for 5 days. Histological sections of calvaria were stained for tartrate-resistant acid phosphatase, and osteoclast numbers were determined. The ratio of calvaria bone resorption was evaluated via microfocal computed tomography reconstruction images.ResultsOsteoclast number and bone res...
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Ginsenoside Rb3 protects cardiomyocytes against hypoxia/reoxygenation injury via activating the antioxidation signaling pathway of PERK/Nrf2/HMOX1
ConclusionOur studies revealed a novel mechanism of G-Rb3 to attenuates oxidative stress via activating the antioxidation signaling pathway of PERK/Nrf2/HMOX1 in vivo and in vitro, which may help us to enrich the theoretical knewledge of Ginsenoside-Rb3 in cardiopretection (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Characterization of polysaccharide from Helicteres angustifolia L. and its immunomodulatory activities on macrophages RAW264.7
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Shuang Sun, Kejuan Li, Long Xiao, Zhongfang Lei, Zhenya ZhangAbstractHelicteres angustifolia L. (H. angustifolia) has been widely used as a remedy against various types of illness relating to immune response, such as inflammations and fever. In order to characterize the structure and identify the immunomodulatory activity of polysaccharide from H. angustifolia, a polysaccharide fraction (SPF3-1) was purified from H. angustifolia by using DEAE Sepharose Fast Flow and Sephacry S-400 chromatography, successively. Physicochemical anal...
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Mitochondrial dysfunction as a mechanism involved in the pathogenesis of cirrhosis-associated cholemic nephropathy
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Reza Heidari, Leila Mandegani, Vahid Ghanbarinejad, Asma Siavashpour, Mohammad Mehdi Ommati, Negar Azarpira, Asma Najibi, Hossein NiknahadAbstractCholemic nephropathy (CN) is a clinical complication associated with cholestasis and chronic liver diseases. CN could lead to renal failure and the need for kidney transplantation if not appropriately managed. On the other hand, although the clinical features of CN are well described, there is no clear idea on the precise cellular and molecular mechanisms of CN. The current study was des...
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Polyphenol-rich Boswellia serrata gum prevents cognitive impairment and insulin resistance of diabetic rats through inhibition of GSK3β activity, oxidative stress and pro-inflammatory cytokines
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Adel A. Gomaa, Rania M. Makboul, Mohamed A. Al-Mokhtar, Mariam A. NicolaAbstractType 2 diabetes (T2D) is associated with accelerated cognitive decline. To date, there is no T2D-specific treatment to prevent or ameliorate cognitive dysfunction. Boswellia serrate (BS) gum has been shown to possess multiple pharmacological actions including anti-inflammatory, anticancer and ant- apoptotic actions. The present study was aimed to investigate the effect of BS on cognitive impairment associated with T2D induced in rats by high fat/high f...
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Mechanistic approach of the inhibitory effect of chrysin on inflammatory and apoptotic events implicated in radiation-induced premature ovarian failure: Emphasis on TGF-β/MAPKs signaling pathway
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Eman M. Mantawy, Riham S. Said, Amal Kamal Abdel-AzizAbstractRadiotherapy is one of the most relevant treatment modalities for various types of malignancies. However, it causes premature ovarian failure (POF) and subsequent infertility in women of reproductive age; hence urging the development of effective radioprotective agents. Chrysin, a natural flavone, possesses several pharmacological activities owing to its antioxidant, anti-inflammatory and anti-apoptotic properties. Therefore, the aim of this study was to investigate the ...
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation
In conclusion, spirulina has a therapeutic potential in aspirin-induced gastric injury by alleviating oxidative stress and inflammation.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

A proteomic analysis of the anti-dengue virus activity of andrographolide
This study therefore sought to further understand the mechanism of action of andrographolide in inhibiting DENV infection of liver cells using a proteomic based approach. Both 1 dimension (D) and 2D proteome systems were used. Initial data was generated through andrographolide treatment of HepG2 cells without DENV infection (1D analysis), while subsequent data was generated through a combination of andrographolide treatment and DENV infection (2D analysis). A total of 17 (1D) and 18 (2D) proteins were identified as differentially regulated. The analyses identified proteins involved in chaperone activities, as well as energ...
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Investigation of the effects of naringin on intestinal ischemia reperfusion model at the ultrastructural and biochemical level
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): E. Bakar, E. Ulucam, A. Cerkezkayabekir, F. Sanal, M. InanAbstractWe aimed to evaluate the ultrastructural effect of reversing cellular damage, occurring in rats due to ischemia-reperfusion (I/R) in the intestine, with naringin implementation through biochemical parameters. Rats were divided the sham/control, I/R and the naringin groups (n = 7). For I/R group, 120 min of ischemia and 120 min of reperfusion was applied to the superior mesenteric artery. In the naringin group, after 120 min, 50&thi...
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Ascorbic acid therapy: A potential strategy against comorbid depression-like behavior in streptozotocin-nicotinamide-induced diabetic rats
This study examined the potency and efficacy of ascorbic acid (AA) in the management of depression-like behavior in diabetic rats. Diabetes mellitus was induced by single intraperitoneal injections of nicotinamide (120 mg/kg) and streptozotocin (65 mg/kg) administered 15 min apart. Diabetic (blood glucose ≥250 mg/dL) rats were subjected to intermittent foot-shocks to induce comorbid depression. Seven groups of diabetes comorbid depressed rats received vehicle (1 mL/kg) or AA (10, 25, 50, 100, 200, or 400 mg/kg) orally for eleven days. Three control groups namely- nondiabetic, di...
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Nrf2 activation and down-regulation of HMGB1 and MyD88 expression by amnion membrane extracts in response to the hypoxia-induced injury in cardiac H9c2 cells
ConclusionThe data indicated that AMPs mediated HO-1 regulation by Nrf2 activation and plays critical protective effects in hypoxia-induced H9c2 injury in vitro by the inhibition of myocardial HMGB1 and MyD88 inflammatory cascade. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Glycoprotein from Mytilus edulis extract inhibits lipid accumulation and improves male reproductive dysfunction in high-fat diet-induced obese rats
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Yi-Cheng Lu, Sabri Sudirman, Chien-Feng Mao, Zwe-Ling KongGraphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Focal selective chemo-ablation of spinal cardiac afferent nerve by resiniferatoxin protects the heart from pressure overload-induced hypertrophy
In conclusion, these results demonstrate that focal chemo-ablation of TRPV1+ afferents in the spinal cord protects the heart from pressure overload-induced cardiac remodeling and cardiac dysfunction, which suggest a novel promising therapeutic method for cardiac hypertrophy and diastolic dysfunction. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Encapsulation of rat cardiomyoblasts with alginate-gelatin microspheres preserves stemness feature in vitro
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Shirin Saberianpour, Abbas Karimi, Sorour Nemati, Hassan Amini, Hamed Alizadeh Sardroud, Majid Khaksar, Mina Mamipour, Mohammad Nouri, Reza RahbarghaziAbstractIntroductionThe emergence of numerous tissue engineering and regenerative medicine techniques cell encapsulation paves a way to heal and restore the function of various injured tissues mainly cardiovascular system. Here, we aimed to investigate the role of alginate-gelatin encapsulation on the dynamic of rat cardiomyoblasts in vitro.Materials and methodsRat cardiomyoblasts c...
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Studies examining the synergy between Dihydrotanshinone and Temozolomide against MGMT+ glioblastoma cells in vitro: Predicting interactions with the blood-brain barrier
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Varun Kumar, Daniel Radin, Donna LeonardiAbstractWe showed previously that Dihydrotanshinone (DHT) augments temozolomide (TMZ) efficacy by inducing reactive oxygen species production in an in vitro model. Here, the underlying basis of the synergistic effect and the ability of DHT to potentially pass the blood brain barrier (BBB) is investigated using an in vitro model. Trypan blue exclusion assays were used to determine effects of DHT/TMZ combinatorial treatment on GBM cell viability. ELISA was utilized to determine effects on NFk...
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Fluctuations of epigenetic regulations in human gastric Adenocarcinoma: How does it affect?
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Ali Akbar Samadani, Seyedeh Elham Noroollahi, Fariborz Mansour-Ghanaei, Ali Rashidy-Pour, Farahnaz Joukar, Ahmad Reza BandegiAbstractGastric cancer (GC) or human gastric adenocarcinoma is one of the most commonplace type of serious cancers and also the most common cause of cancer-related mortality in the world. Relatively, many studies have acknowledged that GC is a multi-factorial pathological situation that environmental factors, particularly dietary ones and H.pylori infection are considered to have a strong key role in the eti...
Source: Biomedicine and Pharmacotherapy - November 3, 2018 Category: Drugs & Pharmacology Source Type: research

Saffron; An updated review on biological properties with special focus on cardiovascular effects
ConclusionsOur study concludes that saffron with wide range of usefulness in medicine may be the potent candidate in the process of new drug production for the treatment of CVDs. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 2, 2018 Category: Drugs & Pharmacology Source Type: research

Chemoresistance caused by the microenvironment of glioblastoma and the corresponding solutions
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Xin Zhang, Kaikai Ding, Jian Wang, Xingang Li, Peng ZhaoAbstractGlioblastoma multiforme (GBM) is the most common and aggressive primary human brain tumor. Although comprehensive therapies combining radiotherapy and chemotherapy after surgery can prolong survival, the prognosis is still poor with a median survival of only 14.6 months. Chemoresistance is one of the major causes of relapse as well as poor survival in glioma patients. Therefore, novel strategies to overcome chemoresistance are desperately needed for improved treatment...
Source: Biomedicine and Pharmacotherapy - November 2, 2018 Category: Drugs & Pharmacology Source Type: research

Effects of iron chelating agent on Schistosoma mansoni infected murine model
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Noha H. Abdelgelil, Manal Z.M. Abdellatif, Ekhlas H. Abdel-Hafeez, Usama S. Belal, Rabie M. Mohamed, Abdel-Razik H. Abdel-Razik, Kamel M.A. Hassanin, Ahmed Abdel-WahabAbstractSchistosomiasis is one of the major health problems in many tropical and developing countries. Infection takes place once cerceriae penetrate human skin, then it changed into schistosomules. The schistosomules takes iron in the form of heme from host's haemoglobin, ferritin and transferrin. Iron is a vital element not only for growth and sexual maturity of sc...
Source: Biomedicine and Pharmacotherapy - November 2, 2018 Category: Drugs & Pharmacology Source Type: research

Signaling pathways involved in the expression of SZNF and the target genes binding with SZNF related to cyadox
In this study, we investigated the pharmacological mechanism of cyadox mediated by SZNF. Firstly, signaling pathways related to cyadox-induced SZNF expression were studied. The results showed that the mRNA level of SZNF reached the peak as early as 4 h after 2 μM cyadox treatment in swine hepatocytes. Several signaling pathways, including JAK2/STAT1, PI3K/Akt, TGF-β/Smad3 and p38, might play critical roles in regulation of SZNF. The JAK2/STAT1, JAK2/PI3K/Akt, PI3K/Akt and myD88 & TAK1 & ASK1 /P38 signaling pathways were firstly activated after cyadox treatment in swine hepatocyte, the T...
Source: Biomedicine and Pharmacotherapy - October 27, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-proliferative activity of Origanum vulgare inhibited lipogenesis and induced mitochondrial mediated apoptosis in human stomach cancer cell lines
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Sri Renukadevi Balusamy, Haribalan Perumalsamy, Md. Amdad Huq, Balamuralikrishnan BalasubramanianAbstractOriganum vulgare commonly known as oregano belongs to mint family (Laminaceae), and native to temperate western and mediterranean region. In our present study, we have identified the bio-active principles of oregano essential oil (EO) and evaluated its apoptotic effects against human stomach cancer cell lines (AGS). The EO altered colony forming characteristics of cancer cell, migration ability of cancer cell and thus prevente...
Source: Biomedicine and Pharmacotherapy - October 21, 2018 Category: Drugs & Pharmacology Source Type: research

Upregulated microRNA miR-21 promotes the progression of lung adenocarcinoma through inhibition of KIBRA and the Hippo signaling pathway
ConclusionMiR-21 suppressed the Hippo signaling pathway and promoted the progression of LAD through targeting KIBRA. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - October 21, 2018 Category: Drugs & Pharmacology Source Type: research

Fibroblast growth factor 21 regulates foam cells formation and inflammatory response in Ox-LDL-induced THP-1 macrophages
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Nan Wang, Jun-yan Li, Shuai Li, Xiao-chen Guo, Tong Wu, Wen-fei Wang, De-shan LiAbstractMacrophages are paramount to the initiation and procession of atherosclerosis, thus targeting macrophages in the progress of atherosclerosis is indispensable. Therefore, we perform in vitro experiments to investigate the effects of FGF-21 on macrophages in the progress of atherosclerosis. First, we use phorbol-12-myristate-13-acetate (PMA), a phorbol ester, to induce THP-1 cells into macrophages as macrophages model. After that we use Ox-LDL t...
Source: Biomedicine and Pharmacotherapy - October 19, 2018 Category: Drugs & Pharmacology Source Type: research

Antagonism of receptor interacting protein 1 using necrostatin-1 in oxidized LDL- induced endothelial injury
In this study, we investigated the role of receptor interacting protein 1 (RIP1), one of the kinases involved in apoptosis and necroptosis mediated by the death receptor tumor necrosis factor receptor (TNFR), in endothelial dysfunction. We show that RIP1 is responsively induced in human umbilical vein endothelial cells (HUVECs) upon ox-LDL treatment. Blockage of RIP1 activity by its antagonist, necrostatin-1, ameliorates ox-LDL-induced nitric oxide (NO) reduction and induction of vascular adhesion molecules, including vascular cell adhesion molecule 1 (VCAM-1) and E-selectin, as well as adhesion of immune cells to endothel...
Source: Biomedicine and Pharmacotherapy - October 18, 2018 Category: Drugs & Pharmacology Source Type: research

The pilocarpine-induced ciliary body contraction affects the elastic modulus and collagen of cornea and sclera in early development
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Yongfang Xie, Mingling Wang, Yang Cong, Min Cheng, Sheng Wang, Guohui WangAbstractThe aim of this study was to investigate the effects of pilocarpine-induced ciliary body constant contraction for a long time period on the elastic modulus and collagen in corneal and scleral tissues in the early developmental stage. Twelve one-month-old New Zealand white rabbits were randomly monocularly treated with pilocarpine to cause ciliary body constant contraction. After 1- and 2-months, the sclera tissues and the eyeballs were obtained to a...
Source: Biomedicine and Pharmacotherapy - October 18, 2018 Category: Drugs & Pharmacology Source Type: research

The effect of celecoxib on blood pressure and plasma oxidant/antioxidant status in co-administration with glucocorticoid in rat
In conclusion, celecoxib did not change blood pressure in glucocorticoid-induced hypertensive rats but may blunt the hypotensive effect of low dose of captopril. Further studies are needed for detailed information addressing the effects of COX-2 inhibitors on blood pressure in concomitant uses with corticosteroids. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - October 18, 2018 Category: Drugs & Pharmacology Source Type: research

Ameliorative effect of Alnus japonica ethanol extract on colitis through the inhibition of inflammatory responses and attenuation of intestinal barrier disruption in vivo and in vitro
This study investigated the effects of ethanol extract from A. japonica bark (AJE) on colonic mucosa injury in mice with dextran sodium sulfate (DSS)-induced colitis. Treatment with AJE ameliorated pathological damage and the histopathologic features of DSS-induced colitis. The administration of AJE also inhibits DSS-induced pro-inflammatory cytokines expression, including interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and cyclooxygenase (COX)-2. Notably, AJE administration attenuated the reduction of tight junction proteins, zonula occludens (ZO)-1 and occludin, in DSS-induced colitis. In addition, A...
Source: Biomedicine and Pharmacotherapy - October 16, 2018 Category: Drugs & Pharmacology Source Type: research

Down-regulation of CASC2 contributes to cisplatin resistance in gastric cancer by sponging miR-19a
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Yingxia Li, Shuai Lv, Hanbing Ning, Kangyan Li, Xiaoyu Zhou, Haiyan Xv, Hongtao WenAbstractIncreasing evidence suggests the involvement of long non-coding RNAs (lncRNAs) in chemoresistance of cancer treatment. However, their function and molecular mechanisms in gastric cancer chemoresistance are still not well elucidated. In the present study, we investigate the functional role of lncRNA cancer susceptibility candidate 2 (CASC2) in cisplatin (DDP) resistance of gastric cancer and discover the underlying molecular mechanism. Resul...
Source: Biomedicine and Pharmacotherapy - October 16, 2018 Category: Drugs & Pharmacology Source Type: research

Kaempferol alleviates ox-LDL-induced apoptosis by up-regulation of miR-26a-5p via inhibiting TLR4/NF-κB pathway in human endothelial cells
ConclusionKaempferol alleviated ox-LDL-induced apoptosis in HAECs by upregulating miR-26a-5p via inactivation of the TLR4/NF-κB signaling pathway, shedding light on the molecular mechanism by which kaempferol alleviated ox-LDL-induced EC apoptosis. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - October 16, 2018 Category: Drugs & Pharmacology Source Type: research

Activation of TGR5 promotes osteoblastic cell differentiation and mineralization
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Qingfeng Wang, Guoqiang Wang, Bin Wang, Huilin YangAbstractImpairment of normal osteoblast differentiation has been associated with bone loss-related disorders, such as osteoporosis. Takeda G-protein coupled receptor 5 (TGR5) has been identified as an important modulator of bile acid and energy homeostasis. Little information regarding the effects of TGR5 on osteoblastic bone formation and matrix mineralization has been reported before. In the current study, we found that TGR5 was expressed in osteoblast-like cell line MC3T3-E1 c...
Source: Biomedicine and Pharmacotherapy - October 16, 2018 Category: Drugs & Pharmacology Source Type: research

Caffeine and high intensity exercise: Impact on purinergic and cholinergic signalling in lymphocytes and on cytokine levels
This study evaluated the effects of caffeine in combination with high-intensity interval training (HIIT) on sensitivity to glucocorticoids and proliferation of lymphocytes, IL-6 and IL-10 levels and NTPDase, adenosine deaminase (ADA) and acetylcholinesterase (AChE) activity in rat lymphocytes. The animals were divided into groups: control, caffeine 4 mg/kg, caffeine 8 mg/kg, HIIT, HIIT plus caffeine 4 mg/kg and HIIT plus caffeine 8 mg/kg. The rats were trained three times a week for 6 weeks for a total workload 23% of body weight at the end of the experiment. Caffeine was administered orally 30&...
Source: Biomedicine and Pharmacotherapy - October 13, 2018 Category: Drugs & Pharmacology Source Type: research

Ginsenoside Rb3 exerts protective properties against cigarette smoke extract-induced cell injury by inhibiting the p38 MAPK/NF-κB and TGF-β1/VEGF pathways in fibroblasts and epithelial cells
In this study, we used cigarette smoke extract (CSE) to establish cell injury models in WI-38 human fetal lung fibroblasts and 16HBE human bronchial epithelial cells. Our results showed that Rb3 protected against CSE-induced cytotoxicity in both cell lines. In addition, it significantly inhibited the secretion of inflammatory factors, such as interleukin-8 and tumor necrosis factor alpha, by inhibiting the phosphorylation of p38 mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB). Moreover, Rb3 pre-treatment led to an increase in the levels of glutathione (GSH) and activities of superoxide dism...
Source: Biomedicine and Pharmacotherapy - October 13, 2018 Category: Drugs & Pharmacology Source Type: research

TSH fraction from Petromica citrina: A potential marine natural product for the treatment of sepsis by Methicillin-resistant Staphylococcus aureus (MRSA)
Conclusion and implicationsThese data suggest that TSH may be an interesting alternative for the treatment infections by Gram-positive resistant bacteria, due to its antimicrobial profile associated with its anti-inflammatory properties.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - October 13, 2018 Category: Drugs & Pharmacology Source Type: research

Alkannin protects human renal proximal tubular epithelial cells from LPS-induced inflammatory injury by regulation of microRNA-210
ConclusionALK attenuated LPS-induced inflammatory injury in HK-2 cells possibly through up-regulating miR-210. The LPS-induced activation of the NF-κB and p38MAPK pathways was attenuated by ALK via regulation of miR-210.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - October 13, 2018 Category: Drugs & Pharmacology Source Type: research

The lncRNA LINC00675 regulates cell proliferation, migration, and invasion by affecting Wnt/β-catenin signaling in cervical cancer
In conclusion, our results implied that LINC00675 promoted cancer cell proliferation, migration, and invasion, and inhibit apoptosis likely by modulating the Wnt/β-catenin pathway. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - October 13, 2018 Category: Drugs & Pharmacology Source Type: research

Green tea extract modulates oxidative tissue injury in beta-thalassemic mice by chelation of redox iron and inhibition of lipid peroxidation
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Pimpisid Koonyosying, Sarawut Kongkarnka, Chairat Uthaipibull, Saovaros Svasti, Suthat Fucharoen, Somdet SrichairatanakoolAbstractIron overload in patients with β-thalassemia can cause oxidative organ dysfunction. Iron chelation along with antioxidant supplementation can ameliorate such complications and prolong lives. Green tea extract (GTE) rich in epigallocatechin-3-gallate (EGCG) exhibits anti-oxidation and iron chelation properties in β-knockout thalassemic (BKO) mice diagnosed with iron overload. We investigated t...
Source: Biomedicine and Pharmacotherapy - October 13, 2018 Category: Drugs & Pharmacology Source Type: research

Synthesis, in vitro and in vivo anti-Trypanosoma cruzi and toxicological activities of nitroaromatic Schiff bases
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Tamires Cunha Almeida, Luis Henrique Gonzaga Ribeiro, Luzia Braga Ferreira dos Santos, Cleiton Moreira da Silva, Renata Tupinambá Branquinho, Marta de Lana, Fernanda Ramos Gadelha, Ângelo de FátimaAbstractChagas disease is a major health problem not only in Latin America but also in Europe and North America due to the spread of this disease into nonendemic areas. In terms of global burden, this major tropical infection is considered to be one of the most neglected diseases, and there are currently only two ava...
Source: Biomedicine and Pharmacotherapy - October 13, 2018 Category: Drugs & Pharmacology Source Type: research

Ellagic acid reveals promising anti-aging effects against d-galactose-induced aging on human neuroblastoma cell line, SH-SY5Y: A mechanistic study
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Vafa Baradaran Rahimi, Vahid Reza Askari, Seyed Hadi MousaviAbstractBackgroundAging is a progressive, accumulative and natural phenomenon that leads to irreversible changes in all molecules, cells, tissues and organs of an organism. Previous studies have demonstrated that d-galactose (DG) imitates human natural aging. EA has also shown many pharmacological properties including anti-inflammatory and anti-oxidant activities.MethodsIn the present study, we are aimed to evaluate anti-aging effects of EA (0.01–10 μM) o...
Source: Biomedicine and Pharmacotherapy - October 13, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of hyperbaric oxygen on the permeability of the blood-brain barrier in rats with global cerebral ischemia/reperfusion injury
ConclusionsHyperbaric oxygen exposure improved the permeability of the blood-brain barrier in rats with global cerebral ischemia/reperfusion injury, and increased expression of caveolin-1 and tight junction protein ZO-1 were involved in the mechanisms. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - October 13, 2018 Category: Drugs & Pharmacology Source Type: research

Down-regulation of miR-500 and miR-628 suppress non-small cell lung cancer proliferation, migration and invasion by targeting ING1
ConclusionThese results brought new insights into the oncogenic role of miR-500 and miR-628 in NSCLC, indicating that miR-500 and miR-628 might be the novel biomarkers for the diagnosis and prognosis of NSCLC.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - October 11, 2018 Category: Drugs & Pharmacology Source Type: research

CAPE-pNO2 attenuates diabetic cardiomyopathy through the NOX4/NF-κB pathway in STZ-induced diabetic mice
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Lu Fan, Qianhan Xiao, Liwen Zhang, Xiaoling Wang, Qin Huang, Sai Li, Xiaoyan Zhao, Zhubo LiAbstractDiabetic cardiomyopathy (DCM) is one of the most severe cardiovascular complications in diabetes. Caffeic acid para-nitro phenethyl ester (CAPE-pNO2) could ameliorate diabetic nephropathy in the diabetic mice in our previous study. This paper was aimed to investigate the effect of CAPE-pNO2 on DCM and its potential mechanism. The DCM mice were established by intraperitoneal injection with streptozotocin (STZ, 50 mg/kg) for 5 ...
Source: Biomedicine and Pharmacotherapy - October 11, 2018 Category: Drugs & Pharmacology Source Type: research

Absorption and efflux characteristics of CP-25 in plasma and peripheral blood mononuclear cells of rats by UPLC-MS/MS
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Yi-jin Wu, Ming-yi Zhao, Jian Wang, Hao Tang, Bin Wang, Feng Xiao, Li-hua Liu, Yun-fang Zhang, Ai-wu Zhou, Chun Wang, Wei WeiAbstractPaeoniflorin-6′-O-benzene sulfonate (code: CP-25), is an active monomer obtained by modifying the structure of paeoniflorin (Pae). CP-25 can alleviate the course of adjuvant arthritis (AA) rats by regulating immune inflammatory response and reducing bone damage. In addition, our research has found that immune cells are important target cells for its anti-inflammatory and immunomodulatory effec...
Source: Biomedicine and Pharmacotherapy - October 11, 2018 Category: Drugs & Pharmacology Source Type: research

Tanshinone IIA promotes IL2-mediated SW480 colorectal cancer cell apoptosis by triggering INF2-related mitochondrial fission and activating the Mst1-Hippo pathway
Publication date: December 2018Source: Biomedicine & Pharmacotherapy, Volume 108Author(s): Jun Qian, Dong Fang, Hong Lu, Yi Cao, Ji Zhang, Rong Ding, Lingchang Li, Jiege HuoAbstractIL-2-based therapy is a promising tool to treat colorectal cancer, but drug resistance always occurs in clinical practice. Mitochondrial fission is a novel target to modulate cancer development and progression. The aim of our study is to explore the effect of IL-2 combined with Tan IIA on SW480 colorectal cancer cell apoptosis in vitro and to determine whether IL-2/Tan IIA cotreatment could reduce SW480 cell viability via activating mitochon...
Source: Biomedicine and Pharmacotherapy - October 11, 2018 Category: Drugs & Pharmacology Source Type: research