Hypoglycemic activity of the extracts of Belamcanda chinensis leaves (BCLE) on KK-Ay mice
In this study, the effects of BCLE on obese diabetes were investigated using the KK-Ay mice. The component F2 of BCLE alleviate hyperglycemia and insulin resistance, as indicated by decreased levels of FBG, AUC, GSP, LDH and insulin. High levels of hepatic G6Pase and PEPCK in KK-Ay mice were markedly attenuated by F2. The inhibitory effect of F2 on GSK-3β and the enhancement effect on liver glycogen demonstrated that F2 could significantly inhibit hepatic gluconeogenesis and glycogen accumulation. The higher PPAR γ showed F2 may prevent insulin resistance by PI3K signal transduction pathway. In addition, the com...
Source: Biomedicine and Pharmacotherapy - December 6, 2018 Category: Drugs & Pharmacology Source Type: research

Dyslipidemia induced inflammatory status, platelet activation and endothelial dysfunction in rabbits: Protective role of 10-Dehydrogingerdione
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Mohamed Mahmoud El-Seweidy, Rawia sarhan Amin, Hebatallah Husseini Atteia, Reham Raafat El-Zeiky, Naif A. Al-gabriAbstract10-Dehydrogingerdione is a novel cholesteryl ester transfer protein (CETP) inhibitor of natural origin. Some synthetic CETP inhibitors have recently been reported to suppress proprotein convertase subtilisin/kexin type 9 (PCSK9). Therefore, the present study aimed mainly to clarify the effect of 10-Dehydrogingerdione on cellular adhesion inflammatory molecules, platelet activation and endothelial dysfunction m...
Source: Biomedicine and Pharmacotherapy - December 6, 2018 Category: Drugs & Pharmacology Source Type: research

Expression of Mac-2 binding protein in human carotid atheroma is associated with plaque instability and clinical manifestations
ConclusionsM2BP is highly expressed in advanced plaques and vulnerable regions and significantly correlated with clinical ischemic manifestations. Therefore, M2BP may serve as an important biomarker of plaque destabilization.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 6, 2018 Category: Drugs & Pharmacology Source Type: research

Targeting Nrf2/HO-1 signaling by crocin: Role in attenuation of AA-induced ulcerative colitis in rats
In conclusion; crocin demonstrated anti-ulcerogenic and coloprotective effect mediated primarily by its antioxidant, anti-inflammatory and anti-apoptotic properties. The therapeutic impact is mediated primarily via enhancement of colon Nrf2 content by 211% in protective protocol and by 350% in curative and HO-1 signaling by 49% in protective protocol and, 288% in the curative protocol. Enhancement of Nrf2 and HO-1 signaling and down-regulation of caspase-3 activity are believed to underly the observed therapeutic effect.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 5, 2018 Category: Drugs & Pharmacology Source Type: research

Antiproliferative and antiangiogenic effect of Amblyomma sculptum (Acari: Ixodidae) crude saliva in endothelial cells in vitro
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Paulo Luiz de Sá Junior, Diana Aparecida Dias Câmara, Juliana Mozer Sciani, Allan Saj Porcacchia, Pâmela Maria Moreira Fonseca, Ronaldo Zucatelli Mendonça, Selene Elifio-Esposito, Simone Michaela SimonsAbstractNeovascularization, a process that includes vasculogenesis and angiogenesis, may be a physiological or pathologic event, but in any cases the phenomenon is related to the formation of vascular net and sprouting of endothelial cells from preexisting blood vessel. The tumor environment, which counts ...
Source: Biomedicine and Pharmacotherapy - December 5, 2018 Category: Drugs & Pharmacology Source Type: research

The effect of divalent metal cations on the αv integrin binding site is ligand and integrin specific
In conclusion, this study demonstrates the need to determine the individual relationship between RGD ligands and the integrins they may engage in vivo, especially when determining selectivity profiles for potential RGD-mimetic small molecule therapeutics, with organ and disease state also considered. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 5, 2018 Category: Drugs & Pharmacology Source Type: research

Dendrobium candidum extract inhibits proliferation and induces apoptosis of liver cancer cells by inactivating Wnt/β-catenin signaling pathway
ConclusionDCE suppressed liver cancer SMMC-7721 and BEL-7404 cells as well as primary liver cancer cells likely though activating mitochondria apoptosis pathway and inducing inhibition of Wnt/β-catenin pathway. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 5, 2018 Category: Drugs & Pharmacology Source Type: research

Tropisetron inhibits sepsis by repressing hyper-inflammation and regulating the cardiac action potential in rat models
The objective of the present investigation was to explore the possible effect of the 5-HT3 receptor antagonist tropisetron on the expression levels of the inflammatory factors interleukin 6 (IL-6), creatine kinase isoenzyme (CK-MB), soluble growth stimulating gene 2 protein (sST2) and immunoglobulin E (IgE), as well as the cardiac action potential in septic rats.MethodsThe cecal ligation and perforation (CLP) method was utilized to construct abdominal infarction in rats. A total of 68 male adult Sprague Dawley rats were used, including 40 for assessing survival and 28 for detecting the expression levels of IL-6 and IgE, my...
Source: Biomedicine and Pharmacotherapy - December 5, 2018 Category: Drugs & Pharmacology Source Type: research

The exploration of novel Alzheimer’s therapeutic agents from the pool of FDA approved medicines using drug repositioning, enzyme inhibition and kinetic mechanism approaches
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Mubashir Hassan, Hussain Raza, Muhammad Athar Abbasi, Ahmed A. Moustafa, Sung-Yum SeoAbstractNovel drug development is onerous, time consuming and overpriced process with particularly low success and relatively high enfeebling rates. To overcome this burden, drug repositioning approach is being used to predict the possible therapeutic effects of FDA approved drugs in different diseases. Herein, we designed a computational and enzyme inhibitory mechanistic approach to fetch the promising drugs from the pool of FDA approved drugs ag...
Source: Biomedicine and Pharmacotherapy - December 4, 2018 Category: Drugs & Pharmacology Source Type: research

Cardiac and pulmonary toxicity of mesoporous silica nanoparticles is associated with excessive ROS production and redox imbalance in Wistar rats
In conclusion, our results demonstrated that MSNs induce cardiotoxicity and pulmonary toxicity via excessive generation of ROS, suppressed antioxidants, inflammation and histological alterations. Further investigations are recommended to understand the molecular mechanism underlying the toxic effects of MSNs and to improve the performance of nanomedicine.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 4, 2018 Category: Drugs & Pharmacology Source Type: research

Nanosoldiers: A promising strategy to combat triple negative breast cancer
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Akshayya Pawar, Priyanka PrabhuAbstractsThe phenomenal rise in cancer over the past few years has made it the second leading cause of death worldwide. Breast cancer constitutes the predominant cancer encountered in women. Triple negative breast cancer (TNBC) is the most notorious form of breast cancer which involves absence of the estrogen, progesterone and human epidermal growth factor receptor (EGFR) on breast cancer cells. It is a real challenge for oncologists owing to the recurrence and metastasis which result in poor progno...
Source: Biomedicine and Pharmacotherapy - December 4, 2018 Category: Drugs & Pharmacology Source Type: research

Cytotoxicity and selectiveness of Brazilian Piper species towards oral carcinoma cells
ConclusionPC-L-D demonstrated great potential for further development as an anticancer drug and could be the key to developing more effective and less toxic therapies against oral cancer.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 4, 2018 Category: Drugs & Pharmacology Source Type: research

Long non-coding RNA SNHG6 enhances cell proliferation, migration and invasion by regulating miR-26a-5p/MAPK6 in breast cancer
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Pengwei Lv, Xinguang Qiu, Yuanting Gu, Xue Yang, Xiaodong Xu, Yunqing YangAbstractThe long non-coding RNA (lncRNA) has recently been shown to be important regulators involved in the progression of various human cancers. Small nucleolar RNA host gene 6 (SNHG6) is a recently identified cancer-related lncRNA. However, the clinical significance and biological function of SNHG6 in breast cancer (BC) are still unclear. In the present study, we found that SNHG6 was highly expressed in BC tissues and cell lines, which was associated with...
Source: Biomedicine and Pharmacotherapy - December 4, 2018 Category: Drugs & Pharmacology Source Type: research

Er Shen Wan extract alleviates polyuria and regulates AQP 2 and AVPR 2 in a rat model of spleen-kidney Yang deficiency–induced diarrhea
ConclusionThis study suggests that ESWP may elicit significant effects on the treatment of polyuria. Potential mechanisms at least partially involve hormone regulation, and alleviating renal pathological damage. Simultaneously, ESWP may alter renal water absorption by increasing AQP 2 and AVPR 2 expression levels. Thus, the in vivo experimental evidence indicates that ESWP has a therapeutic effect on the SKYD syndrome, which is consistent with its traditional usage.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 4, 2018 Category: Drugs & Pharmacology Source Type: research

PD-1/ PD-L1 blockade as a novel treatment for colorectal cancer
We present a comprehensive knowledge of immune therapy through PD-1/PD-L1 blockade that argues how efficient the process is, in colon cancer carcinoma. In this review, we discuss the responsiveness of immunotherapy on PD-1/PD-L1 blockade and various tactics for overcoming weak responses to these checkpoint inhibitors in CRC. More research using controlled trials is required to enable new discoveries to provide continued success with immune-based therapies and grounds for optimism about the future of CRC patients.Graphical abstractThe mechanism of interaction between PD-1+ T-cells and PD-L1/2+ tumor cells. (Source: Biomedic...
Source: Biomedicine and Pharmacotherapy - December 4, 2018 Category: Drugs & Pharmacology Source Type: research

Wuzhi capsule (Schisandra Sphenanthera extract) attenuates liver steatosis and inflammation during non-alcoholic fatty liver disease development
Conclusions: WZ plays a protective role against MCD-induced steatohepatitis. The underlying mechanism likely involves the upregulation of PPAR-α/γ and downregulation of the NF-κB signalling pathway. Based on its beneficial effects on the liver, WZ is a promising therapeutic for NAFLD patients.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 3, 2018 Category: Drugs & Pharmacology Source Type: research

Ivabradine possesses anticonvulsant and neuroprotective action in mice
In conclusion, IVA has anticonvulsant, antioxidant and neuroprotective effects against PTZ- and PICRO-induced seizures. Also, a high affinity of IVA to GABAA receptor was predicted, representing a potential underlying mechanism to these observable effects.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 2, 2018 Category: Drugs & Pharmacology Source Type: research

Urinary proteome analysis of acute hypercoagulable state in rat model induced by ε-aminocaproic acid
This study aimed to investigate systematic changes of urinary proteome in acute hypercoagulable state induced by certain antifibrinolytics. To reduce the effects of both genetic and environmental factors on the urinary proteome, we used a rat model of acute hypercoagulable state induced by an antifibrinolytic agent ε-aminocaproic acid, resembling human hypercoagulable state. Urine samples were collected during acute hypercoagulable state for analysis by liquid chromatography-tandem mass spectrometry (LCMS/MS). Of 65 significantly changed proteins in acute hypercoagulable state, 38 proteins had human orthologs, and ...
Source: Biomedicine and Pharmacotherapy - December 2, 2018 Category: Drugs & Pharmacology Source Type: research

PSORI-CM02 alleviates IMQ-induced mouse dermatitis via differentially regulating pro- and anti-inflammatory cytokines targeting of Th2 specific transcript factor GATA3
Publication date: February 2019Source: Biomedicine & Pharmacotherapy, Volume 110Author(s): Ding-hong Wu, Miao-miao Zhang, Ning Li, Xiong Li, Quan-wei Cai, Wan-lin Yu, Li-ping Liu, Wei Zhu, Chuan-jian LuAbstractThe IL-17-producing CD4+ T cell and γδT cells play critical roles in the pathogenesis of psoriasis (PS). PSORI-CM02 is a representative herbal formula for the treatment for PS in South China. It was confirmed to improve PS without obvious side effects in the clinic. Here we sought to clarify whether and how PSORI-CM02 regulates T cell differentiation and functions in IMQ-induced psoriasis-like BALB/c ...
Source: Biomedicine and Pharmacotherapy - December 2, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of compound sophorae decoction on dextran sodium sulfate (DSS)-induced colitis in mice by regulating Th17/Treg cell balance
ConclusionOverall, this study suggested that compound sophorae decoction significantly improves the symptoms and the pathological damage of mice with colitis and influences the immune function by regulating Th17/Treg cell balance in DSS-induced colitis in mice. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 1, 2018 Category: Drugs & Pharmacology Source Type: research

mircroRNA-152 prevents the malignant progression of atherosclerosis via down-regulation of KLF5
In conclusion, this study illustrates that miR-152 alleviates the pathogenesis of AS through inhibiting inflammatory responses by targeting KLF5, in which β-catenin might involves in. Our study provides a possibility of consideration of miR-152/KLF5 as a target for AS treatment. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 1, 2018 Category: Drugs & Pharmacology Source Type: research

Evaluation of a self-nanoemulsifying docetaxel delivery system
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): S. Akhtartavan, M. Karimi, K. Karimian, N. Azarpira, M. Khatami, H. HeliAbstractA self-nanoemulsifying drug delivery system (SNEDDS) was developed as a novel route to enhance the efficacy of docetaxel lipophilic drug. SNEDDS comprised ethyl oleate, Tween 80 and poly(ethylene glycol) 600, as oil, surfactant and co-surfactant, and formed stabilized monodispersed oil nanodroplets upon dilution in water. SNEDDS represented encapsulation efficiency and loading capacity of 21.4 and 52.7%, respectively. The docetaxel release profile from...
Source: Biomedicine and Pharmacotherapy - December 1, 2018 Category: Drugs & Pharmacology Source Type: research

Vascular endothelial growth factor increased the permeability of respiratory barrier in acute respiratory distress syndrome model in mice
ConclusionsOur data indicate that anti-vascular endothelial growth factor with soluble fms-like tyrosine kinase-1 could maintain the normal structure and function of respiratory membrane in acute respiratory distress syndrome mice model and might be a suitable therapeutic tool for the treatment of acute respiratory distress syndrome.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 1, 2018 Category: Drugs & Pharmacology Source Type: research

The effect of Psidium guajava aqueous leaf extract on liver glycogen enzymes, hormone sensitive lipase and serum lipid profile in diabetic rats
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Toluwani Tella, Bubuya Masola, Samson MukaratirwaAbstractDiabetes mellitus is characterized by hyperglycaemia that results from defects in insulin secretion or insulin action and is accompanied by general disturbances metabolism. Psidium guajava (PG) leaf is known to have antidiabetic effects that include lowering of blood glucose. The aim of the study was to investigate the effect of PG leaf extract on tissue activity of glycogen synthase (GS) and glycogen phosphorylase (GP); tissue activity of hormone sensitive lipase (HSL); ser...
Source: Biomedicine and Pharmacotherapy - December 1, 2018 Category: Drugs & Pharmacology Source Type: research

Zerumbone inhibits migration in ESCC via promoting Rac1 ubiquitination
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Meilin Wang, Jingling Niu, Lei Gao, Yang Gao, Shegan GaoAbstractZerumbone has been reported to maintain the anti-cancer effects in many malignant cells. However, the effect and mechanism of Zerumbone on esophageal squamous cell carcinomas (ESCC) is rarely investigated. Here we report the inhibitory effect of Zerumbone (hereinafter referred to as ZER) on ESCC migration and the underlying molecular mechanism. ZER could inhibit the migration of human esophageal squamous cancer KYSE-30 cells and KYSE-150 cells. ZER induced Rac1 protei...
Source: Biomedicine and Pharmacotherapy - December 1, 2018 Category: Drugs & Pharmacology Source Type: research

Icariin inhibits cell proliferation, migration and invasion by down-regulation of microRNA-625-3p in thyroid cancer cells
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Lei Fang, Wei Xu, Dedi KongAbstractThyroid cancer (TC) is a familiar cancer, which accounts for approximately 1% of the malignant tumors of all cancers worldwide. Recently, icariin (ICA) has been reported to play an anti-tumor role in different cancers. The study aimed to investigate the effect of ICA on TC cells to uncover the regulatory mechanism. The different concentrations of ICA were stimulated SW579 and TPC1 cells, and cell viability, apoptosis, migration, invasion and main factors of these processes were detected by CCK-8,...
Source: Biomedicine and Pharmacotherapy - December 1, 2018 Category: Drugs & Pharmacology Source Type: research

ACY-1215 exhibits anti-inflammatory and chondroprotective effects in human osteoarthritis chondrocytes via inhibition of STAT3 and NF-κB signaling pathways
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Chao Cheng, Wenshan Shan, Wei Huang, Zhenfei Ding, Guanjun Cui, Fuen Liu, Wei Lu, Jiegou Xu, Wei He, Zongsheng YinAbstractCartilage degeneration is a basic pathological feature of osteoarthritis (OA), and there is growing evidence that it is associated with inflammation. ACY-1215, a selective HDAC6 inhibitor, has been reported to have anti-inflammatory effects. Here, we investigated the anti-inflammatory and chondroprotective effects of ACY-1215 in IL-1β-stimulated human primary chondrocytes and C28/I2 cells. The results sugg...
Source: Biomedicine and Pharmacotherapy - December 1, 2018 Category: Drugs & Pharmacology Source Type: research

Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-γ and NF-κB
ConclusionSupplementation with HT improve the WAT dysfunction induced by HDF in mice through the modulation of transcription factors NF-κB, Nrf2, SREBP-1c and PPAR-γ as well as their target genes, involved in inflammation, antioxidant defenses and lipogenesis.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 1, 2018 Category: Drugs & Pharmacology Source Type: research

Wild edible onions — Allium flavum and Allium carinatum — successfully prevent adverse effects of chemotherapeutic drug doxorubicin
The objective of this study was to evaluate potential of two chemically characterized edible wild onion species, Allium flavum and Allium carinatum, to reduce side effects of cytostatic doxorubicin (Dox). Since Dox application is mainly limited due to its high cardiotoxicity, while there are no approved cardioprotective agents for the prevention of Dox adverse effects, new co-treatments are urgently needed. Here, we showed that methanol extracts expressed high antioxidant activity and synergistically increased Dox anticancer activity against human hepatoma (HepG2) and lung carcinoma (A549) cells, while protected normal hum...
Source: Biomedicine and Pharmacotherapy - December 1, 2018 Category: Drugs & Pharmacology Source Type: research

The arrival of predictive biomarkers for monitoring therapy response to natural compounds in cancer drug discovery
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Khalid El Bairi, Atanas G. Atanasov, Mariam Amrani, Said AfqirAbstractIntrinsic or acquired drug resistance, adverse drug reactions and tumor heterogeneity between and within cancer patients limit the efficacy of clinical management of advanced cancers. To overcome these barriers, predictive biomarkers have recently emerged to guide medical oncologists in the selection of cancer patients who will respond to various anticancer treatments and to improve the toxicity to benefit ratio. Notably, targeted therapy has significantly benef...
Source: Biomedicine and Pharmacotherapy - December 1, 2018 Category: Drugs & Pharmacology Source Type: research

The applications of anti-CD20 antibodies to treat various B cells disorders
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Zahra Payandeh, Armina Alagheband Bahrami, Reyhaneh Hoseinpoor, Yousef Mortazavi, Masoumeh Rajabibazl, Azam Rahimpour, Amir Hossein Taromchi, Saeed KhalilAbstractB-lymphocyte antigen CD20 (called CD20) is known as an activated-glycosylated phosphoprotein which is expressed on the surface of all B-cells. CD20 is involved in the regulation of trans-membrane Ca2+ conductance and also play critical roles in cell‐cycle progression during human B cell proliferation and activation. The appearance of monoclonal antibody (mAb) technology...
Source: Biomedicine and Pharmacotherapy - December 1, 2018 Category: Drugs & Pharmacology Source Type: research

Potent anti-cancer activity of Alnus nitida against lung cancer cells; in vitro and in vivo studies
In this study we have evaluated methanol extract of leaf (ANL) and stem bark (ANB) of A. nitida against two lung cancer cell lines; A-549 and H460 (Human non-small lung cancer cell lines) during in vitro assays for growth inhibition. Treatment with ANL and ANB markedly inhibited the growth of both cancer cell lines. Exposure of A-549 and H460 cancer cell lines to ANL and ANB inhibited cell survival, colony growth and migration of cells. Further, treatment of A-549 and H460 with ANL and ANB indicated alteration in actin fibers after staining with rhodamine-phalloidin. Both extracts cause shrinkage and cell cycle arrest duri...
Source: Biomedicine and Pharmacotherapy - December 1, 2018 Category: Drugs & Pharmacology Source Type: research

Cytoprotective role of S14G-humanin (HNG) in ultraviolet-B induced epidermal stem cells injury
In this study, we isolated mouse epidermal stem cells and investigated the cytoprotective effects of HNG on ESCs upon ultraviolet (UV)-B treatment. We show that HNG suppresses UV-B-induced ROS production and increases antioxidant glutathione expression. HNG-pretreated cells exhibit very mild production of cytokines, including TNF-α, IL-1β, and IL-6, upon exposure to UV-B. HNG pretreatment is protective against UV-B-mediated cytotoxicity and promotes ESC survival. Moreover, HNG treatment attenuates the UV-B-induced reduction in mitochondrial membrane potential (MMP) and preserves their identity and stem cell capa...
Source: Biomedicine and Pharmacotherapy - December 1, 2018 Category: Drugs & Pharmacology Source Type: research

Chronic exposure to the opioid tramadol induces oxidative damage, inflammation and apoptosis, and alters cerebral monoamine neurotransmitters in rats
In conclusion, our results indicate that the neurotoxic effect of chronic tramadol consumption is mediated via oxidative stress, inflammation and apoptosis. Tramadol provoked lipid peroxidation, up-regulated inflammation and apoptosis markers and altered neurotransmission in the cerebrum of rats.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - December 1, 2018 Category: Drugs & Pharmacology Source Type: research

Rosmarinic acid reduces the resistance of gastric carcinoma cells to 5-fluorouracil by downregulating FOXO4-targeting miR-6785-5p
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Chen Yu, Dong-qing Chen, Hai-xia Liu, Wei-bing Li, Jian-wei Lu, Ji-feng FengAbstractObjectiveChemoresistance has been a major problem in cancer chemotherapy. The present study aimed to investigate the effect of Rosmarinic acid (RA) on chemoresistance to 5-Fu and its molecular mechanism in gastric carcinoma.MethodsCCK8 cell proliferation and apoptosis assay were used to evaluate the effect of RA on chemoresistance to 5-Fu in GC cells. RNA microarray was used to identify miRNA involved. Expression level of miRNA in GC cells was dete...
Source: Biomedicine and Pharmacotherapy - November 30, 2018 Category: Drugs & Pharmacology Source Type: research

Hsa-let-7g promotes osteosarcoma by reducing HOXB1 to activate NF-kB pathway
In conclusion, hsa-let-7 g is highly expressed in osteosarcoma tissues, and high expression of hsa-let-7 g can promote the occurrence of osteosarcoma by down-regulating HOXB1 and activating NF-kB pathway.Graphical abstractA schematic model of Hsa-let-7 g–HOXB1–NF-kB signaling pathway in osteosarcoma. Mature hsa-let-7 g can bound HOXB1, resulting in downregulation of HOXB1 expression. Meanwhile, NF-kB passway is activated by the overexpression of hsa-let-7 g and downregulation of HOXB1. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 30, 2018 Category: Drugs & Pharmacology Source Type: research

Phytomodulatory proteins promote inhibition of hepatic glucose production and favor glycemic control via the AMPK pathway
In this study the phytomodulatory proteins (LP) from C. procera latex were assessed on glycemic homeostasis.Control animals received a single intravenous dose (5 mg/kg) of LP or saline solution (CTL). Four hours after treatment, the animals were euthanized and their livers were excised for analysis by western blot and RT-PCR AMP-activated protein kinase (AMPK), phosphoenolpyruvate carboxykinase (PEPCK) and tumor necrosis factor alpha (TNF-α). In vivo tests of intraperitoneal tolerance to insulin, glucose and pyruvate were also performed, and the effect of LP administration on fed glycemia was studied followed ...
Source: Biomedicine and Pharmacotherapy - November 30, 2018 Category: Drugs & Pharmacology Source Type: research

The cardiac electrophysiology effects of higenamine in guinea pig heart
ConclusionWe show for the first time that HG produced a predominant action on the sinoatrial node. HG appears to control the cardiac electrophysiology through its predominant effect on the sinoarial node cells, without induction of the ectopic activity that causes cardiac arrhythmias. Thus, HG might be useful for the treatment of bradycardia. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 30, 2018 Category: Drugs & Pharmacology Source Type: research

MicroRNA-1270 modulates papillary thyroid cancer cell development by regulating SCAI
ConclusionHsa-miR-1270 downregulation may suppress human PTC cell development both in vitro and in vivo. The regulatory mechanism of hsa-miR-1270 in PTC may be primarily associated with SCAI. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 30, 2018 Category: Drugs & Pharmacology Source Type: research

Alpinia oxyphylla oil induces apoptosis of hepatocellular carcinoma cells via PI3K/Akt pathway in vitro and in vivo
This study was designed to investigate the anti-tumor activity and the underlying mechanism of PE’s effect on hepatocellular carcinoma (HCC) in vitro and in vivo.Materials and methodThe anti-tumor activity of PE was evaluated by MTT assay and xenograft study. Mechanistic studies of PE were analyzed by Hoechst 33342 staining, Annexin V-FITC/PI double-staining assay, immunohistochemical staining and western blot assay. The toxicity of the PE treatment was verified by the levels of liver and kidney function in nude mice and the H&E staining of their liver and kidney tissues.ResultPE significantly inhibited the growt...
Source: Biomedicine and Pharmacotherapy - November 30, 2018 Category: Drugs & Pharmacology Source Type: research

Differential toxicities of triptolide to immortalized podocytes and the podocytes in vivo
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Mengjie Sun, Hui Song, Yuting Ye, Qianqian Yang, Xiaodong Xu, Xiaodong Zhu, Jiong Zhang, Shaolin Shi, Jinquan Wang, Zhihong LiuAbstractTriptolide (TP) has an anti-proteinuric effect and is used for the treatment of podocytopathies. TP has also been shown to act directly on immortalized podocytes in culture to protect them from injury. In the present study, we examined the effect of TP on healthy podocytes both in vitro and in vivo to better understand the action of TP on podocytes. We found that treatment of TP at 10 ng/ml,...
Source: Biomedicine and Pharmacotherapy - November 30, 2018 Category: Drugs & Pharmacology Source Type: research

Chrysin (5,7-dihydroxyflavone) exerts anxiolytic-like effects through GABAA receptors in a surgical menopause model in rats
In conclusion, the flavonoid chrysin produced anxiolytic-like effects through actions on GABAA receptors in a model of surgical menopause in rats. These findings support the hypothesis that this flavonoid could be a future natural alternative for ameliorating symptoms of anxiety after surgical menopause in women.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 30, 2018 Category: Drugs & Pharmacology Source Type: research

Traditional Chinese medicine Gegen Qinlian decoction ameliorates irinotecan chemotherapy-induced gut toxicity in mice
ConclusionThe present study indicates that GQT extract can ameliorate CPT-11 induced gut toxicity in mice and improve CPT-11 efficacy in colorectal cancer treatment.Graphical abstractA bioactive herbal extract derived from a classic traditional Chinese medicine formula, Gegen Qinlian Decoction, was screened via macroporous resin, characterized by UPLC analysis, and investigated to impair gut-toxicity induced by CPT-11. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 29, 2018 Category: Drugs & Pharmacology Source Type: research

4-Acetylantroquinonol B from antrodia cinnamomea enhances immune function of dendritic cells against liver cancer stem cells
In conclusion, 4-AAQB from Antrodia cinnamomea can enhance immune function of dendritic cells against liver cancer stem cells, and may have the potential to be used for liver cancer prevention and immunotherapy.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 29, 2018 Category: Drugs & Pharmacology Source Type: research

Mechanisms of bergenin treatment on chronic bronchitis analyzed by liquid chromatography-tandem mass spectrometry based on metabolomics
This study aimed to investigate the preventive chronic bronchitis mechanism of Ber by applying a serum metabolomics strategy. In this study, 18 Sprague-Dawley rats were randomly divided into three groups,with six rats in each group. Rats from the CB and Ber groups were exposed to tobacco smoke for 1 hd−1 (1 h per day) for 28 days. Ber was administered orally to Ber rats 3 h after exposure every day, and the others were administered water. According to the morphometric analysis of the airway epithelium and the count of white blood cells in the bronchoalveolar lavage fluid, Ber suppressed the infil...
Source: Biomedicine and Pharmacotherapy - November 29, 2018 Category: Drugs & Pharmacology Source Type: research

Cerebral dopamine neurotrophic factor protects microglia by combining with AKT and by regulating FoxO1/mTOR signaling during neuroinflammation
ConclusionsCDNF combined with AKT and regulated the downstream pathway FoxO1/mTOR in microglia, eventually suppressing the secretion of inflammatory factors. Therefore, CDNF might play a protective role in the neuroinflammation of microglia via AKT/FoxO1/mTOR signaling. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 29, 2018 Category: Drugs & Pharmacology Source Type: research

Protective effects of Cinnamomum zeylanicum L. (Darchini) in acetaminophen-induced oxidative stress, hepatotoxicity and nephrotoxicity in mouse model
In conclusion, the pretreatment with cinnamon provide potential therapeutic applications in acute liver and kidney injury induced by APAP in experimental animal model and it could have therapeutic potential in oxidative stress associated diseases.Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 29, 2018 Category: Drugs & Pharmacology Source Type: research

miR-449a induces EndMT, promotes the development of atherosclerosis by targeting the interaction between AdipoR2 and E-cadherin in Lipid Rafts
In conclusion, miR-449a targeted to AdipoR2, and was a crucial mediator of EndMT and atherosclerosis in ECs through regulating E-cadherin bindability with AdipoR2 in lipid rafts. These results suggested that aim to lipid rafts and miR-449a in chronic EC inflammation response, was a feasible therapy strategy for atherosclerosis. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - November 29, 2018 Category: Drugs & Pharmacology Source Type: research

A simple and rapid-acting approach for the reduction of C-reactive protein
Publication date: January 2019Source: Biomedicine & Pharmacotherapy, Volume 109Author(s): Amir Abbas Momtazi-Borojeni, Seyed Hasan Ayati, Mahmoud Reza Jaafari, Amirhossein SahebkarAbstractC-reactive protein (CRP) is an acute-phase protein which can bind to and aggregate oxidized low-density lipoprotein (ox-LDL) particles, thereby enhancing the uptake of oxLDL by macrophages. This finally leads to the formation of foam cells that are a typical characteristic of atherosclerotic plaques. Serum CRP has been shown to bind to phospholipids such as phophatidylcholine (PC), phosphatidylglycerol (PG) and phosphatidylserine (PS)...
Source: Biomedicine and Pharmacotherapy - November 29, 2018 Category: Drugs & Pharmacology Source Type: research

Icariin ameliorates cisplatin-induced cytotoxicity in human embryonic kidney 293 cells by suppressing ROS-mediated PI3K/Akt pathway
In this study, icariin pretreatment for 24 h significantly ameliorated cisplatin-induced oxidative stress by reducing levels of malondialdehyde (MDA) and reactive oxygen species (ROS), while increasing level of glutathione (GSH) in HEK-293 cells. Furthermore, icariin pretreatment reduced NF-κB phosphorylation and nuclear translocation in HEK-293 cells followed by decreased secretion of IL-1β, TNF-α, and iNOS, suggesting a suppression of inflammatory response. Moreover, icariin pretreatment significantly reduced cellular apoptosis via reduced levels of Bax, cleaved caspase-3/9, and increased anti-apo...
Source: Biomedicine and Pharmacotherapy - November 29, 2018 Category: Drugs & Pharmacology Source Type: research