Antioxidant effects and mechanism of silymarin in oxidative stress induced cardiovascular diseases
We present a comprehensive review regarding the oxidative stress and protective effects of silymarin in CVDs management. We also aim to provide mechanistic insight of the mechanisms of silymarin action in oxidative stress-induced CVDs. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 5, 2018 Category: Drugs & Pharmacology Source Type: research

Oncogenic long noncoding RNA MALAT1 and HCV-related hepatocellular carcinoma
In conclusion, circulatory MALAT1 might represent a putative non-invasive prognostic biomarker indicating worse liver failure score in HCV-related HCC patients with traditional markers. Large-scale verification is warranted in future studies. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - April 5, 2018 Category: Drugs & Pharmacology Source Type: research

Targeted cancer therapy through 17-DMAG as an Hsp90 inhibitor: Overview and current state of the art
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Hassan Mellatyar, Sona Talaei, Younes Pilehvar-Soltanahmadi, Abolfazl Barzegar, Abolfazl Akbarzadeh, Arman Shahabi, Mazyar Barekati-Mowahed, Nosratollah Zarghami Heat shock protein 90 (Hsp90) is an evolutionary preserved molecular chaperone which mediates many cellular processes such as cell transformation, proliferation, and survival in normal and stress conditions. Hsp90 plays an important role in folding, maturation, stabilization and activation of Hsp90 client proteins which all contribute to the development, and proliferat...
Source: Biomedicine and Pharmacotherapy - April 5, 2018 Category: Drugs & Pharmacology Source Type: research

Arginine: Challenges and opportunities of this two-faced molecule in cancer therapy
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Mozhgan Jahani, Fatemeh Noroznezhad, Kamran Mansouri Numerous antitumor therapies have been developed based on the differences in cells’ metabolisms. Regarding the important role of arginine (Arg) in the regulation of multiple metabolic and signaling pathways, its deprivation has been proposed as a good strategy for tumor regression in tumors with defected Arg metabolic enzymes like argininosuccinate synthase 1 (ASS1). However, modulatory effect of Arg on various cancers is also a controversial issue. Therefore, this revi...
Source: Biomedicine and Pharmacotherapy - April 5, 2018 Category: Drugs & Pharmacology Source Type: research

A review on phytochemistry and therapeutic uses of Hibiscus sabdariffa L.
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Ghazala Riaz, Rajni Chopra Hibiscus sabdariffa L. (roselle) belonging to the Malvaceae family is widely grown in many countries. This plant is often used in the traditional medicine being rich in phytochemicals like polyphenols especially anthocyanins, polysaccharides and organic acids thus having enormous prospective in modern therapeutic uses. The study aimed to review and document all the available evidence and information about the calyces of Hibiscus sabdariffa (roselle) with the special focus on their nutritional composit...
Source: Biomedicine and Pharmacotherapy - April 5, 2018 Category: Drugs & Pharmacology Source Type: research

Chitooligosaccharide: An evaluation of physicochemical and biological properties with the proposition for determination of thermal degradation products
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Lucas Phil, Muhammad Naveed, Imran Shair Mohammad, Li Bo, Di Bin Being the most versatile biopolymer, chitooligosaccharide/chitosan oligosaccharide (COS) has been extensively studied for a range of exceptional biological activities and potential developments of novel medical devices and systems in biomedical and pharmaceutical fields. While possessing intrinsic biocompatibility, mucoadhesiveness, and non-toxicity it gained more interests in the biomedical development of novel systems, devices, and pharmaceutical formulations. T...
Source: Biomedicine and Pharmacotherapy - April 5, 2018 Category: Drugs & Pharmacology Source Type: research

Sesquiterpenoids from the root of Panax Ginseng protect CCl4 –induced acute liver injury by anti-inflammatory and anti-oxidative capabilities in mice
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Weidong Wang, Shijie Wang, Jinping Liu, Enbo Cai, Hongyan Zhu, Zhongmei He, Yugang Gao, Pingya Li, Yan Zhao The oxidative stress and inflammatory response play an important role in carbon tetracholoride (CCl4)-induced acute liver injury. In this work, sesquiterpenoids from the root of Panax Ginseng (SPG) were prepared, and then the hepatoprotective effects of SPG against CCl4-induced acute liver injury were investigated and the underlying mechanism was explored in mice. All mice were divided into four groups: the control, CCl4 ...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Umbelliferone prevents oxidative stress, inflammation and hematological alterations, and modulates glutamate-nitric oxide-cGMP signaling in hyperammonemic rats
In conclusion, this study provides evidence that UMB protects against hyperammonemia via attenuation of oxidative stress and inflammation. UMB prevents hyperammonemia associated hematological alterations and therefore represents a promising protective agent against the deleterious effects of excess ammonia. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Anti-arrhythmogenic and anti-inflammatory effects of troxerutin in ischemia/reperfusion injury of diabetic myocardium
Conclusion Preconditioning with TXR could provide cardioprotection by anti-arrhythmic and anti-inflammatory effects against I/R injury in rat hearts. This effect of TXR can introduce this material as a protective agent in cardiovascular diseases. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Pretreatment with taurine prevented brain injury and exploratory behaviour associated with administration of anticancer drug cisplatin in rats
In conclusion, taurine may be a possible protective supplement to reduce cisplatin-induced side-effects including neurotoxicity in patients undergoing cisplatin treatment. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

TNF- α contributes to postmenopausal osteoporosis by synergistically promoting RANKL-induced osteoclast formation
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Li Zha, Li He, Yijian Liang, Hui Qin, Bin Yu, Linli Chang, Li Xue Previous studies showed that inflammatory cytokines promote osteoclast formation, characterized by the function of bone resorption. However, it remains unclear whether inflammatory factors contribute to osteoporosis syndrome in postmenopausal women. Here, we found that postmenopausal women with osteoporosis (PO) had increased levels of TNF-α, compared with those without osteoporosis. TNF-α is highly correlated with the RANK and estrogen levels in PO p...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Linalyl acetate prevents olmesartan-induced intestinal hypermotility mediated by interference of the sympathetic inhibitory pathway in hypertensive rat
In this study, interference with this inhibitory pathway was analyzed in a model of olmesartan-induced intestinal hypermotility (OIH) in rats with nicotine-induced hypertension exposed to chronic immobilizing stress. The effects of the potent inhibitory neurotransmitters norepinephrine (NE) and sodium nitroprusside (SNP), which act via different pathways, were assessed ex vivo, with only NE-modulated frequency and amplitude of spontaneous contractions found to be elevated in OIH rat jejunum. Clinical symptoms frequent in OAE, including atrophy of the intestinal epithelium and weight loss, were observed in these rats. Inter...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Experimental diabetes induced by streptozotocin in the desert gerbil, Gerbillus gerbillus, and the effects of short-term 20-hydroxyecdysone administration
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Aicha Mallek, Jamileh Movassat, Souad Ameddah, Junjun Liu, Nesrine Semiane, Ali Khalkhal, Yasmina Dahmani The present work was aimed at studying the effects of streptozotocin (STZ; 130 mg/kg) in the desert gerbil, Gerbillus gerbillus, and at evaluating the impact of the short-term administration of 20-hydroxyecdysone (20E; 5 mg/kg). We observed that administration of streptozotocin caused a significant increase in plasmatic glucose and a decrease in insulin levels. The plasma lipid profile and liver glycogen content were al...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Involvement of estrogen receptors in silibinin protection of pancreatic β-cells from TNFα- or IL-1β-induced cytotoxicity
This study reports the effect of silibinin on the rat pancreatic β-cell line, INS-1, damaged with pro-inflammatory cytokine, TNFα or IL-1β. Exposure to TNFα or IL-1β for 48 h caused INS-1 cells to reduce the production of insulin as well as cell viability. These actions of TNFα or IL-1β are associated with suppression of the expression of estrogen receptors (ERs). Further study revealed that silibinin protected the suppression in the expression of both ERα and ERβ that were involved in insulin synthesis and release, respectively. Furthermore, evidence is obtained that sili...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Long noncoding RNA SNHG7 accelerates prostate cancer proliferation and cycle progression through cyclin D1 by sponging miR-503
In conclusion, results present that SNHG7 regulates the cycle progression and acts as an oncogenic gene in the prostate cancer tumorigenesis via miR-503/Cyclin D1 pathway, revealing the vital role of lncRNA/miRNA/mRNA axis in prostate cancer carcinogenesis. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Enhanced lipoxygenase/LTD4 signaling accounts for the exaggerated hypertensive and nephrotoxic effects of cyclosporine plus indomethacin in rats
We examined whether these influences relate to the arachidonate/5-lipoxygenase (LOX) pathway. Rats were treated with CSA (20 mg kg−1 day−1), indomethacin (5 mg kg−1 day−1), or their combination for 10 days. Changes in SBP and renal biochemical/histopathological characteristics along with leukotriene levels were determined in rats treated with or without LT receptor antagonists. CSA or indomethacin caused: (i) renal tubular atrophy and interstitial fibrosis, (ii) increases in serum creatinine, blood urea nitrogen (BUN), and renal LTD4, LTB4, TNF-α, TGF-β1, and caspase-3, and (i...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Sanguinarine inhibits epithelial ovarian cancer development via regulating long non-coding RNA CASC2-EIF4A3 axis and/or inhibiting NF- κB signaling or PI3K/AKT/mTOR pathway
Conclusions Our findings reveal that sanguinarine exhibits antitumor effects in epithelial ovarian cancer cells possible via regulating CASC2-EIF4A3 axis and/or inhibiting NF-κB signaling or PI3K/AKT/mTOR pathway. Sanguinarine may serve as a potential therapeutic reagent for epithelial ovarian cancer. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Astragalus polysaccharide protects hypoxia-induced injury by up-regulation of miR-138 in rat neural stem cells
In conclusion, this study demonstrated a protective effect of APS on hypoxia-induced NSC injury. The regulatory mechanism might be mediated by up-regulation of miR-138 and inhibition of the JNK and p38MAPK pathways. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

MicroRNA-132 and microRNA-212 mediate doxorubicin resistance by down-regulating the PTEN-AKT/NF- κB signaling pathway in breast cancer
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Manxin Xie, Ziyi Fu, Jianxiang Cao, Yuan Liu, Jie Wu, Qing Li, Yun Chen Breast cancer is a serious health problem worldwide. Acquisition of multi-drug resistance (MDR) during the treatment of breast cancer is still considered a major clinical obstacle. Despite the biological functions of miRNAs becoming increasingly apparent, the function of miRNAs in regulating drug resistance of breast cancer remains under investigation. Quantitative real-time PCR (qRT-PCR) was used to quantify the expression of miR-132/-212 (miR-132 and miR-...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Epiisopiloturine, an imidazole alkaloid, reverses inflammation and lipid peroxidation parameters in the Crohn disease model induced by trinitrobenzenosulfonic acid in Wistar rats
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Lucas Rodrigues de Carvalho, Tarcisio Vieira de Brito, José Simião da C. Júnior, Genilson José Dias Júnior, Diva de Aguiar Magalhãres, Stefany Guimarães Sousa, Renan Oliveira Silva, Felipe Rodolfo Pereira da Silva, Daniel Fernando Pereira Vasconcelos, Leiz Maria Costa Véras, José Roberto de Sousa de Almeida Leite, Dainesy Santos Martins, Conceição da Silva Martins, Jefferson Soares de Oliveira, André Luiz dos Reis Barbosa Epiisopiloturine (EPI) ...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Silencing ZAP70 prevents HSP65-induced reverse cholesterol transport and NF- κB activation in T cells
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Jing Hu, Tiantian Luo, Dan Xi, Kai Guo, Lu Hu, Jinzhen Zhao, Si Chen, Zhigang Guo T cell activation by antigens binding to the T cell receptor (TCR) must be properly regulated to ensure normal T cell development. The ζ chain-associated 70-kDa protein (ZAP70) is sequentially activated in response to TCR engagement and serves as a critical component of the TCR signaling pathway, which is essential for T cell activation. However, some roles of ZAP70 have not been fully elucidated. In the present study, we analyzed the effects...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Metformin inhibits glioma cells stemness and epithelial-mesenchymal transition via regulating YAP activity
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Xuesong Yuan, Wenfeng Wei, Qing Bao, Hongchun Chen, Peng Jin, Wenqing Jiang This work aims to study the roles and mechanisms of metformin in glioma cells stemness and epithelial-mesenchymal transition. Here, we found that metformin suppressed glioma cells spheroid formation and size, inhibited the expression of glioma stemness-related marker, CD133. Additionally, Metformin attenuated TGF-β-induced epithelial-mesenchymal transition in glioma cells. Mechanistically, metformin inhibited the nuclear abundance of YAP, a key eff...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Trans-anethole prevents hypertension induced by chronic exposure to both restraint stress and nicotine in rats
This study investigated whether trans-anethole would prevent hypertension induced by chronic exposure to both restraint stress and nicotine in rats. Rats received nicotine intraperitoneally for 21 days following restraint stress (2 h/day) and trans-anethole (62, 125, and 250 mg/kg) on days 4, 8, 12, 16 and 20. To confirm the preventive effects of trans-anethole, blood pressure and vascular tone were measured on the last day of the experiment, and compared with the results of nifedipine and aerobic exercise. The ability of trans-anethole, at doses of 125 mg/kg and 250 mg/kg, to prevent hypertension was comparable to...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Nanobodies targeting cortactin proline rich, helical and actin binding regions downregulate invadopodium formation and matrix degradation in SCC-61 cancer cells
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Laurence Bertier, Tim Hebbrecht, Elien Mettepenningen, Natasja De Wit, Olivier Zwaenepoel, Adriaan Verhelle, Jan Gettemans Cortactin is a multidomain actin binding protein that activates Arp2/3 mediated branched actin polymerization. This is essential for the formation of protrusive structures during cancer cell invasion. Invadopodia are cancer cell-specific membrane protrusions, specialized at extracellular matrix degradation and essential for invasion and tumor metastasis. Given the unequivocal role of cortactin at every stag...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

The effectiveness of cyclooxygenase-2 inhibitors and evaluation of angiogenesis in the model of experimental colorectal cancer
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Hilal Gungor, Nevin Ilhan, Hatice Eroksuz Colorectal cancer (CRC) is an important cause of cancer-related deaths worldwide. Early diagnosis and treatment of CRCs are of importance for improving the survival. In the present study, we studied the effects of nonsteroidal anti-inflammatory drugs (NSAIDs)-induced chemopreventive effects on tumor development incidence and angiogenesis in experimental CRC rats. 1,2-Dimethylhydrazine dihydrochloride (DMH) was used as cancer-inducing agent and two NSAIDs (celecoxib and diclofenac) were ...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Panax quinquefolius saponin inhibits endoplasmic reticulum stress-mediated apoptosis and neurite injury and improves functional recovery in a rat spinal cord injury model
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Hai-Cheng Dou, Jun-Yu Chen, Tang-Fei Ran, Wei-Min Jiang The treatment goal in spinal cord injury (SCI) is to repair neurites and suppress cell apoptosis. Panax quinquefolius saponin (PQS) is the major active ingredient of American ginseng and has been demonstrated to have anti-inflammatory and anti-apoptotic roles in various diseases. However, the potential effect of PQS on the pathological process of acute SCI remains unknown. This work tested the effects of PQS on acute SCI and clarified its potential mechanisms. PQS treatmen...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

MicroRNA-625-3p promotes the proliferation, migration and invasion of thyroid cancer cells by up-regulating astrocyte elevated gene 1
Conclusion miR-625-3p promoted proliferation, migration and invasion of thyroid cancer cells by enhancing the expression of AEG-1 and activating downstream Wnt/β-catenin and JNK pathways. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Protective effects of phycocyanin on ischemia/reperfusion liver injuries
In conclusion, the results show the Pc-enriched KH conservation solution is effective in preserving the hepatic graft and protecting it against IRI by acting as a potent antioxidant against the products of oxidative stress. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Quercetin attenuates zymosan-induced arthritis in mice
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Carla F.S. Guazelli, Larissa Staurengo-Ferrari, Ana C. Zarpelon, Felipe A. Pinho-Ribeiro, Kenji W. Ruiz-Miyazawa, Fabiana T.M.C. Vicentini, Josiane A. Vignoli, Doumit Camilios-Neto, Sandra R. Georgetti, Marcela M. Baracat, Rubia Casagrande, Waldiceu A. Verri Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by articular lesions, recruitment of inflammatory cells and increased levels of pro-inflammatory cytokine. The intra-articular administration of zymosan is an experimental model that promotes inflammato...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

LncRNA CBR3-AS1 predicts unfavorable prognosis and promotes tumorigenesis in osteosarcoma
In conclusion, lncRNA CBR3-AS1 serves an oncogenic role to regulate osteosarcoma cells proliferation, migration, invasion and apoptosis, and is an independent poor prognostic factor for osteosarcoma patients. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Atorvastatin dose-dependently promotes mouse lung repair after emphysema induced by elastase
In conclusion, atorvastatin was able to induce lung tissue repair in emphysematous mice. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

MiR-34a-5p mediates sevoflurane preconditioning induced inhibition of hypoxia/reoxygenation injury through STX1A in cardiomyocytes
In this study, the results demonstrated that the expression of STX1A was significantly increased, while miR-34a-5p was dramatically decreased in sev-preconditioning H9c2 cells as compared with cells only under H/R stimulation. Moreover, miR-34a-5p regulated the protective effect of sev-preconditioning in injured H9c2 cells by mediating cell proliferation and cell apoptosis. Additionally, the luciferase report confirmed the targeting reaction between STX1A and miR-34a-5p. Taken together, our study suggested that miR-34a-5p regulated sev-preconditioning induced inhibition of hypoxia/reoxygenation injury through mediating STX...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

miR-424-5p regulates cell proliferation, migration and invasion by targeting doublecortin-like kinase 1 in basal-like breast cancer
In conclusion, miR-424-5p is a tumor suppressive microRNA to regulate tumor cell proliferation, migration and invasion via binding to the functional target DCLK1, and associated with malignant status in basal-like breast cancer. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Resveratrol regulates hyperglycemia-induced modulations in experimental diabetic animal model
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Kanwal Rehman, Kiran Saeed, Syeda Mehak Munawar, Muhammad Sajid Hamid Akash Type 2 diabetes mellitus (T2DM) is a metabolic disorder that is associated with variable degrees of glucose intolerance, impaired insulin secretion, insulin resistance and increased hepatic glucose production. The aim of present study was to investigate the therapeutic potentials of resveratrol (RSV) alone and/or in combination with vitamin-E (Vit-E) against hyperglycemia-induced modulations using experimentally alloxan-induced diabetic animal model. Al...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Bioprospection of Eugenia brasiliensis, a Brazilian native fruit, as a source of anti-inflammatory and antibiofilm compounds
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Josy Goldoni Lazarini, Janaina de Cássia Orlandi Sardi, Marcelo Franchin, Bruno Dias Nani, Irlan Almeida Freires, Juliana Infante, Jonas Augusto Rizzato Paschoal, Severino Matias de Alencar, Pedro Luiz Rosalen The anti-inflammatory and antibiofilm activities as well as toxicity and chemical profile of Eugenia brasiliensis pulp extract (EBE), were evaluated. EBE chemical profile and phenolic content were determined by LC–MS/MS. EBE was tested for its in vitro and in vivo anti-inflammatory activity, including TNF-&al...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Participation of the IKK- α/β complex in the inhibition of the TNF-α/NF-κB pathway by glycine: Possible involvement of a membrane receptor specific to adipocytes
In conclusion, the reduction of TNF-α and IL-6 and suppression of the TNF-α/NF-κB pathway by glycine may be explained in part by inhibition of the IKK-α/β complex, with a possible participation of GlyR in 3T3-L1 adipocytes. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Gefitinib inhibits retina angiogenesis by affecting VEGF signaling pathway
In conclusion, these findings indicate that Gefitinib is critical for the treatment of retina angiogenesis, which is associated with VEGF/Cyclin E/CDK2/CD31 pathway. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Long noncoding RNA MINCR regulates cellular proliferation, migration, and invasion in hepatocellular carcinoma
Conclusions To the best of our know ledge, MINCR in HCC has not been studied. Our findings showed that this study is the first to reveal that MINCR may act as a therapeutic target in HCC. The in-depth exploration of the molecular mechanism is required to illuminate the molecular mechanisms of MINCR in HCC development. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Estrogen: The necessary evil for human health, and ways to tame it
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Seema Patel, Ahmad Homaei, Akondi Butchi Raju, Biswa Ranjan Meher Estrogen is a pivotal enzyme for survival and health in both genders, though their quantum, tropism, tissue-specific distribution, and receptor affinity varies with different phases of life. Converted from androgen via aromatase enzyme, this hormone is indispensable to glucose homeostasis, immune robustness, bone health, cardiovascular health, fertility, and neural functions. However, estrogen is at the center of almost all human pathologies as well-infectious, a...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Stem cell therapy in Asherman syndrome and thin endometrium: Stem cell- based therapy
This study presents a summary of the investigations that indicate the key role of stem cell therapy in regeneration and renovation of defective parts. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

The role of nutrients in the pathogenesis and treatment of migraine headaches: Review
Conclusion Due to the possible side effects of pharmacological drugs and drug addictions, the use of nutrient compounds alone or in combination with routine cures have been proposed. However, further constructive studies are required. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Current approaches for the treatment of premature ovarian failure with stem cell therapy
This article reviews the latest studies on POF to summarize current understanding and future directions. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Role of lncRNAs in the cancer development and progression and their regulation by various phytochemicals
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Baskaran Rathinasamy, Bharath Kumar Velmurugan Long non coding RNAs (lncRNAs) are involved in modulating the expression of other non-coding RNAs (ncRNA), such as microRNAs, or target proteins through the epigenetic, transcriptional, or post-transcriptional regulations. Genomic mutations in cancer reside inside regions that do not code for proteins and these regions are often transcribed into long non coding RNAs (lncRNAs). Emerging evidences have revealed an intense involvement of lncRNAs in the cancer development and progressi...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Central nervous system diseases and Scutellaria: a review of current mechanism studies
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Samira EghbaliFeriz, Akram Taleghani, Zahra Tayarani-Najaran Scutellaria comprises many species traditionally used for cognitive and neurological conditions. In vitro and in vivo studies have supported the value of bioactive compounds of the genus Scutellaria for CNS disorders such as Alzheimer, cerebral ischemia, depression and anxiety. In particular, the effects of plants belonging to the genus Scutellaria and their components are detailed on cognitive ability such as memory, attention and learning. In this review, the pharma...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Current progress of tacrolimus dosing in solid organ transplant recipients: Pharmacogenetic considerations
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Xiao Zhang, Guigao Lin, Liming Tan, Jinming Li Tacrolimus is effective for the prevention of acute rejection, but is also highly toxic and has great intra- and inter-individual variability in transplant patients. Genetic variation and other factors influence the response of an individual to tacrolimus treatment. Therefore, even if therapeutic drug monitoring is universally applied, rejection and toxicity still occur. Although the appropriate action on pharmacogenomic variability provides a cornerstone for the precise tacrolimus...
Source: Biomedicine and Pharmacotherapy - March 22, 2018 Category: Drugs & Pharmacology Source Type: research

Effect of metformin on estrogen and progesterone receptor-positive (MCF-7) and triple-negative (MDA-MB-231) breast cancer cells
In conclusion, short-term exposure to metformin reduces cellular glucose uptake, probably by direct inhibition of GLUT1. However, after long-term exposure to metformin, cellular uptake of glucose is significantly increased, not associated to changes in GLUT1 transcription rates. We suggest that, in the long-term, metformin induces a compensatory increase in glucose uptake in response to cellular energy depletion resulting from its inhibitory effect on mitochondrial oxidative phosphorylation machinery. Metformin-induced dependence of breast cancer cells on glycolytic pathway, associated with an anticarcinogenic effect of th...
Source: Biomedicine and Pharmacotherapy - March 16, 2018 Category: Drugs & Pharmacology Source Type: research

MicRNA-320 facilitates the brain parenchyma injury via regulating IGF-1 during cerebral I/R injury in mice
Conclusions miR-320 may be involved in the regulation of cerebral I/R for brain parenchyma injury by inhibition of IGF-1 pathway. (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 15, 2018 Category: Drugs & Pharmacology Source Type: research

Protective effect of Lespedeza cuneata ethanol extract on Bisphenol A-induced testicular dysfunction in vivo and in vitro
Conclusions These results indicate that LCE prevented BPA-induced testicular dysfunction and cell viability in BPA-treated TM4 sertoli cells. Our study also suggests that LCE has the potential to protect male reproductive health. Graphical abstract (Source: Biomedicine and Pharmacotherapy)
Source: Biomedicine and Pharmacotherapy - March 15, 2018 Category: Drugs & Pharmacology Source Type: research

Ziziphus spina-christi (L.) leaf extract alleviates myocardial and renal dysfunction associated with sepsis in mice
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Mohamed A. Dkhil, Rami B. Kassab, Saleh Al-Quraishy, Mohamed M. Abdel-Daim, Rafat Zrieq, Ahmed E. Abdel Moneim Ziziphus spina-christi (L.), a traditional Arabian medicinal herb, has been used by Egyptians (Bedouin and Nubian) to treat inflammatory symptoms and swellings, pain, and heat since long. We aimed to investigate whether Ziziphus spina-christi leaf extract (ZSCLE) exerted a myocardial and renal protective effect on mice in which sepsis had been induced with cecal ligation and puncture (CLP). Male C57BL/6 mice were divid...
Source: Biomedicine and Pharmacotherapy - March 15, 2018 Category: Drugs & Pharmacology Source Type: research

Lung cancer targeted therapy: Folate and transferrin dual targeted, glutathione responsive nanocarriers for the delivery of cisplatin
Publication date: June 2018 Source:Biomedicine & Pharmacotherapy, Volume 102 Author(s): Sheng Tan, Guoxiang Wang To achieve lung cancer targeted therapy, folic acid (FA) and transferrin (Tf) modified cisplatin (CDDP) loaded nanoparticles were applied for the in vitro and in vivo evaluation. The aim of this research was to develop FA modified SS bonds based prodrug of CDDP (namely FA-ss-CDDP) and Tf modified cystamine-oleic acid (Tf-ss-OA). Further, FA-ss-CDDP and Tf-ss-OA were used to prepare NPs, which could target the lung tumor cells through receptor-mediated pathways to increase the efficiency of CDDP. FA and ...
Source: Biomedicine and Pharmacotherapy - March 15, 2018 Category: Drugs & Pharmacology Source Type: research