Knowledge, attitudes and demographic effect on menopausal experiences among Indian rural women
This study underscored the need for tailored interventions in rural settings, considering the influence of cultural, regional, and demographic factors on menopausal experiences. The findings contributed to bridging the research gap and emphasized the importance of individualized approaches for promoting the well-being of menopausal women in rural communities.PMID:38497080 | PMC:PMC10941773 | DOI:10.6026/973206300200175 (Source: Bioinformation)
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: N Sivasubramanian Chaudhari Pinalben Madhabhai Amita Shilpa Gottlieb B Mahalakshmi Payal Vaghela Sandeep Garg Source Type: research
Amino acid pattern reveals multi-functionality of ORF3 protein from HEV
Bioinformation. 2024 Feb 29;20(2):121-135. doi: 10.6026/973206300200121. eCollection 2024.ABSTRACTThe smallest open reading frame (ORF) encoded protein ORF3 of hepatitis E virus (HEV), recently, has been demonstrated to perform multiple functions besides accessory roles. ORF3 could act as a target for vaccine against HEV infections. The IDR (intrinsically disordered region); IDP (ID protein)/IDPR (ID protein region), plays critical role in various regulatory functions of viruses. The dark proteome of HEV-ORF3 protein including its structure and function was systematically examined by computer predictors to explicate its ro...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Zoya Shafat Asimul Islam Shama Parveen Source Type: research
Molecular docking analysis of flavonoids with AChE and BACE-1
Bioinformation. 2024 Feb 29;20(2):103-109. doi: 10.6026/973206300200103. eCollection 2024.ABSTRACTFlavonoids are promising therapeutics for the treatment of Alzheimer's disease (AD). Therefore, it is of interest to study the anti-AD potential of 35 flavonoids towards the inhibition of AchE and BACE-1. Hence, the physicochemical, pharmacokinetic parameters, toxicity risk and drug-likeliness of the selected 35 flavonoids were computed. Further, the molecular docking analysis of flavonoids with AChE and BACE-1 were completed. A binding energy of -10.42 kcal/mol Epicatechin gallate, -10.16 kcal/mol sterubin and -10.11 kcal/mol...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Sittarthan Viswanathan Thennavan Arumugam Kavimani Subramanian Rengaraj Sivaraj Vimalavathini Ramesh A Hannah Rachel Vasanthi Source Type: research
Deep breathing exercises in easing educational stress among Indian high school students
This study contributes vital insights into stress management strategies for higher secondary students, highlighting the efficacy of incorporating deep breathing exercises into their routine. The observed reductions in stress levels emphasize the potential benefits of practical stress reduction techniques within the educational milieu.PMID:38497065 | PMC:PMC10941770 | DOI:10.6026/973206300200156 (Source: Bioinformation)
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: B Mahalakshmi Katara Mittalben Ghemabhai Amita Shilpa Gottlieb N Sivasubramanian Padmavathi Parthasarathy Source Type: research
Astrovirology and terrestrial life survival
Bioinformation. 2024 Feb 29;20(2):146-150. doi: 10.6026/973206300200146. eCollection 2024.ABSTRACTMicrobial organisms have been implicated in several mass extinction events throughout Earth's planetary history. Concurrently, it can be reasoned from recent viral pandemics that viruses likely exacerbated the decline of life during these periods of mass extinction. The fields of exovirology and exobiology have evolved significantly since the 20th century, with early investigations into the varied atmospheric compositions of exoplanets revealing complex interactions between metallic and non-metallic elements. This diversity in...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Paul Shapshak Milad Zandi Charurut Somboonwit John T Sinnott Source Type: research
Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)
Bioinformation. 2024 Feb 29;20(2):91-102. doi: 10.6026/973206300200091. eCollection 2024.ABSTRACTRift Valley Fever (RVF) is a mosquito-borne viral zoonosis caused by RVFV in humans and livestock. Currently, there are no approved vaccines or antiviral therapies available. Additionally, in Saudi Arabia, there is a lack of a routine screening system to monitor RVFV in humans and animals which hinders to design and develop the preventive measures as well as the prediction of future outbreaks and the potential re-emergence of RVFV. Hence, we have performed the cloning, sequencing, and phylogenetic analysis, of nucleocapsid (N) ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Ahmed Mohamed Hassan Arwa Ahmed Zehairy Al-Judaibi Awatif Abid Sayed Sartaj Sohrab Ibraheem Azhar Esam Source Type: research
Knowledge, perception and usage of E-learning among medical undergraduates in Andhra Pradesh, India
Bioinformation. 2024 Feb 29;20(2):196-201. doi: 10.6026/973206300200196. eCollection 2024.ABSTRACTElectronic gadgets help to get study material outside classroom and it is used for self-directed learning which helps user to overcome limitations of Conventional teaching methods. Medical education is constantly growing and evolving with rapid speed. So, it is necessary to keep the upcoming medical graduates and established medical practitioners updated in this competitive world. For this, E-learning is the important tool in the medical field. This cross-sectional study was conducted in the medical college of Andhra Pradesh. ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Roza Bhaisare Shahana Syed Gaurav Rangari Source Type: research
Disability from cardiovascular diseases at Osh city, Kyrgyz Republic
We report the prevalence of disability in both urban and rural areas, highlighting the impact of regional disparities in medical and social services. Data shows that adult cardiovascular disease impairment in Kyrgyzstan suggests challenges in accessing medical and social support, particularly in rural regions. Thus, the rural-urban divide in critical disability metrics impedes equitable research. Comprehensive assessments and interventions are imperative to mitigate cardiovascular diseases and associated disabilities in both rural and urban populations at Kyrgyz Republic.PMID:38497069 | PMC:PMC10941784 | DOI:10.6026/973206...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Tazhidinovich Gulamov Isabek Kalmatovich Kalmatov Romanbek Sagynbaevich Sydykov Akylbek Temirzhanovich Abylov Kuttubek Nurlan Raiimbekuulu Akbalaevna Akbalaeva Begimai Siddiqui Mohd Faizan Source Type: research
Effect of aerobic exercise on anthropometric parameters among Indian primary school children
This study addresses the rising rates of obesity among school-age children (10-12 years) and investigates the effectiveness of aerobic exercise interventions in improving anthropometric parameters, specifically focusing on BMI and mid-arm circumference (MAC). The study emphasizes the role of schools in shaping children's behaviors and aims to contribute empirical evidence to inform health promotion strategies for this demographic. The research employs a quasi-experimental design, involving 60 school-age children in Visnagar, Gujarat, India. The 12-week aerobic exercise intervention, conducted three times a week, comprises ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: B Mahalakshmi Anjana Jagashibhai Chaudhary Amita Shilpa Gottlieb N Sivasubramanian Padmavathi Parthasarathy G Ramalakshmi P Jamunarani Source Type: research
Molecular docking analysis of marine phytochemicals with BACE-1
Bioinformation. 2024 Feb 29;20(2):151-155. doi: 10.6026/973206300200151. eCollection 2024.ABSTRACTAlzheimer's disease (AD), a debilitating neurodegenerative condition, is characterized by progressive cognitive decline brought about by the deposition of amyloid beta (Aβ) plaques in the brain initiates downstream neuronal dysfunction and death in AD pathogenesis. The β-secretase (BACE-1) enzyme plays a crucial role in generating Aβ from amyloid precursor protein (APP). Hence, we report the virtual screening of marine phytochemicals as BACE-1 inhibitors. 2583 compounds, retrieved from Comprehensive Marine Natural Product D...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Deepak Sheokand Annu Grewal Pawan Kumar Raveena Chauhan Vandana Saini Ajit Kumar Source Type: research
Exploring eating behaviors, knowledge and attitudes of adolescent Indian girls
Bioinformation. 2024 Feb 29;20(2):165-169. doi: 10.6026/973206300200165. eCollection 2024.ABSTRACTData on the eating behaviors, knowledge, and attitudes of adolescent girls in Visnagar, India, focusing on the prevalence of non-communicable diseases [NCDs] and their association with dietary practices is of interest. Adolescence, a crucial developmental phase, sets the foundation for lifelong health habits, necessitating an understanding of the determinants influencing eating behaviors. The research aims to identify gaps in knowledge, attitudes, and practices [KAP], providing insights for culturally sensitive public health s...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: N Sivasubramanian Desai Nehaben Jashubhai B Mahalakshmi Gnanadesigan Ekambaram Ravi Kant Source Type: research
Insights into amyloid precursor protein target through PPI network analysis
Bioinformation. 2024 Feb 29;20(2):140-145. doi: 10.6026/973206300200140. eCollection 2024.ABSTRACTAlzheimer's disease (AD) is the leading cause of dementia worldwide with therapeutic lacunae till date. The beta-amyloid (Aβ) accumulation triggers AD pathogenesis, though clinical trials lowering Aβ have not altered disease outcomes suggesting other interacting factors to be identified for drug design of AD. Therefore, it is of interest to identify potential hub proteins interlinked with disease-driving pathways using a network-based approach for AD therapeutic designing. Literature mining was done to identify proteins impl...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Annu Grewal Deepak Sheokand Raveena Chauhan Vandana Saini Ajit Kumar Source Type: research
Mathematical model for assessing glycemic control in type 2 diabetes mellitus
Bioinformation. 2024 Feb 29;20(2):116-120. doi: 10.6026/973206300200116. eCollection 2024.ABSTRACTGlycated hemoglobin (HbA1c) and glycated albumin (GA) are vital markers for assessing glucose control in diabetes. This cross-sectional study involving 901 diagnosed type 2 diabetics aimed to compare calculated HbA1c, using the formula HbA1c = 2.6 + 0.03 x FBS (mg/dL), with directly measured HbA1c. Simultaneously, the study assessed the agreement between the two methods through regression analysis and explored correlations with various measures of glycemic control. The non-parametric Kolmogorov-Smirnov test indicated a non-nor...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Anitha Misquith Harish Rangareddy Venkateshappa Chikkanarayanappa Ayesha Sultana Srinivasaiah Ashakiran Source Type: research
Adiponectin and HbA1c levels among Indian patients with diabetes mellitus
Bioinformation. 2024 Feb 29;20(2):202-207. doi: 10.6026/973206300200202. eCollection 2024.ABSTRACTAdiponectin is closely related to glucose metabolism and newly diagnosed type 2 diabetes mellitus (T2DM), and other kinds of diabetes linked to the risk of T2DM. Therefore, it is of interest to report the correlation between adiponectin levels and glycosylated hemoglobin (HbA1c) as a diagnostic marker of T2DM and healthy control. Total 210 participants were included of IPD & OPD healthy controls with glycosylated hemoglobin levels under 6% were included. Blood samples, collected using sterile clot activator or plain vials,...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Mohammad Arif Shreya Nigoskar Manish Kumar Verma Source Type: research
Deciphering aging-associated molecular mechanisms in bone marrow derived hematopoietic stem cells in the elderly using NGS data
Bioinformation. 2024 Feb 29;20(2):180-189. doi: 10.6026/973206300200180. eCollection 2024.ABSTRACTAging is a complex process that is not yet fully understood. Despite advancements in research, a deeper understanding of the underlying biological mechanisms is necessary to develop interventions that promote healthy longevity. The aim of this study was to elucidate the complex mechanisms associated with healthy aging and longevity in healthy elderly individuals. The RNA sequencing (RNA-seq) data used in this study was obtained from the Gene Expression Omnibus (GEO) database (accession number GSE104406), which was collected fr...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Hind A Alkhatabi Source Type: research
