Mathematical model for assessing glycemic control in type 2 diabetes mellitus
Bioinformation. 2024 Feb 29;20(2):116-120. doi: 10.6026/973206300200116. eCollection 2024.ABSTRACTGlycated hemoglobin (HbA1c) and glycated albumin (GA) are vital markers for assessing glucose control in diabetes. This cross-sectional study involving 901 diagnosed type 2 diabetics aimed to compare calculated HbA1c, using the formula HbA1c = 2.6 + 0.03 x FBS (mg/dL), with directly measured HbA1c. Simultaneously, the study assessed the agreement between the two methods through regression analysis and explored correlations with various measures of glycemic control. The non-parametric Kolmogorov-Smirnov test indicated a non-nor...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Anitha Misquith Harish Rangareddy Venkateshappa Chikkanarayanappa Ayesha Sultana Srinivasaiah Ashakiran Source Type: research

Adiponectin and HbA1c levels among Indian patients with diabetes mellitus
Bioinformation. 2024 Feb 29;20(2):202-207. doi: 10.6026/973206300200202. eCollection 2024.ABSTRACTAdiponectin is closely related to glucose metabolism and newly diagnosed type 2 diabetes mellitus (T2DM), and other kinds of diabetes linked to the risk of T2DM. Therefore, it is of interest to report the correlation between adiponectin levels and glycosylated hemoglobin (HbA1c) as a diagnostic marker of T2DM and healthy control. Total 210 participants were included of IPD & OPD healthy controls with glycosylated hemoglobin levels under 6% were included. Blood samples, collected using sterile clot activator or plain vials,...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Mohammad Arif Shreya Nigoskar Manish Kumar Verma Source Type: research

Deciphering aging-associated molecular mechanisms in bone marrow derived hematopoietic stem cells in the elderly using NGS data
Bioinformation. 2024 Feb 29;20(2):180-189. doi: 10.6026/973206300200180. eCollection 2024.ABSTRACTAging is a complex process that is not yet fully understood. Despite advancements in research, a deeper understanding of the underlying biological mechanisms is necessary to develop interventions that promote healthy longevity. The aim of this study was to elucidate the complex mechanisms associated with healthy aging and longevity in healthy elderly individuals. The RNA sequencing (RNA-seq) data used in this study was obtained from the Gene Expression Omnibus (GEO) database (accession number GSE104406), which was collected fr...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Hind A Alkhatabi Source Type: research

A 2023 nationwide study on adjustment disorder among first year MBBS students in India
Bioinformation. 2024 Feb 29;20(2):190-195. doi: 10.6026/973206300200190. eCollection 2024.ABSTRACTAmidst the complex transition to medical college, encompassing a myriad of academic, social, and personal adjustments, MBBS students in India confront multifaceted challenges that can precipitate adjustment disorder, a phenomenon understudied within the Indian context. Therefore, it is of interest to assess adjustment disorder among first-year MBBS students within six months of enrolment. We used a Google form encompassing adjustment disorder new-module 20 for data collection and found that 67% of the 401 responses from first-...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Mayank Agarwal Priyanka Sharma Ayan Goswami Roopali Mittal Source Type: research

Bio-ceramics application in Dentistry
Bioinformation. 2024 Feb 29;20(2):136-139. doi: 10.6026/973206300200136. eCollection 2024.ABSTRACTBioceramics have gained significant attention in dentistry due to their unique properties, including biocompatibility, osseointegration, and tissue regeneration. Therefore, it is of interest to report the various applications of bioceramics in dentistry, their advantages, limitations, and future considerations. Bio-ceramics such as zirconia and hydroxyapatite offer high biocompatibility and durability for dental application. They support bone integration for implants, resist wear, and mimic natural tooth aesthetics. Used in cr...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Pratik Surana Kanika Singh Dhull Ashtha Arya Sara Samreen Milind Rajan Anuj Singh Parihar Source Type: research

Impact of oil massage on newborn behavioural responses in rural India
This study, conducted in a rural setting, aims to bridge traditional practices with evidence-based care, exploring the impact of oil massage on newborn behavioural responses. A quasi-experimental design involving 60 newborns (30 in each group) assessed behavioural responses through a pre and post-test approach. Results indicate a significant improvement in selected behavioural responses among newborns receiving oil massage, emphasizing its potential integration into routine care. The control group showed a pre-test mean of 14.83 (SD = 2.41) and a post-test mean of 16.23, while the experimental group exhibited a pre-test me...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: B Mahalakshmi Patel Urvi Sureshbhai Amita Shilpa Gottlieb N Sivasubramanian Gnanadesigan Ekambaram Ravi Kant Source Type: research

Knowledge, attitudes and demographic effect on menopausal experiences among Indian rural women
This study underscored the need for tailored interventions in rural settings, considering the influence of cultural, regional, and demographic factors on menopausal experiences. The findings contributed to bridging the research gap and emphasized the importance of individualized approaches for promoting the well-being of menopausal women in rural communities.PMID:38497080 | PMC:PMC10941773 | DOI:10.6026/973206300200175 (Source: Bioinformation)
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: N Sivasubramanian Chaudhari Pinalben Madhabhai Amita Shilpa Gottlieb B Mahalakshmi Payal Vaghela Sandeep Garg Source Type: research

Amino acid pattern reveals multi-functionality of ORF3 protein from HEV
Bioinformation. 2024 Feb 29;20(2):121-135. doi: 10.6026/973206300200121. eCollection 2024.ABSTRACTThe smallest open reading frame (ORF) encoded protein ORF3 of hepatitis E virus (HEV), recently, has been demonstrated to perform multiple functions besides accessory roles. ORF3 could act as a target for vaccine against HEV infections. The IDR (intrinsically disordered region); IDP (ID protein)/IDPR (ID protein region), plays critical role in various regulatory functions of viruses. The dark proteome of HEV-ORF3 protein including its structure and function was systematically examined by computer predictors to explicate its ro...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Zoya Shafat Asimul Islam Shama Parveen Source Type: research

Molecular docking analysis of flavonoids with AChE and BACE-1
Bioinformation. 2024 Feb 29;20(2):103-109. doi: 10.6026/973206300200103. eCollection 2024.ABSTRACTFlavonoids are promising therapeutics for the treatment of Alzheimer's disease (AD). Therefore, it is of interest to study the anti-AD potential of 35 flavonoids towards the inhibition of AchE and BACE-1. Hence, the physicochemical, pharmacokinetic parameters, toxicity risk and drug-likeliness of the selected 35 flavonoids were computed. Further, the molecular docking analysis of flavonoids with AChE and BACE-1 were completed. A binding energy of -10.42 kcal/mol Epicatechin gallate, -10.16 kcal/mol sterubin and -10.11 kcal/mol...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Sittarthan Viswanathan Thennavan Arumugam Kavimani Subramanian Rengaraj Sivaraj Vimalavathini Ramesh A Hannah Rachel Vasanthi Source Type: research

Deep breathing exercises in easing educational stress among Indian high school students
This study contributes vital insights into stress management strategies for higher secondary students, highlighting the efficacy of incorporating deep breathing exercises into their routine. The observed reductions in stress levels emphasize the potential benefits of practical stress reduction techniques within the educational milieu.PMID:38497065 | PMC:PMC10941770 | DOI:10.6026/973206300200156 (Source: Bioinformation)
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: B Mahalakshmi Katara Mittalben Ghemabhai Amita Shilpa Gottlieb N Sivasubramanian Padmavathi Parthasarathy Source Type: research

Astrovirology and terrestrial life survival
Bioinformation. 2024 Feb 29;20(2):146-150. doi: 10.6026/973206300200146. eCollection 2024.ABSTRACTMicrobial organisms have been implicated in several mass extinction events throughout Earth's planetary history. Concurrently, it can be reasoned from recent viral pandemics that viruses likely exacerbated the decline of life during these periods of mass extinction. The fields of exovirology and exobiology have evolved significantly since the 20th century, with early investigations into the varied atmospheric compositions of exoplanets revealing complex interactions between metallic and non-metallic elements. This diversity in...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Paul Shapshak Milad Zandi Charurut Somboonwit John T Sinnott Source Type: research

Cloning and phylogenetic analysis of N protein gene from Rift Valley Fever Virus (RVFV)
Bioinformation. 2024 Feb 29;20(2):91-102. doi: 10.6026/973206300200091. eCollection 2024.ABSTRACTRift Valley Fever (RVF) is a mosquito-borne viral zoonosis caused by RVFV in humans and livestock. Currently, there are no approved vaccines or antiviral therapies available. Additionally, in Saudi Arabia, there is a lack of a routine screening system to monitor RVFV in humans and animals which hinders to design and develop the preventive measures as well as the prediction of future outbreaks and the potential re-emergence of RVFV. Hence, we have performed the cloning, sequencing, and phylogenetic analysis, of nucleocapsid (N) ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Ahmed Mohamed Hassan Arwa Ahmed Zehairy Al-Judaibi Awatif Abid Sayed Sartaj Sohrab Ibraheem Azhar Esam Source Type: research

Knowledge, perception and usage of E-learning among medical undergraduates in Andhra Pradesh, India
Bioinformation. 2024 Feb 29;20(2):196-201. doi: 10.6026/973206300200196. eCollection 2024.ABSTRACTElectronic gadgets help to get study material outside classroom and it is used for self-directed learning which helps user to overcome limitations of Conventional teaching methods. Medical education is constantly growing and evolving with rapid speed. So, it is necessary to keep the upcoming medical graduates and established medical practitioners updated in this competitive world. For this, E-learning is the important tool in the medical field. This cross-sectional study was conducted in the medical college of Andhra Pradesh. ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Roza Bhaisare Shahana Syed Gaurav Rangari Source Type: research

Disability from cardiovascular diseases at Osh city, Kyrgyz Republic
We report the prevalence of disability in both urban and rural areas, highlighting the impact of regional disparities in medical and social services. Data shows that adult cardiovascular disease impairment in Kyrgyzstan suggests challenges in accessing medical and social support, particularly in rural regions. Thus, the rural-urban divide in critical disability metrics impedes equitable research. Comprehensive assessments and interventions are imperative to mitigate cardiovascular diseases and associated disabilities in both rural and urban populations at Kyrgyz Republic.PMID:38497069 | PMC:PMC10941784 | DOI:10.6026/973206...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: Tazhidinovich Gulamov Isabek Kalmatovich Kalmatov Romanbek Sagynbaevich Sydykov Akylbek Temirzhanovich Abylov Kuttubek Nurlan Raiimbekuulu Akbalaevna Akbalaeva Begimai Siddiqui Mohd Faizan Source Type: research

Effect of aerobic exercise on anthropometric parameters among Indian primary school children
This study addresses the rising rates of obesity among school-age children (10-12 years) and investigates the effectiveness of aerobic exercise interventions in improving anthropometric parameters, specifically focusing on BMI and mid-arm circumference (MAC). The study emphasizes the role of schools in shaping children's behaviors and aims to contribute empirical evidence to inform health promotion strategies for this demographic. The research employs a quasi-experimental design, involving 60 school-age children in Visnagar, Gujarat, India. The 12-week aerobic exercise intervention, conducted three times a week, comprises ...
Source: Bioinformation - March 18, 2024 Category: Bioinformatics Authors: B Mahalakshmi Anjana Jagashibhai Chaudhary Amita Shilpa Gottlieb N Sivasubramanian Padmavathi Parthasarathy G Ramalakshmi P Jamunarani Source Type: research