Physiological 4-phenylbutyrate promotes mitochondrial biogenesis and metabolism in C2C12 myotubes
Biochimie. 2023 Nov 24:S0300-9084(23)00310-3. doi: 10.1016/j.biochi.2023.11.009. Online ahead of print.ABSTRACTType 2 diabetes is characterized by elevated circulating blood metabolites such as glucose, insulin, and branched chain amino acids (BCAA), which often coincide with reduced mitochondrial function. 4-Phenylbutyrate (PBA), an ammonia scavenger, has been shown to activate BCAA metabolism, resolve endoplasmic reticulum (ER) stress, and rescue BCAA-mediated insulin resistance. To determine the effect of PBA on the altered metabolic phenotype featured in type 2 diabetes, the present study investigated the effect of PBA...
Source: Biochimie - November 26, 2023 Category: Biochemistry Authors: Caroline N Rivera Carly E Smith Lillian V Draper Rachel M Watne Andrew J Wommack Roger A Vaughan Source Type: research

Lipids play music at the cellular membrane: From membranes dynamics to signaling via lipid mediators, vesicles and lipid droplets
Biochimie. 2023 Dec;215:1-3. doi: 10.1016/j.biochi.2023.11.002.NO ABSTRACTPMID:38000848 | DOI:10.1016/j.biochi.2023.11.002 (Source: Biochimie)
Source: Biochimie - November 24, 2023 Category: Biochemistry Authors: G érard Lambeau Ez-Zoubir Amri Fr édéric Carrière Source Type: research

Lipids play music at the cellular membrane: From membranes dynamics to signaling via lipid mediators, vesicles and lipid droplets
Biochimie. 2023 Dec;215:1-3. doi: 10.1016/j.biochi.2023.11.002.NO ABSTRACTPMID:38000848 | DOI:10.1016/j.biochi.2023.11.002 (Source: Biochimie)
Source: Biochimie - November 24, 2023 Category: Biochemistry Authors: G érard Lambeau Ez-Zoubir Amri Fr édéric Carrière Source Type: research

Lipid profile in breast cancer: From signaling pathways to treatment strategies
Biochimie. 2023 Nov 20:S0300-9084(23)00309-7. doi: 10.1016/j.biochi.2023.11.008. Online ahead of print.ABSTRACTBreast cancer is the most prevalent cancer in women. Metabolic abnormalities, particularly increased lipid synthesis and uptake, impact the onset and progression of the disease. However, the influence of lipid metabolism in breast cancer varies according to the disease stage and patient's hormone status. In postmenopausal patients, obesity is associated with a higher risk and poor prognosis of luminal tumors, while in premenopausal individuals, it is correlated to BRCA mutated tumors. In fact, the tumor's lipid pr...
Source: Biochimie - November 22, 2023 Category: Biochemistry Authors: Hennrique Taborda Ribas Mari C Sogayar Amalia M Dolga Sheila M B Winnischofer Marina Trombetta-Lima Source Type: research

Sequencing of the Lumbricus terrestris genome reveals degeneracy in its erythrocruorin genes
Biochimie. 2023 Nov 17:S0300-9084(23)00308-5. doi: 10.1016/j.biochi.2023.11.007. Online ahead of print.ABSTRACTThe erythrocruorin of Lumbricus terrestris (LtEc) is a relatively large macromolecular assembly that consists of at least four different hemoglobin subunits (A, B, C, and D) and four linker subunits (L1, L2, L3, and L4). The complexity and stability of this large structure make LtEc an attractive hemoglobin-based oxygen carrier that could potentially be used as a substitute for donated red blood cells. However, the sequences of the LtEc subunit sequences must be determined before a scalable recombinant expression ...
Source: Biochimie - November 19, 2023 Category: Biochemistry Authors: Sean Dowd Luke Lagalante Jack Rahlfs Catherine Sharo Dana Opulente Anthony Lagalante Jacob Elmer Source Type: research

Sequencing of the Lumbricus terrestris genome reveals degeneracy in its erythrocruorin genes
Biochimie. 2023 Nov 17:S0300-9084(23)00308-5. doi: 10.1016/j.biochi.2023.11.007. Online ahead of print.ABSTRACTThe erythrocruorin of Lumbricus terrestris (LtEc) is a relatively large macromolecular assembly that consists of at least four different hemoglobin subunits (A, B, C, and D) and four linker subunits (L1, L2, L3, and L4). The complexity and stability of this large structure make LtEc an attractive hemoglobin-based oxygen carrier that could potentially be used as a substitute for donated red blood cells. However, the sequences of the LtEc subunit sequences must be determined before a scalable recombinant expression ...
Source: Biochimie - November 19, 2023 Category: Biochemistry Authors: Sean Dowd Luke Lagalante Jack Rahlfs Catherine Sharo Dana Opulente Anthony Lagalante Jacob Elmer Source Type: research

Sequencing of the Lumbricus terrestris genome reveals degeneracy in its erythrocruorin genes
Biochimie. 2023 Nov 17:S0300-9084(23)00308-5. doi: 10.1016/j.biochi.2023.11.007. Online ahead of print.ABSTRACTThe erythrocruorin of Lumbricus terrestris (LtEc) is a relatively large macromolecular assembly that consists of at least four different hemoglobin subunits (A, B, C, and D) and four linker subunits (L1, L2, L3, and L4). The complexity and stability of this large structure make LtEc an attractive hemoglobin-based oxygen carrier that could potentially be used as a substitute for donated red blood cells. However, the sequences of the LtEc subunit sequences must be determined before a scalable recombinant expression ...
Source: Biochimie - November 19, 2023 Category: Biochemistry Authors: Sean Dowd Luke Lagalante Jack Rahlfs Catherine Sharo Dana Opulente Anthony Lagalante Jacob Elmer Source Type: research

Basic protein- and peptide-induced stabilization of long-loop DNA G-guadruplexes
This study provides insights into long-loop G-quadruplex stability in a crowded intracellular environment and the recognition of G-quadruplexes by arginine-rich domains of G-quadruplex-binding proteins.PMID:37972915 | DOI:10.1016/j.biochi.2023.11.005 (Source: Biochimie)
Source: Biochimie - November 16, 2023 Category: Biochemistry Authors: Kazuya Tanabe Kouichi Miyazaki Hikari Umeno Marina Takemoto Shu-Ichi Nakano Source Type: research

Basic protein- and peptide-induced stabilization of long-loop DNA G-guadruplexes
This study provides insights into long-loop G-quadruplex stability in a crowded intracellular environment and the recognition of G-quadruplexes by arginine-rich domains of G-quadruplex-binding proteins.PMID:37972915 | DOI:10.1016/j.biochi.2023.11.005 (Source: Biochimie)
Source: Biochimie - November 16, 2023 Category: Biochemistry Authors: Kazuya Tanabe Kouichi Miyazaki Hikari Umeno Marina Takemoto Shu-Ichi Nakano Source Type: research

Basic protein- and peptide-induced stabilization of long-loop DNA G-guadruplexes
This study provides insights into long-loop G-quadruplex stability in a crowded intracellular environment and the recognition of G-quadruplexes by arginine-rich domains of G-quadruplex-binding proteins.PMID:37972915 | DOI:10.1016/j.biochi.2023.11.005 (Source: Biochimie)
Source: Biochimie - November 16, 2023 Category: Biochemistry Authors: Kazuya Tanabe Kouichi Miyazaki Hikari Umeno Marina Takemoto Shu-Ichi Nakano Source Type: research

John Hershey (1934-2023) in memoriam
Biochimie. 2023 Nov 13:S0300-9084(23)00307-3. doi: 10.1016/j.biochi.2023.11.006. Online ahead of print.NO ABSTRACTPMID:37967736 | DOI:10.1016/j.biochi.2023.11.006 (Source: Biochimie)
Source: Biochimie - November 15, 2023 Category: Biochemistry Authors: Richard Buckingham Yoshikazu Nakamura Source Type: research

Glucose transporters (GLUTs): Underreported yet crucial molecules in unraveling testicular toxicity
Biochimie. 2023 Nov 13:S0300-9084(23)00305-X. doi: 10.1016/j.biochi.2023.11.004. Online ahead of print.ABSTRACTGlucose transporters (GLUTs) are crucial in maintaining glucose homeostasis and supporting energy production in various tissues, including the testes. This review article delves into the distribution and function of GLUTs in distinct testicular cell types, namely Leydig cells, Sertoli cells, germ cells, and spermatozoa, shedding light on their significance in the context of male reproductive health-an issue of mounting global concern. Furthermore, this manuscript examines the implications of GLUT dysregulation in ...
Source: Biochimie - November 15, 2023 Category: Biochemistry Authors: Shirsha Mondal Arindam Bandyopadhyay Source Type: research

John Hershey (1934-2023) in memoriam
Biochimie. 2023 Nov 13:S0300-9084(23)00307-3. doi: 10.1016/j.biochi.2023.11.006. Online ahead of print.NO ABSTRACTPMID:37967736 | DOI:10.1016/j.biochi.2023.11.006 (Source: Biochimie)
Source: Biochimie - November 15, 2023 Category: Biochemistry Authors: Richard Buckingham Yoshikazu Nakamura Source Type: research

Glucose transporters (GLUTs): Underreported yet crucial molecules in unraveling testicular toxicity
Biochimie. 2023 Nov 13:S0300-9084(23)00305-X. doi: 10.1016/j.biochi.2023.11.004. Online ahead of print.ABSTRACTGlucose transporters (GLUTs) are crucial in maintaining glucose homeostasis and supporting energy production in various tissues, including the testes. This review article delves into the distribution and function of GLUTs in distinct testicular cell types, namely Leydig cells, Sertoli cells, germ cells, and spermatozoa, shedding light on their significance in the context of male reproductive health-an issue of mounting global concern. Furthermore, this manuscript examines the implications of GLUT dysregulation in ...
Source: Biochimie - November 15, 2023 Category: Biochemistry Authors: Shirsha Mondal Arindam Bandyopadhyay Source Type: research

Dynamic lid domain of Chloroflexus aurantiacus Malonyl-CoA reductase controls the reaction
Biochimie. 2023 Nov 10:S0300-9084(23)00304-8. doi: 10.1016/j.biochi.2023.11.003. Online ahead of print.ABSTRACTMalonyl-Coenzyme A Reductase (MCR) in Chloroflexus aurantiacus, a characteristic enzyme of the 3-hydroxypropionate (3-HP) cycle, catalyses the reduction of malonyl-CoA to 3-HP. MCR is a bi-functional enzyme; in the first step, malonyl-CoA is reduced to the free intermediate malonate semialdehyde by the C-terminal region of MCR, and this is further reduced to 3-HP by the N-terminal region of MCR. Here we present the crystal structures of both N-terminal and C-terminal regions of the MCR from C. aurantiacus. A catal...
Source: Biochimie - November 12, 2023 Category: Biochemistry Authors: Burak V Kabasakal Charles A R Cotton James W Murray Source Type: research