The mitochondrial translocator protein (TSPO, 18kDa): A key multifunctional molecule in liver diseases
Biochimie. 2023 Dec 6:S0300-9084(23)00314-0. doi: 10.1016/j.biochi.2023.11.013. Online ahead of print.ABSTRACTTranslocator protein (TSPO, 18kDa), previously known as peripheral-type benzodiazepine receptor, is an evolutionarily conserved and tryptophan-rich 169-amino-acid protein located on the outer mitochondrial membrane. TSPO plays a crucial role in various fundamental physiological functions and cellular processes. Its expression is altered in pathological conditions, thus rendering TSPO a potential tool for diagnostic imaging and an appealing therapeutic target. The investigation of synthetic TSPO ligands as both agon...
Source: Biochimie - December 8, 2023 Category: Biochemistry Authors: Yuchang Li Liting Chen Vassilios Papadopoulos Source Type: research

Intestinal gluconeogenesis: A translator of nutritional information needed for glycemic and emotional balance
Biochimie. 2023 Nov 29:S0300-9084(23)00313-9. doi: 10.1016/j.biochi.2023.11.012. Online ahead of print.ABSTRACTAt the interface between the outside world and the self, the intestine is the first organ receiving nutritional information. One intestinal function, gluconeogenesis, is activated by various nutrients, particularly diets enriched in fiber or protein, and thus results in glucose production in the portal vein in the post-absorptive period. The detection of portal glucose induces a nervous signal controlling the activity of the central nuclei involved in the regulation of metabolism and emotional behavior. Induction ...
Source: Biochimie - December 1, 2023 Category: Biochemistry Authors: Amandine Gautier-Stein Justine Vily-Petit Fabienne Rajas Gilles Mithieux Source Type: research

Intestinal gluconeogenesis: A translator of nutritional information needed for glycemic and emotional balance
Biochimie. 2023 Nov 29:S0300-9084(23)00313-9. doi: 10.1016/j.biochi.2023.11.012. Online ahead of print.ABSTRACTAt the interface between the outside world and the self, the intestine is the first organ receiving nutritional information. One intestinal function, gluconeogenesis, is activated by various nutrients, particularly diets enriched in fiber or protein, and thus results in glucose production in the portal vein in the post-absorptive period. The detection of portal glucose induces a nervous signal controlling the activity of the central nuclei involved in the regulation of metabolism and emotional behavior. Induction ...
Source: Biochimie - December 1, 2023 Category: Biochemistry Authors: Amandine Gautier-Stein Justine Vily-Petit Fabienne Rajas Gilles Mithieux Source Type: research

Intestinal gluconeogenesis: A translator of nutritional information needed for glycemic and emotional balance
Biochimie. 2023 Nov 29:S0300-9084(23)00313-9. doi: 10.1016/j.biochi.2023.11.012. Online ahead of print.ABSTRACTAt the interface between the outside world and the self, the intestine is the first organ receiving nutritional information. One intestinal function, gluconeogenesis, is activated by various nutrients, particularly diets enriched in fiber or protein, and thus results in glucose production in the portal vein in the post-absorptive period. The detection of portal glucose induces a nervous signal controlling the activity of the central nuclei involved in the regulation of metabolism and emotional behavior. Induction ...
Source: Biochimie - December 1, 2023 Category: Biochemistry Authors: Amandine Gautier-Stein Justine Vily-Petit Fabienne Rajas Gilles Mithieux Source Type: research

Intestinal gluconeogenesis: A translator of nutritional information needed for glycemic and emotional balance
Biochimie. 2023 Nov 29:S0300-9084(23)00313-9. doi: 10.1016/j.biochi.2023.11.012. Online ahead of print.ABSTRACTAt the interface between the outside world and the self, the intestine is the first organ receiving nutritional information. One intestinal function, gluconeogenesis, is activated by various nutrients, particularly diets enriched in fiber or protein, and thus results in glucose production in the portal vein in the post-absorptive period. The detection of portal glucose induces a nervous signal controlling the activity of the central nuclei involved in the regulation of metabolism and emotional behavior. Induction ...
Source: Biochimie - December 1, 2023 Category: Biochemistry Authors: Amandine Gautier-Stein Justine Vily-Petit Fabienne Rajas Gilles Mithieux Source Type: research

Intestinal gluconeogenesis: A translator of nutritional information needed for glycemic and emotional balance
Biochimie. 2023 Nov 29:S0300-9084(23)00313-9. doi: 10.1016/j.biochi.2023.11.012. Online ahead of print.ABSTRACTAt the interface between the outside world and the self, the intestine is the first organ receiving nutritional information. One intestinal function, gluconeogenesis, is activated by various nutrients, particularly diets enriched in fiber or protein, and thus results in glucose production in the portal vein in the post-absorptive period. The detection of portal glucose induces a nervous signal controlling the activity of the central nuclei involved in the regulation of metabolism and emotional behavior. Induction ...
Source: Biochimie - December 1, 2023 Category: Biochemistry Authors: Amandine Gautier-Stein Justine Vily-Petit Fabienne Rajas Gilles Mithieux Source Type: research

Intestinal gluconeogenesis: A translator of nutritional information needed for glycemic and emotional balance
Biochimie. 2023 Nov 29:S0300-9084(23)00313-9. doi: 10.1016/j.biochi.2023.11.012. Online ahead of print.ABSTRACTAt the interface between the outside world and the self, the intestine is the first organ receiving nutritional information. One intestinal function, gluconeogenesis, is activated by various nutrients, particularly diets enriched in fiber or protein, and thus results in glucose production in the portal vein in the post-absorptive period. The detection of portal glucose induces a nervous signal controlling the activity of the central nuclei involved in the regulation of metabolism and emotional behavior. Induction ...
Source: Biochimie - December 1, 2023 Category: Biochemistry Authors: Amandine Gautier-Stein Justine Vily-Petit Fabienne Rajas Gilles Mithieux Source Type: research

Epithelial mesenchymal transition induced nuclear localization of the extracellular matrix protein Fibronectin
In this report, we have shown that EMT induced entry of FN into the nucleus of mouse breast epithelial cells. To our knowledge, this is the first report showing nuclear localization of the extracellular matrix protein Fibronectin during EMT and thereby suggests a possible nuclear function for the ECM protein.PMID:38013092 | DOI:10.1016/j.biochi.2023.11.011 (Source: Biochimie)
Source: Biochimie - November 28, 2023 Category: Biochemistry Authors: Pallabi Debnath Rohit Singh Huirem Arghya Bhowmick Abhrajyoti Ghosh Debanjana Ghosh Paloma Dutta Dibyayan Maity Santanu Palchaudhuri Source Type: research

Interaction of the C-terminal immunoglobulin-like domains (Ig 22-24) of filamin C with human small heat shock proteins
Biochimie. 2023 Nov 26:S0300-9084(23)00311-5. doi: 10.1016/j.biochi.2023.11.010. Online ahead of print.ABSTRACTSmall heat shock proteins are the well-known regulators of the cytoskeleton integrity, yet their complexes with actin-binding proteins are underexplored. Filamin C, a dimeric 560 kDa protein, abundant in cardiac and skeletal muscle, crosslinks actin filaments and contributes to Z-disc formation and membrane-cytoskeleton attachment. Here, we analyzed the interaction of a human filamin C fragment containing immunoglobulin-like domains 22-24 (FLNC22-24) with five small heat shock proteins (HspB1, HspB5, HspB6, HspB7,...
Source: Biochimie - November 28, 2023 Category: Biochemistry Authors: Lydia K Muranova Varvara M Vostrikova Vladislav M Shatov Nikolai N Sluchanko Nikolai B Gusev Source Type: research

Epithelial mesenchymal transition induced nuclear localization of the extracellular matrix protein Fibronectin
In this report, we have shown that EMT induced entry of FN into the nucleus of mouse breast epithelial cells. To our knowledge, this is the first report showing nuclear localization of the extracellular matrix protein Fibronectin during EMT and thereby suggests a possible nuclear function for the ECM protein.PMID:38013092 | DOI:10.1016/j.biochi.2023.11.011 (Source: Biochimie)
Source: Biochimie - November 28, 2023 Category: Biochemistry Authors: Pallabi Debnath Rohit Singh Huirem Arghya Bhowmick Abhrajyoti Ghosh Debanjana Ghosh Paloma Dutta Dibyayan Maity Santanu Palchaudhuri Source Type: research

Interaction of the C-terminal immunoglobulin-like domains (Ig 22-24) of filamin C with human small heat shock proteins
Biochimie. 2023 Nov 26:S0300-9084(23)00311-5. doi: 10.1016/j.biochi.2023.11.010. Online ahead of print.ABSTRACTSmall heat shock proteins are the well-known regulators of the cytoskeleton integrity, yet their complexes with actin-binding proteins are underexplored. Filamin C, a dimeric 560 kDa protein, abundant in cardiac and skeletal muscle, crosslinks actin filaments and contributes to Z-disc formation and membrane-cytoskeleton attachment. Here, we analyzed the interaction of a human filamin C fragment containing immunoglobulin-like domains 22-24 (FLNC22-24) with five small heat shock proteins (HspB1, HspB5, HspB6, HspB7,...
Source: Biochimie - November 28, 2023 Category: Biochemistry Authors: Lydia K Muranova Varvara M Vostrikova Vladislav M Shatov Nikolai N Sluchanko Nikolai B Gusev Source Type: research

Epithelial mesenchymal transition induced nuclear localization of the extracellular matrix protein Fibronectin
In this report, we have shown that EMT induced entry of FN into the nucleus of mouse breast epithelial cells. To our knowledge, this is the first report showing nuclear localization of the extracellular matrix protein Fibronectin during EMT and thereby suggests a possible nuclear function for the ECM protein.PMID:38013092 | DOI:10.1016/j.biochi.2023.11.011 (Source: Biochimie)
Source: Biochimie - November 28, 2023 Category: Biochemistry Authors: Pallabi Debnath Rohit Singh Huirem Arghya Bhowmick Abhrajyoti Ghosh Debanjana Ghosh Paloma Dutta Dibyayan Maity Santanu Palchaudhuri Source Type: research

Interaction of the C-terminal immunoglobulin-like domains (Ig 22-24) of filamin C with human small heat shock proteins
Biochimie. 2023 Nov 26:S0300-9084(23)00311-5. doi: 10.1016/j.biochi.2023.11.010. Online ahead of print.ABSTRACTSmall heat shock proteins are the well-known regulators of the cytoskeleton integrity, yet their complexes with actin-binding proteins are underexplored. Filamin C, a dimeric 560 kDa protein, abundant in cardiac and skeletal muscle, crosslinks actin filaments and contributes to Z-disc formation and membrane-cytoskeleton attachment. Here, we analyzed the interaction of a human filamin C fragment containing immunoglobulin-like domains 22-24 (FLNC22-24) with five small heat shock proteins (HspB1, HspB5, HspB6, HspB7,...
Source: Biochimie - November 28, 2023 Category: Biochemistry Authors: Lydia K Muranova Varvara M Vostrikova Vladislav M Shatov Nikolai N Sluchanko Nikolai B Gusev Source Type: research

Epithelial mesenchymal transition induced nuclear localization of the extracellular matrix protein Fibronectin
In this report, we have shown that EMT induced entry of FN into the nucleus of mouse breast epithelial cells. To our knowledge, this is the first report showing nuclear localization of the extracellular matrix protein Fibronectin during EMT and thereby suggests a possible nuclear function for the ECM protein.PMID:38013092 | DOI:10.1016/j.biochi.2023.11.011 (Source: Biochimie)
Source: Biochimie - November 28, 2023 Category: Biochemistry Authors: Pallabi Debnath Rohit Singh Huirem Arghya Bhowmick Abhrajyoti Ghosh Debanjana Ghosh Paloma Dutta Dibyayan Maity Santanu Palchaudhuri Source Type: research

Physiological 4-phenylbutyrate promotes mitochondrial biogenesis and metabolism in C2C12 myotubes
Biochimie. 2023 Nov 24:S0300-9084(23)00310-3. doi: 10.1016/j.biochi.2023.11.009. Online ahead of print.ABSTRACTType 2 diabetes is characterized by elevated circulating blood metabolites such as glucose, insulin, and branched chain amino acids (BCAA), which often coincide with reduced mitochondrial function. 4-Phenylbutyrate (PBA), an ammonia scavenger, has been shown to activate BCAA metabolism, resolve endoplasmic reticulum (ER) stress, and rescue BCAA-mediated insulin resistance. To determine the effect of PBA on the altered metabolic phenotype featured in type 2 diabetes, the present study investigated the effect of PBA...
Source: Biochimie - November 26, 2023 Category: Biochemistry Authors: Caroline N Rivera Carly E Smith Lillian V Draper Rachel M Watne Andrew J Wommack Roger A Vaughan Source Type: research