Lysophospholipase D from Thermocrispum limits psoriatic inflammation by hydrolyzing epidermal lysoplasmalogen produced by group IIF secreted phospholipase A < sub > 2 < /sub >
Biochimie. 2023 Oct 4:S0300-9084(23)00254-7. doi: 10.1016/j.biochi.2023.09.027. Online ahead of print.ABSTRACTEpidermal lipids play important roles in skin homeostasis and diseases. Psoriasis is an inflammatory disease characterized by keratinocyte hyperproliferation and Th17 immune responses. We previously reported that ethanolamine-type lysoplasmalogen (P-LPE), preferentially produced by group IIF secreted PLA2 (sPLA2-IIF/PLA2G2F) that is expressed in the suprabasal epidermis, promotes epidermal hyperplasia in psoriatic inflammation. Herein, we show that forcible degradation of epidermal P-LPE by topical application of r...
Source: Biochimie - October 6, 2023 Category: Biochemistry Authors: Haruka Hakoi Yoshimi Miki Saki Nomura Kimiko Nakajima Chiaki Terashima-Murase Takuya Takeichi Shigetoshi Sano Masashi Akiyama Shin-Ichi Sakasegawa Makoto Murakami Kei Yamamoto Source Type: research

Milk fat globule size: Unraveling the intricate relationship between metabolism, homeostasis, and stress signaling
Biochimie. 2023 Oct 4:S0300-9084(23)00257-2. doi: 10.1016/j.biochi.2023.10.003. Online ahead of print.ABSTRACTFat is an important component of milk which delivers energy, nutrients, and bioactive molecules from the lactating mother to the suckling neonate. Milk fat consists of a complex mixture of different types of lipids; hundreds of fatty acids, triglycerides, phospholipids, sphingolipids, cholesterol and cholesteryl ester, and glycoconjugates, secreted by the mammary gland epithelial cells (MEC) in the form of a lipid-protein assembly termed the milk fat globule (MFG). The mammary gland in general, and specifically tha...
Source: Biochimie - October 6, 2023 Category: Biochemistry Authors: Noam Tzirkel-Hancock Lior Sharabi Nurit Argov-Argaman Source Type: research

Lysophospholipase D from Thermocrispum limits psoriatic inflammation by hydrolyzing epidermal lysoplasmalogen produced by group IIF secreted phospholipase A < sub > 2 < /sub >
Biochimie. 2023 Oct 4:S0300-9084(23)00254-7. doi: 10.1016/j.biochi.2023.09.027. Online ahead of print.ABSTRACTEpidermal lipids play important roles in skin homeostasis and diseases. Psoriasis is an inflammatory disease characterized by keratinocyte hyperproliferation and Th17 immune responses. We previously reported that ethanolamine-type lysoplasmalogen (P-LPE), preferentially produced by group IIF secreted PLA2 (sPLA2-IIF/PLA2G2F) that is expressed in the suprabasal epidermis, promotes epidermal hyperplasia in psoriatic inflammation. Herein, we show that forcible degradation of epidermal P-LPE by topical application of r...
Source: Biochimie - October 6, 2023 Category: Biochemistry Authors: Haruka Hakoi Yoshimi Miki Saki Nomura Kimiko Nakajima Chiaki Terashima-Murase Takuya Takeichi Shigetoshi Sano Masashi Akiyama Shin-Ichi Sakasegawa Makoto Murakami Kei Yamamoto Source Type: research

Milk fat globule size: Unraveling the intricate relationship between metabolism, homeostasis, and stress signaling
Biochimie. 2023 Oct 4:S0300-9084(23)00257-2. doi: 10.1016/j.biochi.2023.10.003. Online ahead of print.ABSTRACTFat is an important component of milk which delivers energy, nutrients, and bioactive molecules from the lactating mother to the suckling neonate. Milk fat consists of a complex mixture of different types of lipids; hundreds of fatty acids, triglycerides, phospholipids, sphingolipids, cholesterol and cholesteryl ester, and glycoconjugates, secreted by the mammary gland epithelial cells (MEC) in the form of a lipid-protein assembly termed the milk fat globule (MFG). The mammary gland in general, and specifically tha...
Source: Biochimie - October 6, 2023 Category: Biochemistry Authors: Noam Tzirkel-Hancock Lior Sharabi Nurit Argov-Argaman Source Type: research

Characterization of novel truncated apolipoprotein A-I in human high-density lipoprotein generated by sequential treatment with myeloperoxidase and chymase
Biochimie. 2023 Sep 28:S0300-9084(23)00251-1. doi: 10.1016/j.biochi.2023.09.024. Online ahead of print.ABSTRACTHigh-density lipoprotein (HDL) cholesterol is a well-known biomarker, which has been associated with reduction in the risk of cardiovascular diseases (CVD). However, some HDL anti-atherosclerotic functions may be impaired without altered HDL-cholesterol (HDL-C) level via its dysfunctional proteins or other physiological reactions in vivo. We previously showed that activated mast cell-derived chymase could modestly cleave apolipoprotein A-I (apoA-I) in HDL3, and further easily cleave lipid-free apoA-I. In contrast,...
Source: Biochimie - September 29, 2023 Category: Biochemistry Authors: Shao-Jui Lai Takahiro Kameda Maasa Morita Yuka Yamagata Kaoruko Nishizaka Yuna Horiuchi Yukihiro Kobayashi Yoko Usami Jun-Jen Liu Takeshi Kasama Minoru Tozuka Ryunosuke Ohkawa Source Type: research

Characterization of novel truncated apolipoprotein A-I in human high-density lipoprotein generated by sequential treatment with myeloperoxidase and chymase
Biochimie. 2023 Sep 28:S0300-9084(23)00251-1. doi: 10.1016/j.biochi.2023.09.024. Online ahead of print.ABSTRACTHigh-density lipoprotein (HDL) cholesterol is a well-known biomarker, which has been associated with reduction in the risk of cardiovascular diseases (CVD). However, some HDL anti-atherosclerotic functions may be impaired without altered HDL-cholesterol (HDL-C) level via its dysfunctional proteins or other physiological reactions in vivo. We previously showed that activated mast cell-derived chymase could modestly cleave apolipoprotein A-I (apoA-I) in HDL3, and further easily cleave lipid-free apoA-I. In contrast,...
Source: Biochimie - September 29, 2023 Category: Biochemistry Authors: Shao-Jui Lai Takahiro Kameda Maasa Morita Yuka Yamagata Kaoruko Nishizaka Yuna Horiuchi Yukihiro Kobayashi Yoko Usami Jun-Jen Liu Takeshi Kasama Minoru Tozuka Ryunosuke Ohkawa Source Type: research

Characterization of novel truncated apolipoprotein A-I in human high-density lipoprotein generated by sequential treatment with myeloperoxidase and chymase
Biochimie. 2023 Sep 27:S0300-9084(23)00251-1. doi: 10.1016/j.biochi.2023.09.024. Online ahead of print.ABSTRACTHigh-density lipoprotein (HDL) cholesterol is a well-known biomarker, which has been associated with reduction in the risk of cardiovascular diseases (CVD). However, some HDL anti-atherosclerotic functions may be impaired without altered HDL-cholesterol (HDL-C) level via its dysfunctional proteins or other physiological reactions in vivo. We previously showed that activated mast cell-derived chymase could modestly cleave apolipoprotein A-I (apoA-I) in HDL3, and further easily cleave lipid-free apoA-I. In contrast,...
Source: Biochimie - September 29, 2023 Category: Biochemistry Authors: Shao-Jui Lai Takahiro Kameda Maasa Morita Yuka Yamagata Kaoruko Nishizaka Yuna Horiuchi Yukihiro Kobayashi Yoko Usami Jun-Jen Liu Takeshi Kasama Minoru Tozuka Ryunosuke Ohkawa Source Type: research

Characterization of novel truncated apolipoprotein A-I in human high-density lipoprotein generated by sequential treatment with myeloperoxidase and chymase
Biochimie. 2023 Sep 27:S0300-9084(23)00251-1. doi: 10.1016/j.biochi.2023.09.024. Online ahead of print.ABSTRACTHigh-density lipoprotein (HDL) cholesterol is a well-known biomarker, which has been associated with reduction in the risk of cardiovascular diseases (CVD). However, some HDL anti-atherosclerotic functions may be impaired without altered HDL-cholesterol (HDL-C) level via its dysfunctional proteins or other physiological reactions in vivo. We previously showed that activated mast cell-derived chymase could modestly cleave apolipoprotein A-I (apoA-I) in HDL3, and further easily cleave lipid-free apoA-I. In contrast,...
Source: Biochimie - September 29, 2023 Category: Biochemistry Authors: Shao-Jui Lai Takahiro Kameda Maasa Morita Yuka Yamagata Kaoruko Nishizaka Yuna Horiuchi Yukihiro Kobayashi Yoko Usami Jun-Jen Liu Takeshi Kasama Minoru Tozuka Ryunosuke Ohkawa Source Type: research

Characterization of novel truncated apolipoprotein A-I in human high-density lipoprotein generated by sequential treatment with myeloperoxidase and chymase
Biochimie. 2023 Sep 27:S0300-9084(23)00251-1. doi: 10.1016/j.biochi.2023.09.024. Online ahead of print.ABSTRACTHigh-density lipoprotein (HDL) cholesterol is a well-known biomarker, which has been associated with reduction in the risk of cardiovascular diseases (CVD). However, some HDL anti-atherosclerotic functions may be impaired without altered HDL-cholesterol (HDL-C) level via its dysfunctional proteins or other physiological reactions in vivo. We previously showed that activated mast cell-derived chymase could modestly cleave apolipoprotein A-I (apoA-I) in HDL3, and further easily cleave lipid-free apoA-I. In contrast,...
Source: Biochimie - September 29, 2023 Category: Biochemistry Authors: Shao-Jui Lai Takahiro Kameda Maasa Morita Yuka Yamagata Kaoruko Nishizaka Yuna Horiuchi Yukihiro Kobayashi Yoko Usami Jun-Jen Liu Takeshi Kasama Minoru Tozuka Ryunosuke Ohkawa Source Type: research

Characterization of novel truncated apolipoprotein A-I in human high-density lipoprotein generated by sequential treatment with myeloperoxidase and chymase
Biochimie. 2023 Sep 27:S0300-9084(23)00251-1. doi: 10.1016/j.biochi.2023.09.024. Online ahead of print.ABSTRACTHigh-density lipoprotein (HDL) cholesterol is a well-known biomarker, which has been associated with reduction in the risk of cardiovascular diseases (CVD). However, some HDL anti-atherosclerotic functions may be impaired without altered HDL-cholesterol (HDL-C) level via its dysfunctional proteins or other physiological reactions in vivo. We previously showed that activated mast cell-derived chymase could modestly cleave apolipoprotein A-I (apoA-I) in HDL3, and further easily cleave lipid-free apoA-I. In contrast,...
Source: Biochimie - September 29, 2023 Category: Biochemistry Authors: Shao-Jui Lai Takahiro Kameda Maasa Morita Yuka Yamagata Kaoruko Nishizaka Yuna Horiuchi Yukihiro Kobayashi Yoko Usami Jun-Jen Liu Takeshi Kasama Minoru Tozuka Ryunosuke Ohkawa Source Type: research

Isolation and characterization of a lectin-like chitinase from the hepatopancreas of freshwater prawn, Macrobrachium rosenbergii
This study suggests that the chitinase 1 protein with lectin-like properties is possibly induced at the protein level and can be putatively involved in the innate immune response of M. rosenbergii.PMID:37769935 | DOI:10.1016/j.biochi.2023.09.025 (Source: Biochimie)
Source: Biochimie - September 28, 2023 Category: Biochemistry Authors: Sonalina Sahoo Mohan R Badhe Anirban Paul Pramoda Kumar Sahoo Amol R Suryawanshi Debabrata Panda Bindu R Pillai Snigdha Baliarsingh Bharat Bhusan Patnaik Jyotirmaya Mohanty Source Type: research

Metabolic bias: Lipid structures as determinants of their metabolic fates
Biochimie. 2023 Sep 26:S0300-9084(23)00246-8. doi: 10.1016/j.biochi.2023.09.019. Online ahead of print.ABSTRACTCellular lipids have an enormous diversity in their chemical structures, which affect the physicochemical properties of lipids and membranes, as well as their regulatory roles on protein functions. Here, I review additional roles of lipid structures. Multiple studies show that structural differences affect how lipids, even from the same class, are metabolically converted via distinct pathways. I propose the name "structure-guided metabolic bias" for this phenomenon, and discuss its biological relevance. This metab...
Source: Biochimie - September 28, 2023 Category: Biochemistry Authors: Takeshi Harayama Source Type: research

Impaired hepatic lipid metabolism and biomarkers in fatty liver diseases
Biochimie. 2023 Sep 26:S0300-9084(23)00247-X. doi: 10.1016/j.biochi.2023.09.020. Online ahead of print.ABSTRACTThe liver plays a crucial role in lipid metabolism and metabolic homeostasis. Non-Alcoholic Fatty Liver Disease (NAFLD) is the most common chronic liver disease worldwide and currently has no specific treatments. Lifestyle modifications such as weight loss, exercise, and dietary changes are recommended to reduce the risk factors associated with the disease. Oxidized cholesterol products, some phospholipids and diacylglycerols can activate inflammatory pathways and contribute to the progression to Non-Alcoholic Ste...
Source: Biochimie - September 28, 2023 Category: Biochemistry Authors: Francisca S Teixeira L ígia L Pimentel Manuela E Pintado Lu ís M Rodríguez-Alcalá Source Type: research

Isolation and characterization of a lectin-like chitinase from the hepatopancreas of freshwater prawn, Macrobrachium rosenbergii
This study suggests that the chitinase 1 protein with lectin-like properties is possibly induced at the protein level and can be putatively involved in the innate immune response of M. rosenbergii.PMID:37769935 | DOI:10.1016/j.biochi.2023.09.025 (Source: Biochimie)
Source: Biochimie - September 28, 2023 Category: Biochemistry Authors: Sonalina Sahoo Mohan R Badhe Anirban Paul Pramoda Kumar Sahoo Amol R Suryawanshi Debabrata Panda Bindu R Pillai Snigdha Baliarsingh Bharat Bhusan Patnaik Jyotirmaya Mohanty Source Type: research

Metabolic bias: Lipid structures as determinants of their metabolic fates
Biochimie. 2023 Sep 26:S0300-9084(23)00246-8. doi: 10.1016/j.biochi.2023.09.019. Online ahead of print.ABSTRACTCellular lipids have an enormous diversity in their chemical structures, which affect the physicochemical properties of lipids and membranes, as well as their regulatory roles on protein functions. Here, I review additional roles of lipid structures. Multiple studies show that structural differences affect how lipids, even from the same class, are metabolically converted via distinct pathways. I propose the name "structure-guided metabolic bias" for this phenomenon, and discuss its biological relevance. This metab...
Source: Biochimie - September 28, 2023 Category: Biochemistry Authors: Takeshi Harayama Source Type: research