ESX-3 secretion system in Mycobacterium: An overview
Biochimie. 2023 Oct 23:S0300-9084(23)00276-6. doi: 10.1016/j.biochi.2023.10.013. Online ahead of print.ABSTRACTMycobacteria are microorganisms distributed in the environment worldwide, and some of them, such as Mycobacterium tuberculosis or M. leprae, are pathogenic. The hydrophobic mycobacterial cell envelope has low permeation and bacteria need to export products across their structure. Mycobacteria possess specialized protein secretion systems, such as the Early Secretory Antigenic Target 6 secretion (ESX) system. Five ESX loci have been described in M. tuberculosis, called ESX1 to ESX5. The ESX3 secretion system has be...
Source: Biochimie - October 25, 2023 Category: Biochemistry Authors: Ana Laura Granados-Trist án Carlos Eduardo Hern ández-Luna Laura Adiene Gonz ález-Escalante Mar Ãa Elena Camacho-Moll Beatriz Silva-Ram Ãrez Mario Berm údez de León Katia Pe ñuelas-Urquides Source Type: research
Cytotoxic effects of Chartergellus communis wasp venom peptide against melanoma cells
Biochimie. 2023 Oct 23:S0300-9084(23)00278-X. doi: 10.1016/j.biochi.2023.10.015. Online ahead of print.ABSTRACTCancer is a huge public health problem being one of the main causes of death globally. Specifically, melanoma is one of the most threatening cancer types due to the metastatic capacity, treatment resistance and mortality rates. It is evident the urgent need for research on new agents with pharmacological potential for cancer treatment, in order to develop new cancer therapeutic strategies and overcome drug resistance. The present work investigated the anti-tumoral potential of Chartergellus-CP1 peptide, isolated f...
Source: Biochimie - October 25, 2023 Category: Biochemistry Authors: Ver ónica Bastos Simone Pascoal Kamila Lopes M árcia Mortari Helena Oliveira Source Type: research
ESX-3 secretion system in Mycobacterium: An overview
Biochimie. 2023 Oct 23:S0300-9084(23)00276-6. doi: 10.1016/j.biochi.2023.10.013. Online ahead of print.ABSTRACTMycobacteria are microorganisms distributed in the environment worldwide, and some of them, such as Mycobacterium tuberculosis or M. leprae, are pathogenic. The hydrophobic mycobacterial cell envelope has low permeation and bacteria need to export products across their structure. Mycobacteria possess specialized protein secretion systems, such as the Early Secretory Antigenic Target 6 secretion (ESX) system. Five ESX loci have been described in M. tuberculosis, called ESX1 to ESX5. The ESX3 secretion system has be...
Source: Biochimie - October 25, 2023 Category: Biochemistry Authors: Ana Laura Granados-Trist án Carlos Eduardo Hern ández-Luna Laura Adiene Gonz ález-Escalante Mar Ãa Elena Camacho-Moll Beatriz Silva-Ram Ãrez Mario Berm údez de León Katia Pe ñuelas-Urquides Source Type: research
Cytotoxic effects of Chartergellus communis wasp venom peptide against melanoma cells
Biochimie. 2023 Oct 23:S0300-9084(23)00278-X. doi: 10.1016/j.biochi.2023.10.015. Online ahead of print.ABSTRACTCancer is a huge public health problem being one of the main causes of death globally. Specifically, melanoma is one of the most threatening cancer types due to the metastatic capacity, treatment resistance and mortality rates. It is evident the urgent need for research on new agents with pharmacological potential for cancer treatment, in order to develop new cancer therapeutic strategies and overcome drug resistance. The present work investigated the anti-tumoral potential of Chartergellus-CP1 peptide, isolated f...
Source: Biochimie - October 25, 2023 Category: Biochemistry Authors: Ver ónica Bastos Simone Pascoal Kamila Lopes M árcia Mortari Helena Oliveira Source Type: research
ESX-3 secretion system in Mycobacterium: An overview
Biochimie. 2023 Oct 23:S0300-9084(23)00276-6. doi: 10.1016/j.biochi.2023.10.013. Online ahead of print.ABSTRACTMycobacteria are microorganisms distributed in the environment worldwide, and some of them, such as Mycobacterium tuberculosis or M. leprae, are pathogenic. The hydrophobic mycobacterial cell envelope has low permeation and bacteria need to export products across their structure. Mycobacteria possess specialized protein secretion systems, such as the Early Secretory Antigenic Target 6 secretion (ESX) system. Five ESX loci have been described in M. tuberculosis, called ESX1 to ESX5. The ESX3 secretion system has be...
Source: Biochimie - October 25, 2023 Category: Biochemistry Authors: Ana Laura Granados-Trist án Carlos Eduardo Hern ández-Luna Laura Adiene Gonz ález-Escalante Mar Ãa Elena Camacho-Moll Beatriz Silva-Ram Ãrez Mario Berm údez de León Katia Pe ñuelas-Urquides Source Type: research
Anti-smoking drugs cytisine and varenicline reduce cardiac reperfusion injury in rat model of myocardial ischemia
Biochimie. 2023 Oct 21:S0300-9084(23)00274-2. doi: 10.1016/j.biochi.2023.10.011. Online ahead of print.ABSTRACTEvidence to date indicates that activation of nicotinic acetylcholine receptors (nAChRs) can reduce cardiac injury from ischemia and subsequent reperfusion. The use of nAChR agonists in various animal models leads to a reduction in reperfusion injury. Earlier this effect was shown for the agonists of α7 nAChR subtype. In this work, we demonstrated the expression of mRNA encoding α4, α6 and β2 nAChR subunits in the left ventricle of rat heart. In a rat model of myocardial ischemia, we studied the effect of α4Î...
Source: Biochimie - October 23, 2023 Category: Biochemistry Authors: Elvira R Shaykhutdinova Maria S Severyukhina Inna V Kholoshenko Elena A Gondarenko Irina V Shelukhina Elena V Kryukova Alina M Ismailova Elena S Sadovnikova Igor A Dyachenko Arkady N Murashev Victor I Tsetlin Yuri N Utkin Source Type: research
Anti-smoking drugs cytisine and varenicline reduce cardiac reperfusion injury in rat model of myocardial ischemia
Biochimie. 2023 Oct 21:S0300-9084(23)00274-2. doi: 10.1016/j.biochi.2023.10.011. Online ahead of print.ABSTRACTEvidence to date indicates that activation of nicotinic acetylcholine receptors (nAChRs) can reduce cardiac injury from ischemia and subsequent reperfusion. The use of nAChR agonists in various animal models leads to a reduction in reperfusion injury. Earlier this effect was shown for the agonists of α7 nAChR subtype. In this work, we demonstrated the expression of mRNA encoding α4, α6 and β2 nAChR subunits in the left ventricle of rat heart. In a rat model of myocardial ischemia, we studied the effect of α4Î...
Source: Biochimie - October 23, 2023 Category: Biochemistry Authors: Elvira R Shaykhutdinova Maria S Severyukhina Inna V Kholoshenko Elena A Gondarenko Irina V Shelukhina Elena V Kryukova Alina M Ismailova Elena S Sadovnikova Igor A Dyachenko Arkady N Murashev Victor I Tsetlin Yuri N Utkin Source Type: research
Genotypes of the UCP1 gene polymorphisms and cardiometabolic diseases: A multifactorial study of association with disease probability
This study aimed to investigate associations between UCP1 genotype combinations and CMDs or CMD risk factors in the context of non-genetic factors. We performed multiple logistic regression analysis and proposed new methodology of testing different combinations of SNP genotypes. We found that probability of CMDs increased in presence of the three-SNP combination of genotypes with minor alleles of c.-3826A>G and p.Ala64Thr and wild allele of c.-112A>C, with increasing age, body mass index (BMI), body fat percentage (BF%) and may differ between sexes and between countries. The combination of genotypes with c.-3826A>...
Source: Biochimie - October 20, 2023 Category: Biochemistry Authors: Anna E Pravednikova Antonina Nikitich Agata Witkowicz Lidia Karabon Andreas D Flouris Maria Vliora Eleni Nintou Petros C Dinas Monika Szuli ńska Pawe ł Bogdański George S Metsios Victor V Kerchev Levon Yepiskoposyan Oleg V Bylino Svetlana N Larina Bori Source Type: research
Genotypes of the UCP1 gene polymorphisms and cardiometabolic diseases: A multifactorial study of association with disease probability
This study aimed to investigate associations between UCP1 genotype combinations and CMDs or CMD risk factors in the context of non-genetic factors. We performed multiple logistic regression analysis and proposed new methodology of testing different combinations of SNP genotypes. We found that probability of CMDs increased in presence of the three-SNP combination of genotypes with minor alleles of c.-3826A>G and p.Ala64Thr and wild allele of c.-112A>C, with increasing age, body mass index (BMI), body fat percentage (BF%) and may differ between sexes and between countries. The combination of genotypes with c.-3826A>...
Source: Biochimie - October 20, 2023 Category: Biochemistry Authors: Anna E Pravednikova Antonina Nikitich Agata Witkowicz Lidia Karabon Andreas D Flouris Maria Vliora Eleni Nintou Petros C Dinas Monika Szuli ńska Pawe ł Bogdański George S Metsios Victor V Kerchev Levon Yepiskoposyan Oleg V Bylino Svetlana N Larina Bori Source Type: research
Genotypes of the UCP1 gene polymorphisms and cardiometabolic diseases: A multifactorial study of association with disease probability
This study aimed to investigate associations between UCP1 genotype combinations and CMDs or CMD risk factors in the context of non-genetic factors. We performed multiple logistic regression analysis and proposed new methodology of testing different combinations of SNP genotypes. We found that probability of CMDs increased in presence of the three-SNP combination of genotypes with minor alleles of c.-3826A>G and p.Ala64Thr and wild allele of c.-112A>C, with increasing age, body mass index (BMI), body fat percentage (BF%) and may differ between sexes and between countries. The combination of genotypes with c.-3826A>...
Source: Biochimie - October 20, 2023 Category: Biochemistry Authors: Anna E Pravednikova Antonina Nikitich Agata Witkowicz Lidia Karabon Andreas D Flouris Maria Vliora Eleni Nintou Petros C Dinas Monika Szuli ńska Pawe ł Bogdański George S Metsios Victor V Kerchev Levon Yepiskoposyan Oleg V Bylino Svetlana N Larina Bori Source Type: research
In-depth immunorecognition and neutralization analyses of Micrurus mipartitus and M. dumerilii venoms and toxins by a commercial antivenom
Biochimie. 2023 Oct 14:S0300-9084(23)00272-9. doi: 10.1016/j.biochi.2023.10.009. Online ahead of print.ABSTRACTIn Colombia, the Micrurus genus comprises 30 species, including M. mipartitus and M. dumerilii, which are of major clinical relevance due to their wide geographical distribution and the number of snakebites inflicted by them. These neurotoxic envenomations are characterized by neuromuscular paralysis attributed to venom components such as three-finger toxins (3FTx) and phospholipases (PLA2). Additionally, there is limited information available on the neutralizing coverage of commercially available antivenoms, unde...
Source: Biochimie - October 16, 2023 Category: Biochemistry Authors: Juan Diego Piedrahita Ana Cardona-Ruda Jaime Andr és Pereañez Paola Rey-Su árez Source Type: research
High-salt diet induces dyslipidemia through the SREBP2/PCSK9 pathway in dahl salt-sensitive rats
This study, for the first time, shows that an HSD induces dyslipidemia through activation of the SREBP2/PCSK9 pathway, providing new insights into the prevention and treatment of dyslipidemia in patients with salt sensitivity.PMID:37844755 | DOI:10.1016/j.biochi.2023.10.001 (Source: Biochimie)
Source: Biochimie - October 16, 2023 Category: Biochemistry Authors: Ya-Nan Ou-Yang Fen-Fen Deng Yun-Jia Wang Meng Chen Peng-Fei Yang Zhe Yang Zhongmin Tian Source Type: research
In-depth immunorecognition and neutralization analyses of Micrurus mipartitus and M. dumerilii venoms and toxins by a commercial antivenom
Biochimie. 2023 Oct 14:S0300-9084(23)00272-9. doi: 10.1016/j.biochi.2023.10.009. Online ahead of print.ABSTRACTIn Colombia, the Micrurus genus comprises 30 species, including M. mipartitus and M. dumerilii, which are of major clinical relevance due to their wide geographical distribution and the number of snakebites inflicted by them. These neurotoxic envenomations are characterized by neuromuscular paralysis attributed to venom components such as three-finger toxins (3FTx) and phospholipases (PLA2). Additionally, there is limited information available on the neutralizing coverage of commercially available antivenoms, unde...
Source: Biochimie - October 16, 2023 Category: Biochemistry Authors: Juan Diego Piedrahita Ana Cardona-Ruda Jaime Andr és Pereañez Paola Rey-Su árez Source Type: research
High-salt diet induces dyslipidemia through the SREBP2/PCSK9 pathway in dahl salt-sensitive rats
This study, for the first time, shows that an HSD induces dyslipidemia through activation of the SREBP2/PCSK9 pathway, providing new insights into the prevention and treatment of dyslipidemia in patients with salt sensitivity.PMID:37844755 | DOI:10.1016/j.biochi.2023.10.001 (Source: Biochimie)
Source: Biochimie - October 16, 2023 Category: Biochemistry Authors: Ya-Nan Ou-Yang Fen-Fen Deng Yun-Jia Wang Meng Chen Peng-Fei Yang Zhe Yang Zhongmin Tian Source Type: research
In-depth immunorecognition and neutralization analyses of Micrurus mipartitus and M. dumerilii venoms and toxins by a commercial antivenom
Biochimie. 2023 Oct 14:S0300-9084(23)00272-9. doi: 10.1016/j.biochi.2023.10.009. Online ahead of print.ABSTRACTIn Colombia, the Micrurus genus comprises 30 species, including M. mipartitus and M. dumerilii, which are of major clinical relevance due to their wide geographical distribution and the number of snakebites inflicted by them. These neurotoxic envenomations are characterized by neuromuscular paralysis attributed to venom components such as three-finger toxins (3FTx) and phospholipases (PLA2). Additionally, there is limited information available on the neutralizing coverage of commercially available antivenoms, unde...
Source: Biochimie - October 16, 2023 Category: Biochemistry Authors: Juan Diego Piedrahita Ana Cardona-Ruda Jaime Andr és Pereañez Paola Rey-Su árez Source Type: research