A novel fluorescent probe reveals starvation controls the commitment of amyloid precursor protein to the lysosome
Publication date: Available online 19 June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Leanne K. Hein, Pirjo M. Apaja, Kathryn Hattersley, Randall H. Grose, Jianling Xie, Christopher G. Proud, Timothy J. Sargeant Alzheimer's disease is the most important cause of dementia but there is no therapy that has been demonstrated to stop or slow disease progression. Amyloid precursor protein (APP) is the source of amyloid-β (Aβ), which aggregates in Alzheimer's disease to form toxic oligomeric species. The endo-lysosomal system can clear APP and Aβ from the cell if these mol...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - June 20, 2017 Category: Molecular Biology Source Type: research

ANGPTL4 T266M variant is associated with reduced cancer invasiveness
In this study, we compared the characteristics of tumors with and without wild-type (wt) cANGPTL4 and tumors with cANGPTL4 bearing the T266M mutation (T266M cANGPTL4). We found that T266M cANGPTL4 bound to integrin α5β1 with a reduced affinity compared to wt, leading to weaker activation of downstream signaling molecules. The mutant tumors exhibited impaired proliferation, anoikis resistance, and migratory capability and had reduced adenylate energy charge. Further investigations also revealed that cANGPTL4 regulated the expression of Glut2. These findings may explain the differences in the tumor characteristics...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - June 20, 2017 Category: Molecular Biology Source Type: research

Adaptations in rod outer segment disc membranes in response to environmental lighting conditions
Publication date: Available online 20 June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Tatini Rakshit, Subhadip Senapati, Vipul M. Parmar, Bhubanananda Sahu, Akiko Maeda, Paul S.H. Park The light-sensing rod photoreceptor cell exhibits several adaptations in response to the lighting environment. While adaptations to short-term changes in lighting conditions have been examined in depth, adaptations to long-term changes in lighting conditions are less understood. Atomic force microscopy was used to characterize the structure of rod outer segment disc membranes, the site of photon abs...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - June 20, 2017 Category: Molecular Biology Source Type: research

Next Generation Matrix Metalloproteinase Inhibitors – Novel Strategies Bring New Prospects
Publication date: Available online 19 June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Maxim Levin, Yael Udi, Inna Solomonov, Irit Sagi Enzymatic proteolysis of cell surface proteins and extracellular matrix (ECM) is critical for tissue homeostasis and cell signaling. These proteolytic activities are mediated predominantly by a family of proteases termed matrix metalloproteinases (MMPs). The growing evidence in recent years that ECM and non-ECM bioactive molecules (e.g., growth factors, cytokines, chemokines, on top of matrikines and matricryptins) have versatile functions redefine...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - June 19, 2017 Category: Molecular Biology Source Type: research

Proteolytic control of Interleukin-11 and Interleukin-6 biology
Publication date: Available online 16 June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Juliane Lokau, Maria Agthe, Charlotte M. Flynn, Christoph Garbers Interleukin-11 (IL-11) and IL-6 are secreted glycoproteins which fulfill important homeostatic functions. Activation of target cells occurs via membrane-bound IL-11 and IL-6 receptors (IL-11R and IL-6R, respectively). Formation of IL-11/IL-11R and IL-6/IL-6R complexes triggers the recruitment of a homodimer of the ubiquitously expressed signal-transducing β-receptor gp130 (classic signaling). IL-11R and IL-6R can be shed by se...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - June 17, 2017 Category: Molecular Biology Source Type: research

Signal peptide peptidase and SPP-like proteases - possible therapeutic targets?
Publication date: Available online 15 June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Torben Mentrup, Ann-Christine Loock, Regina Fluhrer, Bernd Schröder Signal peptide peptidase (SPP) and the four homologous SPP-like proteases SPPL2a, SPPL2b, SPPL2c and SPPL3 are GxGD-type intramembrane-cleaving proteases (I-CLIPs). In addition to divergent subcellular localisations, distinct differences in the mechanistic properties and substrate requirements of individual family members have been unravelled. SPP/SPPL proteases employ a catalytic mechanism related to that of the γ-sec...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - June 16, 2017 Category: Molecular Biology Source Type: research

BAG3 promotes proliferation of ovarian cancer cells via post-transcriptional regulation of Skp2 expression
Publication date: Available online 15 June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Jing Yan, Chuan Liu, Jing-Yi Jiang, Hans Liu, Chao Li, Xin-Yu Li, Ye Yuan, Zhi-Hong Zong, Hua-Qin Wang Bcl-2 associated athanogene 3 (BAG3) contains modular structure, through which BAG3 interacts with a wide range of proteins, thereby affording its capacity to regulate multifaceted biological processes. BAG3 is often highly expressed and functions as a pro-survival factor in many cancers. However, the oncogenic potential of BAG3 remains not fully understood. The cell cycle regulator, S-phase kin...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - June 16, 2017 Category: Molecular Biology Source Type: research

The plasma membrane: penultimate regulator of ADAM sheddase function
Publication date: Available online 15 June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Karina Reiss, Sucharit Bhakdi Background ADAM10 and ADAM17 are the best characterized members of the ADAM (A Disintegrin and Metalloproteinase) – family of transmembrane proteases. Both are involved diverse physiological and pathophysiological processes. ADAMs are known to be regulated by posttranslational mechanisms. However, emerging evidence indicates that the plasma membrane with its unique dynamic properties may additionally play an important role in controlling sheddase function. Scop...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - June 16, 2017 Category: Molecular Biology Source Type: research

The metalloproteinase ADAM10: a useful therapeutic target?
Publication date: Available online 15 June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Sebastian Wetzel, Lisa Seipold, Paul Saftig Proteolytic cleavage represents a unique and irreversible posttranslational event regulating the function and half-life of many intracellular and extracellular proteins. The metalloproteinase ADAM10 has raised attention since it cleaves an increasing number of protein substrates close to the extracellular membrane leaflet. This “ectodomain shedding” regulates the turnover of a number of transmembrane proteins involved in cell adhesion and re...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - June 16, 2017 Category: Molecular Biology Source Type: research

Corrigendum to “Low dose ouabain stimulates Na-K ATPase 〈alpha〉 1 subunit association with angiotensin II type 1 receptor in renal proximal tubule cells” [Biochim. Biophys. Acta 1863/11 (2016) 2624–2636]
Publication date: Available online 13 June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Corey J. Ketchem, Clayton D. Conner, Rebecca D. Murray, Madalyn DuPlessis, Eleanor D. Lederer, Daniel Wilkey, Michael Merchant, Syed J. Khundmiri (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - June 14, 2017 Category: Molecular Biology Source Type: research

Deep sequencing reveals a global reprogramming of lncRNA transcriptome during EMT
Publication date: Available online 7 June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Jian-You Liao, Jue Wu, Yan-Jie Wang, Jie-Hua He, Wei-Xi Deng, KaiShun Hu, Yu-Chan Zhang, Yin Zhang, Haiyan Yan, Dan-Lan Wang, Qiang Liu, Mu-Sheng Zeng, H. Phillip Koeffler, Erwei Song, Dong Yin Several studies have shown that long non-coding RNAs (lncRNAs) may play an essential role in Epithelial-Mesenchymal Transition (EMT), which is an important step in tumor metastasis; however, little is known about the global change of lncRNA transcriptome during EMT. To investigate how lncRNA transcriptome a...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - June 7, 2017 Category: Molecular Biology Source Type: research

Corrigendum to “interaction of casein kinase 1 delta (CK1 & lt;delta & gt;) with the light chain LC2 of microtubule associated protein 1A (MAP1A) ” [Biochim. Biophys. Acta 1745/2 (2005) 196–2006]
Publication date: Available online 2 June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Sonja Wolff, Zhenyu Xiao, Mathias Wittau, Nadine Süssner, Martin Stöter, Uwe Knippschild (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - June 3, 2017 Category: Molecular Biology Source Type: research

Increasing extracellular Ca2+ sensitizes TNF-alpha-induced vascular cell adhesion molecule-1 (VCAM-1) via a TRPC1/ERK1/2/NF κB-dependent pathway in human vascular endothelial cells
This study provided direct evidence that increasing extracellular Ca2+ enhanced TNF-alpha-induced VCAM-1 activation and monocytes adhesion. Moreover, we identified a novel TRPC1/ERK1/2/NFκB signaling pathway mediating VCAM-1 activation and monocyte adhesion in this pathological process. Our studies indicate that blood calcium levels should be strictly monitored to help prevent CVD, and that TRPC1 might act as a potential target for the treatment and prevention against increased circulating calcium-enhanced CVDs. (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - June 3, 2017 Category: Molecular Biology Source Type: research

β-Cyclodextrin induces the differentiation of resident cardiac stem cells to cardiomyocytes through autophagy
Publication date: August 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1864, Issue 8 Author(s): Xingxing Shi, Wenjing Li, Honghong Liu, Deling Yin, Jing Zhao Cardiac stem cells (CSCs) have emerged as promising cell candidates to regenerate damaged hearts, because of the potential in differentiating to cardiomyocytes. However, the differentiation is difficult to trigger without inducers. Here we reported that β-cyclodextrin (β-CD) increased the expression of cardiac transcription factors (Nkx2.5 and GATA4), structural proteins (cardiac Troponin T, cTnt), transcriptional enhance...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 23, 2017 Category: Molecular Biology Source Type: research

Cortical cytoskeleton dynamics regulates plasma membrane calcium ATPase isoform-2 (PMCA2) activity
In this study, we tested the influence of drugs that change the actin and microtubule polymerization state on the activity and membrane expression of the PMCA transiently expressed in human embryonic kidney (HEK293) cells, which allowed us to observe and quantify these relationships in a live cell, for the first time. We found that disrupting the actin cytoskeleton with cytochalasin D significantly increased PMCA-mediated Ca2+ extrusion (~50–100%) whereas pre-treatment with the F-actin stabilizing agent jasplakinolide caused its full inhibition. When the microtubule network was disrupted by pretreatment of the cells ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 22, 2017 Category: Molecular Biology Source Type: research

Cul3 neddylation is crucial for gradual lipid droplet formation during adipogenesis
Publication date: August 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1864, Issue 8 Author(s): Dawadschargal Dubiel, Willem Bintig, Thilo Kähne, Wolfgang Dubiel, Michael Naumann Cullin 3 (Cul3) belongs to the family of cullins (Cul1–7) providing the scaffold for cullin-RING ubiquitin (Ub) ligases (CRLs), which are activated by neddylation and represent essential E3 ligases of the Ub proteasome system. During adipogenic differentiation neddylated Cul3 accumulates in LiSa-2 preadipocytes. Downregulation of Cul3 and inhibition of neddylation by MLN4924 blocks the formation of l...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 20, 2017 Category: Molecular Biology Source Type: research

Long non-coding RNA AC023115.3 suppresses chemoresistance of glioblastoma by reducing autophagy
In this study, we show that long non-coding RNA AC023115.3 is induced by cisplatin in human glioblastoma cells and that elevated AC023115.3 promotes cisplatin-induced apoptosis by inhibiting autophagy. Further mechanistic studies revealed that AC023115.3 acts as a competing endogenous RNA for miR-26a and attenuates the inhibitory effect of miR-26a on GSK3β, a proline-directed serine-threonine kinase that promotes the degradation of Mcl1, leading to an increase in GSK3β and a decrease in autophagy. Additionally, we discovered that AC023115.3 improves chemosensitivity of glioma cells to cisplatin by regulating the ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 18, 2017 Category: Molecular Biology Source Type: research

Dehydroepiandrosterone sulfate augments blood-brain barrier and tight junction protein expression in brain endothelial cells
Publication date: August 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1864, Issue 8 Author(s): Dimitrios Papadopoulos, Georgios Scheiner-Bobis Tight junctions (TJ) between brain endothelial cells are essential for formation and maintenance of the blood-brain barrier (BBB). Although loss of BBB integrity is associated with several neuropathological disorders, treatments that augment or stabilise the BBB are scarce. Here we show that physiological concentrations of dehydroepiandrosterone sulfate (DHEAS) stimulate the expression of the TJ proteins zonula occludens-1 (ZO-1) and claudin-3 i...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 18, 2017 Category: Molecular Biology Source Type: research

Mechanical stress affects methylation pattern of GNAS isoforms and osteogenic differentiation of hAT-MSCs
Publication date: August 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1864, Issue 8 Author(s): Angeliki-Maria Vlaikou, Dimitrios Kouroupis, Argyro Sgourou, Georgios S. Markopoulos, Eleni Bagli, Maria Markou, Zoe Papadopoulou, Theodore Fotsis, Georgios Nakos, Maria-Eleni E. Lekka, Maria Syrrou Mechanical stress exerts a substantial role on skeletal-cell renewal systems, whereas accumulating evidence suggests that epigenetic mechanisms induce changes and differential gene expression. Although the underlying mechanisms remain to be fully elucidated, our study suggests that the influence o...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 17, 2017 Category: Molecular Biology Source Type: research

p62-Mediated mitochondrial clustering attenuates apoptosis induced by mitochondrial depolarization
Publication date: July 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1864, Issue 7 Author(s): Bin Xiao, Xiao Deng, Grace G.Y. Lim, Wei Zhou, Wuan-Ting Saw, Zhi Dong Zhou, Kah-Leong Lim, Eng-King Tan Parkin/PINK1-mediated mitophagy is implicated in the pathogenesis of Parkinson's disease (PD). Prior to elimination of damaged mitochondria, Parkin translocates to mitochondria and induces mitochondrial clustering. While the mechanism of PINK1-dependent Parkin redistribution to mitochondria is now becoming clear, the role of mitochondrial clustering has been less well understood. In our stud...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 7, 2017 Category: Molecular Biology Source Type: research

Hamburg 2, Announcement ECS 2018
Publication date: June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1864, Issue 6 (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 3, 2017 Category: Molecular Biology Source Type: research

ECS Membership Form_2017
Publication date: June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1864, Issue 6 (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 3, 2017 Category: Molecular Biology Source Type: research

European Calcium Society
Publication date: June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1864, Issue 6 (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 3, 2017 Category: Molecular Biology Source Type: research

Overexpression of STIM1 in neurons in mouse brain improves contextual learning and impairs long-term depression
This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech. (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 3, 2017 Category: Molecular Biology Source Type: research

Mag-Fluo4 in T cells: Imaging of intra-organelle free Ca2+ concentrations
This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech. Graphical abstract (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 3, 2017 Category: Molecular Biology Source Type: research

The selective Bcl-2 inhibitor venetoclax, a BH3 mimetic, does not dysregulate intracellular Ca2+ signaling
This study therefore shows that venetoclax does not dysregulate the intracellular Ca2+ homeostasis in a variety of cell types, which may underlie its limited toxicity in human patients. Furthermore, venetoclax-induced cell death in Bcl-2-dependent cancer cells is not mediated by intracellular Ca2+ overload. This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech. (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 3, 2017 Category: Molecular Biology Source Type: research

The functions of store-operated calcium channels
This article is part of a Special Issue entitled: ECS Meeting edited by Claus Heizmann, Joachim Krebs and Jacques Haiech. (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 3, 2017 Category: Molecular Biology Source Type: research

TRP channels in calcium homeostasis: from hormonal control to structure-function relationship of TRPV5 and TRPV6
Publication date: June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1864, Issue 6 Author(s): Mark K.C. van Goor, Joost G.J. Hoenderop, Jenny van der Wijst Maintaining plasma calcium levels within a narrow range is of vital importance for many physiological functions. Therefore, calcium transport processes in the intestine, bone and kidney are tightly regulated to fine-tune the rate of absorption, storage and excretion. The TRPV5 and TRPV6 calcium channels are viewed as the gatekeepers of epithelial calcium transport. Several calciotropic hormones control the channels at the level of tr...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 3, 2017 Category: Molecular Biology Source Type: research

Obituary Claude Klee
Publication date: June 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Volume 1864, Issue 6 (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 3, 2017 Category: Molecular Biology Source Type: research

Mitochatting – If only we could be a fly on the cell wall
This article is part of a Special Issue entitled: Membrane Contact Sites edited by Christian Ungermann and Benoit Kornmann. (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 2, 2017 Category: Molecular Biology Source Type: research

TCTP regulates spindle assembly during postovulatory aging and prevents deterioration in mouse oocyte quality
Publication date: Available online 2 May 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Hyuk-Joon Jeon, Xiang-Shun Cui, Jing Guo, Jae Man Lee, Jae-Sung Kim, Jeong Su Oh If no fertilization occurs for a prolonged time following ovulation, oocytes experience a time-dependent deterioration in quality both in vivo and in vitro due to processes called postovulatory aging. Because the postovulatory aging of oocytes has marked detrimental effects on embryo development and offspring, many efforts have been made to unveil the underlying mechanisms. Here we showed that translationally controlle...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 2, 2017 Category: Molecular Biology Source Type: research

Withaferin A, a natural compound with anti-tumor activity, is a potent inhibitor of transcription factor C/EBP β
Publication date: Available online 2 May 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Kim D. Falkenberg, Anke Jakobs, Julian C. Matern, Wolfgang Dörner, Sagar Uttarkar, Amke Trentmann, Simone Steinmann, Anna Coulibaly, Caroline Schomburg, Henning D. Mootz, Thomas J. Schmidt, Karl-Heinz Klempnauer Recent work has shown that deregulation of the transcription factor Myb contributes to the development of leukemia and several other human cancers, making Myb and its cooperation partners attractive targets for drug development. By employing a myeloid Myb-reporter cell line we have ide...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 2, 2017 Category: Molecular Biology Source Type: research

G protein-coupled receptor GPR19 regulates E-cadherin expression and invasion of breast cancer cells.
Publication date: Available online 2 May 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Angad Rao, Deron R. Herr Dysregulation of G protein-coupled receptors (GPCRs) is known to be involved in the pathogenesis of a variety of diseases, including cancer initiation and progression. Within this family, approximately 140 GPCRs have no known endogenous ligands and these “orphan” GPCRs remain poorly characterized. The orphan GPCR GPR19 was identified and cloned 2 decades ago, but relatively little is known about its physio-pathological relevance. We observed its expression to be...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - May 2, 2017 Category: Molecular Biology Source Type: research

Transdifferentiation and reprogramming: Overview of the processes, their similarities and differences
Publication date: Available online 28 April 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Artur Cieślar-Pobuda, Viktoria Knoflach, Mikael V. Ringh, Joachim Stark, Wirginia Likus, Krzysztof Siemianowicz, Saeid Ghavami, Andrzej Hudecki, Jason L. Green, Marek J. Łos Reprogramming, or generation of induced pluripotent stem (iPS) cells (functionally similar to embryonic stem cells or ES cells) by the use of transcription factors (typically: Oct3/4, Sox2, c-Myc, Klf4) called “Yamanaka factors” (OSKM), has revolutionized regenerative medicine. However, factors used to induce s...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 28, 2017 Category: Molecular Biology Source Type: research

Rhomboid proteases in human disease: Mechanisms and future prospects
This article is part of a Special Issue entitled: Proteolysis as a Regulatory Event in Pathophysiology edited by Stefan Rose-John. (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 28, 2017 Category: Molecular Biology Source Type: research

Matrix metalloproteinase collagenolysis in health and disease
This article is part of a Special Issue entitled: Matrix Metalloproteinases edited by Rafael Fridman. (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 26, 2017 Category: Molecular Biology Source Type: research

The antimalarial drug artemisinin induces an additional, Sod1-supressible anti-mitochondrial action in yeast
Publication date: Available online 25 April 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Chen Sun, Bing Zhou The molecular action of artemisinins(ARTs) is not well understood. To determine the molecular and cellular basis that might underlie their differential effects observed in anti-malarial and anti-cancer studies, we utilized the yeast Saccharomyces cerevisiae to examine their toxicity profiles and properties. Previously we reported that while both low levels(2-8μM) of artemisinin(ART) and dihydro- artemisinin(DHA) partly depolarize the mitochondrial membranes, inhibiting yea...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 25, 2017 Category: Molecular Biology Source Type: research

Peripheral Membrane Associations of Matrix Metalloproteinases
This article is part of a Special Issue entitled: Matrix Metalloproteinases edited by Rafael Fridman. (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 23, 2017 Category: Molecular Biology Source Type: research

Selective Small-Molecule Inhibitors as Chemical Tools to Define the Roles of Matrix Metalloproteinases in Disease
This article is part of a Special Issue entitled: Matrix Metalloproteinases edited by Rafael Fridman. (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 20, 2017 Category: Molecular Biology Source Type: research

Mitochatting –if only we could be a fly on the cell wall
This article is part of a Special Issue entitled: Membrane Contact Sites edited by Christian Ungermann and Benoit Kornmann. (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 20, 2017 Category: Molecular Biology Source Type: research

Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury
Publication date: Available online 19 April 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Kyung Hwan Jegal, Sang Mi Park, Sam Seok Cho, Sung Hui Byun, Sae Kwang Ku, Sang Chan Kim, Sung Hwan Ki, Il Je Cho Endoplasmic reticulum (ER) stress is characterized by an accumulation of misfolded proteins, and ER stress reduction is essential for maintaining tissue homeostasis. However, the molecular mechanisms that protect cells from ER stress are not completely understood. The present study investigated the role of sestrin 2 (SESN2) on ER stress and sought to elucidate the mechanism responsib...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 19, 2017 Category: Molecular Biology Source Type: research

1 p62-Mediated Mitochondrial Clustering Attenuates Apoptosis Induced by Mitochondrial Depolarization
Publication date: Available online 19 April 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Bin Xiao, Xiao Deng, Grace G.Y. Lim, Wei Zhou, Wuan-Ting Saw, Zhi Dong Zhou, Kah-Leong Lim, Eng-King Tan Parkin/PINK1-mediated mitophagy is implicated in the pathogenesis of Parkinson's disease (PD). Prior to elimination of damaged mitochondria, Parkin translocates to mitochondria and induces mitochondrial clustering. While the mechanism of PINK1-dependent Parkin redistribution to mitochondria is now becoming clear, the role of mitochondrial clustering has been less well understood. In our study...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 19, 2017 Category: Molecular Biology Source Type: research

The ER phagosome connection in the era of membrane contact sites
This article is part of a Special Issue entitled: Membrane Contact Sites edited by Christian Ungermann and Benoit Kornmann. (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 18, 2017 Category: Molecular Biology Source Type: research

A crosstalk between muscarinic and CRF2 receptors regulates cellular adhesion properties of human colon cancer cells
In this study, we investigated the mechanisms through which stress and ACh modulate epithelial cell adhesive properties. We show that ACh-induced activation of mAChR in HT-29 cells results in cell dissociation together with changes in cell-matrix contacts, which correlates with the acquisition of invasive potential consistent with a matrix metalloproteinase (MMP) mode of invasion. These processes result from mAChR subsequent stimulation of the cascade of src/Erk and FAK activation. ACh-induced secretion of laminin 332 leads to α3β1 integrin activation and RhoA-dependent reorganization of the actin cytoskeleton. ...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 18, 2017 Category: Molecular Biology Source Type: research

The Pseudomonas aeruginosa lectin LecA triggers host cell signalling by glycosphingolipid-dependent phosphorylation of the adaptor protein CrkII
Publication date: Available online 17 April 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Shuangshuang Zheng, Thorsten Eierhoff, Sahaja Aigal, Annette Brandel, Roland Thuenauer, Sophie de Bentzmann, Anne Imberty, Winfried Römer The human pathogen Pseudomonas aeruginosa induces phosphorylation of the adaptor protein CrkII by activating the non-receptor tyrosine kinase Abl to promote its uptake into host cells. So far, specific factors of P. aeruginosa, which induce Abl/CrkII signalling, are entirely unknown. In this research, we employed human lung epithelial cells H1299, Chinese...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 17, 2017 Category: Molecular Biology Source Type: research

XIAP Interacts with and Regulates the Activity of FAF1
Publication date: Available online 13 April 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): Marcos J. Caballero-López, Manuel Nieto-Díaz, Mónica Yunta, David Reigada, Teresa Muñoz-Galdeano, Ángela del Águila, Rosa Navarro-Ruíz, Wolfang Pita-Thomas, Dan Lindholm, Rodrigo M. Maza Cell death depends on the balance between the activities of pro- and anti-apoptotic factors. X-linked inhibitor of apoptosis protein (XIAP) plays an important role in the cytoprotective process by inhibiting the caspase cascade and regulating pro-survival signalin...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 14, 2017 Category: Molecular Biology Source Type: research

Matrix metalloproteinases outside vertebrates
This article is part of a Special Issue entitled: Matrix Metalloproteinases edited by Rafael Fridman. (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 10, 2017 Category: Molecular Biology Source Type: research

Cell surface targeting of the Melanocortin 5 receptor (MC5R) requires serine-rich terminal motifs
Publication date: Available online 8 April 2017 Source:Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Author(s): A.R. Rodrigues, D. Sousa, H. Almeida, A.M. Gouveia The Melanocortin 5 Receptor (MC5R) is a cell surface receptor that belongs to the class of G-protein coupled receptors (GPCRs), which comprises an intracellular carboxylic domain, seven transmembrane helices and an extracellular amino terminal. Over the last few years, MC5R has been implicated in the regulation of lipid metabolism in exocrine glands, muscle and even in adipose tissue and its function is quite dependent on its correct cell membran...
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 10, 2017 Category: Molecular Biology Source Type: research

Membrane-type matrix metalloproteases as diverse effectors of cancer progression
This article is part of a Special Issue entitled: Matrix Metalloproteinases edited by Rafael Fridman. (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 5, 2017 Category: Molecular Biology Source Type: research

Function of lipid droplet-organelle interactions in lipid homeostasis
This article is part of a Special Issue entitled: Membrane Contact Sites edited by Christian Ungermann and Benoit Kornmann. (Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research)
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - April 5, 2017 Category: Molecular Biology Source Type: research