Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Stable reduction of STARD4 alters cholesterol regulation and lipid homeostasis
Publication date: Available online 7 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): David B. Iaea, Zachary R. Spahr, Rajesh K. Singh, Robin B. Chan, Bowen Zhou, Rohan Bareja, Olivier Elemento, Gilbert Di Paolo, Xiaoxue Zhang, Frederick R. MaxfieldAbstractSTARD4, a member of the evolutionarily conserved START gene family, is a soluble sterol transport protein implicated in cholesterol sensing and maintenance of cellular homeostasis. STARD4 is widely expressed and has been shown to transfer sterol between liposomes as well as organelles in cells. However, STARD4 knock...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 7, 2020 Category: Lipidology Source Type: research

Inhibition of class I HDACs imprints adipogenesis toward oxidative and brown-like phenotype
Publication date: Available online 2 January 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Alessandra Ferrari, Raffaella Longo, Carolina Peri, Lara Coppi, Donatella Caruso, Antonello Mai, Nico Mitro, Emma De Fabiani, Maurizio CrestaniAbstractObesity is characterized by uncontrolled expansion of adipose tissue mass, resulting in adipocyte hypertrophy (increased adipocyte size) and hyperplasia (increased number of adipocytes). The number of adipose cells is directly related to adipocyte differentiation process from stromal vascular cells to mature adipocytes. It is known tha...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 4, 2020 Category: Lipidology Source Type: research

Carotenoids and fatty liver disease: Current knowledge and research gaps
This article is part of a Special Issue entitled Carotenoids recent advances in cell and molecular biology edited by Johannes von Lintig and Loredana Quadro. (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - January 4, 2020 Category: Lipidology Source Type: research

Diacylglycerol kinase δ destabilizes serotonin transporter protein through the ubiquitin-proteasome system
Publication date: Available online 28 December 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Qiang Lu, Chiaki Murakami, Fumi Hoshino, Yuki Murakami, Fumio SakaneAbstractBrain-specific diacylglycerol kinase (DGK) δ-knockout mice exhibited serotonin transporter (SERT) inhibitor-sensitive obsessive-compulsive disorder-like behaviors. Moreover, SERT protein levels were markedly increased in the DGKδ-deficient brain. However, its molecular mechanisms remain unclear. We found that the catalytic subdomain-a and the coiled-coil structure-containing region of DGKδ interacted wit...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - December 29, 2019 Category: Lipidology Source Type: research

Proliferation of C6 glioma cells requires the phospholipid remodeling enzyme tafazzin independent of cardiolipin composition
Publication date: Available online 26 December 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Lorenz Schild, Mona Döring, Steffen Jansing, Daniela Peter, Gayatri Jagirdar, Carmen Wolke, Andreas Gardemann, Uwe LendeckelAbstractThe mitochondrial phospholipid (CL) has been linked to mitochondrial and cellular functions. It has been postulated that the composition of CL is of impact for mitochondrial energy metabolism and cell proliferation. Although a correlation between CL composition and proliferation could be demonstrated for several cell types, evidence for a causal relat...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - December 27, 2019 Category: Lipidology Source Type: research

Structural and mechanistic aspects of carotenoid cleavage dioxygenases (CCDs)
This article is part of a Special Issue entitled Carotenoids recent advances in cell and molecular biology edited by Johannes von Lintig and Loredana Quadro. (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - December 25, 2019 Category: Lipidology Source Type: research

Structural and functional basis for increased HDL-cholesterol levels due to the naturally occurring V19L mutation in human apolipoprotein A-I
Publication date: Available online 18 December 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Christina Gkolfinopoulou, Angeliki Bourtsala, Angeliki ChroniAbstractSeveral hereditary point mutations in human apolipoprotein A-I (apoA-I) have been associated with low HDL-cholesterol levels and/or increased coronary artery disease (CAD) risk. However, one apoA-I mutation, the V19L, recently identified in Icelanders, has been associated with increased HDL-cholesterol levels and decreased CAD risk. In an effort to gain mechanistic insight linking the presence of this mutation in ...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - December 20, 2019 Category: Lipidology Source Type: research

Hyperalphalipoproteinemic scavenger receptor BI knockout mice exhibit a disrupted epidermal lipid barrier
In conclusion, increased HDL-cholesterol levels in SR-BI−/− can alter the epidermal lipid composition and lipid barrier function similarly as observed in hypercholesterolemia due to elevated levels of apoB-containing lipoproteins. (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - December 20, 2019 Category: Lipidology Source Type: research

Interplay between β-carotene and lipoprotein metabolism at the maternal-fetal barrier
This article is part of a Special Issue entitled Carotenoids recent advances in cell and molecular biology edited by Johannes von Lintig and Loredana Quadro. (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - December 20, 2019 Category: Lipidology Source Type: research

Lipidomic profiles of maternal blood at the earlier stage of gestation and umbilical venous blood in response to supraphysiological hypercholesterolemia versus physiological hypercholesterolemia: An evidence of potential biomarkers and early intervention
ConclusionThis study clarifies the differential lipid profiles to distinguish MSPH from MPH and the pathway which is influenced under the condition of MSPH. Also, it provides a resource to look for potential therapeutic targets for MSPH. (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - December 14, 2019 Category: Lipidology Source Type: research

Carotenoids in human skin
Publication date: Available online 12 December 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Sarah Zerres, Wilhelm StahlAbstractThe skin is shielding our organism from exogenous threats including solar radiation. Carotenoids which are ingested with the diet accumulate in the skin with the highest levels occurring in skin of the forehead and in the palms of the hands. Blood and skin levels of carotenoids increase during supplementation and due to their antioxidant properties and UV-absorbing effects carotenoids are used as photoprotective agents. Systemic photoprotection wi...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - December 13, 2019 Category: Lipidology Source Type: research

Cytological and functional characteristics of fascia adipocytes in rats: A unique population of adipocytes
This study aimed to examine cytological and functional characteristics of fascial adipocytes in rats. Superficial fascia had no adipocytes in neonatal rats but gradually appeared numbers of adipocytes in growing rats. Adipogenic progenitors were found to reside in fascia and had strong ability in spontaneous and induced adipogenic differentiation in vitro. Differentiated fascial adipocytes versus subcutaneous or visceral adipocytes expressed increased adipose triglyceride lipase but decreased beta-adrenoreceptor, perilipin-1 and hormone-sensitive lipase (HSL), thus having high basal lipolysis but low lipolysis response to ...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - December 7, 2019 Category: Lipidology Source Type: research

A high-fat diet enriched in medium chain triglycerides triggers hepatic thermogenesis and improves metabolic health in lean and obese mice
The objective of our study was to evaluate if the replacement of LCT by MCT in high-fat diets could prevent and/or reduce metabolic disorders. For this purpose, two cohorts of C57BL/6 mice were fed during 10 weeks with three isocaloric high-fat diets with variable MCT content. Cohort A was composed of lean mice while cohort B was composed of obese, insulin resistant mice. In cohort A, replacement of LCT by MCT preserved metabolic health, in part by triggering hepatic thermogenesis. We further found that medium chain fatty acids promote thermogenesis markers within cultured hepatocytes in a FFAR1/GPR40-dependent manner. I...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - December 7, 2019 Category: Lipidology Source Type: research

Aquaporin-9 is involved in the lipid-lowering activity of the nutraceutical silybin on hepatocytes through modulation of autophagy and lipid droplets composition
In conclusion, silybin was shown to have molecular effects on signaling pathways that were previously unknown and potentially protect the hepatocyte. These actions intersect TG metabolism, fat-induced autophagy and AQP9-mediated glycerol transport in hepatocytes.Graphical abstract (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - December 7, 2019 Category: Lipidology Source Type: research

Identification of a hormone response element that mediates suppression of APOF by LXR and PPARα agonists
Publication date: Available online 6 December 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Yan Liu, Lahoucine Izem, Richard E. MortonAbstractApolipoprotein F (ApoF) regulates cholesteryl ester transfer protein activity. We previously observed that hepatic APOF mRNA levels are decreased by high fat, cholesterol-enriched diets. Here we show in human liver C3A cells that APOF mRNA levels are reduced by agonists of LXR and PPARα nuclear receptors. This negative regulation requires co-incubation with the RXR agonist, retinoic acid. Bioinformatic analysis of the ~2 kb sequen...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - December 7, 2019 Category: Lipidology Source Type: research