Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Retinoids in health and disease: A role for hepatic stellate cells in affecting retinoid levels
Publication date: Available online 24 February 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Maya W. Haaker, Arie B. Vaandrager, J. Bernd HelmsAbstractVitamin A (retinol) is important for normal growth, vision and reproduction. It has a role in the immune response and the development of metabolic syndrome. Most of the retinol present in the body is stored as retinyl esters within lipid droplets in hepatic stellate cells (HSCs). In case of liver damage, HSCs release large amounts of stored retinol, which is partially converted to retinoic acid (RA). This surge of RA can med...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - February 25, 2020 Category: Lipidology Source Type: research

Skin of atopic dermatitis patients shows disturbed β-glucocerebrosidase and acid sphingomyelinase activity that relates to changes in stratum corneum lipid composition
In this study we analyzed the localization and activity of lipid enzymes β-glucocerebrosidase (GBA) and acid sphingomyelinase (ASM) in the skin of AD patients and controls. Localization of both the expression and activity of GBA and ASM in the epidermis of AD patients was altered, particularly at lesional skin sites. These changes aligned with the altered SC lipid composition. More specifically, abnormal localization of GBA and ASM related to an increase in specific ceramide subclasses [AS] and [NS]. Moreover we related the localization of the enzymes to the amounts of SC ceramide subclasses and free fatty acids (FFAs).We...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - February 22, 2020 Category: Lipidology Source Type: research

Editorial Board
Publication date: May 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Volume 1865, Issue 5Author(s): (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - February 20, 2020 Category: Lipidology Source Type: research

Carotenoid biofortification in crop plants: citius, altius, fortius
This article is part of a Special Issue entitled Carotenoids recent advances in cell and molecular biology edited by Johannes von Lintig and Loredana Quadro. (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - February 16, 2020 Category: Lipidology Source Type: research

Short-chain fatty acid mitigates adenine-induced chronic kidney disease via FFA2 and FFA3 pathways
This study used a murine model of adenine-induced renal failure to investigate whether or not SCFAs can prevent the progression of renal damage. We also examined whether or not these FFA2 and FFA3 proteins have some roles in this protective mechanism in vivo. Immunohistochemical analyses of mouse kidneys showed that FFA2 and FFA3 proteins were expressed mainly in the distal renal tubules and collecting tubules. First, we observed that the administration of propionate mitigated the renal dysfunction and pathological deterioration caused by adenine. Consistent with this, the expression of inflammatory cytokines and fibrosis-...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - February 14, 2020 Category: Lipidology Source Type: research

Evolutionary aspects and enzymology of metazoan carotenoid cleavage oxygenases
Publication date: Available online 12 February 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Eugenia Poliakov, Sheetal Uppal, Igor B. Rogozin, Susan Gentleman, T. Michael RedmondAbstractThe carotenoids are terpenoid fat-soluble pigments produced by plants, algae, and several bacteria and fungi. They are ubiquitous components of animal diets. Carotenoid cleavage oxygenase (CCO) superfamily members are involved in carotenoid metabolism and are present in all kingdoms of life. Throughout the animal kingdom, carotenoid oxygenases are widely distributed and they are completely ...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - February 13, 2020 Category: Lipidology Source Type: research

Carboxyl ester lipase is highly conserved in utilizing maternal supplied lipids during early development of zebrafish and human
This study aimed to examine whether the Cel in zebrafish embryos has a similar role of maternal lipid utilization as in human infants, and how Cel contributes to the utilization of yolk lipids in zebrafish. The cel1 and cel2 genes were expressed ubiquitously in the blastodisc and yolk syncytial layer before 24 hpf, and in the exocrine pancreas after 72 hpf. The cel1 and cel2 morphants exhibited developmental retardation and yolk sac retention. The total cholesterol, cholesterol ester, free cholesterol, and triglyceride were reduced in the morphants' body while accumulated in the yolk (except triglyceride). The FFA content ...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - February 13, 2020 Category: Lipidology Source Type: research

Triglyceride deficiency and diacylglycerol kinase1 activity lead to the upregulation of mevalonate pathway in yeast: A study for the development of potential yeast platform for improved production of triterpenoid
In conclusion, our findings provide a novel strategy to increase MEV pathway precursors by modulating endogenous signal lipids for improved production of terpenoids. (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - February 12, 2020 Category: Lipidology Source Type: research

Comparative anti-inflammatory effects of plant- and marine-derived omega-3 fatty acids explored in an endothelial cell line
This study compared effects of marine- and plant-derived n-3 FAs on EC inflammatory responses. EA.hy926 cells were exposed to ALA, SDA, EPA or DHA prior to stimulation with tumor necrosis factor (TNF)-α. All FAs were shown to be incorporated into ECs in a dose-dependent manner. SDA (50 μM) decreased both production and cell-surface expression of intercellular adhesion molecule (ICAM)-1; however EPA and DHA resulted in greater reduction of ICAM-1 production and expression. EPA and DHA also significantly lowered production of monocyte chemoattractant protein 1, interleukin (IL)-6 and IL-8. ALA, SDA and DHA (50 μM) all...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - February 12, 2020 Category: Lipidology Source Type: research

Generation of new hepatocyte-like in vitro models better resembling human lipid metabolism
Publication date: Available online 11 February 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Camilla Pramfalk, Tomas Jakobsson, Cristy R.C. Verzijl, Mirko E. Minniti, Clara Obensa, Federico Ripamonti, Maria Olin, Matteo Pedrelli, Mats Eriksson, Paolo PariniAbstractIn contrast to human hepatocytes in vivo, which solely express acyl-coenzyme A:cholesterol acyltransferase (ACAT) 2, both ACAT1 and ACAT2 (encoded by SOAT1 and SOAT2) are expressed in primary human hepatocytes and in human hepatoma cell lines. Here, we aimed to create hepatocyte-like cells expressing the ACAT2, b...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - February 12, 2020 Category: Lipidology Source Type: research

Vps39 is required for ethanolamine-stimulated elevation in mitochondrial phosphatidylethanolamine
Publication date: Available online 11 February 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Donna M. Iadarola, Writoban Basu Ball, Prachi P. Trivedi, Guo Fu, Beiyan Nan, Vishal M. GohilAbstractMitochondrial membrane biogenesis requires the import of phospholipids; however, the molecular mechanisms underlying this process remain elusive. Recent work has implicated membrane contact sites between the mitochondria, endoplasmic reticulum (ER), and vacuole in phospholipid transport. Utilizing a genetic approach focused on these membrane contact site proteins, we have discovered...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - February 12, 2020 Category: Lipidology Source Type: research

The role of the C-terminal domain of PCSK9 and SEC24 isoforms in PCSK9 secretion
Publication date: Available online 11 February 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Shi-jun Deng, Yishi Shen, Hong-mei Gu, Shoudong Guo, Shan-Rong Wu, Da-wei ZhangAbstractProprotein convertase subtilisin/kexin type 9 (PCSK9) is a secretory protein that promotes low-density lipoprotein receptor (LDLR) degradation and thereby regulating plasma levels of LDL cholesterol. Previous studies have revealed the role of the C-terminal domain (CTD) of PCSK9 in its secretion, however, how CTD regulates PCSK9 secretion is not completely understood. Additionally, SEC24A, the ca...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - February 12, 2020 Category: Lipidology Source Type: research

Role of lipids in pathophysiology, diagnosis and therapy of hepatocellular carcinoma
Publication date: Available online 10 February 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Christa Buechler, Charalampos AslanidisAbstractHepatocellular carcinoma (HCC) is an aggressive and widespread cancer. Patients with liver cirrhosis of different aetiologies are at a risk to develop HCC. It is important to know that in approximately 20% of cases primary liver tumors arise in a non-cirrhotic liver. Lipid metabolism is variable in patients with chronic liver diseases, and lipid metabolites involved therein do play a role in the development of HCC. Of note, lipid compo...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - February 10, 2020 Category: Lipidology Source Type: research

Automated untargeted stable isotope assisted lipidomics of liver cells on high glucose shows alteration of sphingolipid kinetics
In conclusion we developed an automated powerful algorithm able to model simultaneously hundreds of kinetic curves obtained in a cell culture spiked with a stable isotope tracer, and to analyze the difference between the two different cell models.Graphical abstract (Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids)
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - February 10, 2020 Category: Lipidology Source Type: research

Imbalanced insulin substrate-1 and insulin substrate-2 signaling trigger hepatic steatosis in vitamin D deficient rats: 8-methoxypsoralen, a vitamin D receptor ligand with a promising anti-steatotic action
In this study, we induced VD deficiency by feeding Female Sprague-Dawley rats a VD deficient (VDD) Diet and studied the hepatic changes associated with VD deficiency. Simultaneously, we provided the VDD rats with VD or 8-methoxy psoralen (8-MOP), a suggested vitamin D receptor agonist, to test the reversibility of the hepatic changes. VDD Rats developed borderline non-alcoholic steatohepatitis (NASH) with considerable elevation in hepatic triglycerides, total cholesterol, and malondialdehyde.Furthermore, VD deficiency induced the expression of crucial enzymes and transcription factors involved in denovo lipogenesis, which ...
Source: Biochimica et Biophysica Acta (BBA) Molecular and Cell Biology of Lipids - February 10, 2020 Category: Lipidology Source Type: research