Biochimica et Biophysica Acta (BBA) General Subjects This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

PEGylation-based strategy to identify pathways involved in the activation of apoptotic BAX protein
ConclusionPEGylation-based approach is proven useful to shield individual binding grooves of BAX from apoptotic stimuli. Groove engagement in CG of BAX is required for a full cBid-induced BAX activation. This study has identified differences in the pathways involved during the initiation of BAX activation by full-length cBid protein versus synthetic BimBH3-based peptides.General significanceOur finding is potentially valuable for therapeutic application as the pore-forming activity of 164-PEG is independent from the cBid-mediated apoptotic pathways, but can be administrated by the synthetic short peptides.Graphical abstrac...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - January 26, 2020 Category: Biochemistry Source Type: research

A novel neuronal organoid model mimicking glioblastoma (GBM) features from induced pluripotent stem cells (iPSC)
This study shows the feasibility of generating “off-the shelf” neuronal-like organoid model mimicking GBM using c-met-mutated iPSC aggregates and its potential future use in research. (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - January 22, 2020 Category: Biochemistry Source Type: research

Why do water molecules around small hydrophobic solutes form stronger hydrogen bonds than in the bulk?
Publication date: Available online 21 January 2020Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Franci Merzel, Franc AvbeljAbstractMolecular solutes are known to have a strong effect on the structural and dynamical properties of the surrounding water. In our recent study (PNAS, 114, 322 (2017)) we have identified the presence of strengthened water hydrogen bonds near hydrophobic solutes by using both IR spectroscopy and ab-initio molecular dynamics simulations. The water molecules involved in the enhanced hydrogen bonding have been shown to display extensive structural ordering and restricted mob...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - January 21, 2020 Category: Biochemistry Source Type: research

The lac repressor hinge helix in context: The effect of the DNA binding domain and symmetry
Publication date: Available online 17 January 2020Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Danielle Seckfort, Gillian C. Lynch, B. Montgomery PettittAbstractThe Lac system of genes has been an important model system in understanding gene regulation. When the dimer lac repressor protein binds to the correct DNA sequence, the hinge region of the protein goes through a disorder to order transition. The hinge region is disordered when binding to nonoperator sequences. This region of the protein must pay a conformational entropic penalty to order when it is bound to operator DNA. Structural studi...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - January 18, 2020 Category: Biochemistry Source Type: research

Directly targeting glutathione peroxidase 4 may be more effective than disrupting glutathione on ferroptosis-based cancer therapy
Publication date: Available online 18 January 2020Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Yunpeng Wei, Huanhuan Lv, Atik Badshah Shaikh, Wei Han, Hongjie Hou, Zhihao Zhang, Shenghang Wang, Peng ShangAbstractBackgroundCancer is one of the major threats to human health and current cancer therapies have been unsuccessful in eradicating it. Ferroptosis is characterized by iron-dependence and lipid hydroperoxides accumulation, and its primary mechanism involves the suppression of system Xc−-GSH (glutathione)-GPX4 (glutathione peroxidase 4) axis. Co-incidentally, cancer cells are also metabolic...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - January 18, 2020 Category: Biochemistry Source Type: research