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Editorial Board
Publication date: May 2020Source: Biochimica et Biophysica Acta (BBA) - General Subjects, Volume 1864, Issue 5Author(s): (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - February 20, 2020 Category: Biochemistry Source Type: research

The action of Echis carinatus and Naja naja venoms on human neutrophils; an emphasis on NETosis
ConclusionFor the first time our study demonstrates the distinct action of E. carinatus and N. naja venoms on the process of NETosis. NETosis being a newly explored area in snake venom pharmacodynamics, it is important to study its impact on the various pathophysiological properties induced by snake venoms.SignificanceUnderstanding the varied actions of snake venoms on neutrophils/blood cells and the role of DNase are likely to provide insights for better management of snakebite pathophysiology. (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - February 15, 2020 Category: Biochemistry Source Type: research

A dual PI3 kinase/mTOR inhibitor BEZ235 reverses doxorubicin resistance in ABCB1 overexpressing ovarian and pancreatic cancer cell lines
ConclusionsThese results suggest that BEZ is a non-substrate inhibitor of ABCB1 and is able to effectively re-sensitize cells overexpressing ABCB1 to the effects of DOX.General significanceDual PI3 Kinase/mTOR inhibitor, BEZ has the potential to reverse MDR in cancer patients. (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - February 14, 2020 Category: Biochemistry Source Type: research

S-glutathionylation of human glyceraldehyde-3-phosphate dehydrogenase and possible role of Cys152-Cys156 disulfide bridge in the active site of the protein
ConclusionsS-glutathionylation induces the formation of Cys152-Cys156 disulfide bond in the active site of hGAPDH, which results in structural changes of the protein molecule. Cys156 is important for reactivation of S-glutathionylated GAPDH by glutaredoxin 1.General significanceThe described mechanism may be important for interaction between GAPDH and other proteins and ligands, involved in cell signaling. (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - February 14, 2020 Category: Biochemistry Source Type: research

The effect of UV radiation in the presence of TiO2-NPs on Leishmania major promastigotes
Conclusion: The combined treatment with UV- radiation and TiO2-NPs can be effective in killing the promastigotes of Leishmania major. The proper concentration of NPs and the type of UV-radiation must be taken into consideration. The results suggest improved treatment methods, after proper in vivo studies.Graphical abstract (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - February 14, 2020 Category: Biochemistry Source Type: research

Machine learning and ligand binding predictions: A review of data, methods, and obstacles
Publication date: Available online 10 February 2020Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Sally R. Ellingson, Brian Davis, Jonathan AllenAbstractComputational predictions of ligand binding is a difficult problem, with more accurate methods being extremely computationally expensive. The use of machine learning for drug binding predictions could possibly leverage the use of biomedical big data in exchange for time-intensive simulations. This paper reviews current trends in the use of machine learning for drug binding predictions, data sources to develop machine learning algorithms, and poten...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - February 11, 2020 Category: Biochemistry Source Type: research

Polyamines and its analogue modulates amyloid fibrillation in lysozyme: A comparative investigation
This study, thus, potentiates, the development of a polyamine analogue that can perform as an effective inhibitor targeted towards aggregation of amyloidogenic proteins.Graphical abstract (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - February 9, 2020 Category: Biochemistry Source Type: research

Editorial Board
Publication date: April 2020Source: Biochimica et Biophysica Acta (BBA) - General Subjects, Volume 1864, Issue 4Author(s): (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - February 8, 2020 Category: Biochemistry Source Type: research

Crystal structure of a novel xylose isomerase from Streptomyces sp. F-1 revealed the presence of unique features that differ from conventional classes
ConclusionsWe have characterized two novel xylose isomerases that display distinct functional behavior and harbor unprecedented amino-acid substitutions in the catalytic interface.General significanceOur findings contribute to a better understanding of the functional and structural aspects of xylose isomerases, which might be instrumental for the valorization of the hemicellulosic fraction of vegetal biomass. (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - February 6, 2020 Category: Biochemistry Source Type: research

Radiation activates myeloperoxidase (MPO) to generate active chlorine species (ACS) via a dephosphorylation mechanism - inhibitory effect of LGM2605
ConclusionsWe demonstrate that γ-radiation induces MPO-dependent generation of ACS, which is dependent, at least in part, by protein tyrosine and Ser/Thr dephosphorylation and is reduced by LGM2605. This study identified for the first time a novel protein dephosphorylation-dependent mechanism of radiation-induced MPO activation. (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - February 6, 2020 Category: Biochemistry Source Type: research

Discovery of multidrug efflux pump inhibitors with a novel chemical scaffold
Publication date: Available online 4 February 2020Source: Biochimica et Biophysica Acta (BBA) - General SubjectsAuthor(s): Adam T. Green, Mohammad Moniruzzaman, Connor J. Cooper, John K. Walker, Jeremy C. Smith, Jerry M. Parks, Helen I. ZgurskayaAbstractMultidrug efflux is a major contributor to antibiotic resistance in Gram-negative bacterial pathogens. Inhibition of multidrug efflux pumps is a promising approach for reviving the efficacy of existing antibiotics. Previously, inhibitors targeting both the efflux transporter AcrB and the membrane fusion protein AcrA in the Escherichia coli AcrAB-TolC efflux pump were identi...
Source: Biochimica et Biophysica Acta (BBA) General Subjects - February 5, 2020 Category: Biochemistry Source Type: research

The relation between lignin sequence and its 3D structure
ConclusionsThe 3D structure of lignin is influenced by the overall content of monomeric units and interunit linkages and not by its precise primary sequence.General significanceLignin is assumed to not have a well-defined primary structure. The results presented here demonstrate there are no significant differences in the 3D structure of lignin molecules with the same average composition but different primary sequence. (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - February 5, 2020 Category: Biochemistry Source Type: research

Expression of elastolytic cathepsins in human skin and their involvement in age-dependent elastin degradation
ConclusionCathepsins are powerful elastin-degrading enzymes and capable of generating a multitude of elastokines. They may represent a viable target for intervention strategies to reduce skin ageing. (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - January 31, 2020 Category: Biochemistry Source Type: research

Development and characterisation of a peptidergic N-and C-terminally stabilised mammalian NPY1R agonist which protects against diabetes induction
ConclusionWe present (d-Arg35)-sea lamprey PYY (1–36) as the first-in-class N- and C-terminally stable PYY (1–36) peptide analogue.General significanceEnzymatically stable, long-acting PYY (1–36) peptides highlight the therapeutic benefits of sustained activation of NPYR1's in diabetes. (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - January 30, 2020 Category: Biochemistry Source Type: research

Interactions between PAMAM dendrimers and DOPC lipid multilayers: Membrane thinning and structural disorder
ConclusionsThese results show the complexity of the effect of dendrimer physicochemical properties and the addition method of dendrimers on the structure of mixed dendrimer-DOPC multilayers.General significanceThese insights are useful for fundamental understanding of nanotoxicity and future biomedical application of nanocomposite multilayer materials in which nanoparticles are added for enhanced properties and functionality.Graphical abstract (Source: Biochimica et Biophysica Acta (BBA) General Subjects)
Source: Biochimica et Biophysica Acta (BBA) General Subjects - January 26, 2020 Category: Biochemistry Source Type: research