Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Tailoring the CRISPR system to transactivate coagulation gene promoters in normal and mutated contexts
Publication date: Available online 18 April 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Silvia Pignani, Federico Zappaterra, Elena Barbon, Antonia Follenzi, Matteo Bovolenta, Francesco Bernardi, Alessio Branchini, Mirko PinottiAbstractEngineered transcription factors (TF) have expanded our ability to modulate gene expression and hold great promise as bio-therapeutics. The first-generation TF, based on Zinc Fingers or Transcription-Activator-like Effectors (TALE), required complex and time-consuming assembly protocols, and were indeed replaced in recent years by the CRISPR activati...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - April 20, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: May 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Volume 1862, Issue 5Author(s): (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - April 14, 2019 Category: Genetics & Stem Cells Source Type: research

Zbtb7c is a critical gluconeogenic transcription factor that induces glucose-6-phosphatase and phosphoenylpyruvate carboxykinase 1 genes expression during mice fasting
Publication date: Available online 5 April 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Won-Il Choi, Jae-Hyeon Yoon, Ji-Yang Song, Bu-Nam Jeon, Joo-Man Park, Dong-In Koh, Yong-ho Ahn, Kyung-Sup Kim, In-Kyu Lee, Man-Wook HurAbstractGluconeogenesis is essential for blood glucose homeostasis during fasting and is regulated by various enzymes, which are encoded by gluconeogenic genes. Those genes are controlled by various transcription factors. Zinc finger and BTB domain–containing 7c (Zbtb7c, also called Kr-pok) is a BTB-POZ family transcription factor with proto-oncogenic activity....
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - April 6, 2019 Category: Genetics & Stem Cells Source Type: research

IsomiRs: Expanding the miRNA repression toolbox beyond the seed
This article is part of a Special Issue entitled: ncRNA in control of gene expression edited by Kotb Abdelmohsen. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - April 5, 2019 Category: Genetics & Stem Cells Source Type: research

A non-autonomous role of MKL1 in the activation of hepatic stellate cells
In conclusion, our data suggest that MKL1 contribute to HSC activation in a non-autonomous fashion by promoting CTGF transcription in hepatocytes. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - April 3, 2019 Category: Genetics & Stem Cells Source Type: research

Circular RNAs in myogenesis
This article is part of a Special Issue entitled: ncRNA in control of gene expression edited by Kotb Abdelmohsen. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - April 2, 2019 Category: Genetics & Stem Cells Source Type: research

Inhibition of lysine-specific demethylase LSD1 induces senescence in Glioblastoma cells through a HIF-1α-dependent pathway
Publication date: Available online 2 April 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Carmen D. Saccà, Francesca Gorini, Susanna Ambrosio, Stefano Amente, Deriggio Faicchia, Giuseppe Matarese, Luigi Lania, Barbara MajelloAbstractSenescence is a stress-responsive cellular program that leads to cell cycle arrest. In cancer cells, senescence has profound implications for tumor aggressiveness and clinical outcome, but the molecular events that provoke cancer cells to undergo senescence remain unclear. Herein, we provide evidence that the histone demethylase LSD1/KDM1A supports the g...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - April 2, 2019 Category: Genetics & Stem Cells Source Type: research

The chromatin remodeling protein BRM regulates the transcription of tight junction proteins: Implication in breast cancer metastasis
Publication date: Available online 2 April 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Yuyu Yang, Li Liu, Mingming Fang, Baihui, Yong XuAbstractClaudins are a group of cell tight junction proteins that play versatile roles in cancer biology. Recent studies have correlated down-regulation of Claudins with augmented breast cancer malignancy and poor prognosis. The mechanism underlying repression of Claudin transcription in breast cancer cells is not well understood. Here we report that expression levels of Brahma (BRM) were down-regulated in triple negative breast cancer cells (MDA-...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - April 2, 2019 Category: Genetics & Stem Cells Source Type: research

Adaptor proteins in long noncoding RNA biology
This article is part of a Special Issue entitled: ncRNA in control of gene expression edited by Kotb Abdelmohsen. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - April 2, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: April 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Volume 1862, Issue 4Author(s): (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - March 24, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: March 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Volume 1862, Issue 3Author(s): (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - March 4, 2019 Category: Genetics & Stem Cells Source Type: research

RNA modifications in gene expression control
Publication date: March 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Volume 1862, Issue 3Author(s): Matthias Soller, Rupert Fray (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - March 4, 2019 Category: Genetics & Stem Cells Source Type: research

Dose dependent gene expression is dynamically modulated by the history, physiology and age of yeast cells
Publication date: Available online 2 March 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Amparo Pascual-Ahuir, Eva González-Cantó, Pauline Juyoux, Julia Pable, Daniel Poveda-Huertes, Sandra Saiz-Balbastre, Sonia Squeo, Alvaro Ureña-Marco, Elena Vanacloig-Pedros, Laura Zaragoza-Infante, Markus ProftAbstractCells respond to external stimuli with transient gene expression changes in order to adapt to environmental alterations. However, the dose response profile of gene induction upon a given stress depends on many intrinsic and extrinsic factors. Here we show that the accurate quant...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - March 4, 2019 Category: Genetics & Stem Cells Source Type: research

Leukocyte integrin signaling regulates FOXP1 gene expression via FOXP1-IT1 long non-coding RNA-mediated IRAK1 pathway
Publication date: Available online 2 March 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Can Shi, Jessica Miley, Alison Nottingham, Toshifumi Morooka, Domenick A. Prosdocimo, Daniel I. SimonAbstractLeukocyte integrin-dependent downregulation of the transcription factor FOXP1 is required for monocyte differentiation and macrophage functions, but the precise gene regulatory mechanism is unknown. Here, we identify multi-promoter structure (P1, P2, and P3) of the human FOXP1 gene. Clustering of the β2-leukocyte integrin Mac-1 downregulated transcription from these promoters. We extend ...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - March 4, 2019 Category: Genetics & Stem Cells Source Type: research

Dicer1 is required for pigment cell and craniofacial development in zebrafish
Publication date: Available online 3 March 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Andrea M.J. Weiner, Nadia L. Scampoli, Tomás J. Steeman, Christopher M. Dooley, Elisabeth M. Busch-Nentwich, Robert N. Kelsh, Nora B. CalcaterraAbstractThe multidomain RNase III endoribonuclease DICER is required for the generation of most functional microRNAs (miRNAs). Loss of Dicer affects developmental processes at different levels. Here, we characterized the zebrafish Dicer1 mutant, dicer1sa9205, which has a single point mutation induced by N-ethyl-N-nitrosourea mutagenesis. Heterozygous di...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - March 4, 2019 Category: Genetics & Stem Cells Source Type: research