Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Transcriptionally elevation of miR-494 by new ChlA-F compound via a HuR/JunB axis inhibits human bladder cancer cell invasion
We reported here that ChlA-F treatment significantly induced miR-494 expression and suppressed cell invasion in human MIBC cells. Our results indicated that miR-494 was downregulated in M1 metastatic BC patients in comparison to non-metastatic (M0) BC patients, and such downregulation was also well correlated with over survival rate for MIBC patients. Mechanistically, ChlA-F-induced upregulation of miR-494 was due to a HuR-mediated increase in JunB mRNA stabilization and protein expression, which led to an increase in miR-494 transcription via directly binding to the miR-494 promoter region, while the upregulated miR-494 w...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - June 3, 2019 Category: Genetics & Stem Cells Source Type: research

The chromatin remodeling protein BRG1 links ELOVL3 trans-activation to prostate cancer metastasis
We report that in response to pro-metastatic cues (androgen and TGF-β) BRG1 expression was up-regulated along with Elvol3 in prostate cancer cells. BRG1 over-expression potentiated whereas BRG1 knockdown attenuated prostate cancer cell migration and invasion. Coincidently, Elovl3 was up-regulated following BRG1 over-expression and down-regulated after BRG1 knockdown in prostate cancer cells. Further analysis revealed that BRG1 interacted with and was recruited by retinoic acid receptor-related orphan receptor (RORγ) to the Elovl3 promoter to activate transcription. Chromatin immunoprecipitation (ChIP) profiling demonstra...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - May 31, 2019 Category: Genetics & Stem Cells Source Type: research

Alternative splicing in lung cancer
This article is part of a Special Issue entitled: RNA structure and splicing regulation edited by Francisco Baralle, Ravindra Singh and Stefan Stamm. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - May 31, 2019 Category: Genetics & Stem Cells Source Type: research

Gene expression in bacterial development by Patrick Viollier
Publication date: Available online 29 May 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - May 29, 2019 Category: Genetics & Stem Cells Source Type: research

Towards a deeper annotation of human lncRNAs
This article is part of a Special Issue entitled: ncRNA in control of gene expression edited by Kotb Abdelmohsen. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - May 23, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: June 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Volume 1862, Issue 6Author(s): (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - May 20, 2019 Category: Genetics & Stem Cells Source Type: research

Circular exonic RNAs: when RNA structure meets topology
Publication date: Available online 15 May 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Dmitri D. PervouchineAbstractAlthough RNA circularization was first documented in the 1990s, the extent to which it occurs was not known until recent advances in high-throughput sequencing enabled the widespread identification of circular RNAs (circRNAs). Despite this, many aspects of circRNA biogenesis, structure, and function yet remain obscure. This review focuses on circular exonic RNAs, a subclass of circRNAs that are generated through backsplicing. Here, I hypothesize that RNA secondary str...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - May 15, 2019 Category: Genetics & Stem Cells Source Type: research

DISC1 promotes translation maintenance during sodium arsenite-induced oxidative stress
Publication date: Available online 7 May 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Francisco Fuentes-Villalobos, Carlos Farkas P., Sebastian Riquelme-Barrios, M.E. Armijo, Ricardo Soto-Rifo, Roxana Pincheira, Ariel F. CastroAbstractVariation in Disrupted-in-Schizophrenia 1 (DISC1) increases the risk for neurodegenerative diseases, schizophrenia, and other mental disorders. However, the functions of DISC1 associated with the development of these diseases remain unclear. DISC1 has been reported to inhibit Akt/mTORC1 signaling, a major regulator of translation, and recent studies i...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - May 8, 2019 Category: Genetics & Stem Cells Source Type: research

PTBP1 enhances exon11a skipping in Mena pre-mRNA to promote migration and invasion in lung carcinoma cells
Publication date: Available online 7 May 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Shuaiguang Li, Lianghua Shen, Luyuan Huang, Sijia Lei, Xingdong Cai, Mason Breitzig, Bin Zhang, Annan Yang, Wenzuo Ji, Meiyan Huang, Qing Zheng, Hanxiao Sun, Feng WangAbstractAlternative splicing (AS) events occur in the majority of human genes. AS in a single gene can give rise to different functions among multiple isoforms. Human ortholog of mammalian enabled (Mena) is a conserved regulator of actin dynamics that plays an important role in metastasis. Mena has been shown to have multiple splice ...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - May 7, 2019 Category: Genetics & Stem Cells Source Type: research

HSF1 phosphorylation by cyclosporin A confers hyperthermia sensitivity through suppression of HSP expression
Publication date: Available online 3 May 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Jingyu Shao, Beibei Han, Pengxiu Cao, Bingwei Zhang, Ming Liu, Danyu Li, Nan Zhou, Qiang Hao, Xianglin Duan, Yanzhong Chang, Akira Nakai, Yumei Fan, Ke TanAbstractHeat shock leads to the activation of heat shock factor 1 (HSF1) and up-regulation of a number of heat shock proteins (HSPs). Cyclosporin A (CsA) is an immunosuppressant that has revolutionized organ transplantation in clinical medicine. However, the roles and regulatory mechanisms of CsA on the HSP expression remain largely unknown. Her...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - May 3, 2019 Category: Genetics & Stem Cells Source Type: research

Computational approaches for the discovery of splicing regulatory RNA structures
Publication date: Available online 29 April 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Ryan J. Andrews, Walter N. MossAbstractGlobal RNA structure and local functional motifs mediate interactions important in determining the rates and patterns of mRNA splicing. In this review, we overview approaches for the computational prediction of RNA secondary structure with a special emphasis on the discovery of motifs important to RNA splicing. The process of identifying and modeling potential splicing regulatory structures is illustrated using a recently-developed approach for RNA structu...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - April 30, 2019 Category: Genetics & Stem Cells Source Type: research

Non-coding RNAs as potential therapeutic targets in breast cancer
Publication date: Available online 29 April 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Deepti Tomar, Amit S. Yadav, Dhiraj Kumar, Garima Bhadauriya, Gopal C. KunduAbstractParadigm shifting studies especially involving non-coding RNAs (ncRNAs) during last few decades have significantly changed the scientific perspectives regarding the complexity of cellular signalling pathways. Several studies have shown that the non-coding RNAs, initially ignored as transcriptional noise or products of erroneous transcription; actually regulate plethora of biological phenomena ranging from develo...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - April 30, 2019 Category: Genetics & Stem Cells Source Type: research

A novel role of U1 snRNP: Splice site selection from a distance
Publication date: Available online 28 April 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Ravindra N. Singh, Natalia N. SinghAbstractRemoval of introns by pre-mRNA splicing is fundamental to gene function in eukaryotes. However, understanding the mechanism by which exon-intron boundaries are defined remains a challenging endeavor. Published reports support that the recruitment of U1 snRNP at the 5′ss marked by GU dinucleotides defines the 5′ss as well as facilitates 3′ss recognition through cross-exon interactions. However, exceptions to this rule exist as U1 snRNP recruited a...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - April 29, 2019 Category: Genetics & Stem Cells Source Type: research

Role of RNA secondary structures in regulating Dscam alternative splicing
Publication date: Available online 29 April 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Bingbing Xu, Yang Shi, Yandan Wu, Yijun Meng, Yongfeng JinAbstractAlternative splicing of mRNA precursors is a versatile mechanism of expanding proteomic diversity. The most striking example of this is the Drosophila melanogaster Down syndrome cell adhesion molecule (Dscam1) gene, which potentially encodes 38,016 distinct isoforms by mutually exclusive splicing. The genomic organization of Dscam1 is largely conserved across the pancrustaceans, although the number of splice isoforms varies from ...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - April 29, 2019 Category: Genetics & Stem Cells Source Type: research

Enhancer long-range contacts: The multi-adaptor protein LDB1 is the tie that binds
Publication date: Available online 22 April 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Guoyou Liu, Ann DeanAbstractThe eukaryotic genome is organized at varying levels into chromosome territories, transcriptional compartments and topologically associating domains (TADs), which are architectural features largely shared between different cell types and across species. In contrast, within TADs, chromatin loops connect enhancers and their target genes to establish unique transcriptomes that distinguish cells and tissues from each other and underlie development and differentiation. Ho...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - April 23, 2019 Category: Genetics & Stem Cells Source Type: research