Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Repeat-associated RNA structure and aberrant splicing
This article is part of a Special Issue entitled: RNA structure and splicing regulation edited by Francisco Baralle, Ravindra Singh and Stefan Stamm. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - July 17, 2019 Category: Genetics & Stem Cells Source Type: research

Small non-coding RNA within the endogenous spliceosome and alternative splicing regulation
This article is part of a Special Issue entitled: RNA structure and splicing regulation edited by Francisco Baralle, Ravindra Singh and Stefan Stamm. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - July 17, 2019 Category: Genetics & Stem Cells Source Type: research

MyoD-induced circular RNA CDR1as promotes myogenic differentiation of skeletal muscle satellite cells
Publication date: Available online 16 July 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Li Li, Yuan Chen, Lu Nie, Xue Ding, Xiao Zhang, Wei Zhao, Xiaoli Xu, Bismark Kyei, Dinghui Dai, Siyuan Zhan, Jiazhong Guo, Tao Zhong, Linjie Wang, Hongping ZhangAbstractMany protein coding and non-coding genes interplay in governing skeletal muscle formation. Nevertheless, comparing with the linear transcripts, functions of covalently closed circular RNAs (circRNAs), the new frontier of regulatory non-coding RNA (ncRNAs) molecules, remain largely unknown. Here, we identify CDR1as (antisense to t...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - July 17, 2019 Category: Genetics & Stem Cells Source Type: research

How RNA structure dictates the usage of a critical exon of spinal muscular atrophy gene
This article is part of a Special Issue entitled: RNA structure and splicing regulation edited by Francisco Baralle, Ravindra Singh and Stefan Stamm. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - July 16, 2019 Category: Genetics & Stem Cells Source Type: research

Temperature-dependent regulation of the Escherichia coli lpxT gene
Publication date: Available online 9 July 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Barbara Sciandrone, Francesca Forti, Sara Perego, Federica Falchi, Federica BrianiAbstractThe Lipid A moiety of the lipopolysaccharide can be covalently modified during its transport to the outer membrane by different enzymes, among which the LpxT inner membrane protein. LpxT transfers a phosphate group from the undecaprenyl pyrophosphate to the Lipid A, a modification affecting the stability of the outer membrane and its recognition by the host immune system in Enterobacteria. We previously foun...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - July 10, 2019 Category: Genetics & Stem Cells Source Type: research

m6A methylation modulates adipogenesis through JAK2-STAT3-C/EBPβ signaling
Publication date: Available online 8 July 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Ruifan Wu, Guanqun Guo, Zhen Bi, Youhua Liu, Yuanling Zhao, Nana Chen, Fengqin Wang, Yizhen Wang, Xinxia WangAbstractN6-methyladenosine (m6A), the most abundant internal mRNA modification in eukaryotes, plays a vital role in regulating adipogenesis. However, its underlying mechanism remains largely unknown. Here, we reveal that deletion of m6A demethylase FTO in porcine and mouse preadipocytes inhibits adipogenesis through JAK2-STAT3-C/EBPβ signaling. Mechanistically, FTO deficiency suppresses J...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - July 8, 2019 Category: Genetics & Stem Cells Source Type: research

Combinatorial regulation of alternative splicing
This article is part of a Special Issue entitled: RNA structure and splicing regulation edited by Francisco Baralle, Ravindra Singh and Stefan Stamm. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - July 3, 2019 Category: Genetics & Stem Cells Source Type: research

Maternally expressed gene 3 in metabolic programming
This article is part of a Special Issue entitled: ncRNA in control of gene expression edited by Kotb Abdelmohsen. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - July 2, 2019 Category: Genetics & Stem Cells Source Type: research

More than a messenger: Alternative splicing as a therapeutic target
This article is part of a Special Issue entitled: RNA structure and splicing regulation edited by Francisco Baralle, Ravindra Singh and Stefan Stamm. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - July 2, 2019 Category: Genetics & Stem Cells Source Type: research

Hypoxia-induced RelA/p65 derepresses SLC16A3 (MCT4) by downregulating ZBTB7A
Publication date: Available online 1 July 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Seo-Hyun Choi, Min-Young Kim, Young-So Yoon, Dong-In Koh, Min-Kyeong Kim, Su-Yeon Cho, Kyung-Sup Kim, Man-Wook HurAbstractOverexpressed Solute Carrier Family 16 Member 3 (SLC16A3, also called MCT4) plays a critical role in hypoxic cancer cell growth and proliferation, by expelling glycolysis-derived lactate across the plasma membrane. However, how SLC16A3 expression is regulated, under hypoxic conditions, is poorly understood. FBI-1, encoded by ZBTB7A, is a proto-oncoprotein. Interestingly, under...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - July 1, 2019 Category: Genetics & Stem Cells Source Type: research

RNA binding proteins: Diversity from microsurgeons to cowboys
This article is part of a Special Issue entitled: RNA structure and splicing regulation edited by Francisco Baralle, Ravindra Singh and Stefan Stamm. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - July 1, 2019 Category: Genetics & Stem Cells Source Type: research

KSRP modulates melanoma growth and efficacy of vemurafenib
Publication date: Available online 30 June 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory MechanismsAuthor(s): Wenwen Liu, Chu-Fang Chou, Shanrun Liu, David Crossman, Nabiha Yusuf, Yunkun Wu, Ching-Yi ChenAbstractThe majority of melanomas carry an oncogenic BRAF mutation (BRAFV600E), which results in constitutive kinase activity driving melanoma proliferation. While inhibitors of BRAFV600E (BRAFi) effectively lead to rapid tumor shrinkage, most patients treated with BRAFi develop acquired resistance. Identification of factors as regulators of melanoma growth and as potential sources of resistance is thus...
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - July 1, 2019 Category: Genetics & Stem Cells Source Type: research

Context matters: Regulation of splice donor usage
This article is part of a Special Issue entitled: RNA structure and splicing regulation edited by Francisco Baralle, Ravindra Singh and Stefan Stamm. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - June 14, 2019 Category: Genetics & Stem Cells Source Type: research

Editorial Board
Publication date: July 2019Source: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, Volume 1862, Issue 7Author(s): (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - June 14, 2019 Category: Genetics & Stem Cells Source Type: research

The mechanism of splicing as told by group II introns: Ancestors of the spliceosome
This article is part of a Special Issue entitled: RNA structure and splicing regulation edited by Francisco Baralle, Ravindra Singh and Stefan Stamm. (Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms)
Source: Biochimica et Biophysica Acta (BBA) Gene Regulatory Mechanisms - June 13, 2019 Category: Genetics & Stem Cells Source Type: research