Biochemical and Biophysical Research communications This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Baicalein alleviates intrahepatic cholestasis by regulating bile acid metabolism via an FXR-dependent manner
Biochem Biophys Res Commun. 2024 Feb 17;705:149670. doi: 10.1016/j.bbrc.2024.149670. Online ahead of print.ABSTRACTCholestasis is characterized by impaired bile secretion and flow, leading to the accumulation of toxic bile acids in the liver, further causing inflammatory reaction, fibrosis, and ultimately liver transplantation. Although first-line clinical agents such as Ursodeoxycholic acid (UDCA) and Obeticholic acid (OCA) are available, serious side effects still exist. Therefore, pharmacologic treatment of cholestatic liver disease remains challenging. Here, we used a murine model of cholestasis treated with or without...
Source: Biochemical and Biophysical Research communications - March 5, 2024 Category: Biochemistry Authors: Weifan Huang Yihan Qian Jiacheng Lin Fang Wang Xiaoni Kong Weifeng Tan Source Type: research

Neutrophil extracellular traps inhibit osteoclastogenesis
Biochem Biophys Res Commun. 2024 Feb 29;705:149743. doi: 10.1016/j.bbrc.2024.149743. Online ahead of print.ABSTRACTNeutrophil extracellular traps (NETs) released by neutrophils upon inflammation or infection, act as an innate immune defense against pathogens. NETs also influence inflammatory responses and cell differentiation in host cells. Osteoclasts, which are derived from myeloid stem cells, are critical for the bone remodeling by destroying bone. In the present study, we explores the impact of NETs, induced by the inflammatory agent calcium ionophore A23187, on the differentiation and activation of osteoclasts, potent...
Source: Biochemical and Biophysical Research communications - March 5, 2024 Category: Biochemistry Authors: Kento Numazaki Hiroyuki Tada Takashi Nishioka Eiji Nemoto Kenji Matsushita Itaru Mizoguchi Shunji Sugawara Source Type: research

Mechanisms of chondrocyte regulated cell death in osteoarthritis: Focus on ROS-triggered ferroptosis, parthanatos, and oxeiptosis
Biochem Biophys Res Commun. 2024 Feb 28;705:149733. doi: 10.1016/j.bbrc.2024.149733. Online ahead of print.ABSTRACTOsteoarthritis (OA) is a common chronic inflammatory degenerative disease. Since chondrocytes are the only type of cells in cartilage, their survival is critical for maintaining cartilage morphology. This review offers a comprehensive analysis of how reactive oxygen species (ROS), including superoxide anions, hydrogen peroxide, hydroxyl radicals, nitric oxide, and their derivatives, affect cartilage homeostasis and trigger several novel modes of regulated cell death, including ferroptosis, parthanatos, and oxe...
Source: Biochemical and Biophysical Research communications - March 5, 2024 Category: Biochemistry Authors: Fangyang Fan Cheng Yang Enran Piao Jia Shi Juntao Zhang Source Type: research

The anti-apoptotic role of Ginkgolide B via mitochondrial permeability transition pore inhibition in retinal ischemia-reperfusion
Biochem Biophys Res Commun. 2024 Mar 1;705:149722. doi: 10.1016/j.bbrc.2024.149722. Online ahead of print.ABSTRACTThis research delves into the effectiveness of Ginkgolide B (GB), a compound from Ginkgo biloba, in combating cell death caused by glaucoma, with a focus on mitochondrial impairment and the mitochondrial permeability transition pore (mPTP). Utilizing models of high intraocular pressure and in vitro glaucoma simulations, the study investigates GB's impact on retinal progenitor cells (RPCs) under oxygen-glucose deprivation/reperfusion (OGD/R) and in a rat glaucoma model. The study methodologies included apoptosis...
Source: Biochemical and Biophysical Research communications - March 5, 2024 Category: Biochemistry Authors: Xiou Wang Baoqi Hu Hanyue Zhang Sijia Zhou Wenfei Wu Zizhu Tan Meiqi Sun Qianyan Kang Source Type: research

Reexamining the diverse functions of arginine in biochemistry
Biochem Biophys Res Commun. 2024 Feb 27;705:149731. doi: 10.1016/j.bbrc.2024.149731. Online ahead of print.ABSTRACTArginine in a free-state and as part of peptides and proteins shows distinct tendency to form clusters. In free-form, it has been found useful in cryoprotection, as a drug excipient for both solid and liquid formulations, as an aggregation suppressor, and an eluent in protein chromatography. In many cases, the mechanisms by which arginine acts in all these applications is either debatable or at least continues to attract interest. It is quite possible that arginine clusters may be involved in many such applica...
Source: Biochemical and Biophysical Research communications - March 3, 2024 Category: Biochemistry Authors: Munishwar Nath Gupta Vladimir N Uversky Source Type: research

Metabolomics and miRNA profiling reveals feature of gallbladder cancer-derived biliary extracellular vesicles
CONCLUSIONS: Our findings demonstrate that the contents of exosomes are disease-specific, particularly in gallbladder cancer, and that altered metabolites convey critical information regarding their phenotype. We believe that our metabolomic and miRNA profiling results may provide important insights into the development of gallbladder cancer.PMID:38432111 | DOI:10.1016/j.bbrc.2024.149724 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - March 3, 2024 Category: Biochemistry Authors: Mingyu Kong Da Hee Hong Sanjita Paudel Na Eun Yoon Byung Hwa Jung Myounghoi Kim Tae Hun Kim Jaemin Jeong Dongho Choi Hyunbeom Lee Source Type: research

Glioma induces atypical depression-like behaviors in mice through the 5-HT and glutamatergic synapse pathways
Biochem Biophys Res Commun. 2024 Feb 22;704:149706. doi: 10.1016/j.bbrc.2024.149706. Online ahead of print.ABSTRACTGlioma patients often undertake psychiatric disorders such as depression and anxiety. There are several clinical epidemiological studies on glioma-associated depression, but basic research and corresponding animal experiments are still lacking. Here, we observed that glioma-bearing mice exhibited atypical depression-like behaviors in orthotopic glioma mouse models. The concentrations of monoamine neurotransmitters were detected by enzyme-linked immunosorbent assay (ELISA), revealing a decrease in 5-hydroxytryp...
Source: Biochemical and Biophysical Research communications - March 3, 2024 Category: Biochemistry Authors: Boyang Li Kunnian Ran Zefan Jing Wei Han Xiaozhong Peng Source Type: research

Miro-mediated mitochondrial transport: A new dimension for disease-related abnormal cell metabolism?
Biochem Biophys Res Commun. 2024 Feb 27;705:149737. doi: 10.1016/j.bbrc.2024.149737. Online ahead of print.ABSTRACTMitochondria are versatile and highly dynamic organelles found in eukaryotic cells that play important roles in a variety of cellular processes. The importance of mitochondrial transport in cell metabolism, including variations in mitochondrial distribution within cells and intercellular transfer, has grown in recent years. Several studies have demonstrated that abnormal mitochondrial transport represents an early pathogenic alteration in a variety of illnesses, emphasizing its significance in disease developm...
Source: Biochemical and Biophysical Research communications - March 2, 2024 Category: Biochemistry Authors: Yanxing Li Zhen Yang Shumei Zhang Jianjun Li Source Type: research

CD38 deficient mice are not protected from atherosclerosis
In conclusion, our data suggest that CD38-/- mice are neither protected against nor prone to atherosclerosis compared to WT mice.PMID:38430607 | DOI:10.1016/j.bbrc.2024.149734 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - March 2, 2024 Category: Biochemistry Authors: Xiang Yi Kong Knut H Lauritzen Tuva B ørresdatter Dahl Sverre Holm Maria Belland Olsen Mona Skjelland Christopher Nielsen Annika E Michelsen Thor Ueland P ål Aukrust Bente Halvorsen Øystein Sandanger Source Type: research