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Maternal hypertensive condition alters adipose tissue function and blood pressure sensitivity in offspring
This study aimed to how maternal hypertension affects male offspring growth, focusing on lipid metabolism and blood pressure in mice. Female mice were infused with angiotensin II (Ang II) on gestational day 12. Dysregulation and accumulation of lipid were observed in the placenta of Ang II-induced maternal hypertensive dams, associating with fetal growth restriction. Ang II-offspring showed lower birth weight than in the control-offspring. Isolated and differentiated adipocyte from neonatal mice of Ang II-dams showed higher Pparγ mRNA expression compared with the control group. Lower body weight tendency had continued in ...
Source: Biochemical and Biophysical Research communications - March 23, 2024 Category: Biochemistry Authors: Ren Ozawa Hisataka Iwata Takehito Kuwayama Koumei Shirasuna Source Type: research

METTL16 deficiency attenuates apoptosis through translational control of extrinsic death receptor during nutrient deprivation
Biochem Biophys Res Commun. 2024 Mar 19;708:149802. doi: 10.1016/j.bbrc.2024.149802. Online ahead of print.ABSTRACTMETTL16 is a well-characterized m6A methyltransferase that has been reported to contribute to tumorigenesis in various types of cancer. However, the effect of METTL16 on tumor progression under restricted nutrient conditions, which commonly occur in tumor microenvironment, has yet to be elucidated. Herein, our study initially reported the inhibitory effect of METTL16 depletion on apoptosis under amino acid starvation conditions. Mechanistically, we determined that the METTL16 knockdown represses the expression...
Source: Biochemical and Biophysical Research communications - March 23, 2024 Category: Biochemistry Authors: Qiujie Li Lu Yang Chenxin Zhang Jingying Yuan Jun Zhang Wenjun Tao Jun Zhou Source Type: research

Combined SET7/9 and CDK4 inhibition act synergistically against osteosarcoma
Biochem Biophys Res Commun. 2024 Mar 20;708:149808. doi: 10.1016/j.bbrc.2024.149808. Online ahead of print.ABSTRACTOsteosarcoma is the most common malignant bone tumor. It has a poor prognosis because of a lack of therapeutic targets and strategies. The SET domain-containing lysine-specific methyltransferase, SET7/9, has various functions in different cancer types in tissue-type and signaling context-dependent manners. The role of SET7/9 in osteosarcoma cells is currently controversial and its potential as a therapeutic candidate in osteosarcoma is unknown. In the present study, SET7/9 inhibition or ablation suppressed ost...
Source: Biochemical and Biophysical Research communications - March 23, 2024 Category: Biochemistry Authors: Yingxu Shi Zhonghao Wang Yiming Shao Qianqian Guang Jian Zhang Baorui Liu Chunshen Wu Yexin Wang Ping Sui Source Type: research

Novel air-liquid interface culture model to investigate stiffness-dependent behaviors of alveolar epithelial cells
Biochem Biophys Res Commun. 2024 Mar 15;708:149791. doi: 10.1016/j.bbrc.2024.149791. Online ahead of print.ABSTRACTPulmonary alveoli are functional units in gas exchange in the lung, and their dysfunctions in lung diseases such as interstitial pneumonia are accompanied by fibrotic changes in structure, elevating the stiffness of extracellular matrix components. The present study aimed to test the hypothesis that such changes in alveoli stiffness induce functional alteration of epithelial cell functions, exacerbating lung diseases. For this, we have developed a novel method of culturing alveolar epithelial cells on polyacry...
Source: Biochemical and Biophysical Research communications - March 22, 2024 Category: Biochemistry Authors: Yuto Takahashi Satoru Ito Jungfeng Wang Jeonghyun Kim Takeo Matsumoto Eijiro Maeda Source Type: research

The anti-atherosclerotic effect of Paeonol against the lipid accumulation in macrophage-derived foam cells by inhibiting ferroptosis via the SIRT1/NRF2/GPX4 signaling pathway
Biochem Biophys Res Commun. 2024 Mar 14;708:149788. doi: 10.1016/j.bbrc.2024.149788. Online ahead of print.ABSTRACTAtherosclerosis (AS) is the underlying cause of many severe vascular diseases and is primarily characterized by abnormal lipid metabolism. Paeonol (Pae), a bioactive compound derived from Paeonia Suffruticosa Andr., is recognized for its significant role in reducing lipid accumulation. Our research objective is to explore the link between lipid buildup in foam cells originating from macrophages and the process of ferroptosis, and explore the effect and mechanism of Pae on inhibiting AS by regulating ferroptosi...
Source: Biochemical and Biophysical Research communications - March 22, 2024 Category: Biochemistry Authors: Menglong Gao Lishun Dong Yulong Yang Jinjin Yan Yuning Liang Xiaolin Ma Min Zhou Hongfei Wu Yarong Liu Min Dai Source Type: research

NRF2 regulates EGF stability through OTUD4 in lung adenocarcinoma
Biochem Biophys Res Commun. 2024 Mar 16;708:149798. doi: 10.1016/j.bbrc.2024.149798. Online ahead of print.ABSTRACTNRF2 (NFE2L2) is a transcription factor mainly for regulating cellular antioxidant response and therefore promotes tumor progression. The target genes of NRF2 also play important roles in cellular processes including glucose metabolism, de novo serine synthesis, iron metabolism, etc. Here, by modulating NRF2 expression in lung adenocarcinoma (LUAD) cells, we showed that NRF2 regulated EGF expression at protein level. Furthermore, EGF was identified as a ubiquitinated protein. We predicted three deubiquitinases...
Source: Biochemical and Biophysical Research communications - March 22, 2024 Category: Biochemistry Authors: Shuming Hu Yuan Yuan Ruihan Yan Huikang Xie Rong Cai Jiaqian Xu Source Type: research

Exploring the impact of high-altitude de-acclimatization on renal function: The roles of oxidative and endoplasmic reticulum stress in rat models
CONCLUSION: This study elucidates the pivotal roles of oxidative and endoplasmic reticulum stress in the early-stage renal injury in rats undergoing HADA. Early intervention with the Vit C and TUDCA significantly mitigates renal damage caused by HADA. These findings provide insights into the pathophysiological mechanisms of HADA and suggest potential therapeutic strategies for its future management.PMID:38518722 | DOI:10.1016/j.bbrc.2024.149770 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - March 22, 2024 Category: Biochemistry Authors: Dong-Xin Huang Xia Kang Li-Juan Jiang Dan-Ling Zhu Lin Yang Jing-Ya Luo Meng-Meng Yang Wei Li Guo-Ping Wang Yi Wen Zhu Huang Li-Jun Tang Source Type: research

Exploring the potential of structural modeling and molecular docking for efficient siRNA screening: A promising approach to Combat viral mutants, with a focus on HIV-1
In this study, we present a fully optimized siRNA screening system considering all necessary parameters. Notably, we highlight the critical role of molecular docking simulations between siRNA and two functional domains of the Argonaute protein (PAZ and PIWI) in identifying the most efficient siRNAs, since the appropriate interaction between the guide siRNA strand and the RISC complex is crucial. Through our stringent method, we designed approximately 50 potential siRNAs targeting the HIV-1 vpr gene. Evaluation through XTT, qRT-PCR, and flow cytometry analysis on RAW 264.7 macrophage stable cells revealed negligible cytotox...
Source: Biochemical and Biophysical Research communications - March 22, 2024 Category: Biochemistry Authors: Mohammad Nematian Zahra Noormohammadi Pooneh Rahimi Shiva Irani Ehsan Arefian Source Type: research

Rbm46 inhibits reactive oxygen species in mouse embryonic stem cells through modulating BNIP3-mediated mitophagy
In this study, we reveal the pivotal role of RNA-binding motif protein 46 (RBM46) in ESCs, acting as a direct post transcriptional regulator of ROS levels by modulating BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (Bnip3) mRNA expression. Rbm46 knockout lead to diminished mitochondrial autophagy, culminating in elevated ROS within ESCs, disrupting the delicate balance required for healthy self-renewal. These findings provide insights into a novel mechanism governing ROS regulation in ESCs.PMID:38518724 | DOI:10.1016/j.bbrc.2024.149779 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - March 22, 2024 Category: Biochemistry Authors: Jinchen Zhong Jing Xu Xiaoyang Chen Na Li Sha Li Zhiwen Deng Huimin Feng Xiaohan Ling Chenchen Wang Zhi Zhou Lingsong Li Source Type: research

Differences in glucose homeostasis and islet injury among diverse mice strains post acute pancreatitis
Biochem Biophys Res Commun. 2024 Mar 16;708:149780. doi: 10.1016/j.bbrc.2024.149780. Online ahead of print.ABSTRACTDiverse animal models have been used to study postpancreatitis diabetes mellitus (PPDM) development; however, no study has yet conducted a comparative analysis of the specific differences in glucose homeostasis and islet injury between these models. Therefore, we investigated the differences in pancreatic islet injury and glucose homeostasis among diverse strains in a cerulein-induced acute pancreatitis (AP) model to determine the appropriate animal model for PPDM. BALB/cJ, C57BL/6J, C57BL/6 N, and FVB/NJ mice...
Source: Biochemical and Biophysical Research communications - March 22, 2024 Category: Biochemistry Authors: Deren Du Xinwu Wang Han Zuo Lianglan Li Haibin Hao Gaohuan Hou Ping Gu Jiaqing Shao Zhihui Tong Source Type: research

ID3 is a novel target gene of p53 and modulates lung cancer cell metastasis
Biochem Biophys Res Commun. 2024 Mar 16;708:149789. doi: 10.1016/j.bbrc.2024.149789. Online ahead of print.ABSTRACTThe tumor suppressor p53 prevents cancer development by regulating dozens of target genes with diverse biological functions. Although numerous p53 target genes have been identified to date, the dynamics and function of the regulatory network centered on p53 have not yet been fully elucidated. We herein identified inhibitor of DNA-binding/differentiation-3 (ID3) as a direct p53 target gene. p53 bound the distal promoter of ID3 and positively regulated its transcription. ID3 expression was significantly decrease...
Source: Biochemical and Biophysical Research communications - March 21, 2024 Category: Biochemistry Authors: Mai Nagasaka Chiharu Miyajima Yasumichi Inoue Sakura Hashiguchi Yuya Suzuki Daisuke Morishita Hiromasa Aoki Kohki Toriuchi Ryohei Katayama Mineyoshi Aoyama Hidetoshi Hayashi Source Type: research

Revealing metabolic and biochemical variations via < sup > 1 < /sup > H NMR metabolomics in streptozotocin-nicotinamide-induced diabetic rats treated with metformin
In conclusion, our results identify the best STZ-NA dosage ratio for a rat model to exhibit lean type 2 diabetic features with optimum sensitivity to metformin treatment. The data presented here could be informative to improve our understanding of non-obese diabetes in humans through the identification of possible activated metabolic pathways in the STZ-NA-induced diabetic rats model.PMID:38507867 | DOI:10.1016/j.bbrc.2024.149778 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - March 20, 2024 Category: Biochemistry Authors: Nur Khaleeda Zulaikha Zolkeflee Pei Lou Wong M Maulidiani Nurul Shazini Ramli Azrina Azlan Ahmed Mediani Chau Ling Tham Faridah Abas Source Type: research

The impact of the P2X7 receptor on the tumor immune microenvironment and its effects on tumor progression
This article provides an overview of the structure, function, and pharmacological characteristics of P2X7R. We described the concept and components of tumor immune microenvironment and the influence immune components has on tumors. We also outlined the impact of P2X7R regulation and how it affects the development of tumors and summarized the effects of drugs targeting P2X7R on tumor progression, both past and current, assisting researchers in treating tumors using P2X7R as a target.PMID:38508051 | DOI:10.1016/j.bbrc.2024.149513 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - March 20, 2024 Category: Biochemistry Authors: Yu-Ting Zou Jin-Yuan Li Jun-Yi Chai Yu-Shan Hu Wen-Jun Zhang Qiao Zhang Source Type: research