Biochemical and Biophysical Research communications This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Endothelial CLEC-1b plays a protective role against cancer hematogenous metastasis
Biochem Biophys Res Commun. 2024 Mar 22;708:149819. doi: 10.1016/j.bbrc.2024.149819. Online ahead of print.ABSTRACTMetastasis, which is the spread of cancer cells into distant organs, is a critical determinant of prognosis in patients with cancer, and blood vessels are the major route for cancer cells to spread systemically. Extravasation is a critical process for the hematogenous metastasis; however, its underlying molecular mechanisms remain poorly understood. Here, we identified that senescent ECs highly express C-type lectin domain family 1 member B (CLEC-1b), and that endothelial CLEC-1b inhibits the hematogenous meta...
Source: Biochemical and Biophysical Research communications - March 26, 2024 Category: Biochemistry Authors: Ekura Yamazaki Koji Ikeda Ryota Urata Daisuke Ueno Akiko Katayama Fumiaki Ito Hiroshi Ikegaya Satoaki Matoba Source Type: research

Spexin acts as a novel glucose-lowering factor in grass carp (Ctenopharyngodon idella)
Biochem Biophys Res Commun. 2024 Mar 20;708:149810. doi: 10.1016/j.bbrc.2024.149810. Online ahead of print.ABSTRACTAt present, the physiological roles of various hormones in fish glucose metabolism have been elucidated. Spexin, a 14-amino acids polypeptide, is highly conserved in many species and has functions such as reducing body weight and improving insulin resistance. In this paper, the open reading frame (ORF) of spx21 in grass carp (Ctenopharyngodon idella) was cloned, and the tissue distribution of spx1 and spx2, their direct and indirect regulatory effects on glucose metabolism of grass carp were investigated. The ...
Source: Biochemical and Biophysical Research communications - March 26, 2024 Category: Biochemistry Authors: Yingxin Zhang Junli Wang Liping Yang Xiao Yan Chaobin Qin Guoxing Nie Source Type: research

Feedback activation of CD73-Adenosine axis attenuates the antitumor immunity of STING pathway
In this study, we demonstrated that STING activation enhanced the expression of CD73 and the subsequent production of adenosine in immune cells and cancer cells. Mechanistically, the feedback activation of CD73 depended on the type I IFN/IFNAR axis induced by STING activation. Furthermore, the combination of STING agonist and anti-CD73 mAb markedly blocked tumor growth in vivo by promoting the infiltration of CD8+ T cells and reducing the accumulation of Foxp3+ regulatory T cells (Tregs) in the tumor microenvironment. Our work provides a rationale for the combination of STING agonists and CD73 inhibitors in cancer immunoth...
Source: Biochemical and Biophysical Research communications - March 26, 2024 Category: Biochemistry Authors: Nannan Fu Ziang Zhang Junmin Quan Source Type: research

Amiodarone inhibits the Toll-like receptor 3-mediated nuclear factor κB signaling pathway by blocking organelle acidification
Biochem Biophys Res Commun. 2024 Mar 19;708:149801. doi: 10.1016/j.bbrc.2024.149801. Online ahead of print.ABSTRACTToll-like receptor (TLR) agonists or pro-inflammatory cytokines converge to activate the nuclear factor κB (NF-κB) signaling pathway, which provokes inflammatory responses. In the present study, we identified amiodarone hydrochloride as a selective inhibitor of the TLR3-mediated NF-κB signaling pathway by screening the RIKEN NPDepo Chemical Library. In human umbilical vein endothelial cells (HUVEC), amiodarone selectively inhibited the expression of intercellular adhesion molecule-1 (ICAM-1) induced by poly...
Source: Biochemical and Biophysical Research communications - March 26, 2024 Category: Biochemistry Authors: Yuka Yokota Keiko Takaki Kosuke Baba Saki Sasaki Hiroyuki Hirano Hiroyuki Osada Takao Kataoka Source Type: research

Sesamin alleviates lipid accumulation induced by oleic acid via PINK1/Parkin-mediated mitophagy in HepG2 cells
Biochem Biophys Res Commun. 2024 Mar 22;708:149815. doi: 10.1016/j.bbrc.2024.149815. Online ahead of print.ABSTRACTSesamin, a special compound present in sesame and sesame oil, has been reported a role in regulating lipid metabolism, while the underlying mechanisms remain unclear. Autophagy has been reported associated with lipid metabolism and regarded as a key modulator in liver steatosis. The present work aimed to investigate whether sesamin could exert its protective effects against lipid accumulation via modulating autophagy in HepG2 cells stimulated with oleic acid (OA). Cell viability was evaluated using the CCK-8 m...
Source: Biochemical and Biophysical Research communications - March 26, 2024 Category: Biochemistry Authors: Mengyun Dong Tianliang Zhang Xueli Liang Xinyi Cheng Fuyan Shi Hang Yuan Fengxiang Zhang Qiqi Jiang Xia Wang Source Type: research

Calcium-induced upregulation of energy metabolism heats neurons during neural activity
In this study, we achieved simultaneous imaging of Ca2+ and temperature using the genetically encoded indicators, B-GECO and B-gTEMP. We then compared the spatiotemporal distributions of Ca2+ responses and temperature. Following neural excitation induced by veratridine, an activator of the voltage-gated Na+ channel, we observed an approximately 2 °C increase in cytosolic temperature occurring 30 s after the Ca2+ response. The temperature elevation was observed in the non-nuclear region, while Ca2+ increased throughout the cell body. Moreover, this temperature increase was suppressed under Ca2+-free conditions and by inhib...
Source: Biochemical and Biophysical Research communications - March 24, 2024 Category: Biochemistry Authors: Jiayang Wu Yutaka Shindo Kohji Hotta Cong Quang Vu Kai Lu Tetsuichi Wazawa Takeharu Nagai Kotaro Oka Source Type: research

Real-time monitoring of cortical brain activity in response to acute pain using wide-area Ca < sup > 2+ < /sup > imaging
Biochem Biophys Res Commun. 2024 Mar 18;708:149800. doi: 10.1016/j.bbrc.2024.149800. Online ahead of print.ABSTRACTPrevious human and rodent studies indicated that nociceptive stimuli activate many brain regions that is involved in the somatosensory and emotional sensation. Although these studies have identified several important brain regions involved in pain perception, it has been a challenge to observe neural activity directly and simultaneously in these multiple brain regions during pain perception. Using a transgenic mouse expressing G-CaMP7 in majority of astrocytes and a subpopulation of excitatory neurons, we reco...
Source: Biochemical and Biophysical Research communications - March 24, 2024 Category: Biochemistry Authors: Chihiro Inami Makito Haruta Yasumi Ohta Motoshi Tanaka MinHye So Kazuya Sobue Yasemin Akay Kazuhiko Kume Jun Ohta Metin Akay Masahiro Ohsawa Source Type: research

Circadian rhythms in CYP2A5 expression underlie the time-dependent effect of tegafur on breast cancer
Biochem Biophys Res Commun. 2024 Mar 20;708:149813. doi: 10.1016/j.bbrc.2024.149813. Online ahead of print.ABSTRACTThe chemotherapeutic agent tegafur, a prodrug that prolongs the half-life of fluorouracil (5-FU), exerts antitumor effects against various cancers. Since tegafur is metabolized to 5-FU by CYP2A6 in the liver, the expression of CYP2A6 determines the effect of tegafur. Here, we report that the expression rhythm of Cyp2a5, a homolog of human CYP2A6, in female mice causes dosing time-dependent differences in tegafur metabolism. In the livers of female mice, CYP2A5 expression showed a circadian rhythm, peaking duri...
Source: Biochemical and Biophysical Research communications - March 24, 2024 Category: Biochemistry Authors: Yuya Yoshida Taiki Fukuda Tomohito Tanihara Naoki Nishikawa Serina Iwasa Satoka Adachi Orion Zaitsu Yuma Terada Ryotaro Tsukamoto Hideki Shimoshikiryo Kohei Fukuoka Fumiaki Tsurusaki Kengo Hamamura Kosuke Oyama Akito Tsuruta Satoru Koyanagi Naoya Matsunag Source Type: research

METTL16 deficiency attenuates apoptosis through translational control of extrinsic death receptor during nutrient deprivation
Biochem Biophys Res Commun. 2024 Mar 19;708:149802. doi: 10.1016/j.bbrc.2024.149802. Online ahead of print.ABSTRACTMETTL16 is a well-characterized m6A methyltransferase that has been reported to contribute to tumorigenesis in various types of cancer. However, the effect of METTL16 on tumor progression under restricted nutrient conditions, which commonly occur in tumor microenvironment, has yet to be elucidated. Herein, our study initially reported the inhibitory effect of METTL16 depletion on apoptosis under amino acid starvation conditions. Mechanistically, we determined that the METTL16 knockdown represses the expression...
Source: Biochemical and Biophysical Research communications - March 23, 2024 Category: Biochemistry Authors: Qiujie Li Lu Yang Chenxin Zhang Jingying Yuan Jun Zhang Wenjun Tao Jun Zhou Source Type: research

Combined SET7/9 and CDK4 inhibition act synergistically against osteosarcoma
Biochem Biophys Res Commun. 2024 Mar 20;708:149808. doi: 10.1016/j.bbrc.2024.149808. Online ahead of print.ABSTRACTOsteosarcoma is the most common malignant bone tumor. It has a poor prognosis because of a lack of therapeutic targets and strategies. The SET domain-containing lysine-specific methyltransferase, SET7/9, has various functions in different cancer types in tissue-type and signaling context-dependent manners. The role of SET7/9 in osteosarcoma cells is currently controversial and its potential as a therapeutic candidate in osteosarcoma is unknown. In the present study, SET7/9 inhibition or ablation suppressed ost...
Source: Biochemical and Biophysical Research communications - March 23, 2024 Category: Biochemistry Authors: Yingxu Shi Zhonghao Wang Yiming Shao Qianqian Guang Jian Zhang Baorui Liu Chunshen Wu Yexin Wang Ping Sui Source Type: research