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Airway inflammation in a novel mouse model of asthma-COPD overlap induced by co-exposure to papain and tobacco smoke
In this study, we exposed papain-induced asthma model mice to tobacco smoke to establish an ACO mouse model, in which features of airway inflammation observed in both asthma and COPD were incorporated. This model exhibited distinctive mixed and corticosteroid-resistant airway inflammation and emphysematous changes that are characteristic of ACO. The novel mouse model established here is expected to significantly contribute to elucidating the mechanisms of the broad pathologies of ACO and identifying potential therapeutic targets.PMID:38552552 | DOI:10.1016/j.bbrc.2024.149831 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - March 29, 2024 Category: Biochemistry Authors: Genki Kimura Ai Tagami Rina Fukui Masaki Yaita Tomohiro Miyasaka Source Type: research

miR-200c-141 induces a hybrid E/M state and promotes collective cell migration in MDA-MB-231 cells
In this study, we investigated whether the miR-200 family members play a role in the acquisition of a hybrid epithelial/mesenchymal (E/M) state, which is reported to be associated with cancer malignancy, in mesenchymal MDA-MB-231 cells. Our results demonstrated that the induction of miR-200c-141, a cluster of the miR-200 family member, can induce the expression of epithelial gene and cell-cell junction while mesenchymal markers are retained. Moreover, induction of miR-200c-141 promoted collective migration accompanied by the formation of F-actin cables anchored by adherens junction. These results suggest that the miR-200 f...
Source: Biochemical and Biophysical Research communications - March 29, 2024 Category: Biochemistry Authors: Tomoaki Nagai Misa Sato Michiru Nishita Source Type: research

Inhibition of RAC attenuates Adriamycin-induced podocyte injury
In conclusion, our research suggests that EHT-1864 may be a promising new molecular drug candidate for patients with MCD and FSGS.PMID:38552554 | DOI:10.1016/j.bbrc.2024.149807 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - March 29, 2024 Category: Biochemistry Authors: Hao Wu Yujin Liu Zhanjun Jia Songming Huang Guixia Ding Aihua Zhang Jing Yu Source Type: research

Retinol dehydrogenase 12 (RDH12) knock out may cause hyperuricemia phenotype in mice
Biochem Biophys Res Commun. 2024 Mar 20;709:149809. doi: 10.1016/j.bbrc.2024.149809. Online ahead of print.ABSTRACTHyperuricemia is a chronic metabolic disease caused by purine metabolism disorder. And several gene loci and transporter proteins that associated with uric acid transport functions have been identified. Retinol Dehydrogenase 12 (RDH12), recognized for its role in safeguarding photoreceptors, and our study investigated the potential impact of Rdh12 mutations on other organs and diseases, particularly hyperuricemia. We assessed Rdh12 mRNA expression levels in various tissues and conducted serum biochemical analy...
Source: Biochemical and Biophysical Research communications - March 29, 2024 Category: Biochemistry Authors: Jiaxin Bian Hongyu Chen Junhui Sun Shuai Han Ming Qi Qing Pan Source Type: research

Amyloid precursor protein combinatorial phosphorylation code regulates AMPA receptor removal during distinct forms of synaptic plasticity
Biochem Biophys Res Commun. 2024 Mar 26;709:149803. doi: 10.1016/j.bbrc.2024.149803. Online ahead of print.ABSTRACTSynaptic plasticity is essential for memory encoding and stabilization of neural network activity. Plasticity is impaired in neurodegenerative conditions including Alzheimer disease (AD). A central factor in AD is amyloid precursor protein (APP). Previous studies have suggested APP involvement in synaptic plasticity, but physiological roles of APP are not well understood. Here, we identified combinatorial phosphorylation sites within APP that regulate AMPA receptor trafficking during different forms of synapti...
Source: Biochemical and Biophysical Research communications - March 29, 2024 Category: Biochemistry Authors: Jisoo Lee Daniel T S Pak Source Type: research

Metabolism of toxic benzonitrile and hydroxybenzonitrile isomers via several distinct central pathway intermediates in a catabolically robust Burkholderia sp
Biochem Biophys Res Commun. 2024 Mar 24;709:149822. doi: 10.1016/j.bbrc.2024.149822. Online ahead of print.ABSTRACTAromatic nitriles are of considerable environmental concern, because of their hazardous impacts on the health of both humans and wildlife. In the present study, Burkholderia sp. strain BC1 was observed to be capable of utilizing toxic benzonitrile and hydroxybenzonitrile isomers singly, as sole carbon and energy sources. The results of chromatographic and spectrometric analyses in combination with oxygen uptake and enzyme activity studies, revealed the metabolism of benzonitrile as well as 2-, 3-, and 4-hydrox...
Source: Biochemical and Biophysical Research communications - March 28, 2024 Category: Biochemistry Authors: Mriganka M Karmakar Satamita Deb Tapan K Dutta Source Type: research

scRNA+TCR+BCR-seq revealed the proportions and gene expression patterns of dual receptor T and B lymphocytes in NPC and NLH
Biochem Biophys Res Commun. 2024 Mar 22;709:149820. doi: 10.1016/j.bbrc.2024.149820. Online ahead of print.ABSTRACTWhile the relationship between single receptor lymphocytes and cancer has been deeply researched, the origin and biological roles of dual receptor lymphocytes in tumor microenvironment (TME) remain largely unknown. And since nasopharyngeal carcinoma (NPC) is a type of cancer closely associated with immune infiltration, studying the TME of NPC holds particular significance. Utilizing single-cell RNA sequencing combined with T cell receptor (TCR) and B cell receptor (BCR) sequencing (scRNA + TCR + BCR-seq), we a...
Source: Biochemical and Biophysical Research communications - March 28, 2024 Category: Biochemistry Authors: Yuanning Yao Hengyu Wang Yuanyuan Xu Li Zhang Renping Liu Source Type: research

Effects of intrinsically disordered regions in gp120 underlying HIV neutralization phenotypes
Biochem Biophys Res Commun. 2024 Mar 25;709:149830. doi: 10.1016/j.bbrc.2024.149830. Online ahead of print.ABSTRACTHIV envelope protein gp120 is considered a primary molecular determinant of viral neutralization phenotype due to its critical role in viral entry and immune evasion. The intrinsically disordered regions (IDRs) in gp120 are responsible for their extensive sequence variations and significant structural rearrangements. Despite HIV neutralization phenotype and sequence/structural information of gp120 have been experimentally characterized, there remains a gap in our understanding of the correlation between the vi...
Source: Biochemical and Biophysical Research communications - March 28, 2024 Category: Biochemistry Authors: Yi Li Li Yang Li-Quan Yang Source Type: research

Ascorbic acid predominantly kills cancer stem cell-like cells in the hepatocellular carcinoma cell line Li-7 and is more effective at low cell density and in small spheroids
Biochem Biophys Res Commun. 2024 Mar 22;709:149816. doi: 10.1016/j.bbrc.2024.149816. Online ahead of print.ABSTRACTThe development of therapies that target cancer stem cells (CSCs) is an important challenge in cancer research. The antioxidant system is enhanced in CSCs, which may lead to resistance to existing therapies. Ascorbic acid (AA) has the potential to act as both an antioxidant and a pro-oxidant agent, but its effects on CSCs are a subject of current research. Here, we investigated the effect of AA focusing specifically on CSCs with the hepatocellular carcinoma cell line Li-7. The Li-7 cell line is heterogenous co...
Source: Biochemical and Biophysical Research communications - March 28, 2024 Category: Biochemistry Authors: Yusuke Seyama Kazuhiro Sudo Takeshi Yamada Kiichiro Tsuchiya Yukio Nakamura Source Type: research

Loss of mutant p53 in HaCaT keratinocytes promotes cadmium-induced keratin 17 expression and cell death
CONCLUSIONS: The connection between mutant p53 in HaCaT keratinocytes and increased resistance to cadmium toxicity was demonstrated for the first time. Proteomic profiling revealed that TP53 knockout in HaCaT cells led to the activation of apoptosis regulatory circuits, redox systems, and DNA repair. In addition, our data support the involvement of keratin 17 in the regulation of DNA repair and cell death. Apparently, the induction of keratin 17 is p53-independent but may be inhibited by mutant p53.PMID:38547608 | DOI:10.1016/j.bbrc.2024.149834 (Source: Biochemical and Biophysical Research communications)
Source: Biochemical and Biophysical Research communications - March 28, 2024 Category: Biochemistry Authors: Daniil Romashin Alexander Rusanov Tatiana Tolstova Alexandra Varshaver Alexander Netrusov Peter Kozhin Nataliya Luzgina Source Type: research