Epilepsy is not statistically associated with systemic sclerosis but significantly impacts on mortality: A real-world epidemiological survey-based study
Publication date: Available online 7 March 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Abdulla Watad, Nicola Luigi Bragazzi, Francesco Brigo, Mohammad Adawi, Naim Mahroum, Doron Comaneshter, Daniela Amital, Arnon D. Cohen, Howard AmitalAbstractLittle is known about the relationship between epilepsy and SSc. Our study included 2431 SSc patients and 12,710 age- and sex-matched controls. In 209 controls (1.6%) and 66 SSc patients (2.7%), epilepsy diagnosis was made (not significant). In the multivariate logistic regression analysis, higher age (OR 1.01 [95% CI 1.00–1.02], p = 0.020...
Source: Best Practice and Research Clinical Rheumatology - March 8, 2019 Category: Rheumatology Source Type: research

Cardiovascular morbidity and mortality in ankylosing spondylitis and psoriatic arthritis
Publication date: Available online 6 March 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Jean W. Liew, Sofia Ramiro, Lianne S. GenslerAbstractThe cardiovascular burden in inflammatory rheumatic diseases is well recognized. Recently, this burden has been highlighted in ankylosing spondylitis (also known as radiographic axial spondyloarthritis) and psoriatic arthritis. We review the cardiovascular morbidity and mortality in these diseases, as well as the prevalence and incidence of traditional cardiovascular risk factors. We examine the contribution of anti-inflammatory therapy with nonsteroidal an...
Source: Best Practice and Research Clinical Rheumatology - March 7, 2019 Category: Rheumatology Source Type: research

Current trends in sport and exercise hip conditions: Intra-articular and extra-articular hip pain, with detailed focus on femoroacetabular impingement (FAI) syndrome
Publication date: Available online 4 March 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Joanne Kemp, Alison Grimaldi, Joshua Heerey, Denise Jones, Mark Scholes, Peter Lawrenson, Sally Coburn, Matthew KingAbstractMusculoskeletal conditions, such as hip pain are leading causes of pain and disability. Hip pain is the second most common cause of lower limb musculoskeletal pain, and is commonly seen in active individuals. Hip and groin pain may have intra-articular and extra-articular causes. Femoroacetabular impingement (FAI) syndrome and the associated pathologies are common intra-articular causes ...
Source: Best Practice and Research Clinical Rheumatology - March 6, 2019 Category: Rheumatology Source Type: research

Time to diagnosis of fibromyalgia and factors associated with delayed diagnosis in primary care
Publication date: Available online 4 March 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Omer Gendelman, Howard Amital, Yael Bar-On, Dana Ben-Ami Shor, Daniela Amital, Shmuel Tiosano, Varda Shalev, Gabriel Chodick, Dahlia WeitzmanAbstractFibromyalgia is a complex disorder, and its diagnosis often comprises a challenge for physicians.We aimed to assess the time from the appearance of early symptoms to the definite diagnosis of fibromyalgia and to delineate patient and physician factors associated with this delay.The database of a large healthcare services provider was searched for all fibromyalgia...
Source: Best Practice and Research Clinical Rheumatology - March 6, 2019 Category: Rheumatology Source Type: research

Peripheral spondyloarthritis: Concept, diagnosis and treatment
Publication date: Available online 2 March 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Anna Molto, Joachim SieperAbstractPeripheral spondyloarthritis refers to spondyloarthritis with predominant peripheral (arthritis, enthesitis or dactylitis) involvement. Diagnosis can be challenging, particularly in the absence of SpA extra-articular manifestations such as uveitis, psoriasis or inflammatory bowel disease. Evaluation of disease activity should always include assessment of objective signs of inflammation, particularly in the presence of enthesitis as the sole peripheral manifestation, mainly du...
Source: Best Practice and Research Clinical Rheumatology - March 4, 2019 Category: Rheumatology Source Type: research

Disease modification in axial spondyloarthritis
Publication date: Available online 2 March 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Ismail Sari, Nigil HaroonAbstractThe concept of “disease modification” refers to an intervention that modifies the natural clinical course of the disease along with improvement of symptoms. With regard to this, providing treatment that improves clinical signs and symptoms of axial spondyloarthritis (axSpA) and that impacts disease pathogenesis by slowing/halting bone formation is the main goal of this concept. It has been proven that currently available treatments including biologics and nonsteroi...
Source: Best Practice and Research Clinical Rheumatology - March 4, 2019 Category: Rheumatology Source Type: research

Autoinflammatory/autoimmunity syndrome induced by adjuvants (Shoenfeld's syndrome) in patients after a polypropylene mesh implantation
In conclusion, 40 patients developed symptoms of a systemic illness after a mesh operation. All patients fulfilled the diagnostic criteria for ASIA. One quarter of the patients had an immunodeficiency, whereas in approximately half of the patients, an autoimmune disease developed. We postulate that PP mesh implants may increase the risk of developing (auto)immune diseases by acting as an adjuvant. (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - March 1, 2019 Category: Rheumatology Source Type: research

Central nervous system involvement in rheumatoid arthritis patients and the potential implications of using biological agents
Publication date: Available online 27 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Fabiola Atzeni, Rossella Talotta, Ignazio Francesco Masala, Maria Chiara Gerardi, Roberto Casale, Piercarlo Sarzi-PuttiniAbstractCentral nervous system (CNS) involvement is quite unusual in patients with rheumatoid arthritis (RA), although cerebral vasculitis, rheumatoid nodules and meningitis have all been reported, and patients with RA may also have CNS comorbidities such as stroke and neuro-degenerative and demyelinating syndromes. It has been found that biological drugs, especially anti-tumour necrosi...
Source: Best Practice and Research Clinical Rheumatology - March 1, 2019 Category: Rheumatology Source Type: research

Implementation science to reduce the prevalence and burden of MSK disorders following sport and exercise-related injury
Publication date: Available online 28 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Evert Verhagen, Femke van NassauAbstractAlthough safety in sports and physical activity is an important prerequisite for continuing participation and maintenance of a healthy, physically active lifestyle, to date little effort has been placed upon moving evidence into preventive practice. Amongst researchers it is still often assumed that a program will disseminate itself after proven to be effective. Recently, however, there has been an increased recognition of the importance of theory-driven approaches ...
Source: Best Practice and Research Clinical Rheumatology - March 1, 2019 Category: Rheumatology Source Type: research

Efficacy and survival of golimumab with and without methotrexate in patients with psoriatic arthritis: A retrospective study from daily clinical practice
Publication date: Available online 27 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Kassem Sharif, Omer Gendelman, Pnina Langevitz, Tatiana Reitblat, Abdulla Watad, Yehuda Shoenfeld, Josef Azuri, Howard Amital, Nicola Luigi Bragazzi, Ora ShovmanAbstractGolimumab is a recombinant human monoclonal antibody targeted against tumour necrosis factor-alpha (TNF-α). Golimumab is effective in the management of patients with active psoriatic arthritis (PsA).The aim of this study is to evaluate the clinical efficacy and survival of golimumab monotherapy versus co-administration with methotrex...
Source: Best Practice and Research Clinical Rheumatology - February 27, 2019 Category: Rheumatology Source Type: research

Rheumatoid arthritis and thyroid dysfunction: A cross-sectional study and a review of the literature
Publication date: Available online 26 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Hussein Mahagna, Alyssa Caplan, Abdulla Watad, Nicola Luigi Bragazzi, Kassem Sharif, Shmuel Tiosano, Naim Mahroum, Hen Hendel, Yehuda Shoenfeld, Doron Comaneshter, Arnon D. Cohen, Howard AmitalAbstractThyroid dysfunction appears to show increased prevalence in many autoimmune diseases; however, this comorbidity has not been properly investigated in patients with RA. This issue was addressed in this cross-sectional study.Using the database of the Clalit Health Services (CHS) in Israel, RA patients were pai...
Source: Best Practice and Research Clinical Rheumatology - February 26, 2019 Category: Rheumatology Source Type: research

Mutants of β2-glycoprotein I: Their features and potent applications
Publication date: Available online 26 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Lianhua Shen, Nuriza Ulul Azmi, Xian Wen Tan, Shinsuke Yasuda, Arum Tri Wahyuningsih, Junko Inagaki, Kazuko Kobayashi, Eiji Ando, Takanori Sasaki, Eiji MatsuuraAbstractβ2-Glycoprotein I (β2GPI) is a highly-glycosylated plasma protein composed of five homologous domains which regulates coagulation, fibrinolysis, and/or angiogenesis by interacting to negatively charged hydrophobic molecules and/or with plasminogen and its metabolites. The present study focused on structural and functional cha...
Source: Best Practice and Research Clinical Rheumatology - February 26, 2019 Category: Rheumatology Source Type: research

Mortality of patients with systemic lupus erythematosus admitted to the intensive care unit – A retrospective single-center study
Publication date: Available online 23 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Guy Zamir, Yael Haviv-Yadid, Kassem Sharif, Nicola Luigi Bragazzi, Abdulla Watad, Amir Dagan, Howard Amital, Yehuda Shoenfeld, Ora ShovmanAbstractSystemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that results in increased morbidity and mortality. Under certain conditions, patients with SLE may be admitted to the intensive care unit (ICU) secondary to infectious disease flare-ups or other non-SLE disease conditions that are aggravated by SLE. The aim of our study was to investigate t...
Source: Best Practice and Research Clinical Rheumatology - February 25, 2019 Category: Rheumatology Source Type: research

Managing low back pain in active adolescents
Publication date: Available online 23 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Kieran O'Sullivan, Mary O'Keeffe, Bruce B. Forster, Sadia Raheez Qamar, Andrew van der Westhuizen, Peter B. O'SullivanAbstractAdolescent low back pain has received limited research attention despite its potentially considerable impact on quality of life. The role of diagnostic triage to identify serious or specific pathology and/or order relevant investigations is considered. An overview of contemporary pain mechanisms is provided, with specific reference to the wide range of risk factors for persist...
Source: Best Practice and Research Clinical Rheumatology - February 25, 2019 Category: Rheumatology Source Type: research

Rethinking patellofemoral pain: Prevention, management and long-term consequences
Publication date: Available online 22 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Kay M. Crossley, Marienke van Middelkoop, Christian J. Barton, Adam G. CulvenorAbstractPatellofemoral pain is one of the most common knee complaints, particularly among physically active young individuals. Although once thought to be self-limiting, prospective studies have demonstrated the propensity towards the chronicity of patellofemoral pain (PFP). The pathogenesis of PFP is complex, with multiple interactive pathways suggested to contribute to its onset and persistence. Quadriceps weakness is one of ...
Source: Best Practice and Research Clinical Rheumatology - February 23, 2019 Category: Rheumatology Source Type: research

Mimickers of neuropsychiatric manifestations in systemic lupus erythematosus
Publication date: Available online 22 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Jaqueline Cristina de Amorim, Aline Kuhl Torricelli, Renan Bazuco Frittoli, Aline Tamires Lapa, Sergio San Juan Dertkigil, Fabiano Reis, Lilian TL. Costallat, Marcondes Cavalcante França Junior, Simone AppenzellerAbstractSystemic lupus erythematosus (SLE), presenting with new onset or worsening neuropsychiatric (NP) symptoms, is a challenge in clinical practice. Mimickers such as infections, drug-induced side effects, metabolic abnormalities, malignancies, and alcohol-related disorders have to be e...
Source: Best Practice and Research Clinical Rheumatology - February 23, 2019 Category: Rheumatology Source Type: research

Current trends in sport injury prevention
Publication date: Available online 23 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Carolyn A. Emery, Kati PasanenAbstractParticipation in sport and recreation has important positive implications for public health across the lifespan; however, the burden of sport-related musculoskeletal injury is significant, with the greatest risk being in youth and young adults. Moving upstream to primary prevention of injury is a public health priority that will have significant implications for reducing the long-term consequences of musculoskeletal injury including early post-traumatic osteoarthritis...
Source: Best Practice and Research Clinical Rheumatology - February 23, 2019 Category: Rheumatology Source Type: research

Rituximab induction without maintenance for granulomatosis with polyangiitis and dialysis – Case report and literature review
We describe a case of a 32-year-old woman admitted for pulmonary infiltrates and acute renal failure. Autoimmune workup revealed an elevated titer of proteinase 3-antineutrophil cytoplasmic antibody (PR3-ANCA). The diagnosis of granulomatosis with polyangiitis (GPA) was confirmed by renal biopsy. The patient received induction therapy with IV rituximab (375 mg/m2 per week for 4 weeks) along with systemic high-dose IV corticosteroids and one pulse of IV cyclophosphamide (1000 mg). Rapid deterioration of her kidney function led to pulmonary edema requiring intensive care (ICU) hospitalization. Dialysis and plasmaph...
Source: Best Practice and Research Clinical Rheumatology - February 22, 2019 Category: Rheumatology Source Type: research

Youth sport: Friend or Foe?
Publication date: Available online 21 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Carly D. McKay, Sean P. Cumming, Tracy BlakeAbstractParticipation in youth sport has been promoted as part of a healthy lifestyle, with benefits for physical fitness, social development, and mental wellbeing. Yet, sport carries an inherent risk of injury, which for young athletes may have both immediate and long-term consequences. Amidst significant public debate about the pros and cons of youth sport, this review considers the physiological, psychological, and social factors that inform decisions around ...
Source: Best Practice and Research Clinical Rheumatology - February 22, 2019 Category: Rheumatology Source Type: research

Do the benefits of participation in sport and exercise outweigh the negatives? An academic review
Publication date: Available online 21 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Kathryn Mills, Dean Dudley, Natalie J. CollinsAbstractPublic health campaigns promote regular exercise and physical activity. These campaigns are founded on global recommendations that a combination of aerobic and resistance exercise is required, on a weekly basis, to maximise physical and mental health. However, participation in all forms of sports and physical activity has inherent risks that need to be considered by both health practitioners making activity recommendations and the people participating....
Source: Best Practice and Research Clinical Rheumatology - February 22, 2019 Category: Rheumatology Source Type: research

The diagnostic value of 14-3-3η protein levels in patients with rheumatoid arthritis
Publication date: Available online 21 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): O. Shovman, B. Gilburd, A. Watad, H. Amital, P. Langevitz, N.L. Bragazzi, M. Adawi, D. Perez, G. Bornstein, C. Grossman, M. Lidar, M. Blank, J. Azuri, N.K. Biln, A. Marotta, Y. ShoenfeldAbstract14-3-3η may represent a useful diagnostic biomarker for rheumatoid arthritis (RA). We assessed the prevalence and serum levels of 14-3-3η in patients with RA and in patients with other rheumatic diseases.Serum levels of 14-3-3η were measured in 96 patients with RA, in 101 patients with other rheumatic d...
Source: Best Practice and Research Clinical Rheumatology - February 22, 2019 Category: Rheumatology Source Type: research

Outcomes of patients with systemic sclerosis treated with tocilizumab: Case series and review of the literature
Publication date: Available online 21 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Galia Zacay, Yair LevyAbstractThe treatment of systemic sclerosis (SSc) presents a clinical challenge because of the progressive nature of the disease, relatively poor prognosis, and lack of a proven treatment. In the last 10 years, several studies demonstrated the importance of interleukin 6 (IL6) as a pivotal cytokine in the development of fibrosis and angiopathy, especially in SSc. Tocilizumab, an IL6 receptor antibody, has shown promising results for patients with SSc.A total of 16 patients with SSc w...
Source: Best Practice and Research Clinical Rheumatology - February 22, 2019 Category: Rheumatology Source Type: research

The sacroiliac joint – Victim or culprit
Publication date: Available online 21 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): James Booth, Samuel MorrisAbstractIt is estimated that 10–30% of all low back pain is attributed to the sacroiliac joints. There are many challenges to diagnosing and treating the sacroiliac joints. Central to this challenge is determining whether the sacroiliac joint is the primary source of pain or dysfunction. This paper considers the complexities of diagnosis and management of sacroiliac joint dysfunction by providing a best evidence informed overview of the mechanics of the sacroiliac joint, th...
Source: Best Practice and Research Clinical Rheumatology - February 22, 2019 Category: Rheumatology Source Type: research

Evidence-based recommendations for the management of anterior cruciate ligament (ACL) rupture
The objectives of management are to restore knee function, address psychological barriers to activity participation, prevent further injury and osteoarthritis, and optimize long-term quality of life. The three main treatment options for ACL rupture are (1) rehabilitation as first-line treatment (followed by ACL reconstruction (ACLR) in patients, who develop functional instability), (2) ACLR and post-operative rehabilitation as the first-line treatment, and (3) pre-operative rehabilitation followed by ACLR and post-operative rehabilitation. We provide practical recommendations for informing and discussing management options...
Source: Best Practice and Research Clinical Rheumatology - February 22, 2019 Category: Rheumatology Source Type: research

Emerging treatment options for spondyloarthritis
Publication date: Available online 21 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Murat Torgutalp, Denis PoddubnyyAbstractThe management of spondyloarthritis (SpA) has substantially changed as a consequence of the introduction of biologic disease-modifying antirheumatic drugs (bDMARDs). However, the treatment options in patients with axial SpA (axSpA) not responding to nonsteroidal anti-inflammatory drugs (NSAIDs) had been restricted to tumor necrosis factor alpha (TNFα) inhibitors for almost 15 years. With the approval of secukinumab, an interleukin (IL)-17A inhibitor, there is ...
Source: Best Practice and Research Clinical Rheumatology - February 22, 2019 Category: Rheumatology Source Type: research

Choosing Wisely after a sport and exercise-related injury
Publication date: Available online 22 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Joshua R. Zadro, Ian A. Harris, Christina Abdelshaheed, Carolyn Broderick, Christian J. Barton, James Linklater, Christopher G. MaherAbstractLow-value care is receiving substantial attention in many fields of medicine but little-to-none in sports medicine. Common interventions for sport and exercise-related injuries include medical imaging, medication, surgery and rehabilitation, but there is emerging evidence of the inappropriate use of these interventions.This chapter aims to increase awareness of low-v...
Source: Best Practice and Research Clinical Rheumatology - February 22, 2019 Category: Rheumatology Source Type: research

Anti-DFS70 among HIV-positive individuals – A prospective study
Publication date: Available online 20 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Naim Mahroum, Dolores Perez, Ora Shovman, Abdulla Watad, Boris Gilburd, Howard Amital, Itzik Levy, Yehuda ShoenfeldAbstractAnti-DFS70 is an anti-nuclear antibody directed against the DFS70 protein, which is produced in response to several stressful events. Since its discovery, this autoantigen–antibody complex has drawn the attention of many researchers, yet many questions remain unanswered. The DFS70 protein is crucial for HIV integration into the host DNA; however, the relationship between anti-DF...
Source: Best Practice and Research Clinical Rheumatology - February 20, 2019 Category: Rheumatology Source Type: research

Overview of osteo-articular involvement in systemic sclerosis: Specific risk factors, clinico-sonographic evaluation, and comparison with healthy women from the French OFELY cohort
Publication date: Available online 20 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Sara Thietart, Karine Louati, Marc Gatfosse, Elisabeth Sornay-Rendu, Emeline Gaigneux, Lucie Lemeunier, Philippe Delmaire, Sébastien Riviere, Thibault Mahevas, Jérémie Sellam, Francis Berenbaum, Olivier Fain, Chapurlat Roland, Arsène MekinianAbstractOsteoarticular involvement in systemic sclerosis (SSc) is frequent and varied. Data are scarce on the prevalence and risk factors of osteoporosis (OP). We aimed to assess clinical parameters, radiological parameters, US articular in...
Source: Best Practice and Research Clinical Rheumatology - February 20, 2019 Category: Rheumatology Source Type: research

Toll-like receptor 2 is overexpressed in Familial Mediterranean fever patients and is inhibited by colchicine treatment
Conclusions: TLR2 activation was upregulated in monocytes of FMF patients, and colchicine inhibited this upregulation both in -vitro and in -vivo. This indicates that elevated expression of TLR2 promotes the production of pro-inflammatory cytokines, which may contribute to uncontrolled inflammation in FMF. (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - February 19, 2019 Category: Rheumatology Source Type: research

Serum concentration of surfactant protein D in patients with systemic sclerosis: The potential marker of the interstitial lung disease severity
Publication date: Available online 14 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Anida Grosicka, Ahmed Manasar, Eugene J. Kucharz, Przemyslaw J. KotylaAbstractPulmonary involvement is a severe manifestation of systemic sclerosis (SSc). The study was designed to determine the serum level of surfactant protein D (SP-D) in patients with SSc in relation to clinical and laboratory parameters as well as to analyze dynamics of changes of these indices within one year of observation.SP-D was assayed in 41 patients with SSc and 15 healthy controls. Additionally, pulmonary function tests, chest...
Source: Best Practice and Research Clinical Rheumatology - February 15, 2019 Category: Rheumatology Source Type: research

MMP3 is a reliable marker for disease activity, radiological monitoring, disease outcome predictability, and therapeutic response in rheumatoid arthritis
Publication date: Available online 14 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Aaron Lerner, Sandra Neidhöfer, Sandra Reuter, Torsten MatthiasAbstractMatrix metalloproteinase-3 or MMP3 also known as stromelysin-1 is an enzyme that is actively involved in joint destruction in rheumatoid arthritis (RA) patients. Screening the last three decades, it appears that serum levels of MMP3 reflect positively RA disease activity, joint and bone injury, and radiological erosion and predict disease outcome and drug responsiveness as summarized in several publications reporting outcomes on m...
Source: Best Practice and Research Clinical Rheumatology - February 14, 2019 Category: Rheumatology Source Type: research

Corrigendum to “Overview of changes in RMD epidemiology and outcome development in the last 10 years” [Best Pract Res Clin Rheumatol 32 (2018) 169–173]
Publication date: Available online 7 February 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Suzanne M.M. Verstappen, Loreto Carmona (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - February 8, 2019 Category: Rheumatology Source Type: research

Advances in understanding the pathophysiology of spondyloarthritis
Publication date: Available online 31 January 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Rik J. LoriesAbstractProgressive understanding of the underlying pathophysiology of axial spondyloarthritis has successfully translated into innovative therapeutic strategies and successful management of patients in the clinic. This review summarizes the key roles of the pro-inflammatory cytokines tumor necrosis factor and interleukin-17 in the onset and progression of disease and how these cytokines are instrumental in shaping the concept that enthesitis is a key feature of axial spondyloarthritis. Advanc...
Source: Best Practice and Research Clinical Rheumatology - January 31, 2019 Category: Rheumatology Source Type: research

Index
Publication date: April 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 2Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 7, 2018 Category: Rheumatology Source Type: research

Editorial Board
Publication date: April 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 2Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 7, 2018 Category: Rheumatology Source Type: research

Epidemiology of rheumatic and musculoskeletal diseases
Publication date: April 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 2Author(s): Suzanne M.M. Verstappen, Loreto Carmona (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 7, 2018 Category: Rheumatology Source Type: research

Uveitis in the Spondyloarthopathies
Publication date: December 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 6Author(s): Srilakshmi M. Sharma, Daniel JacksonAbstractUveitis is a frequently occurring extra-articular manifestation of spondyloarthropathies (SpAs), ankylosing spondylitis (AS), reactive arthritis (ReA), psoriatic arthritis (PsA) and inflammatory bowel disease (IBD), occurring in both adults and children with SpA. Uveitis occurs with varying frequency according to the SpA subtype (33% in AS, 6–9% in PsA, 25% in ReA, 13% in undifferentiated SpA and 2–5% in IBD), the presence of HLA-B27 and with increas...
Source: Best Practice and Research Clinical Rheumatology - December 6, 2018 Category: Rheumatology Source Type: research

Index
Publication date: February 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 1Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 5, 2018 Category: Rheumatology Source Type: research

Editorial Board
Publication date: February 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 1Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 5, 2018 Category: Rheumatology Source Type: research

Preface
Publication date: February 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 1Author(s): Raashid Ahmed Luqmani, David Jayne (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 5, 2018 Category: Rheumatology Source Type: research

Index
Publication date: October 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 5Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 1, 2018 Category: Rheumatology Source Type: research

Involvement of epigenetics in osteoarthritis
Publication date: October 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 5Author(s): Rodrigo Coutinho de Almeida, Yolande F.M. Ramos, Ingrid MeulenbeltAbstractOsteoarthritis (OA) is the most prevalent chronic age-related arthritic disease that mainly affects the diarthrodial joints. Nevertheless, there is no treatment currently available that can effectively reduce symptoms or slow down or stop disease progression. The lack of disease-modifying therapies could be explained by the complex pathogenesis of OA, which is still not completely understood. Intertwined epigenetic mechanisms such as...
Source: Best Practice and Research Clinical Rheumatology - December 1, 2018 Category: Rheumatology Source Type: research

Role of the autonomic nervous system in osteoarthritis
Publication date: October 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 5Author(s): Alice Courties, Jérémie Sellam, Francis BerenbaumAbstractJoint homeostasis is affected by local and systemic processes. Catecholaminergic and cholinergic fibers innervate the synovium, trabecular bone, and periosteum. Several studies have investigated the involvement of the autonomic nervous system (ANS) in joint homeostasis and the pathophysiology of osteoarthritis (OA). Various resident cells of osteoarticular tissues express receptors for sympathetic and parasympathetic neurotransmitters (...
Source: Best Practice and Research Clinical Rheumatology - December 1, 2018 Category: Rheumatology Source Type: research

Editorial Board
Publication date: October 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 5Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 1, 2018 Category: Rheumatology Source Type: research

Editorial Board
Publication date: December 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 6Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 1, 2018 Category: Rheumatology Source Type: research

Index
Publication date: December 2017Source: Best Practice & Research Clinical Rheumatology, Volume 31, Issue 6Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - December 1, 2018 Category: Rheumatology Source Type: research

Clinical features and structured clinical evaluation of vasculitis
Publication date: Available online 22 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): C. Ponte, A.F. Águeda, R.A. LuqmaniAbstractSystemic vasculitides are a group of heterogeneous conditions with overlapping patterns of clinical and laboratory manifestations. Moreover, clinical features can be non-specific and seemingly disparate. A major factor in defining optimal therapy and measuring treatment response is careful disease assessment targeting four main domains: activity, damage, prognosis and quality of life/function. Assessment tools such as the Birmingham Activity Score and the ...
Source: Best Practice and Research Clinical Rheumatology - November 24, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology, risk factors and disease outcomes of osteoarthritis
Publication date: Available online 22 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Terence W. O'Neill, Paul S. McCabe, John McBethAbstractOsteoarthritis (OA) is the most frequent form of arthritis and a leading cause of pain and disability worldwide. OA can affect any synovial joint, although the hip, knee, hand, foot and spine are the most commonly affected sites. Knowledge about the occurrence and risk factors for OA is important to define the clinical and public health burden of the disease to understand mechanisms of disease occurrence and may also help to inform the development of ...
Source: Best Practice and Research Clinical Rheumatology - November 24, 2018 Category: Rheumatology Source Type: research

Update on the epidemiology, risk factors and disease outcomes of Juvenile idiopathic arthritis
Publication date: Available online 19 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Jason Palman, Stephanie Shoop-Worrall, Kimme Hyrich, Janet E. McDonaghAbstractJuvenile idiopathic arthritis (JIA) is the most common inflammatory joint condition of childhood and represents seven JIA subtypes characterised by distinct clinical and laboratory variables. Genetic and environmental factors are known to influence JIA, although many unanswered questions remain. Measurement of health outcomes in JIA is imperative for both clinical practice and research. Patient-reported outcomes present particul...
Source: Best Practice and Research Clinical Rheumatology - November 21, 2018 Category: Rheumatology Source Type: research

Genetics and pathogenesis of small-vessel vasculitis
Publication date: Available online 17 November 2018Source: Best Practice & Research Clinical RheumatologyAuthor(s): Alan D. SalamaAbstractSmall-vessel vasculitides are uncommon autoimmune diseases characterised by inflammation and necrosis of arterioles, capillaries and venules, frequently described as various (previously eponymous) clinical syndromes. Some are associated with vessel wall immune complex deposition, whereas others are pauci-immune but paradoxically often associated with circulating anti-neutrophil cytoplasmic antibodies (ANCA). Most is known about the pathogenesis of the pauci-immune ANCA-associated syn...
Source: Best Practice and Research Clinical Rheumatology - November 18, 2018 Category: Rheumatology Source Type: research