Editorial Board
Publication date: February 2019Source: Best Practice & Research Clinical Rheumatology, Volume 33, Issue 1Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - August 18, 2019 Category: Rheumatology Source Type: research

Prevention, management and long-term consequences of sport and exercise-related musculoskeletal disorders
Publication date: February 2019Source: Best Practice & Research Clinical Rheumatology, Volume 33, Issue 1Author(s): Jackie L. Whittaker, Carly D. McKay, Mark E. Batt (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - August 18, 2019 Category: Rheumatology Source Type: research

Index
Publication date: December 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 6Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - August 17, 2019 Category: Rheumatology Source Type: research

Practical issues in the modern management of rheumatic disease
Publication date: December 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 6Author(s): Joseph Markenson, Peter Nash (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - August 17, 2019 Category: Rheumatology Source Type: research

Management of hepatitis B and C infections in rheumatologic disease
Publication date: December 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 6Author(s): Jonathan TL. Cheah, John J. Faragon, Kristen M. MarksAbstractHepatitis B and C viruses present dual considerations in rheumatic disease as both etiologic factors and important comorbidities that must be assessed and addressed. This review summarizes the link between hepatitis B and arthritis and polyarteritis nodosa as well as hepatitis C and arthritis, Sicca syndrome and cryoglobulinemic vasculitis. Recent data pertaining to the antiviral management in these conditions, especially regarding the use of th...
Source: Best Practice and Research Clinical Rheumatology - August 17, 2019 Category: Rheumatology Source Type: research

Editorial Board
Publication date: December 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 6Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - August 17, 2019 Category: Rheumatology Source Type: research

Fragility fractures – Global call to action
Publication date: Available online 8 August 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Karsten E. Dreinhöfer (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - August 10, 2019 Category: Rheumatology Source Type: research

How to investigate: Early axial spondyloarthritis
Publication date: Available online 31 July 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Pedro D. Carvalho, Pedro M. MachadoAbstractAxial spondyloarthritis (axSpA) is a chronic inflammatory condition of the axial skeleton that encompasses radiographic and non-radiographic axSpA and that can lead to chronic pain, structural damage, disability, and loss of quality of life. Scientific advances, including the role of MRI assessment, have led to new diagnostic insights and the creation of a new set of classification criteria for axial and peripheral SpA. New criteria allow the identification of SpA pa...
Source: Best Practice and Research Clinical Rheumatology - August 1, 2019 Category: Rheumatology Source Type: research

Management of difficult osteoporosis
Publication date: Available online 25 July 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Linda A. RussellAbstractOsteoporosis and associated low-impact fractures are common. There is associated morbidity and mortality with low-impact fractures. It is critical to identify which patients would benefit from therapy. General treatment considerations are reviewed. Currently available treatment options are discussed. Certain patient populations pose challenges in the treatment of osteoporosis. An in-depth review of clinically challenging scenarios is presented: Treatment of patients with severe osteopo...
Source: Best Practice and Research Clinical Rheumatology - July 26, 2019 Category: Rheumatology Source Type: research

Suspected very early inflammatory rheumatic diseases in primary care
Publication date: Available online 24 July 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Louise Warburton, Samantha L. Hider, Christian D. Mallen, Ian C. ScottAbstractAs primary care clinicians are typically the first point of contact for patients with musculoskeletal problems, they are crucial to the early diagnosis and treatment of patients with an incident inflammatory arthritis, like rheumatoid arthritis. Current UK and international guidelines recognise this, recommending the prompt referral of patients with suspected persistent synovitis to secondary care. In England and Wales, this is advi...
Source: Best Practice and Research Clinical Rheumatology - July 25, 2019 Category: Rheumatology Source Type: research

Suspected systemic rheumatic diseases in patients presenting with cytopenias
Publication date: Available online 22 July 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Dionysis Nikolopoulos, Christina Adamichou, George BertsiasAbstractCytopenias may herald or concur with the onset of various systemic rheumatic diseases. Accordingly, patients with reduced blood cell counts are often referred for possible underlying autoimmune disease. Initial evaluation aims to exclude nonrheumatic causes such as drug toxicity, infections, or hematological/myelopoiesis disorders. Patient interview and physical examination are critical to unravel features related to or suggestive of rheumatic...
Source: Best Practice and Research Clinical Rheumatology - July 23, 2019 Category: Rheumatology Source Type: research

Early large vessel systemic vasculitis in adults
Publication date: Available online 20 July 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Miguel A. González-Gay, Diana Prieto-Peña, Isabel Martínez-Rodríguez, Mónica Calderon-Goercke, Ignacio Banzo, Ricardo Blanco, Santos CastañedaAbstractGiant cell arteritis (GCA) is the most common vasculitis in individuals older than 50 years in Western countries. In addition to the typical pattern of cranial ischemic manifestations, large vessel vasculitis (LVV) involvement has emerged as a common feature of GCA. Patients with predominant LVV manifestations differ fro...
Source: Best Practice and Research Clinical Rheumatology - July 22, 2019 Category: Rheumatology Source Type: research

The prevalence and impact of comorbid fibromyalgia in inflammatory arthritis
Publication date: Available online 17 July 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Sizheng Steven Zhao, Stephen J. Duffield, Nicola J. GoodsonAbstractFibromyalgia (FM) is one of the most common conditions that rheumatologists encounter. It is characterised by chronic widespread pain, fatigue, sleep disturbances and impaired cognition. The prevalence of comorbid FM among populations with rheumatoid arthritis (RA), axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are considerably higher than among the general population, with pooled prevalence estimates of 18–24% in RA, 14&...
Source: Best Practice and Research Clinical Rheumatology - July 18, 2019 Category: Rheumatology Source Type: research

Preclinical and early systemic lupus erythematosus
Publication date: Available online 12 July 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Mariele Gatto, Francesca Saccon, Margherita Zen, Luca Iaccarino, Andrea DoriaAbstractThe challenge of early diagnosis and treatment is a timely issue in the management of systemic lupus erythematosus (SLE), as autoimmunity starts earlier than its clinical manifestations. Hence, growing efforts for stratification of patients according to the individual risk of developing specific clinical manifestations and/or predicting a better response to a given treatment have led to the proposal of several biomarkers, whi...
Source: Best Practice and Research Clinical Rheumatology - July 13, 2019 Category: Rheumatology Source Type: research

Pain therapy – Are there new options on the horizon?
This article reviews the role of analgesic drugs with a particular emphasis on opioids. Opioids are the oldest and most potent drugs for the treatment of severe pain, but they are burdened by detrimental side effects such as respiratory depression, addiction, sedation, nausea, and constipation. Their clinical application is undisputed in acute (e.g., perioperative) and cancer pain, but their long-term use in chronic pain has met increasing scrutiny and has contributed to the current opioid crisis. We discuss epidemiological data, pharmacological principles, clinical applications, and research strategies aiming at novel opi...
Source: Best Practice and Research Clinical Rheumatology - July 6, 2019 Category: Rheumatology Source Type: research

The management of surgery and therapy for rheumatic disease
Publication date: Available online 5 July 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): C. Ronald MacKenzie, Susan M. Goodman, Andy O. MillerAbstractAs a result of advances in surgery, anesthesiology, and perioperative care, patients of more advanced age and medical complexity are now considered suitable candidates for surgical intervention. Rheumatologists, though frequently called upon to advise their patient in the surgical domain, may not be fully cognizant of the principles underlying medical consultation and therapy in perioperative setting. This paper provides an approach for guiding such ...
Source: Best Practice and Research Clinical Rheumatology - July 5, 2019 Category: Rheumatology Source Type: research

Editorial Board
Publication date: October 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 5Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - June 15, 2019 Category: Rheumatology Source Type: research

Index
Publication date: October 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 5Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - June 15, 2019 Category: Rheumatology Source Type: research

Neuroimaging the pain network – Implications for treatment
Publication date: Available online 12 June 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Martin DiersAbstractIn this chapter, we provide an overview of neuroimaging studies in chronic pain. We start with an introduction about the phenomenology of pain. In the following section, the application of functional and structural imaging techniques is shown in selected chronic pain syndromes (chronic back pain, fibromyalgia syndrome (FMS), phantom limb pain, and complex regional pain syndrome (CRPS)), and commonalities and peculiarities of imaging correlates across different types of chronic pain are dis...
Source: Best Practice and Research Clinical Rheumatology - June 12, 2019 Category: Rheumatology Source Type: research

Management of fragility fractures in India
Publication date: Available online 6 June 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Nishank Mehta, Bhavuk Garg, Rajesh MalhotraAbstractOsteoporosis and fragility fractures have become a major healthcare challenge globally in the recent years. However, this problem has only recently been accorded its due importance in developing countries such as India. India is a model case study for the management of osteoporosis and fragility fractures in a resource-limited setting, as it harbors a large geriatric population and has the highest prevalence of osteopenia globally. It is imperative to identify...
Source: Best Practice and Research Clinical Rheumatology - June 7, 2019 Category: Rheumatology Source Type: research

Index
Publication date: June 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 3Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - June 4, 2019 Category: Rheumatology Source Type: research

Editorial Board
Publication date: June 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 3Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - June 4, 2019 Category: Rheumatology Source Type: research

Index
Publication date: August 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 4Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - June 4, 2019 Category: Rheumatology Source Type: research

Editorial Board
Publication date: August 2018Source: Best Practice & Research Clinical Rheumatology, Volume 32, Issue 4Author(s): (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - June 4, 2019 Category: Rheumatology Source Type: research

Psychological therapies for chronic widespread pain and fibromyalgia syndrome
Publication date: Available online 31 May 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Winfried Häuser, Gareth JonesAbstractPsychological factors such as adverse childhood experiences, traumatic life events, interpersonal conflicts and psychological distress play an important role in the predisposition, onset and severity of chronic widespread pain (CWP) and fibromyalgia syndrome (FMS). Therefore, psychological therapies might have the potential to reduce disability as well as symptom and economic burden in patients with CWP and FMS. Recent interdisciplinary guidelines have suggested differ...
Source: Best Practice and Research Clinical Rheumatology - June 1, 2019 Category: Rheumatology Source Type: research

The role of ferritin and adiponectin as predictors of cartilage damage assessed by arthroscopy in patients with symptomatic knee osteoarthritis
Publication date: Available online 30 May 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Oren Nugzar, Gisele Zandman-Goddard, Hadar Oz, Dror Lakstein, Zeev Feldbrin, Marina ShargorodskyAbstractThe aim of the present study was to evaluate whether circulating serum ferritin and adiponectin (ADP) in the serum and synovial fluid correlate with cartilage damage severity assessed by arthroscopy in patients with knee osteoarthritis.The 40 subjects with symptomatic knee osteoarthritis were divided into four groups according to arthroscopy assessed cartilage damage, using Outerbridge (OB) grading. Group I ...
Source: Best Practice and Research Clinical Rheumatology - May 31, 2019 Category: Rheumatology Source Type: research

Management of difficult polymyalgia rheumatica and giant cell arteritis: Updates for clinical practice
Publication date: Available online 23 May 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Lindsay Lally, Robert SpieraAbstractPolymyalgia rheumatica (PMR) and giant cell arteritis (GCA) represent a family of systemic inflammatory diseases occurring in adults aged 50 years and above. Clinical presentation of PMR/GCA can be variable, making diagnosis at times challenging. There has been an increased appreciation of the role of various large-vessel imaging modalities to help confirm a diagnosis of GCA. Systemic corticosteroids (CS) remain the mainstay of treatment for both PMR and GCA, yet both relaps...
Source: Best Practice and Research Clinical Rheumatology - May 25, 2019 Category: Rheumatology Source Type: research

Non-hip/non-vertebral fractures – How to treat best?
Publication date: Available online 16 May 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Pierre Hoffmeyer, Hermes Miozzari, Nicolas HolzerAbstractFractures of the extremities in the elderly constitute more than two-thirds of all fragility fractures befalling frail, osteoporotic and sarcopenic patients. Although treatment controversies abound, consensus exists. Upper extremity fractures hinder activities of daily living and are debilitating. Open fractures or displaced fractures will need surgical intervention. Wrist fractures treated operatively allow early use of the hand. Most pelvic fractures a...
Source: Best Practice and Research Clinical Rheumatology - May 17, 2019 Category: Rheumatology Source Type: research

Fracture liaison programs
Publication date: Available online 16 May 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Piet Geusens, Sandrine P.G. Bours, Caroline E. Wyers, Joop P. van den BerghAbstractIn view of the high imminent risk of having subsequent fractures after a fracture, early evaluation and treatment decisions to prevent subsequent fractures are advocated. After a hip fracture, the fracture liaison service (FLS) and orthogeriatric care are considered the most appropriate organisational approaches for secondary fracture prevention following a recent fracture.Their introduction and implementation have been shown to...
Source: Best Practice and Research Clinical Rheumatology - May 17, 2019 Category: Rheumatology Source Type: research

Vertebral fragility fractures – How to treat them?
Publication date: Available online 16 May 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Manuela L. Ferreira, Lyn MarchAbstractApproximately 20% of men and women aged 50 years or older will present with a vertebral fragility fracture - a prevalence that steadily increases with age. The condition may be associated with severe pain and disability, significant reductions in overall quality of life, mobility, social participation, sleep quality and increased fear for the future. There is, however, no current consensus on what constitutes the best management of symptomatic vertebral fractures. Moreover...
Source: Best Practice and Research Clinical Rheumatology - May 16, 2019 Category: Rheumatology Source Type: research

Principles and current concepts in the surgical treatment of fragility fractures in the elderly
Publication date: Available online 14 May 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Sascha Halvachizadeh, Henrik Teuber, Hans-Christoph Pape, Florin AllemannAbstractThe constant rise in fragility fractures is proportional to the constant rise in life expectancy. Treatment of fragility fractures can be challenging because of severe fractures, poor bone quality, significant co-morbidities, and reduced mobility. However, new surgical techniques and implants have been developed that address these challenges and show improvement in overall patient outcomes. This review addresses general considerat...
Source: Best Practice and Research Clinical Rheumatology - May 16, 2019 Category: Rheumatology Source Type: research

Secondary fracture prevention: Drug treatment, fall prevention and nutrition requirements
Publication date: Available online 13 May 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): P. Geusens, W.F. Lems, S. Bours, J.P. vd BerghAbstractIn view of the high imminent risk for subsequent fractures, evaluation as early as possible after the fracture will result in early decisions about drug treatment, fall prevention and nutritional supplements.Drug treatment includes anti-resorptive and bone forming agents. Anti-resorptive therapy with broad spectrum fracture prevention and early anti-fracture effects are the first choice. In patients with multiple or severe VFs, the bone forming agent teripa...
Source: Best Practice and Research Clinical Rheumatology - May 14, 2019 Category: Rheumatology Source Type: research

New concepts of pain
Publication date: Available online 13 May 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Anne-Priscille Trouvin, Serge PerrotAbstractActive research is being conducted on musculoskeletal pain, and recent concepts will help clinicians and researchers to develop better approaches:-the new pain taxonomy recently has been modified with a third descriptor with the concept of nociplastic pain.-the latest International Classification of Diseases (ICD-11) includes an IASP task force that developed a new classification system for pain. In this new classification, one can differentiate primary musculoskelet...
Source: Best Practice and Research Clinical Rheumatology - May 14, 2019 Category: Rheumatology Source Type: research

Interdisciplinary care of hip fractures: Orthogeriatric models, alternative models, interdisciplinary teamwork
Publication date: Available online 30 April 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Anette Hylen Ranhoff, Ingvild Saltvedt, Frede Frihagen, Johan Raeder, Sameer Maini, Olav SletvoldAbstractHip fractures are common among older people, and the prognosis is serious in terms of mobility, independence in daily life activities, and cognition, with 42% of patients never achieving the same function as before the fracture. Norway has the highest incidence of hip fractures, and the important tasks are to improve patient care and prevent new fractures.The aim was to develop Norwegian Guidelines for In...
Source: Best Practice and Research Clinical Rheumatology - April 30, 2019 Category: Rheumatology Source Type: research

Opportunities and challenges in the treatment of psoriatic arthritis
Publication date: Available online 25 April 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Oliver FitzGerald, Christopher RitchlinAbstractIn this chapter, we review the opportunities and challenges posed by the treatment options currently available in the treatment of psoriatic arthritis. Both established and new or emerging treatment options are discussed using a domain-based approach. Finally, approaches to how treatment can be optimized together with some clinical pearls are presented and discussed. With the increasing treatment options available, we need a better way of deciding which treatmen...
Source: Best Practice and Research Clinical Rheumatology - April 26, 2019 Category: Rheumatology Source Type: research

Macrophagic myofasciitis-associated dysfunctioning: An update of neuropsychological and neuroimaging features
Publication date: Available online 24 April 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Mehdi Aoun Sebaiti, Marie Abrivard, Paul Blanc-Durand, Axel Van Der Gucht, Sarah Souvannanorath, Paul Kauv, Romain K. Gherardi, Emmanuel Itti, François Jérôme AuthierAbstractMacrophagic myofasciitis (MMF) syndrome is a subtype of autoimmune/inflammatory syndrome induced by adjuvants (ASIA) or Shoenfeld's syndrome, characterized by the presence of stereotyped inflammatory lesions at muscle biopsy attesting the long-term persistence of aluminum hydroxide particles at the site of previous im...
Source: Best Practice and Research Clinical Rheumatology - April 25, 2019 Category: Rheumatology Source Type: research

Preface: Pearls in autoimmunity
Publication date: Available online 22 April 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Carlo Perricone, Yehuda Shoenfeld (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - April 23, 2019 Category: Rheumatology Source Type: research

Hepatitis B and C infection in patients undergoing biologic and targeted therapies for rheumatic diseases
This article summarizes the prevalence and risk factors of hepatitis B and C reactivation in patients with rheumatic diseases undergoing biologic and targeted therapies, as well as the recommendations for screening, monitoring, and treatment of these infections. (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - April 20, 2019 Category: Rheumatology Source Type: research

The forefront of autoimmunity
Publication date: Available online 19 April 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Carlo Perricone, Yehuda Shoenfeld (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - April 20, 2019 Category: Rheumatology Source Type: research

Physical activity, exercise and rheumatoid arthritis: Effectiveness, mechanisms and implementation
Publication date: Available online 17 April 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): George S. Metsios, George D. KitasAbstractRheumatoid arthritis (RA) is characterised by functional disability, pain, fatigue and body composition alterations that can further impact on the physical dysfunction seen in RA. RA is also associated with systemic manifestations, most notably an increased risk for cardiovascular disease. There is strong evidence to suggest that increasing physical activity and/or exercise can simultaneously improve symptoms and reduce the impact of systemic manifestations in RA. Ho...
Source: Best Practice and Research Clinical Rheumatology - April 19, 2019 Category: Rheumatology Source Type: research

Myositis in clinical practice—relevance of new antibodies
Publication date: Available online 17 April 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Siamak Moghadam-Kia, Rohit Aggarwal, Chester V. OddisAbstractNovel classification schemes for idiopathic inflammatory myopathy are based on serologic and histopathologic features. The presence of specific myositis autoantibodies may correspond to particular clinical phenotypes. Patients with a known diagnosis of inflammatory myopathy require a prompt clinical evaluation and the assessment of myositis-associated autoantibodies. Patients possessing autoantibodies associated with ILD or those with any pulmonary...
Source: Best Practice and Research Clinical Rheumatology - April 19, 2019 Category: Rheumatology Source Type: research

Management of vaccination in rheumatic disease
Publication date: Available online 17 April 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Peter K.K. Wong, Patrick HanrahanAbstractAutoimmune inflammatory rheumatic diseases (AIIRD) such as rheumatoid arthritis and spondyloarthritis, including psoriatic arthritis and ankylosing spondylitis are associated with an increased risk of infection due to a combination of the immunosuppressive effect of the AIIRD, comorbidities, and use of corticosteroids and the immunosuppressive effect of conventional synthetic disease-modifying antirheumatic drugs (DMARDs), targeted synthetic (ts-) DMARDs, and biologic...
Source: Best Practice and Research Clinical Rheumatology - April 19, 2019 Category: Rheumatology Source Type: research

Management of pregnancy and lactation
Publication date: Available online 15 April 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Lisa R. Sammaritano, Bonnie L. BermasAbstractManagement of pregnancy in patients with rheumatic and musculoskeletal disorders is both challenging and rewarding. Most patients with rheumatic disease can have a successful pregnancy. Pregnancy outcome is improved when maternal autoimmune disease is stable or quiescent. Prepregnancy evaluation and counseling is important to identify risk factors for adverse maternal and pregnancy outcomes and to guide therapy and monitoring. Severe disease-related damage, diseas...
Source: Best Practice and Research Clinical Rheumatology - April 16, 2019 Category: Rheumatology Source Type: research

A comparison of a fluorescence enzyme immunoassay versus indirect immunofluorescence for initial screening of connective tissue diseases: Systematic literature review and meta-analysis of diagnostic test accuracy studies
Publication date: Available online 15 April 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Michelle Elaine Orme, Carmen Andalucia, Sigrid Sjölander, Xavier BossuytAbstractThe aim was to compare indirect immunofluorescence (IIF) and fluorescence enzyme immunoassay (FEIA) for initial screening of connective tissue diseases (CTDs) and to evaluate whether combining IIF with FEIA adds value.A comprehensive systematic literature review was conducted to identify fully paired, cross-sectional or case–control studies on ANA screening of CTD reporting results for IIF and FEIA. Study quality was a...
Source: Best Practice and Research Clinical Rheumatology - April 16, 2019 Category: Rheumatology Source Type: research

Checkpoint inhibitor-associated autoimmunity
Publication date: Available online 15 April 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Karim Ladak, Anne R. BassAbstractCheckpoint inhibitors (CI) have revolutionized the management of many cancers but can result in immune-related adverse events (IRAE). In this chapter, we review the clinical manifestations and management of the most common IRAE, plus less common IRAE, such as inflammatory arthritis, of particular interest to rheumatologists. We review the mechanism of action of CI, predictors of IRAE, and the impact of IRAE on cancer outcomes. The study of IRAE is in its infancy; there are ve...
Source: Best Practice and Research Clinical Rheumatology - April 16, 2019 Category: Rheumatology Source Type: research

Malignancy and rheumatoid arthritis: Epidemiology, risk factors and management
Publication date: Available online 15 April 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Diederik De Cock, Kimme HyrichAbstractRheumatoid arthritis (RA) is a chronic inflammatory condition that can result in pain and functional disability. It is also associated with an increased occurrence of comorbidities, including an increased risk of certain cancers such as lung cancer and lymphoma. The aetiopathogenesis of this increased cancer risk is likely multifactorial and includes shared risk factors as well as chronic inflammation. There is also a concern that the treatment for RA itself may increase...
Source: Best Practice and Research Clinical Rheumatology - April 16, 2019 Category: Rheumatology Source Type: research

Management of complex gout in clinical practice: Update on therapeutic approaches
Publication date: Available online 12 April 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Ravi K. Narang, Nicola DalbethAbstractIncreasing therapeutic options are available for gout management. Anti-inflammatory agents are used in the acute management of gout flares, and interleukin-1 inhibitors are effective for those unable to take conventional anti-inflammatory treatments. Lowering of serum urate remains the cornerstone of effective long-term management. Allopurinol is the first-line urate-lowering therapy, and a gradual dose-escalation strategy to serum urate target is recommended. Febuxostat...
Source: Best Practice and Research Clinical Rheumatology - April 14, 2019 Category: Rheumatology Source Type: research

Recent advances in spondyloarthritis
Publication date: Available online 13 April 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Denis Poddubnyy, Nigil Haroon (Source: Best Practice and Research Clinical Rheumatology)
Source: Best Practice and Research Clinical Rheumatology - April 14, 2019 Category: Rheumatology Source Type: research

An overview of biologic disease-modifying antirheumatic drugs in axial spondyloarthritis and psoriatic arthritis
Publication date: Available online 21 March 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Anthony So, Robert Davies InmanAbstractBiologic disease-modifying antirheumatic drugs (bDMARDs) are engineered proteins with high affinity for various proinflammatory immune mediators to reduce inflammation and its sequelae in various rheumatic diseases. These medications, introduced at the advent of the 21st century, have revolutionized the treatment of axial spondyloarthritis (including ankylosing spondylitis) and psoriatic arthritis. Currently approved bDMARDs for axial spondyloarthritis are etanercept, i...
Source: Best Practice and Research Clinical Rheumatology - March 21, 2019 Category: Rheumatology Source Type: research

A pragmatic approach to prevent post-traumatic osteoarthritis after sport or exercise-related joint injury
Publication date: Available online 14 March 2019Source: Best Practice & Research Clinical RheumatologyAuthor(s): Jackie L. Whittaker, Ewa M. RoosAbstractLower extremity musculoskeletal injuries are common in sport and exercise, and associated with increased risk of obesity and post-traumatic osteoarthritis (PTOA). Unlike other forms of osteoarthritis, PTOA is common at a younger age and associated with more rapid progression, which may impact career choices, long-term general health and reduce quality of life. Individuals who suffer an activity-related joint injury and present with abnormal joint morphology, elevated a...
Source: Best Practice and Research Clinical Rheumatology - March 15, 2019 Category: Rheumatology Source Type: research