Best Practice and Research. Clinical Obstetrics and Gynaecology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

WHO guidelines and the role of the physician in task sharing in safe abortion care
Publication date: Available online 29 July 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Caron Kim, Annik Sorhaindo, Bela GanatraAbstractGlobally, many women undergo unsafe abortion despite the fact that abortion is extremely safe when done in accordance with recommended guidelines. As such, a high number of women suffer from abortion-related complications and unsafe abortion remains an important cause of maternal mortality. The high percentage of unsafe abortion is attributed to the inability of women to access safe abortion services. A critical barrier to access is the lack of trained p...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - July 30, 2019 Category: OBGYN Source Type: research

Immunotherapy for Recurrent Pregnancy Loss
Publication date: Available online 30 July 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Howard CarpAbstractWhen immunomodulation is used on an unselected population with recurrent miscarriage (RM), there is no improvement the live birth rate. However, when the population is selected for a poor prognosis, or immune phenomena, immunotherapy has been shown to be effective. This review discusses four immunomodulatory agents, paternal leucocyte immunization, intravenous immunoglobulin (IVIG), intralipid and filgrastim. The presence of embryonic aneuploidy may confound the results of treatment...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - July 30, 2019 Category: OBGYN Source Type: research

Premature Ovarian Insufficiency and Autoimmune diseases
Publication date: Available online 29 July 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Noam Domniz, Dror MeirovAbstractPremature ovarian insufficiency (POI) is a clinical syndrome defined by loss of ovarian activity before the age of 40 years and has a potentially devastating effect upon woman's health, physically and psychologically. An underlying autoimmune disease has been identified at approximately 20% of POI patients, the most common of which are disorders of the thyroid and adrenals. Nevertheless, in the majority of cases, the etiology is unknown., the damage mechanism to the ova...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - July 29, 2019 Category: OBGYN Source Type: research

The Moral Imperative of Reproductive Rights, Health, and Justice
Publication date: Available online 29 July 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Willie J. ParkerAbstractReproductive health (abortion, contraception, sex education, and assisted reproductive technologies) is being eroded by regressive laws and policies shaped by political conservatism, both domestically and internationally. Framing this aspect of women’s health care as immoral, abortion opponents claim a moral high ground that results in a deference by reproductive health advocates who fail to raise moral arguments in rebuttal to these assertions, unnecessarily. This paper argu...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - July 29, 2019 Category: OBGYN Source Type: research

Preface: Volume 60
Publication date: Available online 20 July 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Howard Carp (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - July 26, 2019 Category: OBGYN Source Type: research

Use of immunomodulators to treat endometriosis
Publication date: Available online 29 June 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Alexander Kotlyar, Hugh Taylor, Thomas D'HoogheAbstractBoth animal and human studies have demonstrated that endometriosis involves numerous levels of immune dysfunction. From aberrant cytokine signaling to shifts in immune cell populations, it is clear that endometriosis develops in the setting of an elevated pro-inflammatory state. This elevated level of inflammation could exacerbate the morbidity seen in this chronic disease. Consequently, numerous immunomodulating therapies have been tested in both...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - July 20, 2019 Category: OBGYN Source Type: research

Preface
Publication date: Available online 20 July 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Howard Carp (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - July 20, 2019 Category: OBGYN Source Type: research

Progestogens and immunology
Publication date: Available online 5 July 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): J. Szekeres-Bartho, A.E. SchindlerAbstractFifty percent of fetal antigens are of paternal origin. These are recognized by the maternal immune system, thereby resulting in lymphocyte activation and the induction of progesterone receptors (PRs) in immune cells. Upon binding of progesterone to PRs on lymphocytes, a downstream mediator called progesterone-induced blocking factor (PIBF) is produced. The full-length PIBF is a 90 kDa protein; however, because of alternative splicing, several smaller isoforms...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - July 19, 2019 Category: OBGYN Source Type: research

Foreword abortion: Professional responsibility beyond safe healthcare
Publication date: Available online 2 July 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Mahmoud F. Fathalla (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - July 13, 2019 Category: OBGYN Source Type: research

First trimester termination of pregnancy
Publication date: Available online 12 July 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Man-Wa Lui, Pak-Chung HoAbstractFirst trimester termination of pregnancy (TOP) is a safe and effective procedure. The complete abortion rates of surgical and medical abortion are around 97% and 95% respectively. Vacuum aspiration (VA) either by electrical suction or manual aspiration is the method of choice for surgical TOP. Risk of significant bleeding is <= 5% in VA while major complications occur in <1%. The risk of infection after VA can be reduced significantly by the use of prophylactic ...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - July 13, 2019 Category: OBGYN Source Type: research

Progestogens and Immunology“
Publication date: Available online 5 July 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): J. Szekeres-Bartho, E. Schindler A.AbstractFifty per cent of fetal antigens are of paternal origin. These are recognized by the maternal immune system, resulting in lymphocyte activation and the induction of progesterone receptors in immune cells. Upon progesterone binding a downstream mediator called the progesterone induced blocking factor (PIBF) is produced. The full length PIBF is a 90 kDa protein, however, due to alternative splicing, several smaller isoforms are also produced. While the 90 kDa mo...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - July 7, 2019 Category: OBGYN Source Type: research

Providing medical abortion services through pharmacies: Evidence from Nepal
Publication date: Available online 5 July 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Mahesh C. PuriAbstractDespite the legalization of abortion in 2002, has made extensive efforts to expand services throughout the country, access to safe abortion care remains constrained in Nepal, particularly in remote areas where trained providers and equipment are scarce. Expanding access to medical abortion (MA) through pharmacy workers could be a promising avenue to reach such women with safe and convenient care but neither Nepali law nor World Health Organizations (WHO) recommended pharmacy provi...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - July 7, 2019 Category: OBGYN Source Type: research

Cervical cerclage in twin pregnancy
Publication date: Available online 4 July 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Xiaowu Huang, S.H. Saravelos, Tin-Chiu Li, Rui Huang, Ruonan Xu, Qiaoyun Zhou, Ning Ma, Enlan XiaAbstractCervical cerclage in women with twin pregnancy is not routinely indicated but appears to be beneficial in subjects with a history of preterm birth or very short cervix or dilated cervix. There is a paucity of literature data regarding transabdominal or laparoscopic cervical cerclage (LCC) in twin pregnancy. It is uncertain whether LCC is more effective than transvaginal cerclage. Our own experience ...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - July 5, 2019 Category: OBGYN Source Type: research

Endoscopic fetal surgery for neural tube defects
Publication date: Available online 29 June 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Denise Araujo LapaAbstractPrenatal repair of open spina bifida reduces shunt rates and may improve postnatal motor and neurodevelopmental outcomes. The hysterotomy required for the open fetal surgery leaves subsequent pregnancies at risk of uterine rupture. Hysterotomy site rupture confers significant morbidity and mortality risks for both mother and fetus. Fetoscopic repair is feasible and seems to achieve the same, postnatal neurological outcomes as those of the open repair. Fetoscopy can be accompl...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - July 4, 2019 Category: OBGYN Source Type: research

Emergency contraception and impact on abortion rates
Publication date: Available online 3 July 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): L. Michie, S.T. CameronAbstractEmergency contraception (EC) is a drug or a device that is taken after sexual intercourse to prevent unintended pregnancy. The most effective EC is the copper bearing intrauterine device (Cu-IUD) but oral EC methods are more commonly used and include a single dose of either levonorgestrel (1.5 mg) or ulipristal acetate (30mg). Although all EC methods are extremely safe, access to EC is often limited due to prevailing misconceptions over how EC works. Although EC can preve...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - July 4, 2019 Category: OBGYN Source Type: research