Pregnancy And Autoimmune Diseases
Publication date: Available online 14 November 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Emily C. SomersAbstractAutoimmune diseases (AID) are more prevalent in women than men, and pregnancy-related factors such as hormonal modulation and fetal microchimerism may influence future risk of maternal AID. For women with AID, optimizing reproductive health requires a continuum of multidisciplinary care that initiates well before the desire for pregnancy is articulated. Family planning is essential so that pregnancy can be timed when disease is stable and to allow for appropriate medication ...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 14, 2019 Category: OBGYN Source Type: research

Ong term outcome of children born from mothers with autoimmune diseases
Publication date: Available online 13 November 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Cecilia Nalli, Jessica Galli, Maria Grazia Lazzaroni, Laura Andreoli, Elisa Fazzi, Angela TincaniAbstractAutoimmune diseases often affect young women and this may represent a problem in the family planning. Pregnancies in these patients may carry several complications but nowadays the continue amelioration in treatment and management have greatly improved the pregnancy outcome. The main concern of these women obviously are the short- and long-term outcome of their children. A child born from a wom...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 13, 2019 Category: OBGYN Source Type: research

Immunology in obstetrics and gynaecology - Multiple choice questions Vol. 60
Publication date: October 2019Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 60Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 1, 2019 Category: OBGYN Source Type: research

Advances in reproductive surgery – Multiple choice answers Vol. 59
Publication date: October 2019Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 60Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 1, 2019 Category: OBGYN Source Type: research

Editorial Board
Publication date: October 2019Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 60Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 1, 2019 Category: OBGYN Source Type: research

Index
Publication date: October 2019Source: Best Practice & Research Clinical Obstetrics & Gynaecology, Volume 60Author(s): (Source: Best Practice and Research Clinical Obstetrics and Gynaecology)
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - November 1, 2019 Category: OBGYN Source Type: research

Contraception and preconception counseling in women with autoimmune disease
Publication date: Available online 8 October 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Lisa R. SammaritanoAbstractAppropriate contraception and preconception counseling are critical for women of reproductive age with systemic autoimmune diseases (AIDs) because clinical diagnosis, rheumatology medications, and disease activity may impact the safety or efficacy of certain contraceptives as well as the risk of adverse pregnancy outcomes. The presence of antiphospholipid (aPL) antibodies (anticardiolipin, anti-β2 glycoprotein I, and lupus anticoagulant) is the most important determinant ...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - October 26, 2019 Category: OBGYN Source Type: research

Assisted Reproductive Technologies For Women With Rheumatic Aid
Publication date: Available online 23 October 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Michael D. LockshinAbstractART procedures are safe for women with rheumatic autoimmune diseases (rAID) when illness is inactive. Medications incompatible with pregnancy should change to alternative, pregnancy-compatible medications months before planned ART procedures to allow time to verify the substitute medication’s efficacy and tolerability. Medications compatible with pregnancy should continue, as should anticoagulation (warfarin changing to low molecular weight heparin) before pregnancy beg...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - October 24, 2019 Category: OBGYN Source Type: research

Antiphospholipid syndrome: Diagnosis and management in the obstetric patient
Publication date: Available online 17 October 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Erol Arslan, D. Ware BranchAbstractAntiphospholipid syndrome (APS) is a rare condition characterized clinically by thrombotic events or pregnancy complications and confirmed by one or more repeatedly positive anti-phospholipid (aPL) antibodies on two or more occasions at least 12 weeks apart. Several factors are thought to have roles in pathogenesis of adverse obstetric events related to APS, including platelet and endothelial cell activation, complement activation, and ultimate activation of the t...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - October 18, 2019 Category: OBGYN Source Type: research

Pregnancy in Myositis and Scleroderma
Publication date: Available online 18 October 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Sirajum Munira, Lisa Christopher-StineAbstractMyositis and scleroderma are both rare autoimmune diseases with female predominance and often occur before and during reproductive years. The rarity of diseases explains the low frequency of concurrent disease and pregnancy. Like other autoimmune diseases, myositis and scleroderma may be more active during pregnancy as well. To date, many patients with myositis and scleroderma can have favorable pregnancy outcomes with careful management. This chapter p...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - October 18, 2019 Category: OBGYN Source Type: research

Pregnancy and rheumatoid arthritis
Publication date: Available online 9 October 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Emily Adele LittlejohnAbstractRheumatoid arthritis commonly affects women of childbearing age. Fertility, family planning, control of disease activity and birth outcomes are all important issues to be discussed at preconception counseling. New data has offered insight on trends of fertility, disease control during pregnancy, and birth outcomes. This chapter provides an updated overview on expected disease course and management issues at each juncture with a particular focus on maintenance of tight d...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - October 11, 2019 Category: OBGYN Source Type: research

Paternal safety of anti-rheumatic medications
Publication date: Available online 8 October 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Bonnie L. BermasAbstractResearch into the safety of medications used to treat rheumatic diseases in men wishing to conceive is lacking. When evaluating medication safety for potential fathers, there are two major reproductive issues to consider first whether a drug induces infertility and second whether a drug can cause adverse pregnancy outcomes. Cyclopshophamide is the only medication used in rheumatic disease management that causes irreversible infertility. All men prescribed cyclophosphamide sho...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - October 9, 2019 Category: OBGYN Source Type: research

Contraception and Pre-conception Counseling in Women with Autoimmune Disease
Publication date: Available online 8 October 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Lisa R. SammaritanoAbstractAppropriate contraception and preconception counseling are critical for women of reproductive age with systemic autoimmune diseases since clinical diagnosis, rheumatology medications, and disease activity may impact the safety or efficacy of certain contraceptives as well as the risk of adverse pregnancy outcomes. The presence of antiphospholipid antibodies (anticardiolipin, anti-β2 Glycoprotein I and lupus anticoagulant) is the most important determinant of contraception...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - October 9, 2019 Category: OBGYN Source Type: research

Pregnancy and Systemic Lupus Erythematosus
Publication date: Available online 8 October 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Michelle PetriAbstractAs SLE onset is often in young adulthood, pregnancy is common and is usually successful. Pregnancy, though, is considered high-risk due to a combination of maternal (lupus flare, diabetes, pre-eclampsia) and fetal (miscarriage, intrauterine fetal demise, preterm birth, intrauterine growth restriction, congenital heart block) risks.Pregnancy should be planned for a time of good control of SLE (on allowable medications). The antimalarial hydroxychloroquine should be continued. Th...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - October 9, 2019 Category: OBGYN Source Type: research

Autoimmune-Mediated Congenital Heart Block
Publication date: Available online 8 October 2019Source: Best Practice & Research Clinical Obstetrics & GynaecologyAuthor(s): Benjamin Wainwright, Rohit Bhan, Catherine Trad, Rebecca Cohen, Amit Saxena, Jill Buyon, Peter IzmirlyAbstractAutoimmune-mediated congenital heart block (CHB) is a severe manifestation of neonatal lupus in which conduction tissues of the fetal heart are damaged. This occurs due to passive transference of maternal Ro (SSA) and La (SSB) autoantibodies, and subsequent inflammation and fibrosis of the atrioventricular (AV) node. Notably, the disease manifests after the fetal heart has structurally devel...
Source: Best Practice and Research Clinical Obstetrics and Gynaecology - October 9, 2019 Category: OBGYN Source Type: research