Editorial Board
Publication date: June 2019Source: Best Practice & Research Clinical Endocrinology & Metabolism, Volume 33, Issue 3Author(s): (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - October 9, 2019 Category: Endocrinology Source Type: research

Autoimmune Polyglandular Diseases
Publication date: Available online 4 October 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): George J. Kahaly, Lara FrommerAbstractAutoimmune polyglandular diseases (APD) are defined as the presence of two autoimmune –induced endocrine failures. With respect to the significant morbidity and potential mortality of APD, the diagnostic objective is to detect APD at an early stage, with the advantage of less frequent complications, effective therapy and better prognosis. This requires that patients at risk be regularly screened for subclinical endocrinopathies prior to clinical ...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - October 5, 2019 Category: Endocrinology Source Type: research

Modern endocrine surgery – striving for a better quality of life
Publication date: Available online 28 September 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Henning Dralle, Frank Weber (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 29, 2019 Category: Endocrinology Source Type: research

Value of ileus-prophylactic surgery for metastatic neuroendocrine midgut tumours
Publication date: Available online 25 September 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Frank Weber, Henning DralleAbstractNeuroendocrine tumours of the small intestine (SINET) are a rare disease. However, a rising incidence rate and excellent long-term survival, even in the setting of metastatic disease lead to a high prevalence of SINET of up to 11/100.000. At the time of diagnosis, most patients already suffer from metastatic disease.About one third of patients demonstrate localized or regional metastatic disease at time of presentation. For those patients the indicatio...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 26, 2019 Category: Endocrinology Source Type: research

Editorial Board
Publication date: April 2019Source: Best Practice & Research Clinical Endocrinology & Metabolism, Volume 33, Issue 2Author(s): (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 25, 2019 Category: Endocrinology Source Type: research

The epidemiology, diagnosis and treatment of Prolactinomas: The old and the new
Publication date: April 2019Source: Best Practice & Research Clinical Endocrinology & Metabolism, Volume 33, Issue 2Author(s): Philippe Chanson, Dominique MaiterPrevalence and incidence of prolactinomas are approximately 50 per 100,000 and 3–5 new cases/100,000/year. The pathophysiological mechanism of hyperprolactinemia-induced gonadotropic failure involves kisspeptin neurons. Prolactinomas in males are larger, more invasive and less sensitive to dopamine agonists (DAs). Macroprolactin, responsible for pseudohyperprolactinemia is a frequent pitfall of prolactin assay.DAs still represent the primary therapy f...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 25, 2019 Category: Endocrinology Source Type: research

Autoimmune diseases and pregnancy
Publication date: Available online 11 September 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Angela Tincani, Cecilia Nalli, Jamilya Khizroeva, Victoria Bitsadze, Andrea Lojacono, Laura Andreoli, Yehuda Shoenfeld, Alexander MakatsariyaPregnancy in autoimmune diseases remains an argument of debate. In last years great improvements were done and with the correct medical support women with disease such as Systemic Lupus Erythematosus or Antiphospholipid Syndrome can afford a pregnancy and have healthy babies. The starting point is a good counselling. Women should be informed about ...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 19, 2019 Category: Endocrinology Source Type: research

Insights into the autoimmune aspect of premature ovarian insufficiency
Publication date: Available online 16 September 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Kassem Sharif, Abdulla Watad, Charlie Bridgewood, Darja Kanduc, Howard Amital, Yehuda ShoenfeldAbstractPremature ovarian insufficiency (POI) refers to a continuum of decreasing ovarian function in women before the age of 40. To date, the cause of POI in the majority of cases remain unresolved. Many cases has been linked to genetic, toxic, infections, enzymatic and iatrogenic causes.A key function of the immune system is to identify and differentiate “self” and “non sel...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 17, 2019 Category: Endocrinology Source Type: research

Treatment of patients with Graves' disease and the appropriate extent of thyroidectomy
Publication date: Available online 31 August 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Iuliana D. Bobanga, Christopher R. McHenryGraves' disease is an autoimmune disorder caused by thyroid stimulating auto-antibodies directed against the thyrotropin receptor on thyroid follicular cells. It is the most common cause of hyperthyroidism and is associated with cardiovascular, ophthalmologic and other systemic manifestations. Three treatment options are available for Graves' disease: anti-thyroid drugs, radioactive iodine and thyroidectomy. While thyroidectomy is the least common ...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 16, 2019 Category: Endocrinology Source Type: research

Prolactin and autoimmunity: the hormone as an inflammatory cytokine
Publication date: Available online 11 September 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Vânia Vieira Borba, Gisele Zandman-Goddard, Yehuda ShoenfeldAbstractNowadays, more than 80 autoimmune disorders are recognized, in which an aberrant immune response against different organs and tissues plays a crucial role. Hormonal homeostasis has great influence in achieving competent and healthy immune system function. Prolactin has a bioactive function acting as a hormone and a cytokine. It influences the immune system modulation, mainly inhibiting the negative selection of au...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 11, 2019 Category: Endocrinology Source Type: research

“Autoimmune Diseases and Pregnancy”
Publication date: Available online 11 September 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Angela Tincani, Cecilia Nalli, Jamilya Khizroeva, Victoria Bitsadze, Andrea Lojacono, Laura Andreoli, Yehuda Shoenfeld, Alexander MakatsariyaAbstractPregnancy in autoimmune diseases remains an argument of debate. In last years great improvements were done and with the correct medical support women with disease such as Systemic Lupus Erythematosus or Antiphospholipid Syndrome can afford a pregnancy and have healthy babies. The starting point is a good counselling. Women should be informe...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 11, 2019 Category: Endocrinology Source Type: research

Exacerbations of autoimmune diseases during pregnancy and postpartum
Publication date: Available online 11 September 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Vânia Vieira Borba, Gisele Zandman-Goddard, Yehuda ShoenfeldAbstractAutoimmune diseases represent a complex heterogeneous group of disorders that occur as a results of immune homeostasis dysregulation and loss of self-tolerance. Interestingly, more than 80% of the cases are found among women at reproductive age. Normal pregnancy is associated with remarkable changes in the immune and endocrine signaling required to tolerate and support the development and survival of the placenta ...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 11, 2019 Category: Endocrinology Source Type: research

Universal Screening For Thyroid Disease During Pregnancy Should Be Performed
Publication date: Available online 6 September 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Alex Stagnaro-Green, Allan Dong, Mary D. StephensonAbstractThyroid disease can significantly impact the pregnant woman and her child. Human and animal studies have firmly linked overt hypothyroidism and overt hyperthyroidism to miscarriage, preterm delivery and other adverse pregnancy outcomes. Overt hypothyroidism and overt hyperthyroidism affect 1% of all pregnancies. Treatment is widely available, and if detected early, results in decreased rates of adverse outcomes. Universal screeni...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 6, 2019 Category: Endocrinology Source Type: research

Constitutional delay of puberty versus congenital hypogonadotropic hypogonadism: genetics, management and updates
Publication date: Available online 5 September 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Taneli Raivio, Päivi J. MiettinenAbstractDelayed puberty (DP) affects approximately 2% of adolescents. In the vast majority of patients in both sexes, it is due to constitutional delay of growth and puberty (CDGP), a self-limited condition in which puberty starts later than usual but progresses normally. However, some CDGP patients may benefit from medical intervention with low-dose sex steroids or peroral aromatase inhibitor letrozole (only for boys). Other causes of DP include per...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 5, 2019 Category: Endocrinology Source Type: research

Management of disorders of sex development – With a focus on development of the child and adolescent through the pubertal years
This articles will discuss clinical and genetic diagnosis, decisions regarding sex of rearing, ethical dilemmas, medical management of the infant and of the child or adolescent presenting for the first time with a DSD. Surgical options, timing and management are outlined. (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 4, 2019 Category: Endocrinology Source Type: research

Contemporary surgical management of the Zollinger-Ellison syndrome in Multiple Endocrine Neoplasia type 1
Publication date: Available online 31 August 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Max B. Albers, Jerena Manoharan, Detlef K. BartschAbstractAbout 30% of patients with MEN1 develop a Zollinger-Ellison syndrome. Meanwhile it is well established that the causative gastrinomas are almost exclusively localized in the duodenum and not in the pancreas, MEN1 gastrinomas occur multicentric and are associated with hyperplastic gastrin cell lesions and tiny gastrin-producing micro tumors in contrast to sporadic duodenal gastrinomas. Regardless of the high prevalence of early lymph...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 2, 2019 Category: Endocrinology Source Type: research

Treatment of patients with Graves’ disease and the appropriate extent of thyroidectomy
Publication date: Available online 31 August 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Iuliana D. Bobanga, Christopher R. McHenryAbstractGraves’ disease is an autoimmune disorder caused by thyroid stimulating auto-antibodies directed against the thyrotropin receptor on thyroid follicular cells. It is the most common cause of hyperthyroidism and is associated with cardiovascular, ophthalmologic and other systemic manifestations. Three treatment options are available for Graves’ disease: anti-thyroid drugs, radioactive iodine and thyroidectomy. While thyroidectomy ...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 2, 2019 Category: Endocrinology Source Type: research

Impact of surgical volume and surgical outcome assessing registers on the quality of thyroid surgery
Publication date: Available online 31 August 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Neil Patel, David Scott-CoombesAbstractThe available evidence concerning the relationship between volume and outcome for thyroid surgery is assessed in this article. Morbidity forms the principal surrogate marker of thyroid surgery quality for which postoperative hypocalcaemia and recurrent laryngeal nerve injuries are most commonly reported upon. Whilst there is an abundance of published data for these outcomes, interpretation to recommend annual volume thresholds is challenging. This is ...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 2, 2019 Category: Endocrinology Source Type: research

Surgical approach to the substernal goiter
This article addresses the important anatomical considerations when resecting a large substernal goiter, and also reviews various extracervical approaches. (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - August 23, 2019 Category: Endocrinology Source Type: research

Puberty
Publication date: Available online 31 July 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Margaret Zacharin (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - August 15, 2019 Category: Endocrinology Source Type: research

Impact of fluorescence and autofluorescence on surgical strategy in benign and malignant neck endocrine diseases
Publication date: Available online 10 August 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Anatoliy V. Rudin, Eren BerberAbstractFluorescence and autofluorescence have been shown by several recent studies to be valuable adjuncts in identifying parathyroid glands during thyroidectomy and parathyroidectomy. The aim of this chapter is to review the impact of this new technology on surgical strategy concerning preservation of parathyroid glands during thyroidectomy, identification of hyperactive parathyroid glands in hyperparathyroidism, and their potential role in advanced thyroid ...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - August 11, 2019 Category: Endocrinology Source Type: research

The role of intraoperative parathyroid hormone (IOPTH) determination for identification and surgical strategy of sporadic multiglandular disease in primary hyperparathyroidism (pHPT)
Publication date: Available online 8 August 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Jagdeep Singh Bhangu, Philipp RissAbstractIntraoperative PTH monitoring (IOPTH) made minimally invasive parathyroidectomy in patients with primary HPT possible. However, with the increasing accuracy of preoperative localization studies there is a growing discussion if IOPTH is necessary in patients with localized single gland disease (concordant preoperative localization studies). Different interpretation criteria have been developed – each with their particular advantages and disadva...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - August 9, 2019 Category: Endocrinology Source Type: research

The burden of disease for pituitary patients
Publication date: Available online 2 August 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Nienke R. BiermaszAbstractPituitary diseases are rare conditions with severe chronic multiorgan and multisystemic morbidity requiring complex multidisciplinary treatment and usually life-long drug treatment. Most cases are caused by functioning or non-functioning pituitary adenoma. From the patient’s perspective, the burden of disease is caused by the tumour itself and associated compression symptoms, interventions, hormone excess and deficiencies, systemic manifestations of these end...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - August 4, 2019 Category: Endocrinology Source Type: research

Update in pituitary disorders
Publication date: Available online 2 August 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Philippe Chanson (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - August 4, 2019 Category: Endocrinology Source Type: research

Preface: Puberty
Publication date: Available online 31 July 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Margaret Zacharin (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - August 1, 2019 Category: Endocrinology Source Type: research

The optimal surgical techniques for pituitary tumors
Publication date: Available online 27 July 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): M. Buchfelder, S.M. Schlaffer, Y. ZhaoAbstractIn this paper, the currently used and well evaluated techniques for the surgery of pituitary tumors will be reviewed. Since the first surgical approaches to pituitary tumors more than 100 years have elapsed. Various surgical techniques have been developed, refined and standardized. Most of these tumors are to date treated via transsphenoidal approaches. Many pituitary adenomas, particularly, smaller, enclosed ones, can be completely excised and a...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - July 29, 2019 Category: Endocrinology Source Type: research

Surgical approaches and results of treatment for hereditary paragangliomas
Publication date: Available online 27 July 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Maurizio Iacobone, Amanda Belluzzi, Francesca TorresanAbstractParagangliomas (PGL) are rare neuroendocrine tumours; parasympathetic PGL are predominantly non-secreting and located at the skull base and neck, while sympathetic PGL are typically catecholamine-secreting and located at abdomino-pelvic level. Approximately 40% of PGL may be caused by germline mutations; hereditary variants should be suspected especially in case of positive family history, early onset, multifocal, or recurrent PGL...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - July 29, 2019 Category: Endocrinology Source Type: research

Endocrine disrupters and possible contribution to pubertal changes
Publication date: Available online 27 July 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Julie Fudvoye, David Lopez-Rodriguez, Delphine Franssen, Anne-Simone ParentAbstractThe onset of puberty strongly depends on organizational processes taking place during the fetal and early postnatal life. Therefore, exposure to environmental pollutants such as Endocrine disrupting chemicals (EDCs) during critical periods of development can result in delayed/advanced puberty and long-term reproductive consequences. Human evidence of altered pubertal timing after exposure to endocrine disrupti...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - July 29, 2019 Category: Endocrinology Source Type: research

MANAGEMENT OF DISORDERS OF SEX DEVELOPMENT With a focus on development of the child and adolescent through the pubertal years
This articles will discuss clinical and genetic diagnosis, decisions regarding sex of rearing, ethical dilemmas, medical management of the infant and of the child or adolescent presenting for the first time with a DSD. Surgical options, timing and management are outlined. (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - July 29, 2019 Category: Endocrinology Source Type: research

Volume–outcome relationship in adrenal surgery: A review of existing literature
Publication date: Available online 12 July 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Hadiza S. Kazaure, Julie A. SosaThe relationship between operative volume and perioperative outcomes after several oncologic operations is well documented. Recent studies on adrenalectomy reveal a robust association between higher surgeon volume and improved patient outcomes. Statistical analyses have demonstrated that outcomes are improved when surgeons perform at least six adrenalectomies annually; based on this threshold definition of a ‘high-volume’ surgeon, more than 80% of ...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - July 20, 2019 Category: Endocrinology Source Type: research

Primary Gonadal Failure
Publication date: Available online 12 July 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Dr Asmahane Ladjouze, Dr Malcolm DonaldsonAbstractThe term primary gonadal failure encompasses not only testicular insufficiency in 46,XY males and ovarian insufficiency in 46,XX females, but also those disorders of sex development (DSD) which result in gender assignment that is at variance with the genotype and gonadal type. In boys, causes of gonadal failure include Klinefelter and other aneuploidy syndromes, bilateral cryptorchidism, testicular torsion, and forms of 46,XY DSD such as part...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - July 13, 2019 Category: Endocrinology Source Type: research

Volume-Outcome Relationship in Adrenal Surgery: A Review of Existing Literature
Publication date: Available online 12 July 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Hadiza S. Kazaure, Julie A. SosaAbstractThe relationship between operative volume and perioperative outcomes after several oncologic operations is well documented. Recent studies on adrenalectomy reveal a robust association between higher surgeon volume and improved patient outcomes. Statistical analyses have demonstrated that outcomes are improved when surgeons perform at least six adrenalectomies annually; based on this threshold definition of a ‘high-volume’ surgeon, more than...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - July 13, 2019 Category: Endocrinology Source Type: research

Pre- and intraoperative diagnostic requirements, benefits and risks of minimally invasive and robotic surgery for neuroendocrine tumors of the pancreas
Publication date: Available online 10 July 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Joseph Gharios, Elisabeth Hain, Anthony Dohan, Fréderic Prat, Benoit Terris, Jérôme Bertherat, Romain Coriat, Sébastien GaujouxAbstractPancreatic neuroendocrine tumours (PanNET) are rare tumours, accounting for 1% to 2% of all pancreatic neoplasms. These tumors are classified as functioning neuroendocrine tumours (F-PanNETs) or non-functioning (NF-PanNETs) depends on whether the tumour is associated with clinical hormonal hypersecretion syndrome or not. In the last...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - July 11, 2019 Category: Endocrinology Source Type: research

The Epidemiology, Diagnosis And Treatment Of Prolactinomas:The Old And The New
Publication date: Available online 10 July 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Philippe Chanson, Dominique MaiterAbstractPrevalence and incidence of prolactinomas are approximately 50 per 100,000 and 3-5 new cases/100,000/year. The pathophysiological mechanism of hyperprolactinemia-induced gonadotropic failure involves kisspeptin neurons. Prolactinomas in males are larger, more invasive and less sensitive to dopamine agonists (DAs). Macroprolactin, responsible for pseudohyperprolactinemia is a frequent pitfall of prolactin assay.DAs still represent the primary therapy ...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - July 11, 2019 Category: Endocrinology Source Type: research

Endoscopic, transanal, laparoscopic, and transabdominal management of rectal neuroendocrine tumors
Publication date: Available online 9 July 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Louis de Mestier, Diane Lorenzo, Caroline Fine, Jérôme Cros, Olivia Hentic, Thomas Walter, Yves Panis, Anne Couvelard, Guillaume Cadiot, Philippe RuszniewskiAbstractRectal neuroendocrine tumors (RNET) are rare tumors but their prevalence is constantly increasing due to a prolonged survival and rising incidence related to a growing number of colonoscopies and improved knowledge. Their main prognostic determinant is tumor stage. While most RNET are localized, their management shoul...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - July 10, 2019 Category: Endocrinology Source Type: research

The surgical dilemma of primary surgery for follicular thyroid neoplasms
Publication date: Available online 9 July 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Julia I. Staubitz, Petra B. Musholt, Thomas J. MusholtAbstractFollicular thyroid carcinoma is the second most prevalent form of differentiated thyroid carcinoma, following papillary thyroid carcinoma. Preoperative diagnosis is hampered by the fact that fine-needle aspiration cytology as well as supplemental molecular analysis cannot unambiguously distinguish between follicular thyroid carcinoma and benign follicular thyroid adenoma. The 2017 WHO classification defines three histological subty...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - July 10, 2019 Category: Endocrinology Source Type: research

Female Fertility preservation in DSD
Publication date: Available online 9 July 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Dr Rashi Kalra, Dr Melissa Cameron, Catharyn SternAbstractDisorders of sex development (DSD) are a group of complex conditions that can affect chromosomal, gonadal, and/or phenotypical sex with a highly variable fertility potential amongst affected individuals. In this review we discuss fertility issues facing patients affected by DSD and Turner syndrome and summarise the literature on fertility and reproductive outcomes. We will also discuss fertility preservation prior to gonadotoxic treatm...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - July 10, 2019 Category: Endocrinology Source Type: research

The impact of childhood cancer and its treatment on puberty and subsequent hypothalamic pituitary and gonadal function, in both boys and girls
Publication date: Available online 9 July 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Christina Wei, Elizabeth CrowneAbstractChildhood cancer survivors (CCS) are at an increased risk of endocrine disorders. Disorders of the hypothalamic-pituitary-gonadal (HPG) axis are a particular concern because of their impact on pubertal development and future fertility and may be of central (hypothalamic or pituitary damage) or primary (gonadal) origin. Hypogonadism may present as pubertal disorders during adolescence and subsequent infertility in adulthood but should be anticipated to en...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - July 10, 2019 Category: Endocrinology Source Type: research

Volume–outcome relationship in parathyroid surgery
ConclusionsThere are insufficient data to dogmatically conclude a minimum number of cases required to achieve optimal surgical results. However, extrapolation from the inclusive studies support the conclusions that higher operative volumes improve cure rates and decrease the rates of complications, recurrent disease, and perioperative costs. Endocrine Surgery fellowships or mentorships may help prepare the less experienced surgeon for successful outcomes. Although reticent to offer firm minimal volume requirements, we have made suggestions in this manuscript. (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - July 7, 2019 Category: Endocrinology Source Type: research

Volume-Outcome Relationship in Parathyroid Surgery
ConclusionsThere are insufficient data to dogmatically conclude a minimum number of cases required to achieve optimal surgical results. However, extrapolation from the inclusive studies support the conclusions that higher operative volumes improve cure rates and decrease the rates of complications, recurrent disease, and perioperative costs. Endocrine Surgery fellowships or mentorships may help prepare the less experienced surgeon for successful outcomes. Although reticent to offer firm minimal volume requirements, we have made suggestions in this manuscript. (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - June 17, 2019 Category: Endocrinology Source Type: research

Editorial Board
Publication date: February 2019Source: Best Practice & Research Clinical Endocrinology & Metabolism, Volume 33, Issue 1Author(s): (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - June 16, 2019 Category: Endocrinology Source Type: research

Hemithyroidectomy for benign euthyroid asymmetric nodular goitre
ConclusionsAMNG is a common clinical and surgical problem. Depending on the extent of the disease and individual surgeon preferences, either unilateral or bilateral thyroidectomy can be performed. Hemithyroidecomy can be considered for some patients with AMNG and the low risk of recurrent disease as a safer alternative to total thyroidectomy but it requires life-long follow-up, is associated with a higher recurrence risk and a need for revision thyroidectomy in selected subjects. (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - June 16, 2019 Category: Endocrinology Source Type: research

Gynaecology problems in puberty
Publication date: Available online 14 June 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Sonia R. Grover, DirectorAbstractWith the onset of puberty a range of problems may be encountered by the young girl. Some of these include a range of gynaecological issues relating to delayed onset of puberty, delayed menarche, atypical pubertal changes and the identification of anomalies of the genital tract. The distinction between physiological events and pathological problems is important to avoid unnecessary distress and anxiety. The onset of cyclic hormonal changes also provokes a numb...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - June 16, 2019 Category: Endocrinology Source Type: research

Impact of continuous intraoperative vagus stimulation on intraoperative decision making in favor of or against bilateral surgery in benign goiter
Publication date: Available online 6 June 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Rick Schneider, Andreas Machens, Gregory Randolph, Dipti Kamani, Kerstin Lorenz, Henning DralleAbstractThe advent of continuous vagus stimulation (CVS), eliminating lag time between nerve preparation with potential trauma and stimulation, has transformed the intraoperative surgical strategy in thyroid surgery. Continuous intraoperative nerve monitoring empowers the surgeon to be optimally aware of traction-related injury to the recurrent laryngeal nerve (RLN). Electromyographic precursor lesi...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - June 7, 2019 Category: Endocrinology Source Type: research

Value of monopolar and bipolar radiofrequency ablation for the treatment of benign thyroid nodules
Publication date: Available online 6 June 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Harald Dobnig, Karin AmreinAbstractOnly a few thyroid nodules are perceived as functional or optically disturbing. If there is a need for action, surgical intervention is the long-term standard by which thermoablative procedures (radiofrequency-, laser-, microwave ablation, high intensity focused ultrasound) must be measured against in terms of safety, effectiveness and patient satisfaction. Prior to intervention assessment of the dignity of the nodule by ultrasound-guided fine needle aspirat...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - June 7, 2019 Category: Endocrinology Source Type: research

Indications, Benefits And Risks Of Transoral Thyroidectomy
Publication date: Available online 4 June 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Daqi Zhang, Dawon Park, Hui Sun, Angkoon Anuwong, Ralph Tufano, Hoon Yub Kim, Gianlorenzo DionigiAbstractThe advancement of minimally invasive surgery in the field of endocrine surgery over the last 2 decades has fostered the attempt of natural orifice transluminal endoscopic surgery (NOTES) for thyroidectomy and parathyroidectomy via oral incisions. This technically demanding surgery is currently being evaluated in a number of specialised centres. The procedure has gained popularity worldwid...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - June 4, 2019 Category: Endocrinology Source Type: research

Surgical Management of the Compromised Recurrent Laryngeal Nerve in Thyroid Cancer
Publication date: Available online 4 June 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Marika D. Russell, Dipti Kamani, Gregory W. RandolphAbstractSurgical management of thyroid cancer requires careful consideration of the recurrent laryngeal nerve and its impact on glottic function. Management of the compromised recurrent laryngeal nerve is a complex task, requiring synthesis of multiple elements. The surgeon must have an appreciation for preoperative recurrent laryngeal nerve function, intraoperative anatomic and electromyographic information, disease characteristics, and rel...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - June 4, 2019 Category: Endocrinology Source Type: research

Risk-Oriented Concept of Treatment for Intrathyroid Papillary Thyroid Cancer
Publication date: Available online 4 June 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Dana M. Hartl, Julien Hadoux, Joanne Guerlain, Ingrid Breuskin, Fabienne Haroun, Sophie Bidault, Sophie Leboulleux, Livia LamartinaAbstractAdapting treatment and follow-up according to the risk of recurrence and/or death from thyroid cancer is a relatively recent concept of “personnalized” medicine, developed particularly to avoid overtreatment of low-risk thyroid cancer which represents the majority of thyroid cancers diagnosed in the world today. For low-risk thyroid cancer, thi...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - June 4, 2019 Category: Endocrinology Source Type: research

Modern neuro-ophthalmological evaluation of patients with pituitary disorders
Publication date: Available online 30 May 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Anne-Laure Vié, Gérald RaverotAbstractPituitary adenomas can manifest as ophthalmological symptoms, such as decreased vision, impaired visual field or diplopia. It is important to recognize these neuro-ophthalmological syndromes to achieve early diagnosis and treatment and to improve prognosis. Currently, ophthalmological examination includes precise measuring instruments, such as optical coherence tomography (OCT), which allows the evaluation of optic atrophy related to compres...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - May 31, 2019 Category: Endocrinology Source Type: research

Modern Imaging of Pituitary Adenomas
This article reviews current recommendations for imaging of PA, examines the potential added value that alternative MR sequences and/or CT can offer, and considers how the use of functional/molecular imaging might allow definitive treatment to be recommended for a subset of patients who would otherwise be deemed unsuitable for (further) surgery and/or RT. (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - May 29, 2019 Category: Endocrinology Source Type: research