Effects of Ojeok ‐san on the Pharmacokinetics of Celecoxib at Steady‐state in Healthy Volunteers
Abstract Ojeok‐san is a frequently used herbal medication for the management of osteoarthritic pain. We evaluated the effect of Ojeok‐san on the pharmacokinetics of celecoxib at steady‐state in healthy individuals. An open‐label, fixed‐sequence, two‐period, two‐treatment cross‐over study was conducted. In period I, the individuals received celecoxib capsule 200 mg once daily for 4 days. In period II, only Ojeok‐san (14.47 g/pack, three times daily) was administered for 4 days, followed by co‐administration with celecoxib for 4 days. On the fourth (final) day of administration, Ojeok‐san was administer...
Source: Basic and Clinical Pharmacology and Toxicology - March 15, 2018 Category: Drugs & Pharmacology Authors: Sang ‐In Park, Ji‐Young Park, Min‐Ju Park, Sung‐Vin Yim, Bo‐Hyung Kim Tags: Original Article Source Type: research

The Sphingosine 1 ‐Phosphate Analogue FTY720 Alleviates Seizure‐induced Overexpression of P‐Glycoprotein in Rat Hippocampus
Basic&Clinical Pharmacology&Toxicology,Volume 123, Issue 1, Page 14-20, July 2018. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - March 13, 2018 Category: Drugs & Pharmacology Authors: Fei Gao , Ying Gao , Fangling Meng , Chunmei Yang , Jiangfeng Fu , Yajun Li Source Type: research

The Sphingosine 1 ‐Phosphate Analogue FTY720 Alleviates Seizure‐induced Overexpression of P‐Glycoprotein in Rat Hippocampus
Basic&Clinical Pharmacology&Toxicology, EarlyView. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - March 13, 2018 Category: Drugs & Pharmacology Source Type: research

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Basic&Clinical Pharmacology&Toxicology, Ahead of Print. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - March 13, 2018 Category: Drugs & Pharmacology Source Type: research

The Sphingosine 1 ‐Phosphate Analogue FTY720 Alleviates Seizure‐induced Overexpression of P‐Glycoprotein in Rat Hippocampus
In this study, we tested the hypothesis that FTY720, a sphingosine 1‐phosphate (S1P) analogue used for treating multiple sclerosis, modulates the up‐regulation of P‐gp and improves brain delivery of phenytoin (PHT) through S1P receptor 1 in the hippocampus of a pilocarpine‐induced rat model of status epilepticus (SE). We administered vehicle, FTY720 or FTY720+ W146 (an S1P receptor 1 antagonist) to SE rats. Forty‐eight hours after SE, we dissected the hippocampus and measured P‐gp expression, NF‐κB activity and levels of inflammatory mediators (TNF‐α and COX‐2) by Western blotting and enzyme‐linked im...
Source: Basic and Clinical Pharmacology and Toxicology - March 13, 2018 Category: Drugs & Pharmacology Authors: Fei Gao, Ying Gao, Fangling Meng, Chunmei Yang, Jiangfeng Fu, Yajun Li Tags: Original Article Source Type: research

Issue Information
Basic&Clinical Pharmacology&Toxicology,Volume 122, Issue 4, Page 365-366, April 2018. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - March 12, 2018 Category: Drugs & Pharmacology Source Type: research

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Basic&Clinical Pharmacology&Toxicology,Volume 122, Issue 4, Page 365-366, April 2018. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - March 12, 2018 Category: Drugs & Pharmacology Source Type: research

Issue Information
(Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - March 12, 2018 Category: Drugs & Pharmacology Tags: Issue Information Source Type: research

Prognostic Factors in Acute Aluminium Phosphide Poisoning: A Risk ‐Prediction Nomogram Approach
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - March 12, 2018 Category: Drugs & Pharmacology Authors: Esmaeil Farzaneh, Hassan Ghobadi, Mahdieh Akbarifard, Samaneh Nakhaee, Alireza Amirabadizadeh, Ghodrat Akhavanakbari, Daniel E. Keyler, Omid Mehrpour Tags: Original Article Source Type: research

CYP Induction and Xeno ‐Sensing Receptors PXR, CAR, AHR and PPARα at the Crossroads of Toxicokinetics and Toxicodynamics
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - March 12, 2018 Category: Drugs & Pharmacology Authors: Jukka Hakkola, Camilla Bernasconi, Sandra Coecke, Lysiane Richert, Tommy B Andersson, Olavi Pelkonen Tags: Mini ‐Review Source Type: research

Pharmacokinetics of Tildrakizumab (MK ‐3222), an Anti‐IL‐23 Monoclonal Antibody, Following Intravenous or Subcutaneous Administration in Healthy Subjects
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - March 6, 2018 Category: Drugs & Pharmacology Authors: Sauzanne Khalilieh, Peter Hodsman, Christine Xu, Anjela Tzontcheva, Shirley Glasgow, Diana Montgomery Tags: Original Article Source Type: research

Statins do not Increase the Rate of Bleeding among Warfarin Users
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - March 5, 2018 Category: Drugs & Pharmacology Authors: Maarit Jaana Korhonen, Pekka Tiittanen, Helena Kastarinen, Arja Helin ‐Salmivaara, Milka Hauta‐aho, Maria Rikala, Risto Huupponen Tags: Original Article Source Type: research

Use of Dicloxacillin and Risk of Pregnancy among Users of Oral Contraceptives
In conclusion, our study found no evidence for an increased risk of oral contraceptive failure when using dicloxacillin. However, acknowledging study limitations, we suggest use of supplementary barrier methods during treatment with dicloxacillin, until our findings are confirmed in further studies. This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - March 5, 2018 Category: Drugs & Pharmacology Authors: Anton Potteg ård, Anne Broe, Tore B. Stage, Kim Brøsen, Jesper Hallas, Per Damkier Tags: Original Article Source Type: research

Inhibition of In Vitro Metabolism of Opioids by Skeletal Muscle Relaxants
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - March 5, 2018 Category: Drugs & Pharmacology Authors: David E. Moody, Yueqiao Fu, Wenfang B. Fang Tags: Original Article Source Type: research

A Cross ‐Sectional Study to Assess the Modulation of Wnt Inhibitors following Anti‐Epileptic Drug Therapy and their Correlation with Vitamin‐D and RANKL in Indian Women with Epilepsy
This article is protected by copyright. All rights reserved. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - March 5, 2018 Category: Drugs & Pharmacology Authors: Bushra Parveen, Manjari Tripathi, Divya Vohora Tags: Original Article Source Type: research