Human Leukocyte Antigen: Class I Allele Frequencies and Haplotype Distributionin a Tertiary Care Hospital in Bangladesh
Human leukocyte antigen (HLA) are cell surface glycoproteins encoded by Major Histocompatibility Complex (MHC) geneof human genome. HLA antigen frequency and haplotype distribution are useful for determining disease associations, origin, migration and genetic relationships between populations and predicting the outcome of transplantation. Thus, the present study was carried outto identify HLA class I (HLA-A and HLA-B) antigen and haplotype distribution among a selected Bangladeshi population. This retrospective study was conducted among 1070 individuals who were referred by cliniciansfor HLA typing at the Tissue Typing Lab...
Source: Bangladesh Medical Research Council Bulletin - June 6, 2018 Category: International Medicine & Public Health Source Type: research

Disseminated Herpes Zoster in a Patient with Acute Lymphoblastic Leukaemia: A case study
Varicella zoster virus (VZV) is a member of Herpesviridae family. It can cause two distinct clinical entities: varicella (chickenpox) and herpes zoster (shingles).1,2Herpes Zoster(HZ) is painful, vesicular rash in a limited area on one side of body due to the reactivation of latent VZV in dorsal root ganglia.Involvement of three or more dermatomes is known as disseminated zoster and seen in immunocompromised individuals.It can occur at any age. The risk of herpes zoster increases with old age and in patients with reduced cell mediated immunity such as haematological malignancies, immunosuppressive therapies, HIV infection ...
Source: Bangladesh Medical Research Council Bulletin - June 6, 2018 Category: International Medicine & Public Health Source Type: research

Outcome of Surgical Induction of Labourin a Combined Military Hospital
This study was aimed to assess the effectiveness and safety of surgical induction of labour in term and postdated pregnancy.This prospective clinical study was conducted in the in-patient Department of Obstetrics and Gynecology, Combined Military Hospital (CMH), Dhaka from July, 2005 to June 2006. A total of 100 pregnant women with term and postdated pregnancy were selected for the study by simple random sampling. The particulars of the patient, detailed menstrual and obstetric history, induction delivery interval, mode of delivery and foetal outcome and maternal complications were recorded. The results were analysed by St...
Source: Bangladesh Medical Research Council Bulletin - June 6, 2018 Category: International Medicine & Public Health Source Type: research

Gastroesophageal Reflux Disease: Prevalence and ItsRisk Factors in Rural Bangladesh
Gastroesophageal Reflux Disease (GERD) is a global disease, and evidence suggests that its prevalence is increasing. Prevalence estimates show considerable geographic variation.According to WHO, prevalence of GERD in far EastAsia currently consistently lower than 10%,which is 8-20% in India. No such population based dataare available in Bangladesh. Thus, the studywas designed to determine the prevalence of GERD and its risk factors inrural community of Bangladesh.This descriptive, cross-sectional study was carried outfrom January to June 2015 by using validated questionnaire through door to door interview among randomly se...
Source: Bangladesh Medical Research Council Bulletin - June 6, 2018 Category: International Medicine & Public Health Source Type: research

Perceptions on Breast Cancer Pattern: Medical Help Seeking Among Breast Cancer Patients
Perception on breast cancer influences the help seeking pattern of breast cancer patients. Negative perception causes delay in help seeking. Outcome or survival rate of breast cancer has a relation on perception. A cross sectional study was done during July 2015-June 2016, to assess the perception on breast cancer and to find out the help seeking pattern and extent of help seeking time among breast cancer patients. A total of 200 patients were selected following the convenient method of sampling from National Institute of Cancer Research and Hospital. Dhaka. Face to face interviews were taken from the diagnosed breast canc...
Source: Bangladesh Medical Research Council Bulletin - June 6, 2018 Category: International Medicine & Public Health Source Type: research

Cockroach Associated Foodborne Pathogens: Distribution and Antibiogram
Cockroaches are among the most common pests in public dwellings and health facilities. Owing to their close association with man and all his surroundings they are consideredas potential carrier and transmitter of human diseases. In hospital, cockroaches are the possible vector of nosocomial infection, specially for the transmission of drug resistant bacteria. The aim of the present study was to identify the major cockroach species, to isolate common foodborne pathogens from cockroach and to determine the antibiotic susceptibility pattern of isolated bacteria. This casecontrol study was conducted on cockroaches captured fro...
Source: Bangladesh Medical Research Council Bulletin - June 6, 2018 Category: International Medicine & Public Health Source Type: research

Triple-phase multidetector computed tomography:an evaluation of hepatic space occupying lesion in cirrhotic patients
Hepatocellular carcinoma (HCC) is a common tumor with an incidence of 1 - 6 % among cirrhotic patients. Dysplastic nodule often occurs within regenerative cirrhotic nodules. They can show low or high grade dysplasia. MRI best differentiates this iso-or hypo intense lesion from hyper intense HCC. The current study was designed to assess the usefulness of Triple-phase multiphasic multidetector computed tomography (MDCT) in evaluation of hepatic space occupying lesion in cirrhotic patients.This cross sectional study was carried out in Radiology and Imaging department in collaboration with Hepatology and Hepatobiliary surgery ...
Source: Bangladesh Medical Research Council Bulletin - June 6, 2018 Category: International Medicine & Public Health Source Type: research

Current Trend of Caesarean Section in a Tertiary Care Military Hospital
Caesarean section rates are increasing worldwide. It contributes to substantial maternal and perinatal morbidity and mortality.South Asian countries including Bangladesh have recorded substantial increases in caesarean sectionrates over the past decade. In Bangladesh, the caesarean incidence rate was 2.6 percent in 2001 and 12.2 percent in 2010. So, the incidence rate increased five times over the last decade.This descriptive cross sectional study was conducted at Combined Military Hospital (CMH), Savar, Dhaka during January 2014 to December 2015, aimed to assess the current trend of mode of deliveries of babies. A total o...
Source: Bangladesh Medical Research Council Bulletin - June 6, 2018 Category: International Medicine & Public Health Source Type: research

Risk Factors of Major Depressive Disorder in Parkinson ’s Disease
Depression in idiopathic Parkinson ’s disease is highly prevalent that can significantly impair the quality of life. Its exact mechanism of development is still poorly understood. It is well studied in western population but data from Asia especially in the South Asian region is limited. Considering this, to identify the potential risk factors of depression,a cross-sectional study was conducted among Parkinson’s disease patients attending a tertiary care hospital in Bangladesh between July 2013-June 2014, in the Department of Neurology, ShaheedSuhrawardy Medical College and Hospital in Dhaka, Bangladesh. One hu...
Source: Bangladesh Medical Research Council Bulletin - June 6, 2018 Category: International Medicine & Public Health Source Type: research

Clinical Evaluation of Scalpel Er: YAG Laser 2940nm and Conventional Surgery Incisions Wound After Oral Soft Tissue Biopsy
(Source: Bangladesh Medical Research Council Bulletin)
Source: Bangladesh Medical Research Council Bulletin - April 17, 2018 Category: International Medicine & Public Health Source Type: research

Kawasaki Disease Hospitalization: Outcomes in Two Tertiary Care Hospitals in Bangladesh
Kawasaki disease (KD) is an acute self-limiting inflammatory disease associated with vasculities, affecting predominantly medium sized vessels and encountered these cases infrequently in clinical practice. The most concerning complication is coronary artery aneurysm (CAA) leading to myocardial infarction or sudden death. Fever is the essential feature. Kawasaki disease is invariably associated with an inflammatory process with elevated C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and white blood cell count. Early recognition and treatment with IVIG (Intravenous venous immunoglobulin), and Aspirin showed h...
Source: Bangladesh Medical Research Council Bulletin - April 16, 2018 Category: International Medicine & Public Health Source Type: research

Evaluation of Transpedicular Surgical Decompression withLong Segment Stabilization in Thoracic and Thoracolumbar SpinalTuberculosis
Pott ’s disease is a common cause of neurological complications and kyphotic deformity.When deformity progressed that may lead to painful costo-pelvic impingement, respiratory distress, risk of paralysis of muscle of lower limb and consequent reduction in quality andlongevity oflife. The treatmentstrat egy is to avoid neurological complication and achieve a near normal spine. In tuberculosis, spinal column may become unstable. Pathological fracture or dislocation of a diseased vertebral body may occur due to mechanical insult. Surgical decompression causefurther instability.The insertion of a meta llic implant is to ...
Source: Bangladesh Medical Research Council Bulletin - April 16, 2018 Category: International Medicine & Public Health Source Type: research

Antibiotic Resistance Pattern and Stewardship Programme in Critical Care Settings
Sensitivity pattern of isolates from patients ’ specimens associated with infection, admitted to the critical care centers with empiric or prophylactic antibiotic use were assessed. Till identification of the organism and resultant sensitivity awaited; and compared with sensitive antibiotic to the isolates which could be used for management. This analytical cross sectional study carried out during the period of April 2016 to July 2016 in the Critical Care Centre (CCC) of Combined Military Hospital, Dhaka Cantonment. Urine and other specimens including wound swab, pus, sputum, tracheal aspirate, catheter tip, nasal sw...
Source: Bangladesh Medical Research Council Bulletin - April 16, 2018 Category: International Medicine & Public Health Source Type: research

Hepatitis: Knowledge and Awareness among the Infected Population
Hepatitis viruses are serious global public health problem and rapidly spreading in the developing countries due to factors like illiteracy, lack of health education, poverty. The aim of this study was to assess the level of knowledge and awareness of hepatitis infected people toward the disease, its consequences, routes of transmission of virus and preventive measures including vaccination. This cross-sectional study was carried out in the Department of Microbiology of Dhaka Medical Collage, Dhaka, Bangladesh from February to August 2013 among 2254 male jobseekers to Malaysia. History was taken and information was collect...
Source: Bangladesh Medical Research Council Bulletin - April 16, 2018 Category: International Medicine & Public Health Source Type: research

Evaluation of Neck Mass by Multidetector Computed Tomography and Histopathological Comparison.
Diagnostic usefulness of multidetector computed tomography (MDCT) scan in the evaluation of neck mass was assessed in this study in terms of sensitivity, specificity, positive and negative predictive value and accuracy in respect to characterise the lesion as benign and malignant, based on different parameters by comparing computed tomography and histopathological findings. This cross sectional study was carried out on 57 patients in the Department of Radiology and Imaging, Sir Salimullah Medical College and Mitford Hospital, Dhaka from January 2014 to December 2015, with a 16 slice multidetector CT scanner and the reports...
Source: Bangladesh Medical Research Council Bulletin - April 16, 2018 Category: International Medicine & Public Health Source Type: research

Clinical Accuracy of Electronic Apex Locator in Measuring Working Length during Root Canal Treatment
Obtaining a correct working length is critical to success of endodontic therapy. The procedure for establishment of working length should be performed using techniques that have been proven to give valuable and accurate results and methods that are practical and efficacious. The development of the electronic apex locator has helped to assess the working length more accurate and predictable. So the objective of this in vivo-ex vivo study was to evaluate the clinical accuracy of electronic apex locator in measuring the working length of the root canal in vivo, and comparing the lengths so measured, to the actual working leng...
Source: Bangladesh Medical Research Council Bulletin - April 15, 2018 Category: International Medicine & Public Health Source Type: research

Morphological Variations of the Liver in Autopsies of the Iranian Population
Knowledge about the variations in liver is essential for surgeons and radiologists, so as to prevent wrong interpretation and diagnosis. So far, no data are available on the standard characteristics of normal liver in the Iranian population. Hence, the aim of this study was to evaluate the standard data of a normal liver including weight, length, width, thickness and lobes variations of the liver of Iranians. This cross sectional study was perfomed on 600 cadavers in Mashhad Legal Medicine Center in 2016. After obtaining demographic characteristics of cadavers, the weight, length, width, thickness and variations of the liv...
Source: Bangladesh Medical Research Council Bulletin - April 15, 2018 Category: International Medicine & Public Health Source Type: research

BK Virus Infection:A Hidden Threat for Renal Transplant Recipients
BK virus (BKV) infection has become an important concern for renal transplant recipients, as it may cause nephropathy in transplant patients receiving immunosuppressive therapy resulting in renal dysfunction and possibly, graft loss. This crosssectional study was carried out at the Department of Virology, Bangabandhu Sheikh Mujib Medical University (BSMMU) from March 2015 to June 2016, aimedto detect the incidence of BKV infection among transplant recipients from Bangladesh. A total of 30randomly selected adult renal transplant recipients and 15 healthy controls were included in this study.Their blood and urine samples wer...
Source: Bangladesh Medical Research Council Bulletin - April 15, 2018 Category: International Medicine & Public Health Source Type: research

Association of Platelet Parameters in Acute Coronary Syndrome before and after Anti-platelet Therapy
In this study, the baseline characteristics of study patients were measured. Platelet counts were 273.1 ±50.15 x 109/L in patients with ACS and 290.78±74.86 x 109/L in control subjects in 1st sample and 284.56 ±41.93 x 109/L in patients with ACS in 2nd sample. In 1st samples, platelet counts were slightly low in patients with ACS compared to controls and 2nd samples. There were no statistical significant differences between the groups and the samples. MPV was 12.48 ±1.17 fl and 10.45±0.66 fl in patients with ACS and controls and 11.55±1.08 fl in 2nd sample in ACS cases. PDW was 16....
Source: Bangladesh Medical Research Council Bulletin - January 4, 2018 Category: International Medicine & Public Health Source Type: research

Effects of Varicocelectomy on Abnormal Semen Parameters in Patients with Clinically Palpable Varicocele
Prevalence of varicocele is approximately 15.1% of the general population. Studies showed that surgical correction of clinically palpable varicocele could improve the semen parameters. However, there is scarce of study to demonstrate post-operative outcome of varicocelectomy among the patients with abnormal semen parameter. Therefore, this study tried to compare the microscopic changes in sperm concentration, sperm motility, and sperm morphology before and after varicocelectomy. This quasi-experimental study was done in Urology Department of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh from Novemb...
Source: Bangladesh Medical Research Council Bulletin - January 4, 2018 Category: International Medicine & Public Health Source Type: research

Potency Determination of Essential Drug Samples Manufactured By Medium and Small Pharmaceutical Industries in Bangladesh
Drugs are considered highly essential and sensitive items for saving lives. Pharmaceutical sector in Bangladesh has grown from strength to strength over the last 40 years and evolved from an import dependent to self-reliant, export oriented sector. But counterfeit, adulterated and sub-standard drugs, though small in percentage, still remain to be a threat in the local market. The purpose of this study is to determine potency of some essential drugs, which are used vigorously by sub-urban and rural people and manufactured by randomly selected small and medium pharmaceutical industries of Bangladesh. The study revealed that ...
Source: Bangladesh Medical Research Council Bulletin - January 4, 2018 Category: International Medicine & Public Health Source Type: research

Gentamicin in Newborn Sepsis: Once Daily Dose versus Twice Daily Dose
Gentamicin is commonly used as first line drug in neonatal sepsis. It is usually used in combination with other drugs. It is a nephrotoxic and an ototoxic drug. Long term use causes renal failure and hearing impairment. Its efficacy depends on the peak concentration, and its toxicity is related to the trough concentration. There is no set protocol of using gentamicin in neonate in Bangladesh, whether it should be used once daily or twice, it is till debatable in this perspective. In daily practice, it is not followed up trough and peak concentration of gentamicin, so it is not known the renal and hearing status of the baby...
Source: Bangladesh Medical Research Council Bulletin - January 4, 2018 Category: International Medicine & Public Health Source Type: research

Birth Prevalence of Congenital Cytomegalovirus (CMV) infection in a cohort of pregnant women in Bangladesh
Cytomegalovirus (CMV) is a frequent cause of congenital infection in humans in all regions of the world. In contrast to most congenital viral infections, congenital CMV infection and disease have been consistently demonstrated in populations with a high seroprevalence. Three hundred pregnant women were studied prospectively in their 1st, 2nd and 3rd trimester to determine the seroprevalence and seroconversion of CMV in pregnancy. After birth, babies were also tested for anti CMV IgM to determine the rate of birth prevalence. Anti CMV IgG and IgM tests were performed by chemiluminescence methods. All 300 (100%) pregnant wom...
Source: Bangladesh Medical Research Council Bulletin - January 4, 2018 Category: International Medicine & Public Health Source Type: research

Clinical and Radiographic Efficacy of Portland Cement as Pulpotomy Material in Human Primary Molar
Mineral trioxide aggregates (MTA) has been considered one of the most effective pulpotomy materials as it induces the formation of dentine at a greater rate with superior structural integrity, minimal inflammation and nominal hyperplasia. Portland cement (PC), posing the principal chemical elements with similar mechanisms of action, physical properties and biocompatibility like MTA, may be considered as effective alternative for the same. So, the objective of the study was to compare the clinical and radiographic outcome of Portland cement and mineral trioxide aggregates as pulpotomy material in primary teeth. A total of 4...
Source: Bangladesh Medical Research Council Bulletin - January 4, 2018 Category: International Medicine & Public Health Source Type: research

Prevalence of anti-HBc total positivity in an impoverished Urban Community in Banglades
The infection with the Hepatitis B virus (HBV) is a global health problem. Hepatitis B virus (HBV) infections are rapidly spreading in developing countries due to the lack of health education, poverty, illiteracy and Hepatitis B vaccination. No widespread population based data of HBV is available in the country's aspect. So, a population-based serological survey was done to determine the prevalence of the Hepatitis B core antibody total (IgM+IgG) in an impoverished Urban Community in Dhaka, Bangladesh. A descriptive cross-sectional study was conducted among 384 healthy individuals and age between 18-60 years from the urban...
Source: Bangladesh Medical Research Council Bulletin - January 4, 2018 Category: International Medicine & Public Health Source Type: research

Splenic Volume: Correlation between Ultrasonogram and Standard CT Measurements
Evaluation of splenic enlargement is important in the diagnosis and management of various diseases including liver disease, lymphoma and other primary or metastatic neoplasm. This cross sectional study was conducted in the department of radiology and imaging in Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic Disorders (BIRDEM) from July 2007 to June 2009. The main objective of the study was to find out a more accurate sonographic measurement of splenic volume that well correlate with gold standard computed tomography (CT) volume. A total of 228 subjects were included in the study. A...
Source: Bangladesh Medical Research Council Bulletin - January 4, 2018 Category: International Medicine & Public Health Source Type: research

Propranolol Versus corticosteroids for Infantile Hemangiomas: A Randomized Control Trial in a Tertiary care Hospital
Infantile hemangiomas are the most common vascular tumor of infancy and childhood. Sometimes these lesions interfere with normal function& produce serious disfigurement that is unlikely to resolve on its own and then treatment is required. While evidence most supports the use of corticosteroids, there is no well- studied or Federal Drug Administration (FDA) approved systemic therapy for haemangiomas of Infancy. Dramatic improvement of complicated haemangioma by propranolol has recently been reported, but to date, details for initiating therapy, monitoring and potential risks in relation to Corticosteroids were not comp...
Source: Bangladesh Medical Research Council Bulletin - January 2, 2018 Category: International Medicine & Public Health Source Type: research

Helicobacter pylori cagA gene Polymorphism in Patients with Gastroduodenal Diseases
Helicobacter pylori is a genetically diverse bacterial pathogen and itsCagA gene is a major virulence factor that plays an important role in gastroduodenal pathologies. The biological function of cagA depends on tyrosine phosphorylation within the EPIYA (Glutamate-Proline-Isoleucine-Tyrosine-Alanine) motifs at the C-terminal region of the protein. This region may undergo polymorphism to give different types of EPIYA motifs. EPIYA motif diversity may provide a useful tool for prediction ofH. pylori pathogenic activity and accurate determination of number and type of cagA EPIYA motifs could identify the virulentH. pylori. Th...
Source: Bangladesh Medical Research Council Bulletin - January 2, 2018 Category: International Medicine & Public Health Source Type: research

Incretin Hormones and Insulin Responses During OGTT in Newly Diagnosed T2DM Patients
Several research groups have reported variable results about incretin effects of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1(GLP-1) particularly, as well as cytokines balance in type 2 diabetes mellitus (T2DM). The present case-control prospective interventional study was conducted in 2014-2015 at Medical College for Women& Hospital, Dhaka, investigating responses of incretin hormones and insulin to oral glucose tolerance test (OGTT) in Bangladeshi subjects. Blood samples were collected from 36 OGTT positive adult T2DM patients (Pt) and 30 normal adults (NC) at'0'minute (fasting) and ...
Source: Bangladesh Medical Research Council Bulletin - January 2, 2018 Category: International Medicine & Public Health Source Type: research

Risk Factors for Cardiovascular Diseases Among Urban Schoolchildren from Affluent Families
Smoking, physical inactivity, obesity, raised blood pressure, low dietary intake of vegetables and fruits have been identified as risk factors for cardiovascular diseases. The study was aimed to find out the extent of risk factors for cardiovascular diseases among adolescent schoolchildren from affluent families of Dhaka city. This cross sectional study was done among 386 students of two English medium high schools during July 2006 to June 2007. Sixty one percent of the sample was boys. The children were of 10-18 years age group (mean=13.5 years). Half of the parents had postgraduate education, fathers mostly businessmen a...
Source: Bangladesh Medical Research Council Bulletin - January 2, 2018 Category: International Medicine & Public Health Source Type: research

Per Rectal Bleeding in Children: Experiences in the Department of Paediatric Surgery in BSMMU
This study was carried out in an attempt to find out causes, presentation and the proper management that can be offered to the affected infants and children.This retrospective study was carried out from January 2012 to December 2014 in the department of Paediatric Surgery of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. All patients presenting with the complaint of per rectal bleeding were included.   But patients who needed emergency surgical intervention were excluded from this study. The data were reviewed for gender, age, causes of rectal bleeding and type, number, site, recurrence rate a...
Source: Bangladesh Medical Research Council Bulletin - January 2, 2018 Category: International Medicine & Public Health Source Type: research

Core Competency of Mid-level Public Health Managers in Bangladesh
Bangladesh has been making remarkable progress in health sector. Despite, there are some areas where further intervention is required. People-centered health systems cannot be strengthened without competent management. Core competencies are the essential knowledge, skills and attitudes required for the practice of public health. This was a first kind of effort to assess the core competencies of mid-level public health managers, working at different tiers of health system in Bangladesh.   This descriptive cross-sectional study was conducted from July 2012 to June 2013, to assess the core competencies of mid-level publi...
Source: Bangladesh Medical Research Council Bulletin - January 2, 2018 Category: International Medicine & Public Health Source Type: research

Determination of HER-2/neu gene Status by Chromogenic in Situ Hybridisation Assay on Borderline (2+) Immunohistochemistry Cases in Patients with Invasive Breast Carcinoma: An Experimental Study on Preserved Tissue
HER-2 (also known as HER-2/neu) is a member of the epidermal growth factor (EGF) receptor family. The amplification of oncogene HER-2 is presented in 20 to 30% of breast cancers and results in an increase of the protein expression. HER-2 over expression has also been shown to correlate with poor prognosis. It is associated with poorly differentiated high grade tumors with lymph node involvement, greater risk of recurrence and relative resistance to some types of chemotherapy. The receptor is however a target for treatment with anti HER-2 antibody trastuzumab (Herceptin). Immunohistochemistry analysis for HER 2 scoring is s...
Source: Bangladesh Medical Research Council Bulletin - January 2, 2018 Category: International Medicine & Public Health Source Type: research

Hospital Based Gestational Age Specific Birth Charts in Urban Bangladesh
This study aimed to develop such growth chart in Bangladesh, to exactly evaluate an individual newborn ’s growth pattern by comparing growth of its different parts with that of a standard one. A cross sectional observational study conducted at fifteen non-government maternity centers located in different parts of Dhaka, Narayanganj and Narsingdi. Birth weight, birth length, head and chest circumfer ences of five thousand one hundred and five singleton newborns’ with gestational ages ranging from 35 to 42 weeks were recorded during June 2014 to July 2015. Trained Physicians and paramedics of respective centers r...
Source: Bangladesh Medical Research Council Bulletin - December 14, 2017 Category: International Medicine & Public Health Source Type: research

Fanconi Anaemia – A Rare Case Report
Fanconi anaemia is a rare and most common form of inherited aplastic anaemia. It is mostly autosmal (except one x link) recessive disorder characterized by diverse congenital malformations, progressive pancytopenia, and predisposition to both haematological malignancy and solid tumours. Congenital malformation varies from patient to patient and may affect the skeletal system as well as organ systems. Highly variable phenotypic   presentation with clinical menifestations makes difficult for diagnosis in some cases. Chromosomal breakage study induce by Mitomycin-C (MMC)/Diepoxybutane(DEB) provide a unique cellular marke...
Source: Bangladesh Medical Research Council Bulletin - April 18, 2017 Category: International Medicine & Public Health Source Type: research

Fanconi Anaemia – A Rare Case Report
Fanconi anaemia is a rare and most common form of inherited aplastic anaemia. It is mostly autosmal (except one x link) recessive disorder characterized by diverse congenital malformations, progressive pancytopenia, and predisposition to both haematological malignancy and solid tumours. Congenital malformation varies from patient to patient and may affect the skeletal system as well as organ systems. Highly variable phenotypic   presentation with clinical menifestations makes difficult for diagnosis in some cases. Chromosomal breakage study induce by Mitomycin-C (MMC)/Diepoxybutane(DEB) provide a unique cellular marke...
Source: Bangladesh Medical Research Council Bulletin - April 18, 2017 Category: International Medicine & Public Health Source Type: research

Incidence of Negative Appendicectomy: Correlation Between Clinical, Peroperative and Histopathological Findings
Appendicitis is one of the most difficult diagnostic problems to confront the emergency physician and it is the most common intra-abdominal condition requiring emergency surgery. The term “Negative appendicectomy” used for operation done for suspected appendicitis, in which the appendix is found to be normal on histological evaluation. The study aimed to find out the incidence of negative appendicectomy evaluating the correlation between clinical, per-operative and histopathologi cal findings. It was a prospective study of 100 cases clinically diagnosed as acute appendicitis selected over a period of one year (...
Source: Bangladesh Medical Research Council Bulletin - April 17, 2017 Category: International Medicine & Public Health Source Type: research

Continuation of Indoor Prescribed Antibiotics in the Outpatient Treatment of Neonatal Sepsis
Neonatal sepsis is a common problem whose antibiotic treatment is usually recommended whilst admitted in hospital for at least 10-14 days. Families in Bangladesh however are reluctant to stay in hospital to complete the treatment for such a long time due to reasons such as financial difficulties and either or both are working parents. This leads to incomplete treatment of neonatal sepsis. We hypothesised that after initial improvement in neonatal sepsis with injectable antibiotics whilst admitted, the same treatment could be safely continued in the outpatient setting to complete the full course. This intervention study was...
Source: Bangladesh Medical Research Council Bulletin - April 17, 2017 Category: International Medicine & Public Health Source Type: research

Role of Whole-Body Tc 99m MDP Bone Scintigraphy for Evaluating Skeletal Metastasis in Patients with Lung Cancer
Lung cancer is the third most common site of origin of metastatic cancer deposits in bone, after breast and prostate. It ’s metastasis to bone is one of the most aggressive tumors and has a very unfavorable prognosis.  This retrospective descriptive study was designed to detect the skeletal metastasis of   carcinoma (Ca) lung patient by Tc 99m MDP bone scan.The medical records of all patients attended between January 2015 and July 2015 with a diagnosis of lung cancer were reviewed. Lung cancer in all patients was confirmed pathologically, and patients underwent whole-body bone scan for evaluating skele...
Source: Bangladesh Medical Research Council Bulletin - April 17, 2017 Category: International Medicine & Public Health Source Type: research

Socio-demographic Determinants of Water Treatment in Cholera Patients and Clinical Presentation of Disease: A Decade of Observation from a Large Urban Diarrhoeal Disease Hospital in Bangladesh
Cholera remains a health problem around the globe including Bangladesh, and  claims thousands of lives and places a substantial strain on public health resources. Data collected from 4,894 cholera patients who presented to Dhaka Hospital of icddr,b between 2004 and 2013, and were analysed to assess the socio-demographic determinants of water treatment and their impact on c holera, and examine the possible influence of water treatment on changing clinico-pathologic predictors in cholera patients. Results of this study consistently showed strong association between water treatment and male sex, family income, slum resid...
Source: Bangladesh Medical Research Council Bulletin - April 17, 2017 Category: International Medicine & Public Health Source Type: research

Role of MDCT Scan in the Evaluation of Pancreatic Mass with Histopathological Correlation
Diagonstic imaging plays a critical role in evaluation of the adenocarcinoma of the pancreas- the 4th leading cause of death for the cancer globally. The purpose of this study was to determine the role of multidetector computed tomography (MDCT) in evaluation of pancreatic tumors. The prospective and study was carried out in Dhaka, Bangladesh during the period of July, 2013 to December 2014. Amongst 47 publish with suspected pancreatic lesion (having positive CT scan findings). Patients underwent histopathology of their lesions, the report of which was used as gold standard for comparing the role of CT scan in evaluating s...
Source: Bangladesh Medical Research Council Bulletin - April 17, 2017 Category: International Medicine & Public Health Source Type: research

Molecular Analysis of HLA-DR and Their Association with Systemic Lupus Erythematosus
Systemic lupus erythematosus (SLE) is an autoimmune disease that develops within a complex network of genetic and immunologic factors. Both genetic and environmental factors strongly influence the      development of SLE. But genetic factors are more important both in determining the overall susceptibility to SLE and in influencing immunologic heterogenecity in affected subjects. Now it is accepted that major histocompatibility complex (MHC) genes particularly HLA (Human leukocyte antige n) class II constitute a part of the genetic factor for susceptibility to develop SLE. To determine the associat...
Source: Bangladesh Medical Research Council Bulletin - April 17, 2017 Category: International Medicine & Public Health Source Type: research

Biochemical Bone Markers for Early Detection of Osteopaenia of Prematurity
Osteopaenia of prematurity (OOP) imposes the risk of fractures and growth failure to premature infants. Studies have investigated the validity of biochemical markers of osteopaenia but till date it is not established. So, this study was intended to examine the diagnostic performance of biochemical markers in early detection of osteopaenia of prematurity. This prospective study was conducted in the Neonatal Intensive Care Unit (NICU), Department of Neonatology, Bangabandhu Sheikh Mujib Medical University during June 2013 to February 2014. A total of 100 premature infants with gestational age ≤ 34 weeks were consecutively...
Source: Bangladesh Medical Research Council Bulletin - April 17, 2017 Category: International Medicine & Public Health Source Type: research