An unexpected journey for BNIP3
Autophagy. 2024 Mar 6:1-2. doi: 10.1080/15548627.2024.2312038. Online ahead of print.ABSTRACTMitophagy is a cellular process that enables the selective degradation of damaged, dysfunctional, or superfluous mitochondria. During mitophagy, specific proteins recognize and tag mitochondria for degradation. These tagged mitochondria are engulfed by specialized structures called phagophores that then mature into autophagosomes/mitophagosomes. Mitophagosomes subsequently transport their mitochondrial cargo to lysosomes, where the mitochondria are broken down and recycled. While the PINK1-PRKN-dependent mitophagy pathway is well u...
Source: Autophagy - March 7, 2024 Category: Cytology Authors: Jos é M Delgado Christopher J Shoemaker Source Type: research
WDR83/MORG1 inhibits RRAG GTPase-MTORC1 signaling to facilitate basal autophagy
Autophagy. 2024 Mar 7:1-2. doi: 10.1080/15548627.2024.2322457. Online ahead of print.ABSTRACTMacroautophagy/autophagy is a conserved lysosomal degradation process composed of both selective and nonselective degradation pathways. The latter occurs upon nutrient depletion. Selective autophagy exerts quality control of damaged organelles and macromolecules and is going on also under nutrient-replete conditions. Proper regulation of autophagy is vital for cellular homeostasis and prevention of disease. During nutrient availability, autophagy is inhibited by the MTORC1 signaling pathway. However, selective, basal autophagy occu...
Source: Autophagy - March 7, 2024 Category: Cytology Authors: Athanasios Kournoutis Trond Lamark Terje Johansen Yakubu Princely Abudu Source Type: research
An unexpected journey for BNIP3
Autophagy. 2024 Mar 6:1-2. doi: 10.1080/15548627.2024.2312038. Online ahead of print.ABSTRACTMitophagy is a cellular process that enables the selective degradation of damaged, dysfunctional, or superfluous mitochondria. During mitophagy, specific proteins recognize and tag mitochondria for degradation. These tagged mitochondria are engulfed by specialized structures called phagophores that then mature into autophagosomes/mitophagosomes. Mitophagosomes subsequently transport their mitochondrial cargo to lysosomes, where the mitochondria are broken down and recycled. While the PINK1-PRKN-dependent mitophagy pathway is well u...
Source: Autophagy - March 7, 2024 Category: Cytology Authors: Jos é M Delgado Christopher J Shoemaker Source Type: research
CLU (clusterin) and PPARGC1A/PGC1 α coordinately control mitophagy and mitochondrial biogenesis for oral cancer cell survival
In conclusion, CLU and PPARGC1A are essential for sustained cancer cell growth by activating mitophagy and mitochondrial biogenesis, respectively, and their inhibition could provide better therapeutic benefits against oral cancer.PMID:38447939 | DOI:10.1080/15548627.2024.2309904 (Source: Autophagy)
Source: Autophagy - March 6, 2024 Category: Cytology Authors: Prakash P Praharaj Srimanta Patra Amruta Singh Debasna P Panigrahi Hwa Y Lee Mohammad F Kabir Muhammad K Hossain Samir K Patra Birija S Patro Shankargouda Patil Daniel J Klionsky Han J Chae Sujit K Bhutia Source Type: research
International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis
Autophagy. 2024 Mar 5. doi: 10.1080/15548627.2024.2319901. Online ahead of print.ABSTRACTMacroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell death characterized by unrestricted lipid peroxidation in the context of heterogeneous and plastic mechanisms. Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through th...
Source: Autophagy - March 5, 2024 Category: Cytology Authors: Xin Chen Andrey S Tsvetkov Han-Ming Shen Ciro Isidoro Nicholas T Ktistakis Andreas Linkermann Werner J H Koopman Hans-Uwe Simon Lorenzo Galluzzi Shouqing Luo Daqian Xu Wei Gu Olivier Peulen Qian Cai David C Rubinsztein Jen-Tsan Chi Donna D Zhang Changfeng Source Type: research
Autophagy-the crossword puzzle
Autophagy. 2024 Mar 5:1-3. doi: 10.1080/15548627.2024.2323258. Online ahead of print.ABSTRACTIt's April, so it is time to lighten up (think April Fools' Day). In this issue of the journal, I have two different sets of puzzles for you. Of course, these are not just for your amusement; there is an educational component as well. For example, the crossword puzzle requires you to think about autophagy and perhaps do some searching for names or terms that you are less familiar with (the Guidelines is always a good source of information in this regard). In addition, the crossword puzzle uses official HGNC nomenclature unless othe...
Source: Autophagy - March 5, 2024 Category: Cytology Authors: Daniel J Klionsky Source Type: research
Autophagy-the crossword puzzle answers
Autophagy. 2024 Mar 5:1. doi: 10.1080/15548627.2024.2323287. Online ahead of print.ABSTRACTThis is the answers page so you should not be looking at this page unless you have exhausted the possibility of filling in additional words. Are you certain you are done? Maybe you want to put the puzzle aside for another day and come back to it? No? Okay then, take a look.PMID:38442892 | DOI:10.1080/15548627.2024.2323287 (Source: Autophagy)
Source: Autophagy - March 5, 2024 Category: Cytology Authors: Daniel J Klionsky Source Type: research
International consensus guidelines for the definition, detection, and interpretation of autophagy-dependent ferroptosis
Autophagy. 2024 Mar 5. doi: 10.1080/15548627.2024.2319901. Online ahead of print.ABSTRACTMacroautophagy/autophagy is a complex degradation process with a dual role in cell death that is influenced by the cell types that are involved and the stressors they are exposed to. Ferroptosis is an iron-dependent oxidative form of cell death characterized by unrestricted lipid peroxidation in the context of heterogeneous and plastic mechanisms. Recent studies have shed light on the involvement of specific types of autophagy (e.g. ferritinophagy, lipophagy, and clockophagy) in initiating or executing ferroptotic cell death through th...
Source: Autophagy - March 5, 2024 Category: Cytology Authors: Xin Chen Andrey S Tsvetkov Han-Ming Shen Ciro Isidoro Nicholas T Ktistakis Andreas Linkermann Werner J H Koopman Hans-Uwe Simon Lorenzo Galluzzi Shouqing Luo Daqian Xu Wei Gu Olivier Peulen Qian Cai David C Rubinsztein Jen-Tsan Chi Donna D Zhang Changfeng Source Type: research
Autophagy-the crossword puzzle
Autophagy. 2024 Mar 5:1-3. doi: 10.1080/15548627.2024.2323258. Online ahead of print.ABSTRACTIt's April, so it is time to lighten up (think April Fools' Day). In this issue of the journal, I have two different sets of puzzles for you. Of course, these are not just for your amusement; there is an educational component as well. For example, the crossword puzzle requires you to think about autophagy and perhaps do some searching for names or terms that you are less familiar with (the Guidelines is always a good source of information in this regard). In addition, the crossword puzzle uses official HGNC nomenclature unless othe...
Source: Autophagy - March 5, 2024 Category: Cytology Authors: Daniel J Klionsky Source Type: research
Autophagy-the crossword puzzle answers
Autophagy. 2024 Mar 5:1. doi: 10.1080/15548627.2024.2323287. Online ahead of print.ABSTRACTThis is the answers page so you should not be looking at this page unless you have exhausted the possibility of filling in additional words. Are you certain you are done? Maybe you want to put the puzzle aside for another day and come back to it? No? Okay then, take a look.PMID:38442892 | DOI:10.1080/15548627.2024.2323287 (Source: Autophagy)
Source: Autophagy - March 5, 2024 Category: Cytology Authors: Daniel J Klionsky Source Type: research
Lopinavir enhances anoikis by remodeling autophagy in a circRNA-dependent manner
In this study, we identified a novel circRNA, circSPECC1, that interacted with ATG4B. CircSPECC1 facilitated liquid-liquid phase separation of ATG4B, which boosted the ubiquitination and degradation of ATG4B in gastric cancer (GC) cells. Thus, pharmacological addition of circSPECC1 May serve as an innovative approach to suppress autophagy by targeting ATG4B. Specifically, the circSPECC1 underwent significant m6A modification in GC cells and was subsequently recognized and suppressed by the m6A reader protein ELAVL1/HuR. The activation of the ELAVL1-circSPECC1-ATG4B pathway was demonstrated to mediate anoikis resistance in ...
Source: Autophagy - March 4, 2024 Category: Cytology Authors: Yaran Wu Yang Chen Xiaojing Yan Xufang Dai Yaling Liao Jing Yuan Liting Wang Dong Liu Dun Niu Liangbo Sun Lingxi Chen Yang Zhang Li Xiang An Chen Shuhui Li Wei Xiang Zhenhong Ni Ming Chen Fengtian He Mingzhen Yang Jiqin Lian Source Type: research
Autophagy sustains mitochondrial respiration and determines resistance to BRAF < sup > V600E < /sup > inhibition in thyroid carcinoma cells
Autophagy. 2024 Mar 4:1-15. doi: 10.1080/15548627.2024.2312790. Online ahead of print.ABSTRACTBRAFV600E is the most prevalent mutation in thyroid cancer and correlates with poor prognosis and therapy resistance. Although selective inhibitors of BRAFV600E have been developed, more advanced tumors such as anaplastic thyroid carcinomas show a poor response in clinical trials. Therefore, the study of alternative survival mechanisms is needed. Since metabolic changes have been related to malignant progression, in this work we explore metabolic dependencies of thyroid tumor cells to exploit them therapeutically. Our results show...
Source: Autophagy - March 4, 2024 Category: Cytology Authors: Sergio D íaz-Gago Javier Vicente-Guti érrez Jose Manuel Ruiz-Rodr íguez Josep Calafell Alicia Álvarez-Álvarez Marina Lasa Antonio Chiloeches Pablo Baquero Source Type: research
Lopinavir enhances anoikis by remodeling autophagy in a circRNA-dependent manner
In this study, we identified a novel circRNA, circSPECC1, that interacted with ATG4B. CircSPECC1 facilitated liquid-liquid phase separation of ATG4B, which boosted the ubiquitination and degradation of ATG4B in gastric cancer (GC) cells. Thus, pharmacological addition of circSPECC1 May serve as an innovative approach to suppress autophagy by targeting ATG4B. Specifically, the circSPECC1 underwent significant m6A modification in GC cells and was subsequently recognized and suppressed by the m6A reader protein ELAVL1/HuR. The activation of the ELAVL1-circSPECC1-ATG4B pathway was demonstrated to mediate anoikis resistance in ...
Source: Autophagy - March 4, 2024 Category: Cytology Authors: Yaran Wu Yang Chen Xiaojing Yan Xufang Dai Yaling Liao Jing Yuan Liting Wang Dong Liu Dun Niu Liangbo Sun Lingxi Chen Yang Zhang Li Xiang An Chen Shuhui Li Wei Xiang Zhenhong Ni Ming Chen Fengtian He Mingzhen Yang Jiqin Lian Source Type: research
Autophagy sustains mitochondrial respiration and determines resistance to BRAF < sup > V600E < /sup > inhibition in thyroid carcinoma cells
Autophagy. 2024 Mar 4:1-15. doi: 10.1080/15548627.2024.2312790. Online ahead of print.ABSTRACTBRAFV600E is the most prevalent mutation in thyroid cancer and correlates with poor prognosis and therapy resistance. Although selective inhibitors of BRAFV600E have been developed, more advanced tumors such as anaplastic thyroid carcinomas show a poor response in clinical trials. Therefore, the study of alternative survival mechanisms is needed. Since metabolic changes have been related to malignant progression, in this work we explore metabolic dependencies of thyroid tumor cells to exploit them therapeutically. Our results show...
Source: Autophagy - March 4, 2024 Category: Cytology Authors: Sergio D íaz-Gago Javier Vicente-Guti érrez Jose Manuel Ruiz-Rodr íguez Josep Calafell Alicia Álvarez-Álvarez Marina Lasa Antonio Chiloeches Pablo Baquero Source Type: research
General autophagy-dependent and -independent lipophagic processes collaborate to regulate the overall level of lipophagy in yeast
In this study, we report new findings about the regulation of lipophagy by analyzing, under different culture conditions, both the engulfment of LDs into the vacuole and the degradation of LD surface proteins. We find that the degradation of LD surface proteins relies on autophagy and can occur independently of lipophagy. Furthermore, glucose restriction can trigger an ATG1-independent lipophagic process, depending on the glucose concentration in the mediums. In summary, we describe an ATG-independent lipophagic process in yeast, such that the overall level of lipophagy in cells is governed by a dynamic balance between the...
Source: Autophagy - March 1, 2024 Category: Cytology Authors: Na Kang Jinling Tan Sisi Yan Leiying Lin Qiang Gao Source Type: research
