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The relationship between fractional anisotropy value and tumor microarchitecture in late-stage rat glioma
Conclusions The FA value of rat glioma tumor in the late stage can preoperatively provide an accurate, reliable and noninvasive imaging monitoring method to evaluate the microstructure of glioma (cell density, the extent of angiogenesis, fiber bundle integrity and tumor cell infiltration and so on), predict the biological behavior of the tumor and make out surgical plan. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - June 21, 2017 Category: Tropical Medicine Source Type: research

Doubled dosage of sofosbuvir is expected for inhibiting Zika virus infection
Publication date: Available online 15 June 2017 Source:Asian Pacific Journal of Tropical Medicine Author(s): Somsri Wiwanitkit, Viroj Wiwanitkit Sofosbuvir is a new antiviral drug that has been recommended for management of hepatitis C virus (HCV) for a few years. New researches support that sofosbuvir might be useful for the management of Zika virus infection. Based on the pharmacological activity, inhibiting the HCV RNA-dependent RNA polymerase (RdRp or NS5 protein), sofosbuvir is proposed for its effectiveness against Zika virus infection. Here, the authors used a mathematical modelling theoretical approach to predi...
Source: Asian Pacific Journal of Tropical Medicine - June 21, 2017 Category: Tropical Medicine Source Type: research

In  vitro and in vivo cytochrome P450 3A enzyme inhibition by Aframomum melengueta and Denniettia tripetala extracts
Conclusions Herbal preparations containing these plants' extracts should be used with caution especially in patients on CYP450 3A substrate medications. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - June 21, 2017 Category: Tropical Medicine Source Type: research

Anticancer activity test of ethyl acetate extract of endophytic fungi isolated from soursop leaf (Annona muricata L.)
Conclusions The endophytic fungi isolated from soursop leaf has the potential to be used as a source of anticancer agents. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - June 21, 2017 Category: Tropical Medicine Source Type: research

Promising antileishmanial effectiveness of doxorubicin and Doxil against Leishmania major: an in vitro assay
Conclusions Our findings demonstrated the efficacy of both doxorubicin and its pegylated liposomal formulation on Leishmania major at low concentrations. Further researches are needed for evaluating the safety of drugs in animal model particularly as topical formulation. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - June 20, 2017 Category: Tropical Medicine Source Type: research

In vitro and in vivo cytochrome P450 3A enzyme inhibition by Aframomum melengueta and Denniettia tripetala extracts
Conclusions Herbal preparations containing these plants’ extracts should be used with caution especially in patients on CYP450 3A substrate medications. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - June 17, 2017 Category: Tropical Medicine Source Type: research

Atractylenolide Ⅰ protects against lipopolysaccharide-induced disseminated intravascular coagulation by anti-inflammatory and anticoagulation effect
Conclusions ATL-Ⅰ has protective effect on LPS-induced DIC, which can elevate the survival rate, reduce organ damage, improve the function of blood coagulation and suppress TNF-α expression by inhibiting the activation of NF-κB signaling pathway. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - June 17, 2017 Category: Tropical Medicine Source Type: research

Effect of dietary supplementation with olive and sunflower oils on lipid profile and liver histology in rats fed high cholesterol diet
Conclusions HC+OO diet has high absorption velocity in the acinar zone 1 of liver compared to the HC+SO diet. Based on this, the reduction of the LDL-C, VLDL-C and CT serum levels in the animals treated with HC+OO diet can be caused by the delay in the FA release to the blood. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - June 16, 2017 Category: Tropical Medicine Source Type: research

Doubled dosage of sofosbuviris expected for inhbiting Zika virus infection
Publication date: Available online 15 June 2017 Source:Asian Pacific Journal of Tropical Medicine Author(s): Somsri Wiwanitkit, Viroj Wiwanitkit Sofosbuvir is a new antiviral drug that has been recommended for management of hepatitis C virus (HCV) for a few years. New researches support that sofosbuvir might be useful for the management of Zika virus infection. Based on the pharmacological activity, inhibiting the HCV RNA-dependent RNA polymerase (RdRp or NS5 protein), sofosbuvir is proposed for its effectiveness against Zika virus infection. Here, the authors used a mathematical modelling theoretical approach to predi...
Source: Asian Pacific Journal of Tropical Medicine - June 16, 2017 Category: Tropical Medicine Source Type: research

Intervention effect and mechanism of curcumin in chronic urinary tract infection in rats
Conclusions Curcumin can significantly improve the symptoms of chronic urinary tract infections, protect renal tubular function, and also decline inflammatory responses by influencing the expressions of TLR2 mRNA and TLR4 mRNA so as to exert its curative effect on chronic urinary tract infections. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - June 16, 2017 Category: Tropical Medicine Source Type: research

Xanthine oxidase inhibitors from Archidendron clypearia (Jack.) I.C. Nielsen: Results from systematic screening of Vietnamese medicinal plants
Conclusions From this investigation, four Vietnamese medicinal plants were identified to have XO inhibitory effects with IC50 values of the methanol extracts below 30 μg/mL. Compound (−)-7-O- galloyltricetiflavan was identified as an XO inhibitor from Archidendron clypearia with IC50 value of 25.5 μmol/L. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - June 16, 2017 Category: Tropical Medicine Source Type: research

Experimental study on the apoptosis of cervical cancer Hela cells induced by juglone through c-Jun N-terminal kinase/c-Jun pathway
Conclusion Juglone can increase the expression of apoptotic molecules in mitochondrial pathway and death receptor pathway by activating JNK/c-Jun pathway, thus inducing apoptosis of cervical cancer cells. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - June 16, 2017 Category: Tropical Medicine Source Type: research

Antioxidant and hepatoprotective potentials of novel endophytic fungus Achaetomium sp., from Euphorbia hirta
Conclusions The results reveal that the metabolites produced by endophytic fungi isolated from Euphorbia hirta could be novel natural products that could lead to new drug discovery. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - June 16, 2017 Category: Tropical Medicine Source Type: research

The ralationship between fractional anisotropy value and tumor microarchitecture in late-stage rat glioma
Conclusions The FA value of rat glioma tumor in the late stage can preoperatively provide an accurate, reliable and noninvasive imaging monitoring method to evaluate the microstructure of glioma (cell density, the extent of angiogenesis, fiber bundle integrity and tumor cell infiltration and so on), predict the biological behavior of the tumor and make out surgical plan. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - June 16, 2017 Category: Tropical Medicine Source Type: research

Protective effects of Balanites aegyptiaca extract, melatonin and ursodeoxycholic acid against hepatotoxicity induced by methotrexate in male rats
Conclusions BA may be as promising as MEL in the hepatoprotection against MTX toxicity through their antioxidant and radical scavenging activities. In addition, it is not recommended to co-administer UDCA with MTX as it enhanced inflammation and damage to the liver. (Source: Asian Pacific Journal of Tropical Medicine)
Source: Asian Pacific Journal of Tropical Medicine - June 16, 2017 Category: Tropical Medicine Source Type: research