Asian Journal of Pharmaceutical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The solute carrier transporters and the brain: physiological and pharmacological implications
Publication date: Available online 13 November 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Chengliang Hu, Lei Tao, Xizhi Cao, Ligong ChenAbstractSolute carriers (SLCs) are the largest family of transmembrane transporters that determine the exchange of various substances, including nutrients, ions, metabolites, and drugs across biological membranes. To date, the presence of about 287 SLC genes have been identified in the brain, among which mutations or the resultant dysfunctions of 71 SLC genes have been reported to be correlated with human brain disorders. Although increasing interest in SLCs have focuse...
Source: Asian Journal of Pharmaceutical Sciences - November 13, 2019 Category: Drugs & Pharmacology Source Type: research

Oxidation-strengthened disulfide-bridged prodrug nanoplatforms with cascade facilitated drug release for synergetic photochemotherapy
Publication date: Available online 9 November 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Bin Yang, Lin Wei, Yuequan Wang, Na Li, Bin Ji, Kaiyuan Wang, Xuanbo Zhang, Shenwu Zhang, Shuang Zhou, Xiaohui Yao, Hang Song, Yusheng Wu, Haotian Zhang, Qiming Kan, Tao Jin, Jin SunAbstractOne of the major barriers in utilizing prodrug nanocarriers for cancer therapy is the slow release of parent drug in tumors. Tumor cells generally display the higher oxidative level than normal cells, and also displayed the heterogeneity in terms of redox homeostasis level. We previously found that the disulfide bond-linkage demo...
Source: Asian Journal of Pharmaceutical Sciences - November 9, 2019 Category: Drugs & Pharmacology Source Type: research

Pharmacologic inducers of the uric acid exporter ABCG2 as potential drugs for treatment of gouty arthritis
Publication date: Available online 7 November 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Bojana Ristic, Mohd Omar Faruk Sikder, Yangzom D. Bhutia, Vadivel GanapathyAbstractUric acid is the end product of purine catabolism and its plasma levels are maintained below its maximum solubility in water (6–7 mg/dl). The plasma levels are tightly regulated as the balance between the rate of production and the rate of excretion, the latter occurring in urine (kidney), bile (liver) and feces (intestinal tract). Reabsorption in kidney is also an important component of this process. Both excretion and reabsorption...
Source: Asian Journal of Pharmaceutical Sciences - November 8, 2019 Category: Drugs & Pharmacology Source Type: research

The Design and Synthesis of Dextran-Doxorubicin Prodrug-based pH-Sensitive Drug Delivery System for Improving Chemotherapy Efficacy
Publication date: Available online 6 November 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Xiaoli Zhang, Tian Zhang, Xianbin Ma, Yajun Wang, Yi Lu, Die Jia, Xiaohua Huang, Jiucun Chen, Zhigang Xu, Feiqiu WenAbstractTumor cells show acidic conditions compared with normal cells, which further inspires scientist to build nanocarrier responsive to tumor microenvironment (TME) for enhancing tumor therapeutic efficacy. Here, we report a pH-sensitive and biocompatible polyprodrug based on dextran-doxorubicin (DOX) prodrug (DOXDT) for enhanced chemotherapy. High-density DOX component was covalently decorated on t...
Source: Asian Journal of Pharmaceutical Sciences - November 7, 2019 Category: Drugs & Pharmacology Source Type: research

Microsponges for dermatological applications: Perspectives and challenges
Publication date: Available online 9 July 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Sheefali Mahant, Sunil Kumar, Sanju Nanda, Rekha RaoAbstractDermatological disorders have a huge psychosocial impact, causing significant impairment of patient's life. Topical therapy plays a pivotal role in management of such disorders. Conventional topical delivery systems result in overmedication/undermedication, leading to adverse effects and reduction in therapeutic efficacy. Consequently, researchers have been striving towards the development of alternative delivery systems for dermatological applications. In the ...
Source: Asian Journal of Pharmaceutical Sciences - October 10, 2019 Category: Drugs & Pharmacology Source Type: research

Tumor microenvironment responsive drug delivery systems
Publication date: Available online 26 September 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Qunye He, Jun Chen, Jianhua Yan, Shundong Cai, Hongjie Xiong, Yanfei Liu, Dongming Peng, Zhenbao Liu, Miao MoAbstractConventional tumor-targeted drug delivery systems (DDSs) face challenges, such as unsatisfied systemic circulation, low targeting efficiency, poor tumoral penetration, and uncontrolled drug release. Recently, tumor cellular molecules-triggered DDSs have aroused great interests in addressing such dilemmas. With the introduction of several additional functionalities, the properties of these smart DDSs...
Source: Asian Journal of Pharmaceutical Sciences - September 27, 2019 Category: Drugs & Pharmacology Source Type: research

Development of novel cationic microemulsion as parenteral adjuvant for influenza vaccine
Publication date: Available online 10 September 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Sakalanunt Lamaisakul, Angkana Tantituvanont, Vimolmas Lipipun, Garnpimol RitthidejAbstractSqualene-based oil-in-water (O/W) emulsions have been used as effective and safe adjuvants in approved influenza vaccines. However, there are concerns regarding the safety and side effects of increasing risk of narcolepsy. In present study, novel O/W microemulsions (MEs) containing wheat germ oil, d-alpha tocopheryl polyethylene glycol 1000 succinate (TPGS) and Cremophor EL (CreEL) or Solutol HS15 were formulated with/withou...
Source: Asian Journal of Pharmaceutical Sciences - September 11, 2019 Category: Drugs & Pharmacology Source Type: research

Recent Advances Of Biomimetic Nano-systems in the Diagnosis and Treatment of Tumor
Publication date: Available online 5 September 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Anning Li, Jiawei Zhao, Jingru Fu, Jia Cai, Peng ZhangAbstractThe lack of effective methods of diagnosis and treatment presents a major barrier to combat against tumor. The biomimetic concept is an emerging field that expresses great application potential in tumor fighting. Strategy for combining nano-systems with biomimetic technology has gained increasing attention that is proved bioinspired, environmentally benign, and promising. Herein, we provide an up-to-date review of biomimetic nano-systems as well as their...
Source: Asian Journal of Pharmaceutical Sciences - September 5, 2019 Category: Drugs & Pharmacology Source Type: research

Redox dual-stimuli responsive drug delivery systems for improving tumor-targeting ability and reducing adverse side effects
Publication date: Available online 21 August 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Ruirui Li, Feifei Peng, Jia Cai, Dandan Yang, Peng ZhangAbstractCancer is a big challenge that has plagued the human beings for ages and one of the most effective treatments is chemotherapy. However, the low tumor-targeting ability limits the wide clinical application of chemotherapy. The microenvironment plays a critical role in many aspects of tumor genesis. It generates the tumor vasculature and it is highly implicated in the progression to metastasis. To maintain a suitable environment for tumor progression, ther...
Source: Asian Journal of Pharmaceutical Sciences - August 21, 2019 Category: Drugs & Pharmacology Source Type: research

The Influence of Genetic Polymorphisms in Drug Metabolism Enzymes and Transporters on the Pharmacokinetics of Different Fluvastatin Formulations
Publication date: Available online 26 July 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Qian Xiang, Weidang Wu, Nan Zhao, Chuan Li, Junyu Xu, Lingyue Ma, Xiaodan Zhang, Qiufen Xie, Zhuo Zhang, Jiancheng Wang, Weiren Xu, Xia Zhao, Yimin CuiAbstractThe purpose of the present study was to investigate the impact of genetic polymorphism on fluvastatin pharmacokinetics. In addition, we compared the fluvastatin pharmacokinetics differences between extended-release (ER) 80 mg tablet and immediate-release (IR) 40 mg capsule in terms of drug metabolism enzyme and transporter genetic polymorphisms. In this open-labe...
Source: Asian Journal of Pharmaceutical Sciences - July 26, 2019 Category: Drugs & Pharmacology Source Type: research

Assembling structurally customizable synthetic carriers of siRNA through thermodynamically self-regulated process
This study demonstrates that our previously reported polywraplex, a synthetic siRNA carrier consisting of a uni-molecular polyplex core of customizable size and a self-assembled tri-block copolymer envelop, may be constructed using dendrimers as the crosslinking junctions. Replacing the branched low molecular weight PEI with polyamidoamine (PAMAM) dendrimer in the zeta potential regulated polymerization resulted in the similar network structured cationic polymer with electron microscopically visible crosslinking junctions. This visibility may offer a convenient way to characterize the molecular structure of the rationally ...
Source: Asian Journal of Pharmaceutical Sciences - July 24, 2019 Category: Drugs & Pharmacology Source Type: research

Ratiometric delivery of doxorubicin and berberine by liposome enables superior therapeutic index than Doxil®
Publication date: Available online 18 July 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Ruoshi Zhang, Yingxi Zhang, Yue Zhang, Xin Wang, Xuanming Gao, Yuyan Liu, Xuanbo Zhang, Zhonggui He, Dun Wang, Yongjun WangAbstractAlthough the appearance of Doxil alleviated the cardiotoxicity of DOX, the progression-free survival of patients was not prolonged compared with traditional medication regimens, and side effects such as hand-foot syndrome has occurred. In order to solve this dilemma, we have designed a novel co-delivery strategy to construct a co-loaded liposome of berberine (BER) and doxorubicin (DOX), whi...
Source: Asian Journal of Pharmaceutical Sciences - July 20, 2019 Category: Drugs & Pharmacology Source Type: research

Sprinkle Formulations—A Review of Commercially Available Products
Publication date: Available online 8 July 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Han Sol Lee, Jeong Jun Lee, Myeong Gyu Kim, Ki Taek Kim, Cheong Weon Cho, Dae Duk Kim, Jae Young LeeAbstractCurrently, sixty-five original sprinkle drug products are available in various dosage forms including tablets, powders, granules, immediate-release capsules, extended-release capsules, delayed-release capsules, and multiparticulate drug delivery systems. By sprinkling on soft food vehicles, these products provide dosing flexibility and convenience of administration, which potentially improve the compliance of pati...
Source: Asian Journal of Pharmaceutical Sciences - July 9, 2019 Category: Drugs & Pharmacology Source Type: research

Microsponge for dermatological applications: Perspectives and Challenges
Publication date: Available online 9 July 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Sheefali Mahant, Sunil Kumar, Sanju Nanda, Rekha RaoAbstractDermatological disorders have a huge psychosocial impact causing significant impairment of patient's life. Topical therapy plays a pivotal role in management of such disorders. Conventional topical delivery systems result in overmedication/undermedication, leading to adverse effects and reduction in therapeutic efficacy. Consequently, researchers have been striving towards development of alternative delivery systems for dermatological applications. In the last ...
Source: Asian Journal of Pharmaceutical Sciences - July 9, 2019 Category: Drugs & Pharmacology Source Type: research

Advances in nanotechnology-based delivery systems for EGFR tyrosine kinases inhibitors in cancer therapy
Publication date: Available online 5 July 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Xiaohan Zhou, Kun Shi, Ying Hao, Chengli Yang, Ruoyu Zha, Cheng Yi, Zhiyong QianAbstractOral tyrosine kinase inhibitors (TKIs) against epidermal growth factor receptor (EGFR) family have been introduced into the clinic to treat human malignancies for decades. Despite superior properties of EGFR-TKIs as small molecule targeted drugs, their applications are still restricted due to their low solubility, capricious oral bioavailability, large requirement of daily dose, high binding tendency to plasma albumin and initial/acq...
Source: Asian Journal of Pharmaceutical Sciences - July 6, 2019 Category: Drugs & Pharmacology Source Type: research