Asian Journal of Pharmaceutical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Regorafenib-loaded poly (lactide-co-glycolide) microspheres designed to improve transarterial chemoembolization therapy for hepatocellular carcinoma
In conclusion, the obtained REGO microspheres demonstrated promising therapeutic effects against HCC when combined with TACE.Graphical abstractREGO-loaded PLGA microspheres demonstrated superior anti-angiogenic effect, potential of antagonizing miriplatin resistance and remarkable antitumor efficacy compared with miriplatin monotherapy. (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - February 21, 2020 Category: Drugs & Pharmacology Source Type: research

Enhanced lysosome escape mediated by 1,2-dicarboxylic-cyclohexene anhydride-modified poly-L-lysine dendrimer as a gene delivery system
Publication date: Available online 6 February 2020Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Jianmin Shen, Jing Chen, Jingbo Ma, Linlan Fan, Xiaoli Zhang, Ting Yue, Yaping Yan, Yuhang ZhangAbstractAntisense oligodeoxynucleotide (ASODN) can directly interfere a series of biological events of the target RNA derived from tumor cells through Watson-Crick base pairing, in turn, plays antitumor therapeutic roles. In the study, a novel HIF-1α ASODN-loaded nanocomposite was formulated to efficiently deliver gene to the target RNA. The physicochemical properties of nanocomposite were characterized using TEM, FTIR, ...
Source: Asian Journal of Pharmaceutical Sciences - February 7, 2020 Category: Drugs & Pharmacology Source Type: research

Recent trends on wound management; new therapeutic choices based on polymeric carriers
Publication date: Available online 23 January 2020Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Mehmet Evren Okur, Ioannis D. Karantas, Zeynep Şenyiğit, Neslihan Üstündağ Okur, Panoraia I. SiafakaAbstractWound healing is an unmet therapeutic challenge among medical society since wound assessment and management is a complex procedure including several factors playing major role in healing process. Wounds can mainly be categorized as acute or chronic. It is well referred that the acute wound displays normal wound physiology while healing, in most cases, is seemed to progress through the normal phases of wou...
Source: Asian Journal of Pharmaceutical Sciences - January 23, 2020 Category: Drugs & Pharmacology Source Type: research

Advanced delivery strategies facilitating oral absorption of heparins
Publication date: Available online 9 January 2020Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Guihua Fang, Bo TangAbstractHeparins show great anticoagulant effect with few side effects, and are administered by subcutaneous or intravenous route in clinics. To improve patient compliance, oral administration is an alternative route. Nonetheless, oral administration of heparins still faces enormous challenges due to the multiple obstacles. This review briefly analyzes a series of barriers ranging from poorly physicochemical properties of heparins, to harsh biological barriers including gastrointestinal degradatio...
Source: Asian Journal of Pharmaceutical Sciences - January 10, 2020 Category: Drugs & Pharmacology Source Type: research

NIR-triggered Thermo-Responsive Biodegradable Hydrogel with Combination of Photothermal and Thermodynamic Therapy for Hypoxic Tumor
Publication date: Available online 10 January 2020Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Xiaoqi Sun, Di Liu, Xiaoyu Xu, Yifeng Shen, Yanjuan Huang, Zishan Zeng, Meng Xia, Chunshun ZhaoAbstractHypoxia is a typical feature of solid tumors, which highly limits the application of the oxygen-dependent therapy. Also, the dense and hyperbaric tumor tissues impede the penetration of nanoparticles into the deep tumor. Thereby, we designed a novel localized injectable hydrogel combining the photothermal therapy (PTT) and the thermodynamic therapy (TDT), which is based on the generation of free radicals even in th...
Source: Asian Journal of Pharmaceutical Sciences - January 10, 2020 Category: Drugs & Pharmacology Source Type: research

Dynamic micelles with detachable PEGylation at tumoral extracellular pH for enhanced chemotherapy
Publication date: Available online 3 January 2020Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Guoqing Yan, Panpan Zhang, Jun Wang, Xin Wang, Rupei TangAbstractAlthough surface PEGylation of nanomedicines can decrease serum protein adsorption in vivo, it also blocks uptake by tumor cells. This dilemma could be overcome by employing detachably PEGylated strategy at tumoral extracellular microenvironment to achieve improved cellular uptake while prolonged circulation times. Herein, the amphiphilic graft copolymers with pH-sensitive ortho ester-linked mPEG in side chains and polyurethanes in backbone, can self-as...
Source: Asian Journal of Pharmaceutical Sciences - January 3, 2020 Category: Drugs & Pharmacology Source Type: research

Nanoparticle cancer vaccines: design considerations and recent advances
Publication date: Available online 31 December 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Jingjing Liu, Lei Miao, Jiying Sui, Yanyun Hao, Guihua HuangAbstractVaccines therapeutics manipulate host's immune system and have broad potential for cancer prevention and treatment. However, due to poor immunogenicity and limited safety, fewer cancer vaccines have been successful in clinical trials. Over the past decades, nanotechnology has been exploited to deliver cancer vaccines, eliciting long-lasting and effective immune responses. Compared to traditional vaccines, cancer vaccines delivered by nanomaterials ...
Source: Asian Journal of Pharmaceutical Sciences - January 1, 2020 Category: Drugs & Pharmacology Source Type: research

Biointerface engineering nanoplatforms for cancer-targeted drug delivery
Publication date: Available online 30 December 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Huaiyu Zhang, Shujun Dong, Zhongmin Li, Xiangru Feng, Weiguo Xu, Catrina Mae S Tulinao, Yang Jiang, Jianxun DingAbstractOver the past decade, nanoparticle-based therapeutic modalities have become promising strategies in cancer therapy. Selective delivery of anticancer drugs to the lesion sites is critical for elimination of the tumor and an improved prognosis. Innovative design and advanced biointerface engineering have promoted the development of various nanocarriers for optimized drug delivery. Keeping in mind th...
Source: Asian Journal of Pharmaceutical Sciences - December 31, 2019 Category: Drugs & Pharmacology Source Type: research

A stepwise optimization strategy to formulate in situ gelling formulations comprising fluconazole-hydroxypropyl-beta-cyclodextrin (FL-HP-β-CD) complex loaded niosomal vesicles and Eudragit nanoparticles for enhanced antifungal activity and prolonged ocular delivery
This study was intended to improve and prolong its ocular availability. FL niosomal vesicles were prepared using span 60. Also, polymeric nanoparticles were prepared using cationic Eudragit RS100 and Eudragit RL100. The investigated particles had adequate entrapment efficiency (EE%), nanoscale particle size and high zeta potential. Subsequently, formulations were optimized using full factorial design. FL-HP-beta-cyclodextrin (FL-HP-β-CD) complex was encapsulated in selected Eudragit nanoprticles (FL-CD-ERS1) and niosmal vesicles. The niosomes were further coated with cationic and bioadhesive chitosan (FL-CD-Nios-ch). EE% ...
Source: Asian Journal of Pharmaceutical Sciences - December 24, 2019 Category: Drugs & Pharmacology Source Type: research

Development of 3D Bioprinting: From Printing Methods to Biomedical Applications
Publication date: Available online 17 December 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Zeming Gu, Jianzhong Fu, Hui Lin, Yong HeAbstractBiomanufacturing of tissues/organs in vitro is our big dream, driven by two needs: organ transplantation and accurate tissue models. Over the last decades, 3D bioprinting has been widely applied in the construction of many tissues/organs such as skins, vessels, hearts, etc., which can not only lay a foundation for the grand goal of organ replacement, but also be served as in vitro models committed to pharmacokinetics, drug screening and so on. As organs are so compli...
Source: Asian Journal of Pharmaceutical Sciences - December 18, 2019 Category: Drugs & Pharmacology Source Type: research

An overview on recent in vivo biological application of cerium oxide nanoparticles
This article reviews recent articles dealing with in vivo studies of CNPs towards Alzheimer's disease, obesity, liver inflammation, cancer, sepsis, amyotrophic lateral sclerosis, acute kidney injury, radiation-induced tissue damage, hepatic ischemia reperfusion injury, retinal diseases and constipation. In vivo anti-cancer studies revealed the effectiveness of CNPs to reduce tumor growth and angiogenesis in melanoma, ovarian, breast and retinoblastoma cancer cell-induced mice, with their conjugation with folic acid, doxorubicin, CPM, or CXC receptor-4 antagonist ligand eliciting higher efficiency. After conjugation with tr...
Source: Asian Journal of Pharmaceutical Sciences - November 27, 2019 Category: Drugs & Pharmacology Source Type: research

Intranasal Delivery of Paeoniflorin Nanocrystals for Brain Targeting
Publication date: Available online 26 November 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Chaoyin Wu, Benyue Li, Yi Zhang, Tingting Chen, Chuangrong Chen, Wei Jiang, Qi Wang, Tongkai ChenAbstractPaeoniflorin (PA) is an anti-Parkinson Chinese medicine with inferior bioavailability and difficulty in delivery to the brain. This research is to develop an efficacious PA nanocrystal formulation (PA-NCs) that is suitable for intranasal administration to treat Parkinson's disease (PD). PA-NCs were fabricated through an antisolvent precipitation method using TPGS as the stabilizer. The rod-shaped PA-NCs had part...
Source: Asian Journal of Pharmaceutical Sciences - November 26, 2019 Category: Drugs & Pharmacology Source Type: research

Quantitative prediction of the bitterness of atomoxetine hydrochloride and taste-masked using hydroxypropyl-β-cyclodextrin: A biosensor evaluation and interaction study
In this study, the taste-masking efficiency of 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD) was assessed by Euclidean distances on a principle component analysis (PCA) map with the SA402B Taste Sensing System, and the host-guest interactions were investigated by differential scanning calorimetry (DSC), powder X-ray diffraction (XRD), nuclear magnetic resonance (NMR) spectroscopy and scanning electron microscopy (SEM). Biosensor evaluation and characterization of the inclusion complex indicated that atomoxetine HCl could actively react with 2-hydroxypropyl-β-cyclodextrin.Graphical abstractThe quantitative bitterness of atom...
Source: Asian Journal of Pharmaceutical Sciences - November 26, 2019 Category: Drugs & Pharmacology Source Type: research

Stimulatory effect on the transport mediated by organic anion transporting polypeptide 2B1
Publication date: Available online 13 November 2019Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Jiro Ogura, Hiroaki Yamaguchi, Nariyasu ManoAbstractDrug-drug interaction (DDI) is one of causes of adverse drug events and can result in life-threatening consequences. Organic anion-transporting polypeptide (OATP) 2B1 is a major uptake transporter in the intestine and contributes to transport various clinically used therapeutic agents. The intestine has a high risk of DDI, because it has a special propensity to be exposed to a high concentration of drugs. Thus, understanding drug interaction mediated by OATP2B1 in...
Source: Asian Journal of Pharmaceutical Sciences - November 14, 2019 Category: Drugs & Pharmacology Source Type: research

Enhanced anticancer effect of doxorubicin by TPGS-coated liposomes with Bcl-2 siRNA-corona for dual suppression of drug resistance
In conclusion, TPGS-coated cationic liposomes with Bcl-2 siRNA corona had the capacity to inhibit MDR dual-pathways and subsequently improved the anti-tumor activity of the chemotherapeutic agent co-delivered to a level that cannot be achieved by inhibiting a MDR single way.Graphical abstract (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - November 13, 2019 Category: Drugs & Pharmacology Source Type: research