Asian Journal of Pharmaceutical Sciences This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

In vitro/vivo assessment of praziquantel nanocrystals: Formulation, characterization, and pharmacokinetics in beagle dogs
Publication date: Available online 17 August 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Ruyi Yang, Tao Zhang, Jiang Yu, Yan Liu, Yingli Wang, Zhonggui HeAbstractTo investigate the impact of particle size on in vitro/vivo performance of praziquantel (PZQ), nanocrystals (NCs) and microcrystals (MCs) of PZQ were prepared using the methods of wet milling and jet milling, respectively. PZQ NCs and MCs were characterized with dynamic light scattering, laser particle size analyzer, transmission electron microscopy, differential scanning calorimetry, X-ray powder diffraction and fourier transform infrared spect...
Source: Asian Journal of Pharmaceutical Sciences - August 17, 2018 Category: Drugs & Pharmacology Source Type: research

Vesicular nanocarrier based treatment of skin fungal infections: Potential and emerging trends in nanoscale pharmacotherapy
Publication date: Available online 16 August 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Shivani Verma, Puneet UtrejaAbstractOccurrence of skin fungal infections is increasing nowadays and their presence is more prominent in patients suffering from immunocompromised diseases like AIDS. Skin fungal infections are a major cause of visits by patients to dermatology clinics. Although, a large number of antifungal agents are available for treatment of skin fungal infections, but, their toxic profile and physicochemical characteristics reduce therapeutic outcome. When these antifungal agents are delivered topi...
Source: Asian Journal of Pharmaceutical Sciences - August 16, 2018 Category: Drugs & Pharmacology Source Type: research

A method of elevated temperatures coupled with magnetic stirring to predict real time release from long acting progesterone PLGA microspheres
Publication date: Available online 14 August 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Mingzhu Ye, Hongliang Duan, Lixia Yao, Yicheng Fang, Xiaoyu Zhang, Ling Dong, Feifei Yang, Xinggang Yang, Weisan PanAbstractThe object of the study was to develop a quick and reproducible accelerated in vitro release method to predict and deduce the function of the real time (37 °C) release for long acting PLGA microspheres. The method could be described in several steps. First, the release of the microspheres were studied using the sample and separate method at 37 °C with normal orbital shaking and elevated temp...
Source: Asian Journal of Pharmaceutical Sciences - August 14, 2018 Category: Drugs & Pharmacology Source Type: research

Insight into the preformed albumin corona on in vitro and in vivo performances of albumin-selective nanoparticles
Publication date: Available online 9 August 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Zhenbao Li, Dan Li, Wenjuan Zhang, Peng Zhang, Qiming Kan, Jin SunAbstractPreformed albumin corona of albumin-nonselective nanoparticles (NPs) is widely exploited to inhibit the unavoidable protein adsorption upon intravenous administration. However, very few studies have concerned the preformed albumin corona of albumin-selective NPs. Herein, we report a novel type of albumin-selective NPs by decorating 6-maleimidocaproyl polyethylene glycol stearate (SA) onto PLGA NPs (SP NPs) surface, taking albumin-nonselective PL...
Source: Asian Journal of Pharmaceutical Sciences - August 9, 2018 Category: Drugs & Pharmacology Source Type: research

Special Issue: Pharmaceutical Innovation
Publication date: Available online 31 July 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Pornsak Sriamornsak, Duangratana ShuwisitkulAbstract“Pharmaceutical innovation” is an interdisciplinary area of the pharmaceutical sciences including drug development with a focus on manufacturing, process control, and technology, among many other subfields of research. In this special issue, we have invited all participants attended the International Conference and Exhibition on Pharmaceutical Sciences and Technology 2018 under the theme of pharmaceutical innovation and translational research for human health, hel...
Source: Asian Journal of Pharmaceutical Sciences - July 31, 2018 Category: Drugs & Pharmacology Source Type: research

Small GTPases: structure, biological function and its interaction with nanoparticles
Publication date: Available online 31 July 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Siyang Song, Wenshu Cong, Shurong Zhou, Yujie Shi, Wenbing Dai, Hua Zhang, Xueqing Wang, Bing He, Qiang ZhangAbstractSmall GTPase is a kind of GTP-binding protein commonly found in eukaryotic cells. It plays an important role in cytoskeletal reorganization, cell polarity, cell cycle progression, gene expression and many other significant events in cells, such as the interaction with foreign particles. Therefore, it is of great scientific significance to understand the biological properties of small GTPases as well as t...
Source: Asian Journal of Pharmaceutical Sciences - July 31, 2018 Category: Drugs & Pharmacology Source Type: research

Percutaneous absorption and brain distribution facilitation of borneol on tetramethylpyrazine in a microemulsion-based transdermal therapeutic system
In this study we show that the percutaneous absorption and brain distribution of tetramethylpyrazine (TMP) is enhanced when combined with borneol (BN) in a microemulsion-based transdermal therapeutic system (ME-TTS). The formulation of the TMP and BN microemulsion (TEM-BN-ME) was optimized in in vitro skin permeation studies following a uniform experimental design. Male Sprague-Dawley rats were used for the in vivo pharmacokinetic and tissue distribution studies of TMP-BN-ME-TTS. In the pharmacokinetic study, the TMP-BN-ME-TTS treated rats had significantly higher (P < 0.05) Cmax and AUC of TMP than the TMP-ME-TTS trea...
Source: Asian Journal of Pharmaceutical Sciences - July 29, 2018 Category: Drugs & Pharmacology Source Type: research

Phyto-phospholipid complexes (phytosomes): A novel strategy to improve the bioavailability of active constituents
Publication date: Available online 27 July 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Mei Lu, Qiujun Qiu, Xiang Luo, Xinrong Liu, Jing Sun, Cunyang Wang, Xiangyun Lin, Yihui Deng, Yanzhi SongAbstractAlthough active constituents extracted from plants show robust in vitro pharmacological effects, low in vivo absorption greatly limits the widespread application of these compounds. A strategy of using phyto-phospholipid complexes represents a promising approach to increase the oral bioavailability of active constituents, which is consist of ‘‘label-friendly” phospholipids and active constituents. Hydr...
Source: Asian Journal of Pharmaceutical Sciences - July 27, 2018 Category: Drugs & Pharmacology Source Type: research

Research progress of in-situ gelling ophthalmic drug delivery system
Publication date: Available online 24 May 2018Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Yumei Wu, Yuanyuan Liu, Xinyue Li, Dereje Kebebe, Bing Zhang, Jing Ren, Jun Lu, Jiawei Li, Shouying Du, Zhidong LiuAbstractBlindness and vision impairment are the most devastating global health problems resulting in a substantial economic and social burden. Delivery of drug to particular parts of the anterior or posterior segment has been a major challenge due to various protective barriers and elimination mechanisms associated with the unique anatomical and physiological nature of the ocular system. Drug administration...
Source: Asian Journal of Pharmaceutical Sciences - July 22, 2018 Category: Drugs & Pharmacology Source Type: research

Study of penetration mechanism of labrasol on rabbit cornea by Ussing chamber, RT-PCR assay, Western blot and immunohistochemistry
This study was performed to further elucidate the action mechanism of labrasol on the corneal penetration. In this research, the fluorescein sodium, a marker of passive paracellular transport of tight junction, was selected as the model drug to assess the effect of labrasol on in vitro corneal permeability. To investigate the continuous and real-time influence of labrasol on the membrane permeability and integrity, the Ussing chamber system was applied to monitor the electrophysiological parameters. And, furthermore, we elucidated the effect of labrasol on excised cornea at the molecular level by application of RT-PCR, Wes...
Source: Asian Journal of Pharmaceutical Sciences - July 18, 2018 Category: Drugs & Pharmacology Source Type: research

Welcome to this special issue of AJPS on Inhalation drug delivery
Publication date: Available online 8 September 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Philippe Rogueda, Hui Xin Ong, Oscar Liu, Darragh Murnane (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Antiurolithiatic activity of Alternanthera tenella Colla in ethylene glycol induced urolithiasis in rats
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Sahithi Adepu, Raviraj Anand Devkar, Shilpee Chaudhary, Manganahalli Manjunath Setty (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Phytochemical investigation and antihyperglycemic activity of leaves of Aegle marmelos (L.) Correa
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Soe Sandar Phyo, Win Myint, Khine Khine Lwin, Aye Kyi, Myint Myint Than (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Neuroprotective action of Gmelina arborea (bark) and Punica granatum (peel) extracts
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Pai Vasudev, C.S. Shreedhara, K.S. Chandrashekar, D. Yamini (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research

Physiological and gene expressional alternation in obesity animal model for ADME/PK characterization
Publication date: Available online 25 November 2015Source: Asian Journal of Pharmaceutical SciencesAuthor(s): Sung-Hoon Ahn (Source: Asian Journal of Pharmaceutical Sciences)
Source: Asian Journal of Pharmaceutical Sciences - July 10, 2018 Category: Drugs & Pharmacology Source Type: research