Decreased AKAP4/PKA signaling pathway in high DFI sperm affects sperm capacitation
This study intends to explore the reason for the decreased fertilization rate observed in high sperm DFI (H-DFI) patients during IVF-ET. In addition, the study investigates the expression of AKAP, protein kinase A regulatory subunit (PKARII), and SPA17 between H-DFI and low sperm DFI (L-DFI) patients. SPA17 at the transcriptional level is abnormal, the translational level increases in H-DFI patients, and the expression of AKAP4/PKARII protein decreases. H2O2 has been used to simulate oxidative stress damage to spermatozoa during the formation of sperm DFI. It indicates that H2O2 increases the expression of sperm SPA17 prot...
Source: Asian Journal of Andrology - September 11, 2023 Category: Urology & Nephrology Authors: Kun Zhang Xiu-Hua Xu Jian Wu Ning Wang Gang Li Gui-Min Hao Jin-Feng Cao Source Type: research
When is the best surgical time for benign prostate hyperplasia treatment?
Asian J Androl. 2023 Aug 15. doi: 10.4103/aja202339. Online ahead of print.NO ABSTRACTPMID:37695245 | DOI:10.4103/aja202339 (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - September 11, 2023 Category: Urology & Nephrology Authors: Lucas Mira Gon C ássio Riccetto Source Type: research
Comparison of cytokine levels in prostatic secretion between the IIIa and IIIb subtypes of prostatitis
Asian J Androl. 2023 Aug 22. doi: 10.4103/aja202336. Online ahead of print.ABSTRACTChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), also known as National Institutes of Health (NIH) type III prostatitis, is a common disorder with an unclear etiology and no known curative treatments. Based on the presence or absence of leukocytes in expressed prostatic secretion (EPS), CP/CPPS is classified further into IIIa (inflammatory) and IIIb (noninflammatory) subtypes. However, the severity of symptoms is not entirely consistent with the white blood cell (WBC) count. Following the preliminary finding of a link between infl...
Source: Asian Journal of Andrology - September 11, 2023 Category: Urology & Nephrology Authors: Cheng-Lin Han Yu-Xuan Deng Peng Hu Bin-Tao Hu Tao Wang Ji-Hong Liu Ming-Chao Li Source Type: research
Sperm acrosin activity may be a useful factor in choosing between ICSI and IVF for infertile male patients
Asian J Androl. 2023 Aug 22. doi: 10.4103/aja202337. Online ahead of print.ABSTRACTThe clinical applications of acrosin activity are limited. We analyzed 61 578 male partners in infertile couples who visited the outpatient department of the Reproductive and Genetic Hospital of CITIC-Xiangya (Changsha, China) between August 2014 and December 2019 to determine the reference ranges and thresholds for acrosin activity in infertile Chinese men; to determine whether correlations exist between acrosin activity and age, sperm concentration, sperm morphology, or sperm motility; and to evaluate whether acrosin activity could serve a...
Source: Asian Journal of Andrology - September 11, 2023 Category: Urology & Nephrology Authors: Ye-Na Hu Liang Hu Xin-Yu Yin Huan Zhang Yang-Qin Peng Gang Liu Ge Lin Wei-Na Li Source Type: research
The impact of the COVID-19 pandemic on erectile function in Chinese CP/CPPS patients
This study aimed to investigate the impact of the coronavirus disease 2019 (COVID-19) pandemic on erectile function in Chinese patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). A retrospective study was conducted on 657 CP/CPPS patients who visited The Third Xiangya Hospital of Central South University (Changsha, China) from November 2018 to November 2022. Patients were divided into two groups based on the timeline before and after the COVID-19 outbreak in China. The severity of CP/CPPS, penile erection status, anxiety, and depression was evaluated using the National Institutes of Health-Chronic Pro...
Source: Asian Journal of Andrology - September 11, 2023 Category: Urology & Nephrology Authors: Wei-Jie Song Ji-Wei Huang Yuan Liu Wei Ding Zhi Long Le-Ye He Source Type: research
