A giant scrotal pendulous fibroma mimicking a supernumerary testis
Asian J Androl. 2023 Oct 17. doi: 10.4103/aja202354. Online ahead of print.NO ABSTRACTPMID:37856195 | DOI:10.4103/aja202354 (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - October 19, 2023 Category: Urology & Nephrology Authors: Luigi Quaresima Rocco Francesco Delle Fave Giordano Polisini Daniela Fasanella Willy Giannubilo Source Type: research

Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells
In this study, we engineered an inducible male germ cell-specific knockout caseinolytic mitochondrial matrix peptidase X (ClpxcKO) mouse model to investigate the function of ClpX in meiosis. We found that disrupting Clpx in male mice induced germ cell apoptosis and led to an absence of sperm in the epididymis. Specifically, it caused asynapsis of homologous chromosomes and impaired meiotic recombination, resulting in meiotic arrest in the zygotene-to-pachytene transition phase. The loss of ClpX compromised the double-strand break (DSB) repair machinery by markedly reducing the recruitment of DNA repair protein RAD51 homolo...
Source: Asian Journal of Andrology - October 19, 2023 Category: Urology & Nephrology Authors: Hai-Wei Feng Yu Zhao Yan-Ling Gao Dong-Teng Liu Li-Jun Huo Source Type: research

A giant scrotal pendulous fibroma mimicking a supernumerary testis
Asian J Androl. 2023 Oct 17. doi: 10.4103/aja202354. Online ahead of print.NO ABSTRACTPMID:37856195 | DOI:10.4103/aja202354 (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - October 19, 2023 Category: Urology & Nephrology Authors: Luigi Quaresima Rocco Francesco Delle Fave Giordano Polisini Daniela Fasanella Willy Giannubilo Source Type: research

Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells
In this study, we engineered an inducible male germ cell-specific knockout caseinolytic mitochondrial matrix peptidase X (ClpxcKO) mouse model to investigate the function of ClpX in meiosis. We found that disrupting Clpx in male mice induced germ cell apoptosis and led to an absence of sperm in the epididymis. Specifically, it caused asynapsis of homologous chromosomes and impaired meiotic recombination, resulting in meiotic arrest in the zygotene-to-pachytene transition phase. The loss of ClpX compromised the double-strand break (DSB) repair machinery by markedly reducing the recruitment of DNA repair protein RAD51 homolo...
Source: Asian Journal of Andrology - October 19, 2023 Category: Urology & Nephrology Authors: Hai-Wei Feng Yu Zhao Yan-Ling Gao Dong-Teng Liu Li-Jun Huo Source Type: research

A giant scrotal pendulous fibroma mimicking a supernumerary testis
Asian J Androl. 2023 Oct 17. doi: 10.4103/aja202354. Online ahead of print.NO ABSTRACTPMID:37856195 | DOI:10.4103/aja202354 (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - October 19, 2023 Category: Urology & Nephrology Authors: Luigi Quaresima Rocco Francesco Delle Fave Giordano Polisini Daniela Fasanella Willy Giannubilo Source Type: research

Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells
In this study, we engineered an inducible male germ cell-specific knockout caseinolytic mitochondrial matrix peptidase X (ClpxcKO) mouse model to investigate the function of ClpX in meiosis. We found that disrupting Clpx in male mice induced germ cell apoptosis and led to an absence of sperm in the epididymis. Specifically, it caused asynapsis of homologous chromosomes and impaired meiotic recombination, resulting in meiotic arrest in the zygotene-to-pachytene transition phase. The loss of ClpX compromised the double-strand break (DSB) repair machinery by markedly reducing the recruitment of DNA repair protein RAD51 homolo...
Source: Asian Journal of Andrology - October 19, 2023 Category: Urology & Nephrology Authors: Hai-Wei Feng Yu Zhao Yan-Ling Gao Dong-Teng Liu Li-Jun Huo Source Type: research

A giant scrotal pendulous fibroma mimicking a supernumerary testis
Asian J Androl. 2023 Oct 17. doi: 10.4103/aja202354. Online ahead of print.NO ABSTRACTPMID:37856195 | DOI:10.4103/aja202354 (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - October 19, 2023 Category: Urology & Nephrology Authors: Luigi Quaresima Rocco Francesco Delle Fave Giordano Polisini Daniela Fasanella Willy Giannubilo Source Type: research

Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells
In this study, we engineered an inducible male germ cell-specific knockout caseinolytic mitochondrial matrix peptidase X (ClpxcKO) mouse model to investigate the function of ClpX in meiosis. We found that disrupting Clpx in male mice induced germ cell apoptosis and led to an absence of sperm in the epididymis. Specifically, it caused asynapsis of homologous chromosomes and impaired meiotic recombination, resulting in meiotic arrest in the zygotene-to-pachytene transition phase. The loss of ClpX compromised the double-strand break (DSB) repair machinery by markedly reducing the recruitment of DNA repair protein RAD51 homolo...
Source: Asian Journal of Andrology - October 19, 2023 Category: Urology & Nephrology Authors: Hai-Wei Feng Yu Zhao Yan-Ling Gao Dong-Teng Liu Li-Jun Huo Source Type: research

A giant scrotal pendulous fibroma mimicking a supernumerary testis
Asian J Androl. 2023 Oct 17. doi: 10.4103/aja202354. Online ahead of print.NO ABSTRACTPMID:37856195 | DOI:10.4103/aja202354 (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - October 19, 2023 Category: Urology & Nephrology Authors: Luigi Quaresima Rocco Francesco Delle Fave Giordano Polisini Daniela Fasanella Willy Giannubilo Source Type: research

Caseinolytic mitochondrial matrix peptidase X is essential for homologous chromosome synapsis and recombination during meiosis of male mouse germ cells
In this study, we engineered an inducible male germ cell-specific knockout caseinolytic mitochondrial matrix peptidase X (ClpxcKO) mouse model to investigate the function of ClpX in meiosis. We found that disrupting Clpx in male mice induced germ cell apoptosis and led to an absence of sperm in the epididymis. Specifically, it caused asynapsis of homologous chromosomes and impaired meiotic recombination, resulting in meiotic arrest in the zygotene-to-pachytene transition phase. The loss of ClpX compromised the double-strand break (DSB) repair machinery by markedly reducing the recruitment of DNA repair protein RAD51 homolo...
Source: Asian Journal of Andrology - October 19, 2023 Category: Urology & Nephrology Authors: Hai-Wei Feng Yu Zhao Yan-Ling Gao Dong-Teng Liu Li-Jun Huo Source Type: research

Abnormal cortical surface-based spontaneous and functional connectivity in the whole brain in lifelong premature ejaculation patients
This study leveraged functional magnetic resonance imaging (fMRI), a noninvasive technique, to explore these neural mechanisms. We conducted resting-state fMRI scans on 36 PE patients and 22 healthy controls (HC), and collected data on Premature Ejaculation Diagnostic Tool (PEDT) scores and intravaginal ejaculation latency time (IELT). Employing a surface-based regional homogeneity (ReHo) approach, we analyzed local neural synchronous spontaneous activity, diverging from previous studies that utilized a volume-based ReHo method. Areas with significant ReHo differences between PE and HC groups underwent surface-based functi...
Source: Asian Journal of Andrology - October 6, 2023 Category: Urology & Nephrology Authors: Si-Yan Xing Jia-Ming Lu Yue-Hui Jiang Tong Wang Guang-Jun Du Bai-Bing Yang Qing-Qiang Gao Bin Wang Ning Wu Chun-Lu Xu Tao Song Yu-Tian Dai Source Type: research

Commentary on "The impact of the COVID-19 pandemic on erectile function in Chinese CP/CPPS patients"
Asian J Androl. 2023 Oct 6. doi: 10.4103/aja202347. Online ahead of print.NO ABSTRACTPMID:37800905 | DOI:10.4103/aja202347 (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - October 6, 2023 Category: Urology & Nephrology Authors: Dariusz Kalka Jana Gebala Malgorzata Biernikiewicz Source Type: research

The current situation of semen analysis in China, based on a survey of 296 laboratories
Asian J Androl. 2023 Oct 3. doi: 10.4103/aja202346. Online ahead of print.NO ABSTRACTPMID:37800924 | DOI:10.4103/aja202346 (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - October 6, 2023 Category: Urology & Nephrology Authors: Long-Long Fu Ying Liu Xiao-Wei Wang Fang Zhou Ying Guo Wen-Hong Lu Yi-Qun Gu Source Type: research

Abnormal cortical surface-based spontaneous and functional connectivity in the whole brain in lifelong premature ejaculation patients
This study leveraged functional magnetic resonance imaging (fMRI), a noninvasive technique, to explore these neural mechanisms. We conducted resting-state fMRI scans on 36 PE patients and 22 healthy controls (HC), and collected data on Premature Ejaculation Diagnostic Tool (PEDT) scores and intravaginal ejaculation latency time (IELT). Employing a surface-based regional homogeneity (ReHo) approach, we analyzed local neural synchronous spontaneous activity, diverging from previous studies that utilized a volume-based ReHo method. Areas with significant ReHo differences between PE and HC groups underwent surface-based functi...
Source: Asian Journal of Andrology - October 6, 2023 Category: Urology & Nephrology Authors: Si-Yan Xing Jia-Ming Lu Yue-Hui Jiang Tong Wang Guang-Jun Du Bai-Bing Yang Qing-Qiang Gao Bin Wang Ning Wu Chun-Lu Xu Tao Song Yu-Tian Dai Source Type: research

Commentary on "The impact of the COVID-19 pandemic on erectile function in Chinese CP/CPPS patients"
Asian J Androl. 2023 Oct 6. doi: 10.4103/aja202347. Online ahead of print.NO ABSTRACTPMID:37800905 | DOI:10.4103/aja202347 (Source: Asian Journal of Andrology)
Source: Asian Journal of Andrology - October 6, 2023 Category: Urology & Nephrology Authors: Dariusz Kalka Jana Gebala Malgorzata Biernikiewicz Source Type: research