Reply to “Does Rheumatoid Arthritis Cause an Obesity Paradox?”
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 17, 2018 Category: Rheumatology Authors: Jeffrey A. Sparks, Elizabeth W. Karlson Tags: Reply to Letter to the Editor Source Type: research
The Role of Autophagy in the Degradation of Misfolded HLA ‐B27 Heavy Chains
ConclusionThese results demonstrate for the first time that both autophagy and ERAD play a role in the elimination of excess HLA class I heavy chains expressed in transgenic rats. We found no evidence that HLA‐B27 expression modulated the autophagy pathway. Our results suggest that impaired ubiquitination of HLA‐B27 may play a role in the accumulation of misfolded disulfide‐linked dimers, whose elimination can be enhanced by activation of autophagy. Manipulation of the autophagy pathway should be further investigated as a potential therapeutic avenue in spondyloarthritis.This article is protected by copyright. All ri...
Source: Arthritis and Rheumatism - January 17, 2018 Category: Rheumatology Authors: Fatemeh Navid, Gerlinde Layh ‐Schmitt, Keith A. Sikora, Antony Cougnoux, Robert A. Colbert Tags: Full Length Source Type: research
Antiphospholipid Antibodies Inhibit Trophoblast Toll ‐like Receptor and Inflammasome Negative Regulators
ConclusionBasal TAM receptor function and autophagy may serve to inhibit trophoblast TLR and inflammasome function, respectively. Impaired TAM receptor signaling and autophagy by anti‐β2GPI aPL may allow subsequent TLR and inflammasome activity leading to a robust inflammatory response.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 17, 2018 Category: Rheumatology Authors: Melissa J Mulla, Ingrid C. Weel, Julie A. Potter, Stefan M. Gysler, Jane E. Salmon, Maria T.S. Pera çoli, Carla V. Rothlin, Lawrence W. Chamley, Vikki M. Abrahams Tags: Full Length Source Type: research
Selective activation of tumor necrosis factor receptor 2 induces anti ‐inflammatory responses and alleviates experimental arthritis
ConclusionsSummarizing, our data argue for the use of TNFR2‐selective therapeutics as an effective approach in treating arthritic disease and possibly other inflammatory and autoimmune diseases.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 17, 2018 Category: Rheumatology Authors: Roman Fischer, Marcel Proske, Ma ëlle Duffey, Hubert Stangl, George F. Martinez, Nathalie Peters, Alexandra Kraske, Rainer H. Straub, John R. Bethea, Roland E. Kontermann, Klaus Pfizenmaier Tags: Full Length Source Type: research
Does Rheumatoid Arthritis Cause an Obesity Paradox? Comment on the study by Sparks et al
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 17, 2018 Category: Rheumatology Authors: Joshua F. Baker, Gail Kerr, Ted R. Mikuls Tags: Letter to the Editor Source Type: research
The molecular basis for dysregulated activation of NKX2 ‐5 in vascular remodelling of systemic sclerosis
ConclusionsNKX2‐5 is genetically associated with scleroderma, pulmonary hypertension and fibrosis. Functional evidence revealed a regulatory mechanism which results in NKX2‐5 transcriptional activation in PASMC through the interaction of an upstream promoter and a novel downstream enhancer. This mechanism can act as a model for NKX2‐5 activation in cardiovascular disease characterised by vascular remodelling.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 17, 2018 Category: Rheumatology Authors: Athina Dritsoula, Ioannis Papaioannou, Sandra G. Guerra, Carmen Fonseca, Javier Martin, Ariane L. Herrick, David J. Abraham, Christopher P. Denton, Markella Ponticos Tags: Full Length Source Type: research
Clinical Images: Etanercept ‐induced lymphocytic infiltration of Jessner‐Kanof
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 10, 2018 Category: Rheumatology Authors: No émie Abbad, Tristan Lanal, Céline Brenuchon, Gauthier Morel, Xavier Deprez Tags: Clinicopathologic Conference Source Type: research
Editorial: Wnt Signaling Related to Subchondral Bone Density and Cartilage Degradation in Osteoarthritis
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 9, 2018 Category: Rheumatology Authors: David B. Burr, Achint Utreja Tags: Editorial Source Type: research
Wnt Signaling Related to Subchondral Bone Density and Cartilage Degradation in Osteoarthritis
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 9, 2018 Category: Rheumatology Authors: David B. Burr, Achint Utreja Tags: Editorial Source Type: research
Clinical Images: Unilateral plantar erythema nodosum in sarcoidosis
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 5, 2018 Category: Rheumatology Authors: Axel J. Hueber, Georg Schett, Bernhard Manger Tags: Clinical Images Source Type: research
Reply: X chromosome short arm involvement in autoimmune diseases: comment on the report by Sharma, et al
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 5, 2018 Category: Rheumatology Authors: R. Hal Scofield, Rohan Sharma, Valerie M. Harris Tags: Reply to Letter to the Editor Source Type: research
X chromosome short arm involvement in autoimmune diseases: comment on the report by Sharma, et al
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 5, 2018 Category: Rheumatology Authors: Wesley Brooks Tags: Letter to the Editor Source Type: research
Editorial: Prevalence of Arthritis Revisited
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 3, 2018 Category: Rheumatology Authors: Jeffrey N. Katz Tags: Editorial Source Type: research
Updated Estimates Suggest a Much Higher Prevalence of Arthritis in United States Adults Than Previous Ones
ConclusionArthritis prevalence in the US population has been substantially underestimated, especially among adults younger than 65 years of age. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 3, 2018 Category: Rheumatology Authors: S. Reza Jafarzadeh, David T. Felson Tags: Original Article Source Type: research
Reply
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 3, 2018 Category: Rheumatology Authors: Cory A. Perugino, John H. Stone Tags: Reply Source Type: research
