Aneurysm formation after stent grafting in vascular Beh çet's disease
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 29, 2018 Category: Rheumatology Authors: Suguru Honda, Fumio Hirano, Mariko Mouri, Hisanori Hasegawa, Hitoshi Kohsaka Tags: Clinical Images Source Type: research
Efficacy and Safety of Atacicept in Patients With Systemic Lupus Erythematosus
ConclusionAtacicept treatment showed evidence of efficacy in SLE, particularly in HDA and serologically active patients. Reductions in disease activity and severe flare were observed with atacicept treatment, with an acceptable safety profile. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 29, 2018 Category: Rheumatology Authors: Joan T. Merrill, Daniel J. Wallace, Stephen Wax, Amy Kao, Patricia A. Fraser, Peter Chang, David Isenberg, Tags: Original Article Source Type: research
Nomenclature of Cutaneous Vasculitis
ConclusionStandardized names and definitions are a prerequisite for developing validated classification and diagnostic criteria for cutaneous vasculitis. Accurate identification of specifically defined variants of systemic and skin‐limited vasculitides requires knowledgeable integration of data from clinical, laboratory, and pathologic studies. This proposed nomenclature of vasculitides affecting the skin, the D‐CHCC, provides a standard framework both for clinicians and for investigators. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 29, 2018 Category: Rheumatology Authors: Cord H. Sunderk ötter, Bernhard Zelger, Ko‐Ron Chen, Luis Requena, Warren Piette, J. Andrew Carlson, Jan Dutz, Peter Lamprecht, Alfred Mahr, Elisabeth Aberer, Victoria P. Werth, David A. Wetter, Seiji Kawana, Raashid Luqmani, Camille Frances, Joseph Tags: Special Article Source Type: research
Clinical Connections
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 29, 2018 Category: Rheumatology Tags: Clinical Connections Source Type: research
In This Issue
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 29, 2018 Category: Rheumatology Tags: In This Issue Source Type: research
Issue Information
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 29, 2018 Category: Rheumatology Tags: Issue Information Source Type: research
Brief Report: Drugs Implicated in Systemic Autoimmunity Modulate Neutrophil Extracellular Trap Formation
ConclusionMedications commonly implicated in drug‐induced autoimmunity trigger NET formation displaying distinct protein cargo, via common and specific pathways. NETosis may play a role in the pathogenesis of drug‐induced autoimmunity. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 23, 2018 Category: Rheumatology Authors: Jorge A. Irizarry ‐Caro, Carmelo Carmona‐Rivera, Daniella M. Schwartz, Sami S. Khaznadar, Mariana J. Kaplan, Peter C. Grayson Tags: Brief Report Source Type: research
Mavrilimumab, a fully human granulocyte ‐macrophage colony‐stimulating factor receptor α monoclonal antibody: long‐term safety and efficacy in patients with rheumatoid arthritis
ConclusionMavrilimumab long‐term treatment maintained response and was well‐tolerated with no TEAE incidence increase. Safety data were comparable with both phase IIb qualifying studies.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 23, 2018 Category: Rheumatology Authors: Gerd R Burmester, Iain B McInnes, Joel M Kremer, Pedro Miranda, Ji ří Vencovský, Alex Godwood, Marius Albulescu, M Alex Michaels, Xiang Guo, David Close, Michael Weinblatt Tags: Full Length Source Type: research
Twin DNA methylation profiling reveals flare ‐dependent interferon signature and B‐cell promoter hypermethylation in systemic lupus erythematosus
ConclusionHypomethylation of interferon‐regulated genes occurs in all major cellular compartments in SLE twins. The observed B‐cell promoter hypermethylation is a novel finding with potential significance for SLE pathogenesis.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 23, 2018 Category: Rheumatology Authors: Constance J Ulff ‐Møller, Fazila Asmar, Yi Liu, Anders J Svendsen, Florence Busato, Kirsten Grønbæk, Jörg Tost, Søren Jacobsen Tags: Full Length Source Type: research
Lessons learned from Chikungunya in the Americas
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 23, 2018 Category: Rheumatology Authors: Jonathan J. Miner, Deborah J. Lenschow Tags: Editorial Source Type: research
The Association between HLA Genetic Susceptibility Markers and Sonographic Enthesitis in Psoriatic Arthritis
ConclusionHLA‐B*27 is associated with more severe sonographic enthesitis in PsA, particularly in patients with longer disease duration. This finding highlights the possible role of genetic variants in predisposing to PsA subphenotypes.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 23, 2018 Category: Rheumatology Authors: Ari Polachek, Richard Cook, Vinod Chandran, Fatima Abji, Dafna Gladman, Lihi Eder Tags: Full Length Source Type: research
Review: Defining a Unified Vascular Phenotype in Systemic Sclerosis
Microcirculation impairment and related vasculopathy are hallmarks of systemic sclerosis (SSc). Digital ulceration is second only to Raynaud's phenomenon as a vascular complication occurring in patients with SSc. Digital ulcers are painful and generate disability. Furthermore, patients may develop recurrent digital ulcers, and it is reasonable to question whether the outcomes of such patients might be different from those of patients who are not affected. Recently, several registries have provided relevant information about digital ulcers. Male sex and severe skin disease appear to be the main associated factors observed i...
Source: Arthritis and Rheumatism - January 22, 2018 Category: Rheumatology Authors: Yannick Allanore, Oliver Distler, Marco Matucci ‐Cerinic, Christopher P. Denton Tags: Review Source Type: research
Accumulation of Antigen ‐Driven Lymphoproliferations in Complement Receptor 2/CD21−/low B Cells From Patients With Sjögren's Syndrome
ConclusionClonal lymphoproliferations in patients with SS preferentially accumulate in the autoreactive CD21−/low B cell compartment often expanded in these subjects, and recognition of self antigens may drive the clonal B cell expansion while further refining BCR self‐reactivity. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 18, 2018 Category: Rheumatology Authors: Salom é Glauzy, Marco Boccitto, Jason M. Bannock, Fabien R. Delmotte, David Saadoun, Patrice Cacoub, John A. Ice, Kathy L. Sivils, Judith A. James, Sandra L. Wolin, Eric Meffre Tags: Original Article Source Type: research
Clinical Images: Arthritis in melorheostosis —an uncommon feature in a rare disease
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 17, 2018 Category: Rheumatology Authors: Enrico Selvi, Marco Bardelli, Giacomo Maria Guidelli Tags: Clinical Images Source Type: research
Features, Treatment and Outcomes of Macrophage Activation Syndrome in Childhood ‐onset Systemic Lupus Erythematosus
ConclusionsMAS was most likely to develop concomitantly with cSLE diagnosis. The majority of the MAS patients were successfully treated with corticosteroids with no MAS relapses. Although the numbers were small, there was a higher risk of death associated with MAS compared to those without MAS.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - January 17, 2018 Category: Rheumatology Authors: R. Ezequiel Borgia, Maya Gerstein, Deborah M. Levy, Earl D. Silverman, Linda T. Hiraki Tags: Full Length Source Type: research
