Association of Tumor Necrosis Factor Inhibitor Treatment With Reduced Indices of Subclinical Atherosclerosis in Patients With Psoriatic Disease
ConclusionOur findings indicate that TNFi treatment is associated with reduced progression of carotid plaques in men and improvement in vascular inflammation in both men and women with psoriatic disease. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 6, 2018 Category: Rheumatology Authors: Lihi Eder, Aditya A. Joshi, Amit K. Dey, Richard Cook, Evan L. Siegel, Dafna D. Gladman, Nehal N. Mehta Tags: Original Article Source Type: research
Validation of a Definition of Flare in Patients With Established Gout
ConclusionThe definition of gout flare that requires fulfillment of at least 3 of 4 patient‐reported criteria is now validated to be sensitive, specific, and accurate for gout flares, as demonstrated using an independent large international patient sample. The availability of a validated gout flare definition will improve the ascertainment of an important clinical outcome in studies of gout. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 6, 2018 Category: Rheumatology Authors: Angelo L. Gaffo, Nicola Dalbeth, Kenneth G. Saag, Jasvinder A. Singh, Elizabeth J. Rahn, Amy S. Mudano, Yi ‐Hsing Chen, Ching‐Tsai Lin, Sandra Bourke, Worawit Louthrenoo, Janitzia Vazquez‐Mellado, Hansel Hernández‐Llinas, Tuhina Neogi, Ana Beatri Tags: Brief Report Source Type: research
18F ‐Fluorodeoxyglucose–Positron Emission Tomography As an Imaging Biomarker in a Prospective, Longitudinal Cohort of Patients With Large Vessel Vasculitis
ConclusionFDG‐PET provides information about vascular inflammation that is complementary to, and distinct from, clinical assessment in LVV. FDG‐PET scan activity during clinical remission was associated with future clinical relapse. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 6, 2018 Category: Rheumatology Authors: Peter C. Grayson, Sara Alehashemi, Armin A. Bagheri, Ali Cahid Civelek, Thomas R. Cupps, Mariana J. Kaplan, Ashkan A. Malayeri, Peter A. Merkel, Elaine Novakovich, David A. Bluemke, Mark A. Ahlman Tags: Original Article Source Type: research
Lack of effect of teriparatide on joint erosions in rheumatoid arthritis is an expected result: comment on the article by Solomon et al
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 6, 2018 Category: Rheumatology Authors: Giovanni Adami, Maurizio Rossini, Ombretta Viapiana, Angelo Fassio, Luca Idolazzi, Giovanni Orsolini, Davide Gatti Tags: Letters Source Type: research
Association of Defective Regulation of Autoreactive Interleukin ‐6–Producing Transitional B Lymphocytes With Disease in Patients With Systemic Sclerosis
ConclusionOur findings provide new insights into mechanisms underlying defective B lymphocyte responses in patients with SSc and their contribution to disease. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 6, 2018 Category: Rheumatology Authors: Taher E. Taher, Voon H. Ong, Jonas Bystrom, Sophie Hillion, Quentin Simon, Christopher P. Denton, Jacques ‐Olivier Pers, David J. Abraham, Rizgar A. Mageed Tags: Original Article Source Type: research
Group for Research and Assessment of Psoriasis and Psoriatic Arthritis/Outcome Measures in Rheumatology Consensus ‐Based Recommendations and Research Agenda for Use of Composite Measures and Treatment Targets in Psoriatic Arthritis
ConclusionConsensus was not reached on a continuous measure of disease activity. In the interim, the group recommended several composites. Consensus was reached on a treatment target of VLDA/MDA. An extensive research agenda was composed and recommends that data on all PsA clinical domains be collected in ongoing studies. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 6, 2018 Category: Rheumatology Authors: Laura C. Coates, Oliver FitzGerald, Joseph F. Merola, Josef Smolen, Leonieke J. J. Mens, Heidi Bertheussen, Wolf ‐Henning Boehncke, Kristina Callis Duffin, Willemina Campbell, Maarten Wit, Dafna Gladman, Alice Gottlieb, Jana James, Arthur Kavanaugh, Lar Tags: Special Article Source Type: research
Sex Differences in Health Care Utilization, End ‐Stage Renal Disease, and Mortality Among Medicaid Beneficiaries With Incident Lupus Nephritis
ConclusionIn this cohort of patients with incident LN, ESRD and mortality were extremely high overall but were not increased among males compared to females. In this vulnerable population, biologic and health care utilization differences by sex may not significantly affect outcomes. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 6, 2018 Category: Rheumatology Authors: Candace H. Feldman, Anna Broder, Hongshu Guan, Jinoos Yazdany, Karen H. Costenbader Tags: Original Article Source Type: research
Cancer Immunotherapy in Patients With Preexisting Rheumatic Disease: The Mayo Clinic Experience
ConclusionTo our knowledge, this represents the largest single‐center cohort of patients with rheumatic diseases who were exposed to modern cancer immunotherapy. Only a minority of these patients experienced a flare of their preexisting rheumatic disease or any other IRAE. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 6, 2018 Category: Rheumatology Authors: Michael D. Richter, Olga Pinkston, Lisa A. Kottschade, Heidi D. Finnes, Svetomir N. Markovic, Uma Thanarajasingam Tags: Brief Report Source Type: research
Novel UNC13D intronic variant disrupting a NF κB enhancer in a patient with recurrent macrophage activation syndrome and systemic juvenile idiopathic arthritis
ConclusionThese findings highlight that intronic variants in key regulatory regions may be associated with MAS in patients with SJIA, and support deep sequencing approaches when causative coding variants are not identified.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 6, 2018 Category: Rheumatology Authors: Grant S. Schulert, Mingce Zhang, Ammar Husami, Ndate Fall, Hermine Brunner, Kejian Zhang, Randy Q. Cron, Alexei A. Grom Tags: Brief Report Source Type: research
TGF β activation primes canonical Wnt signaling through the downregulation of AXIN2
ConclusionsThis study highlights the importance of reduced AXIN2 bioavailability in mediating the increased canonical Wnt response observed in SSc fibroblasts. This novel mechanism extends our understanding of the processes involved in Wnt/β‐catenin‐driven pathology and supports the rationale for targeting the TGFβ pathway to regulate the aberrant Wnt signaling observed during fibrosis.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 6, 2018 Category: Rheumatology Authors: Justin Gillespie, Rebecca L Ross, Clarissa Corinaldesi, Filomena Esteves, Emma Derrett ‐Smith, Michael F McDermott, Gina M Doody, Christopher P Denton, Paul Emery, Francesco Del Galdo Tags: Full Length Source Type: research
Long ‐term safety and efficacy of belimumab in patients with systemic lupus erythematosus: a continuation of the Phase 3 United States BLISS‐76 trial
ConclusionsThese long‐term exposure results confirm the previously observed safety and efficacy profiles of belimumab in patients with SLE. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 6, 2018 Category: Rheumatology Authors: Richard A Furie, Daniel J Wallace, Cynthia Aranow, James Fettiplace, Barbara Wilson, Prafull Mistry, David A Roth, D Gordon Tags: Full Length Source Type: research
Editorial commentary on the paper by Kindstedt et al: Marginal jawbone loss is associated with onset of RA and is related to plasma level of RANKL
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 6, 2018 Category: Rheumatology Authors: Paola de Pablo Tags: Editorial Source Type: research
Paraparesis revealing tophaceous gout
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 6, 2018 Category: Rheumatology Authors: Pierre Pottecher, Pierre Martz, Paul Ornetti Tags: Clinical Image Source Type: research
A multi centre retrospective analysis evaluating performance of synovial biopsy techniques: arthroscopic vs. ultrasound guided vs. blind needle biopsy
ConclusionsThese data support the integration of US‐guided methods along with arthroscopic biopsy for clinical trial protocols necessitating sequential sampling of synovium from large and small joints for both histological and molecular analysis. BN biopsy may be considered if graded synovial tissue is not required for subsequent analyses.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 6, 2018 Category: Rheumatology Authors: Frances Humby, Vasco Rom ão, Antonio Manzo, Andrew Filer, Serena Bugatti, Elsa Vieira‐Sousa, Stephen Kelly, Mihir Wechalekar, Manzoor Ahmed, Vidalba Rocher, Rebecca Hands, Carlomaurizio Montecucco, Joao Fonseca, Costantino Pitzalis Tags: Full Length Source Type: research
2015 Rheumatology Workforce Study: The Role of Graduate Medical Education in Adult Rheumatology
ConclusionThe current U.S. adult rheumatology workforce is in jeopardy of accelerated decline at a time when demands on the workforce face tremendous growth. The current GME training structure cannot support the increased demand. Potential strategies to address this gap include innovative mechanisms for GME funding to increase fellowship training positions, incentives for pursuing rheumatology training (e.g., loan repayment programs), and novel means for recruitment of care to underserved areas of the U.S.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - February 5, 2018 Category: Rheumatology Authors: Marcy B. Bolster, Anne R. Bass, Jonathan S. Hausmann, Chad Deal, Marcia Ditmyer, Kamilah L. Greene, Seetha U. Monrad, Daniel F. Battafarano Tags: Full Length Source Type: research
