An amino acid motif in HLA ‐DRβ1 distinguishes patients with uveitis in juvenile idiopathic arthritis
ConclusionOur findings highlight a genetically distinct, sexually‐dimorphic feature of JIA‐uveitis compared to non‐uveitis JIA. The association indicates the potential involvement for antigen presentation by HLA‐DRβ1 in the development of uveitis in JIA. This work will advance our progress towards treating and preventing sight‐threatening complications of uveitis in children with JIA.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Anne ‐Mieke J. W. Haasnoot, Marco W. Schilham, Sylvia Kamphuis, Petra C. E. Hissink Muller, Arnd Heiligenhaus, Dirk Foell, Kirsten Minden, Roel A. Ophoff, Timothy R. D. J. Radstake, Anneke I. Den Hollander, Tjitske H. C. M. Reinards, Sanne Hiddingh, Nic Tags: Full Length Source Type: research
Patient perceptions of the Raynaud's Condition Score diary provide insight into its performance in clinical trials of Raynaud's phenomenon
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: John D Pauling, Lesley A Saketkoo, Robyn T Domsic Tags: Letter to the Editor Source Type: research
Reply: Pauling, et al., Efficacy and Safety of Selexipag in Adults With Raynaud's Phenomenon Secondary to Systemic Sclerosis
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Christopher P. Denton, Ariane L. Herrick Tags: Reply to Letter to the Editor Source Type: research
Chronic active arthritis driven by macrophages without involvement of T cells
ConclusionChronic active arthritis can be driven by macrophages without the involvement of T and B cells in the adaptive immune system.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Cecilia Hagert, Outi Sareila, Tiina Kelkka, Kutty Selva Nandakumar, Mattias Collin, Bingze Xu, Simon Gu érard, Johan Bäcklund, Sirpa Jalkanen, Rikard Holmdahl Tags: Full Length Source Type: research
Dysbiotic subgingival microbial communities in periodontally healthy patients with rheumatoid arthritis
ConclusionsOur data demonstrates that the oral microbiome in RA is enriched for inflammophilic and citrulline producing organisms, which may play a role in the production of autoantigenic citrullinated peptides in RA.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Isabel Lopez ‐Oliva, Akshay D. Paropkari, Shweta Saraswat, Stefan Serban, Zehra Yonel, Praveen Sharma, Paola de Pablo, Karim Raza, Andrew Filer, Iain Chapple, Thomas Dietrich, Melissa M. Grant, Purnima S. Kumar Tags: Full Length Source Type: research
Association Between Marginal Jawbone Loss and Onset of Rheumatoid Arthritis and Relationship to Plasma Levels of RANKL
ConclusionMarginal jawbone loss preceded the clinical onset of RA symptoms, but this was observed only in nonsmokers. Moreover, marginal jawbone loss was significantly greater in RANKL‐positive presymptomatic subjects compared with RANKL‐negative presymptomatic subjects and was highest in presymptomatic subjects positive for both ACPA and RANKL. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Elin Kindstedt, Linda Johansson, Py Palmqvist, Cecilia Koskinen Holm, Heidi Kokkonen, Ingegerd Johansson, Solbritt Rantap ää Dahlqvist, Pernilla Lundberg Tags: Original Article Source Type: research
Chikungunya Arthritis Mechanisms in the Americas
ConclusionThis is one of the largest observational studies involving analysis of the synovial fluid of chikungunya arthritis patients. Synovial fluid analysis revealed no detectable chikungunya virus. This finding suggests that chikungunya virus may cause arthritis through induction of potential host autoimmunity, suggesting a role for immunomodulating agents in the treatment of chikungunya arthritis, or that low‐level viral persistence exists in synovial tissue only and is undetectable in synovial fluid. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Aileen Y. Chang, Karen A. O. Martins, Liliana Encinales, St. Patrick Reid, Marlon Acu ña, Carlos Encinales, Christian B. Matranga, Nelly Pacheco, Carlos Cure, Bhavarth Shukla, Teofilo Ruiz Arteta, Richard Amdur, Lisa H. Cazares, Melissa Gregory, Michael Tags: Original Article Source Type: research
Increased Expression and Modulated Regulatory Activity of Coinhibitory Receptors PD ‐1, TIGIT, and TIM‐3 in Lymphocytes From Patients With Systemic Sclerosis
ConclusionThe altered expression and regulatory capacity of co‐IRs in SSc lymphocytes may contribute to disease pathophysiology by modulating the cytokine‐mediated cross‐talk of immune cells and fibroblasts at sites of inflammation and/or fibrosis. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Michelle Fleury, Anna C. Belkina, Elizabeth A. Proctor, Christopher Zammitti, Robert W. Simms, Douglas A. Lauffenburger, Jennifer E. Snyder ‐Cappione, Robert Lafyatis, Hans Dooms Tags: Original Article Source Type: research
Effects of HLA –B27 on Gut Microbiota in Experimental Spondyloarthritis Implicate an Ecological Model of Dysbiosis
ConclusionThe effects of HLA–B27 on gut microbiota and dysbiosis in SpA are highly dependent on the host genetic background and/or environment, despite convergence of dysregulated immune pathways. These results implicate an ecological model of dysbiosis, with the effects of multiple microbes contributing to the aberrant immune response, rather than a single or small number of microbes driving pathogenesis. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 7, 2018 Category: Rheumatology Authors: Tejpal Gill, Mark Asquith, Stephen R. Brooks, James T. Rosenbaum, Robert A. Colbert Tags: Original Article Source Type: research
Frequency of Chronic Joint Pain Following Chikungunya Virus Infection
ConclusionThis is the first report to describe the frequency of chikungunya virus–related arthritis in the Americas after a 20‐month follow‐up. The high frequency of chronic disease highlights the need for the development of prevention and treatment methods. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 2, 2018 Category: Rheumatology Authors: Aileen Y. Chang, Liliana Encinales, Alexandra Porras, Nelly Pacheco, St. Patrick Reid, Karen A. O. Martins, Shamila Pacheco, Eyda Bravo, Marianda Navarno, Alejandro Rico Mendoza, Richard Amdur, Priyanka Kamalapathy, Gary S. Firestein, Jeffrey M. Bethony, Tags: Original Article Source Type: research
Antibody Responses to Citrullinated and Noncitrullinated Antigens in the Sputum of Subjects With Rheumatoid Arthritis and Subjects at Risk for Development of Rheumatoid Arthritis
ConclusionThese findings suggest that sputum antibody reactivity to particular citrullinated and noncitrullinated proteins/peptides is specific for RA and for subjects at risk of RA, and the association of these proteins/peptides with NETs may be a key feature of early RA–related autoimmunity in the lung. These results further support the hypothesis that the lung plays a role in early RA–related autoimmunity. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 2, 2018 Category: Rheumatology Authors: M. Kristen Demoruelle, Emily Bowers, Lauren J. Lahey, Jeremy Sokolove, Monica Purmalek, Nickie L. Seto, Michael H. Weisman, Jill M. Norris, Mariana J. Kaplan, V. Michael Holers, William H. Robinson, Kevin D. Deane Tags: Original Article Source Type: research
Features, Treatment, and Outcomes of Macrophage Activation Syndrome in Childhood ‐Onset Systemic Lupus Erythematosus
ConclusionMAS was most likely to develop concomitantly with childhood‐onset SLE diagnosis. The majority of the MAS patients were successfully treated with corticosteroids with no MAS relapses. Although the numbers were small, there was a higher risk of death associated with MAS compared to SLE without MAS. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 2, 2018 Category: Rheumatology Authors: R. Ezequiel Borgia, Maya Gerstein, Deborah M. Levy, Earl D. Silverman, Linda T. Hiraki Tags: Original Article Source Type: research
A CD8 α‐ Subset of CD4+SLAMF7+ Cytotoxic T Cells is Expanded in Patients with IgG4‐Related Disease and Decreases following Glucocorticoid Treatment
ConclusionsA subset of CD8α‐CD4+SLAMF7+ cytotoxic TEM cells is oligoclonally expanded in patients with active IgG4‐RD. This population contracts following glucocorticoid‐induced remission. Further characterization of this cell population may provide prognostic information and targets for therapeutic intervention.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 2, 2018 Category: Rheumatology Authors: Emanuel Della ‐Torre, Emanuele Bozzalla‐Cassione, Clara Sciorati, Eliana Ruggiero, Marco Lanzillotta, Silvia Bonfiglio, Hamid Mattoo, Cory A. Perugino, Enrica Bozzolo, Lucrezia Rovati, Paolo Giorgio Arcidiacono, Gianpaolo Balzano, Dejan Lazarevic, Chi Tags: Full Length Source Type: research
Differential clinical associations of anti ‐nuclear matrix protein‐2 autoantibodies in patients with idiopathic inflammatory myopathies
ConclusionThis study indicated that anti‐NXP‐2 autoantibodies served as a useful marker for disease activity, especially in patients without calcinosis. The differential associations between anti‐NXP‐2 autoantibody levels and disease activity suggested a phenotypic difference between patients with and without calcinosis.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 1, 2018 Category: Rheumatology Authors: Hanbo Yang, Xin Lu, Qinglin Peng, Wei Jiang, Jingli Shi, Yamei Zhang, He Chen, Guochun Wang Tags: Full Length Source Type: research
A Randomized, Double ‐Blind, Parallel‐Group, Placebo‐Controlled, Multiple‐Dose Study to Evaluate AMG 557 in Patients With Systemic Lupus Erythematosus and Active Lupus Arthritis
ConclusionsAMG 557 showed safety and potential efficacy, supporting further evaluation of the clinical efficacy of ICOSL blockade in patients with SLE.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - March 1, 2018 Category: Rheumatology Authors: Laurence E. Cheng, Zahir Amoura, Benjamin Cheah, Falk Hiepe, Barbara A. Sullivan, Lei Zhou, Gregory E. Arnold, Wayne H. Tsuji, Joan T. Merrill, James B. Chung Tags: Brief Report Source Type: research
