Association of Distinct Fine Specificities of Anti −Citrullinated Peptide Antibodies With Elevated Immune Responses to Prevotella intermedia in a Subgroup of Patients With Rheumatoid Arthritis and Periodontitis
ConclusionThis study identifies 2 groups of ACPA fine specificities associated with different RA risk factors. One is predominantly linked to smoking and shared epitope, and the other links anti–cTNC5 and cCK13‐1 to infection with the periodontal pathogen P intermedia. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 30, 2017 Category: Rheumatology Authors: Anja Schwenzer, Anne ‐Marie Quirke, Anna M. Marzeda, Alicia Wong, Anna B. Montgomery, Harlan R. Sayles, Sigrun Eick, Katarzyna Gawron, Maria Chomyszyn‐Gajewska, Katarzyna Łazarz‐Bartyzel, Simon Davis, Jan Potempa, Benedikt M. Kessler, Roman Fischer Tags: Original Article Source Type: research
Earliest Phase of Systemic Sclerosis Typified by Increased Levels of Inflammatory Proteins in the Serum
ConclusionSSc patients with preclinical/early SSc and those with established, yet nonfibrotic, disease exhibit clear molecular alterations that are associated with faster rates of disease evolution. These data open novel avenues for disease interception in SSc. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 30, 2017 Category: Rheumatology Authors: Marta Cossu, Lenny Bon, Carlo Preti, Marzia Rossato, Lorenzo Beretta, Timothy R. D. J. Radstake Tags: Original Article Source Type: research
2017 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Adult and Juvenile Idiopathic Inflammatory Myopathies and Their Major Subgroups
ConclusionThe European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) classification criteria for IIM have been endorsed by international rheumatology, dermatology, neurology, and pediatric groups. They employ easily accessible and operationally defined elements, and have been partially validated. They allow classification of “definite,” “probable,” and “possible” IIM, in addition to the major subgroups of IIM, including juvenile IIM. They generally perform better than existing criteria. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 27, 2017 Category: Rheumatology Authors: Ingrid E. Lundberg, Anna Tj ärnlund, Matteo Bottai, Victoria P. Werth, Clarissa Pilkington, Marianne Visser, Lars Alfredsson, Anthony A. Amato, Richard J. Barohn, Matthew H. Liang, Jasvinder A. Singh, Rohit Aggarwal, Snjolaug Arnardottir, Hector Chinoy, Tags: Special Article Source Type: research
ACR Announcements
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 27, 2017 Category: Rheumatology Tags: ACR Announcements Source Type: research
Reply
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 27, 2017 Category: Rheumatology Authors: Ken Yoshida, Kentaro Noda, Taro Ukichi, Kazuhiro Furuya, Daitaro Kurosaka Tags: Letters Source Type: research
Muscle ultrasonography is a potential tool for detecting fasciitis in dermatomyositis and polymyositis: comment on the article by Yoshida et al
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 27, 2017 Category: Rheumatology Authors: Kavish J. Bhansing, Marieke H. Rosmalen, Baziel G. Engelen, Piet L. Riel, Sigrid Pillen, Madelon C. Vonk Tags: Letters Source Type: research
Rituximab therapy and the highly polymorphic Fc region of IgG: comment on the article by Cartin ‐Ceba et al
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 27, 2017 Category: Rheumatology Authors: Janardan P. Pandey Tags: Letters Source Type: research
Error in Optimized Calcium Dosage Shown in Table 2 of the Article by Buckley et al (Arthritis Rheumatol, August 2017)
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 27, 2017 Category: Rheumatology Tags: Errata Source Type: research
Error in Spelling of Author Name in the Article by Fang et al (Arthritis Rheumatol, August 2016)
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 27, 2017 Category: Rheumatology Tags: Errata Source Type: research
Clinical Images: Ochronotic arthropathy
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 27, 2017 Category: Rheumatology Authors: Kashif Jafri, Lianne S. Gensler, Thomas M. Link Tags: Clinical Images Source Type: research
Safety and Efficacy of Intravenous Golimumab in Patients With Active Psoriatic Arthritis
ConclusionPatients receiving IV golimumab at 2 mg/kg had significantly greater improvements in the signs and symptoms of PsA and less radiographic progression through week 24. AEs were consistent with those seen with other anti–tumor necrosis factor agents. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 27, 2017 Category: Rheumatology Authors: Arthur Kavanaugh, M. Elaine Husni, Diane D. Harrison, Lilianne Kim, Kim Hung Lo, Jocelyn H. Leu, Elizabeth C. Hsia Tags: Original Article Source Type: research
Co ‐Occurrence and Characteristics of Patients With Axial Spondyloarthritis Who Meet Criteria for Fibromyalgia
ConclusionDeveloping management approaches that would address the significant unmet clinical needs of the 1 in 5 patients with axial SpA who meet criteria for FM should be a research priority. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 27, 2017 Category: Rheumatology Authors: Gary J. Macfarlane, Maxwell S. Barnish, Ejaz Pathan, Kathryn R. Martin, Kirstie L. Haywood, Stefan Siebert, Jonathan Packham, Fabiola Atzeni, Gareth T. Jones Tags: Original Article Source Type: research
Therapeutic Modulation of Plasmacytoid Dendritic Cells in Experimental Arthritis
ConclusionThe therapeutic effects of imiquimod on joint inflammation and bone destruction are dependent on TLR‐7 sensing by PDCs and type I IFN signaling. Our findings indicate that local recruitment and activation of PDCs represents an attractive therapeutic opportunity for RA patients. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 27, 2017 Category: Rheumatology Authors: Ramzi Nehmar, Ghada Alsaleh, Benjamin Voisin, Vincent Flacher, Alexandre Mariotte, Victoria Saferding, Antonia Puchner, Birgit Niederreiter, Thierry Vandamme, Gernot Schabbauer, Philippe Kastner, Susan Chan, Peggy Kirstetter, Martin Holcmann, Christopher Tags: Original Article Source Type: research
Synovial Immunophenotype and Anti –Citrullinated Peptide Antibodies in Rheumatoid Arthritis Patients
ConclusionThe results of this prospective study demonstrate that the levels of synovial B cell infiltrates and lymphoid aggregates were significantly higher in ACPA+ RA patients, especially those who were naive to treatment. In addition, ACPA+ subjects developed more erosions during progression of the disease and had higher serum levels of CXCL13. The EULAR response to therapy in ACPA+ RA patients was associated with increased levels of T cell and macrophage markers. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 27, 2017 Category: Rheumatology Authors: Carl Orr, Aurelie Najm, Monika Biniecka, Trudy McGarry, Chin ‐Teck Ng, Francis Young, Ursula Fearon, Douglas J. Veale Tags: Original Article Source Type: research
Clinical Connections
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - October 27, 2017 Category: Rheumatology Tags: Clinical Connections Source Type: research
