No Effects of Teriparatide on Joint Erosions in Rheumatoid Arthritis: An expected result
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 28, 2017 Category: Rheumatology Authors: Giovanni Adami, Maurizio Rossini, Ombretta Viapiana, Angelo Fassio, Luca Idolazzi, Giovanni Orsolini, Davide Gatti Tags: Letter to the Editor Source Type: research
Reply
This study demonstrated that the bone formation achieved with PTH was additive to the anti‐resorptive effects of the anti‐TNF agent. Thus, PTH might have the potential to repair erosions in patients with RA whose inflammation is well controlled by an anti‐TNF agent.
This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 28, 2017 Category: Rheumatology Authors: Ellen M. Gravallese, Jonathan Kay, Jeffrey Duryea, Daniel H. Solomon Tags: Reply to Letter to the Editor Source Type: research
Inflammatory cytokines stabilize SOXC transcription factors to mediate the transformation of fibroblast ‐like synoviocytes in arthritic disease
ConclusionSOXC proteins are targets and pivotal mediators of pro‐inflammatory cytokines during FLS transformation in arthritic diseases. Their targeting could thus improve current strategies to treat these and possibly other inflammatory diseases.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 28, 2017 Category: Rheumatology Authors: Pallavi Bhattaram, George Muschler, Viktor Wixler, V éronique Lefebvre Tags: Full Length Source Type: research
GRAPPA ‐OMERACT consensus‐based recommendations and research agenda for use of composite measures and treatment targets in PsA
ConclusionsConsensus was not reached on a continuous measure of disease activity. In the interim the group recommends several composites. Consensus was reached on a treatment target of VLDA/MDA. An extensive research agenda was composed and recommends that data on all PsA clinical domains be collected in ongoing studies.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 28, 2017 Category: Rheumatology Authors: Laura C Coates, Oliver FitzGerald, Joseph F. Merola, Josef Smolen, Leonieke J. J. van Mens, Heidi Bertheussen, Wolf ‐Henning Boehncke, Kristina Callis Duffin, Willemina Campbell, Maarten de Wit, Dafna Gladman, Alice Gottlieb, Jana James, Arthur Kavanaug Tags: Full Length Source Type: research
Sex Differences in Healthcare Utilization, End ‐stage Renal Disease and Mortality among Medicaid Beneficiaries with Incident Lupus Nephritis
ConclusionIn this incident LN cohort, ESRD and mortality were extremely high overall, but not increased among males compared to females. In this vulnerable population, biologic and healthcare utilization differences by sex may not significantly affect outcomes.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 28, 2017 Category: Rheumatology Authors: Candace H. Feldman, Anna Broder, Hongshu Guan, Jinoos Yazdany, Karen H. Costenbader Tags: Full Length Source Type: research
Defective regulation of autoreactive IL ‐6‐producing transitional B lymphocytes is associated with disease in patients with systemic sclerosis
ConclusionThe study provides new insights into mechanisms underlying defective B lymphocyte responses in patients with SSc and their contribution to pathology.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 28, 2017 Category: Rheumatology Authors: Taher E Taher, Voon H Ong, Jonas Bystrom, Sophie Hillion, Quentin Simon, Christopher P Denton, Jacques ‐Olivier Pers, David J Abraham, Rizgar A Mageed Tags: Full Length Source Type: research
CD4+ and B lymphocyte expression quantitative traits at rheumatoid arthritis risk loci in untreated early arthritis: implications for causal gene identification
ConclusionOur findings further refine understanding of candidate causal genes in RA pathogenesis, providing an important platform from which downstream functional studies may be prioritised and directed towards particular cell types.This article is protected by copyright. All rights reserved. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 28, 2017 Category: Rheumatology Authors: Nishanthi Thalayasingam, Nisha Nair, Andrew J Skelton, Jonathan Massey, Amy E Anderson, Alexander D Clark, Julie Diboll, Dennis W Lendrem, Louise N Reynard, Heather J Cordell, Stephen Eyre, John D Isaacs, Anne Barton, Arthur G Pratt Tags: Full Length Source Type: research
ACR Announcements
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 28, 2017 Category: Rheumatology Tags: ACR Announcements Source Type: research
Contents, Volume 69, 2017
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 28, 2017 Category: Rheumatology Tags: Contents, Volume 69, 2017 Source Type: research
Reviewers
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 28, 2017 Category: Rheumatology Authors: Richard J. Bucala Tags: Reviewers Source Type: research
Systemic inflammation and endothelial dysfunction —a possible link between osteoarthritis and hypertension: comment on the article by Niu et al
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 28, 2017 Category: Rheumatology Authors: Jos é Mario Sabio Tags: Letters Source Type: research
Effects of Febuxostat in Early Gout
ConclusionUrate‐lowering therapy with febuxostat improved magnetic resonance imaging–determined synovitis and reduced the incidence of gout flares in subjects with early gout. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 28, 2017 Category: Rheumatology Authors: Nicola Dalbeth, Kenneth G. Saag, William E. Palmer, Hyon K. Choi, Barbara Hunt, Patricia A. MacDonald, Ulrich Thienel, Lhanoo Gunawardhana Tags: Original Article Source Type: research
Efficacy and Safety of Selexipag in Adults With Raynaud's Phenomenon Secondary to Systemic Sclerosis
ConclusionTreatment with selexipag did not reduce the number of RP attacks compared with placebo. The safety profile of selexipag was similar to that previously reported. This study provides important information about the feasibility of eDiary reporting of RP attacks in clinical trials. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 28, 2017 Category: Rheumatology Authors: Christopher P. Denton, Éric Hachulla, Gabriela Riemekasten, Andreas Schwarting, Jean‐Marie Frenoux, Aline Frey, Franck‐Olivier Le Brun, Ariane L. Herrick, Tags: Original Article Source Type: research
Association of the Presence of Anti –Carbamylated Protein Antibodies in Early Arthritis With a Poorer Clinical and Radiologic Outcome
ConclusionOur findings indicate that anti‐CarP antibodies are present in one‐third of patients with early arthritis and in one‐fourth of the RF‐negative and ACPA‐negative patients. They are particularly associated with a more severe radiographic outcome. Anti‐CarP antibody positivity may help to accurately identify those at risk of erosive evolution in an early arthritis population. (Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 28, 2017 Category: Rheumatology Authors: Marie ‐Elise Truchetet, Stéphanie Dublanc, Thomas Barnetche, Olivier Vittecoq, Xavier Mariette, Christophe Richez, Patrick Blanco, Michael Mahler, Cécile Contin‐Bordes, Thierry Schaeverbeke, Tags: Original Article Source Type: research
Editorial: Anti –Citrullinated Protein Antibody, Anti–Carbamylated Protein Antibody, and Rheumatoid Arthritis: Azurophilic Granules Sing the Blues
(Source: Arthritis and Rheumatism)
Source: Arthritis and Rheumatism - November 28, 2017 Category: Rheumatology Authors: William F. C. Rigby, Sladjana Skopelja ‐Gardner, Jonathan D. Jones Tags: Editorial Source Type: research
